(-)-Epigallocatechin-3-gallate alleviates spatial memory impairment in APP/PS1 mice by restoring IRS-1 signaling defects in the hippocampus

Molecular and Cellular Biochemistry

Volumn 380, Issue 1-2, 2013, Pages 211-218

  Jia, Ning ^a   Han, Kun ^b   Kong, Jing Jing ^c   Zhang, Xiu Mei ^b   Sha, Sha ^a   Ren, Gui Ru ^a   Cao, Yun Peng ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

^b JINZHOU MEDICAL UNIVERSITY   (China)

^c DALIAN MEDICAL UNIVERSITY   (China)

Author keywords

Alzheimer's disease; APP PS1 mice; EGCG; Insulin receptor substrate 1; JNK

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; EPIGALLOCATECHIN GALLATE; GLYCOGEN SYNTHASE KINASE 3BETA; INSULIN RECEPTOR SUBSTRATE 1; PROTEIN KINASE B; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME PHOSPHORYLATION; FEMALE; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; INSULIN RESISTANCE; LEARNING DISORDER; MAZE TEST; MEMORY DISORDER; MOUSE; NONHUMAN; SIGNAL TRANSDUCTION; SPATIAL MEMORY; TRANSGENIC MOUSE; TREATMENT DURATION; WESTERN BLOTTING;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; BLOTTING, WESTERN; CATECHIN; DISEASE MODELS, ANIMAL; FEMALE; GLYCOGEN SYNTHASE KINASE 3; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; INSULIN RECEPTOR SUBSTRATE PROTEINS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAZE LEARNING; MEMORY DISORDERS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; PEPTIDE FRAGMENTS; PHOSPHORYLATION; PRESENILIN-1; PROTO-ONCOGENE PROTEINS C-AKT; SERINE; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

MUS;

EID: 84879795488     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-013-1675-x     Document Type: Article

References (20)

1. Chiu SL, Chen CM, Cline HT (2008) Insulin receptor signaling regulates synapse number, dendritic plasticity, and circuit function in vivo. Neuron 58:708-719
2. Bosco D, Plastino M, Cristiano D, Colica C, Ermio C, De Bartolo M, Mungari P, Fonte G, Consoli D, Consoli A, Fava A (2012) Dementia is associated with insulin resistance in patients with Parkinson's disease. J Neurol Sci 315:39-43
3. de la Monte SM (2012) Brain insulin resistance and deficiency as therapeutic targets in Alzheimer's disease. Curr Alzheimer Res 9:35-66
4. Hirosumi J, Tuncman G, Chang L et al (2002) A central role for JNK in obesity and insulin resistance. Nature 420:333-336
5. Bomfim TR, Forny-Germano L, Sathler LB et al (2012) An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease-associated Aβ oligomers. J Clin Invest 122:1339-1353
6. Yamato M, Shiba T, Ide T, Seri N, Kudo W, Ando M, Yamada K, Kinugawa S, Tsutsui H (2012) High-fat diet-induced obesity and insulin resistance were ameliorated via enhanced fecal bile acid excretion in tumor necrosis factor-alpha receptor knockout mice. Mol Cell Biochem 359:161-167
7. Balasubramanyam M, Aravind S, Gokulakrishnan K, Prabu P, Sathishkumar C, Ranjani H, Mohan V (2011) Impaired miR-146a expression links subclinical inflammation and insulin resistance in Type 2 diabetes. Mol Cell Biochem 351:197-205
8. Gual P, Le Marchand-Brustel Y, Tanti JF (2005) Positive and negative regulation of insulin signaling through IRS-1 phosphorylation. Biochimie 87:99-109
9. Li Y, Zhao S, Zhang W et al (2011) Epigallocatechin-3-O-gallate (EGCG) attenuates FFAs-induced peripheral insulin resistance through AMPK pathway and insulin signaling pathway in vivo. Diabetes Res Clin Pract 93:205-214
10. Deng YT, Chang TW, Lee MS, Lin JK (2012) Suppression of free fatty acid-induced insulin resistance by phytopolyphenols in C2C12 mouse skeletal muscle cells. J Agric Food Chem 60:1059-1066
11. Kim B, Feldman EL (2012) Insulin resistance in the nervous system. Trends Endocrinol Metab 23:133-141
12. Engel T, Lucas JJ, Hernández F, Avila J (2007) A mouse model to study tau pathology related with tau phosphorylation and assembly. J Neurol Sci 257:250-254
13. Koyama Y, Abe K, Sano Y et al (2004) Effects of green tea on gene expression of hepatic gluconeogenic enzymes in vivo. Planta Med 70:1100-1102
14. Rezai-Zadeh K, Shytle D, Sun N et al (2005) Green tea epigallocatechin-3-gallate (EGCG) modulates amyloid precursor protein cleavage and reduces cerebral amyloidosis in Alzheimer transgenic mice. J Neurosci 25:8807-8814
15. Gokulakrisnan A, Jayachandran Dare B, Thirunavukkarasu C (2011) Attenuation of the cardiac inflammatory changes and lipid anomalies by (-)-epigallocatechin-gallate in cigarette smoke-exposed rats. Mol Cell Biochem 354:1-10
16. Shankar S, Marsh L, Srivastava RK (2013) EGCG inhibits growth of human pancreatic tumors orthotopically implanted in Balb C nude mice through modulation of FKHRL1/FOXO3a and neuropilin. Mol Cell Biochem 372:83-94
17. Rezai-Zadeh K, Arendash GW, Hou H et al (2008) Green tea epigallocatechin-3-gallate (EGCG) reduces beta-amyloid mediated cognitive impairment and modulates tau pathology in Alzheimer transgenic mice. Brain Res 1214:177-187
18. Lee JW, Lee YK, Ban JO et al (2009) Green tea (-)-epigallocatechin-3- gallate inhibits beta-amyloid-induced cognitive dysfunction through modification of secretase activity via inhibition of ERK and NF-kappaB pathways in mice. J Nutr 139:1987-1993
19. Haass C, Selkoe DJ (2007) Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide. Nat Rev Mol Cell Biol 8:101-112
20. Talbot K, Wang HY, Kazi H et al (2012) Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline. J Clin Invest 122:1316-1338