A functional role for adult hippocampal neurogenesis in spatial pattern separation

Science

Volumn 325, Issue 5937, 2009, Pages 210-213

  Clelland, C D ^a,b   Choi, M ^b   Romberg, C ^c   Clemenson Jr , G D ^a   Fragniere, A ^b   Tyers, P ^b   Jessberger, S ^d   Saksida, L M ^c,e   Barker, R A ^b,f   Gage, F H ^a   Bussey, T J ^c,e  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c UK   (United Kingdom)

^d ETH ZURICH   (Switzerland)

^e UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^f ADDENBROOKE S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

LENTIVIRUS VECTOR; WNT PROTEIN;

ADULT; BRAIN; NEUROLOGY; RODENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARM; ARTICLE; CONTROLLED STUDY; DENTATE GYRUS; FEMALE; HIPPOCAMPUS; KNOCKOUT GENE; LOW ENERGY RADIATION; MAZE TEST; MOUSE; NERVE CELL; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PRIORITY JOURNAL; SPATIAL DISCRIMINATION; SPATIAL MEMORY; STIMULATION; TASK PERFORMANCE; VISUAL DISCRIMINATION;

ANIMALS; CUES; DENTATE GYRUS; DISCRIMINATION LEARNING; FEMALE; HIPPOCAMPUS; MAZE LEARNING; MEMORY; MICE; MICE, INBRED C57BL; NEUROGENESIS; NEURONS; PSYCHOMOTOR PERFORMANCE; SPACE PERCEPTION;

MAMMALIA; MUS;

EID: 67650450542     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1173215     Document Type: Article

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32. We thank M. J. Armstrong and J. B. Aimone for useful input and discussions, M. L. Gage for editorial comments, and J. Simon for assistance with figures. This work was funded in part by James S. McDonnell, Lookout, and Mather's Foundations; the Kavli Institute for Brain and Mind; and NIH (grant NS-050217) (F.H.G.), and also by the NIHR Biomedical Research Centre Award to the University of Cambridge and generous donations from patients and families to the Huntington's and Parkinson's Disease Research Clinics at the Brain Repair Centre, University of Cambridge (R.A.B.). This work was also supported in part by MaxNetAging and NCCR Neural Plasticity and Repair Grants (S.J.) and Marshall's and Jack Kent Cooke Foundation scholarships (C.D.C.).