Cognitive dysfunction precedes neuropathology and motor abnormalities in the YAC128 mouse model of Huntington's disease

Journal of Neuroscience

Volumn 25, Issue 16, 2005, Pages 4169-4180

  Van Raamsdonk, Jeremy M ^a,b   Pearson, Jacqueline ^a,b   Slow, Elizabeth J ^a,b   Hossain, Sazzad M ^a,b   Leavitt, Blair R ^a,b   Hayden, Michael R ^a,b  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b British Columbia Research Institute   (Canada)

Author keywords

Behavior; Cognition; Huntington's disease; Learning; Memory; Mouse model

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUDITORY THRESHOLD; COGNITIVE DEFECT; CONTROLLED STUDY; DISEASE COURSE; HABITUATION; HUNTINGTON CHOREA; LEARNING DISORDER; MAZE TEST; MODEL; MOTOR DYSFUNCTION; MOUSE; NEUROPATHOLOGY; NONHUMAN; OPEN FIELD BEHAVIOR; PREPULSE INHIBITION; PRIORITY JOURNAL; ROTAROD TEST; SWIMMING; WILD TYPE;

ACOUSTIC STIMULATION; AGE FACTORS; ANALYSIS OF VARIANCE; ANIMALS; BEHAVIOR, ANIMAL; COGNITION DISORDERS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, RADIATION; EXPLORATORY BEHAVIOR; HABITUATION, PSYCHOPHYSIOLOGIC; HUNTINGTON DISEASE; INHIBITION (PSYCHOLOGY); MAZE LEARNING; MEMORY; MICE; MOTOR ACTIVITY; MOVEMENT DISORDERS; PSYCHOMOTOR PERFORMANCE; REFLEX, ACOUSTIC; ROTAROD PERFORMANCE TEST; SWIMMING; TIME FACTORS;

EID: 17644368893     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.0590-05.2005     Document Type: Article

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