Pleiotropic protective effects of phytochemicals in Alzheimer's disease

Oxidative Medicine and Cellular Longevity

Volumn , Issue , 2012, Pages

  Davinelli, Sergio ^a   Sapere, Nadia ^a   Zella, Davide ^b   Bracale, Renata ^a   Intrieri, Mariano ^a   Scapagnini, Giovanni ^a  

^a UNIVERSITY OF MOLISE   (Italy)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER'S DISEASE; ANTI-INFLAMMATORY MECHANISM; ANTIOXIDANT ACTIVITIES; CURCUMIN; DRUG CANDIDATES; MOLECULAR EVENTS; MOLECULAR TARGETS; MULTIPLE LEVELS; NEURODEGENERATIVE DISORDERS; NEUROPROTECTIVE AGENTS; PHYTOCHEMICALS; POLYPHENOLS; PROTECTIVE EFFECTS; RESVERATROL; THERAPEUTIC AGENTS; THERAPEUTIC VALUES;

PHENOLS;

NEURODEGENERATIVE DISEASES;

AMYLOID PRECURSOR PROTEIN; CATALASE; CURCUMIN; EPIGALLOCATECHIN GALLATE; GLUTATHIONE PEROXIDASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; KELCH LIKE ECH ASSOCIATED PROTEIN 1; LONGVIDA; MALONALDEHYDE; NITRIC OXIDE; PLANT MEDICINAL PRODUCT; PROTEIN KINASE C; REACTIVE OXYGEN METABOLITE; RESVERATROL; STAT3 PROTEIN; SUPEROXIDE DISMUTASE; SYNUCLEIN; TRANSCRIPTION FACTOR NRF2; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; CATECHIN; DRUG DERIVATIVE; NEUROPROTECTIVE AGENT; POLYPHENOL; STILBENE DERIVATIVE;

ALZHEIMER DISEASE; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; BRAIN NERVE CELL; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG STRUCTURE; DRUG TARGETING; HIPPOCAMPUS; HUMAN; LIPID PEROXIDATION; MITOCHONDRION; NERVE DEGENERATION; NEUROFIBRILLARY TANGLE; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PATHOGENESIS; PLEIOTROPY; REVIEW; SENILE PLAQUE; SIGNAL TRANSDUCTION; CHEMISTRY; METABOLISM;

ALZHEIMER DISEASE; CATECHIN; CURCUMIN; HUMANS; NEUROPROTECTIVE AGENTS; NF-E2-RELATED FACTOR 2; POLYPHENOLS; STILBENES;

EID: 84862297718     PISSN: 19420900     EISSN: 19420994     Source Type: Journal    
DOI: 10.1155/2012/386527     Document Type: Review

References (115)

1. Butterfield D. A., Griffin S., Munch G., Pasinetti G. M., Amyloid -peptide and amyloid pathology are central to the oxidative stress and inflammatory cascades under which Alzheimer's disease brain exists Journal of Alzheimer's Disease 2002 4 3 193 201 (Pubitemid 35006051)
2. Heneka M. T., O'Banion M. K., Inflammatory processes in Alzheimer's disease Journal of Neuroimmunology 2007 184 1-2 69 91 (Pubitemid 46365992)
3. Wollen K. A., Alzheimer's disease: the pros and cons of pharmaceutical, nutritional, botanical, and stimulatory therapies, with a discussion of treatment strategies from the perspective of patients and practitioners Alternative Medicine Review 2010 15 3 223 244
4. Williams R., Biomarkers: warning signs Nature 2011 475 7355 S5 S7
5. Singh M., Arseneault M., Sanderson T., Murthy V., Ramassamy C., Challenges for research on polyphenols from foods in Alzheimer's disease: bioavailability, metabolism, and cellular and molecular mechanisms Journal of Agricultural and Food Chemistry 2008 56 13 4855 4873 (Pubitemid 352039080)
6. Le Bars P. L., Katz M. M., Berman N., Itil T. M., Freedman A. M., Schatzberg A. F., A placebo-controlled, double-blind, randomized trial of an extract of Ginkgo biloba for dementia Journal of the American Medical Association 1997 278 16 1327 1332 (Pubitemid 27449692)
7. Ammon H. P., Wahl M. A., Pharmacology of Curcuma longa Planta Medica 1991 57 1 1 7
8. Payton F., Sandusky P., Alworth W. L., NMR study of the solution structure of curcumin Journal of Natural Products 2007 70 2 143 146 (Pubitemid 46447622)
9. Das K. C., Das C. K., Curcumin (diferuloylmethane), a singlet oxygen 1 O 2 quencher Biochemical and Biophysical Research Communications 2002 295 1 62 66 (Pubitemid 34743775)
10. Ramsewak R. S., DeWitt D. L., Nair M. G., Cytotoxicity, antioxidant and anti-inflammatory activities of curcumins IIII from Curcuma longa Phytomedicine 2000 7 4 303 308 (Pubitemid 30618495)
11. Ono K., Hasegawa K., Naiki H., Yamada M., Curcumin has potent anti-amyloidogenic effects for Alzheimer's -amyloid fibrils in vitro Journal of Neuroscience Research 2004 75 6 742 750 (Pubitemid 38296087)
12. Scapagnini G., Vasto S., Abraham N. G., Caruso C., Zella D., Galvano F., Modulation of nrf2/are pathway by food polyphenols: a nutritional neuroprotective strategy for cognitive and neurodegenerative disorders Molecular Neurobiology 2011 44 2 202
13. Sreejayan A., Rao M. N., Nitric oxide scavenging by curcuminoids Journal of Pharmacy and Pharmacology 1997 49 1 105 107 (Pubitemid 27051040)
14. Tnnesen H. H., Msson M., Loftsson T., Studies of curcumin and curcuminoids. XXVII. Cyclodextrin complexation: solubility, chemical and photochemical stability International Journal of Pharmaceutics 2002 244 1-2 127 135 (Pubitemid 35245453)
15. Sharma R. A., Gescher A. J., Steward W. P., Curcumin: the story so far European Journal of Cancer 2005 41 13 1955 1968 (Pubitemid 41557681)
16. Itokawa H., Shi Q., Akiyama T., Morris-Natschke S. L., Lee K. H., Recent advances in the investigation of curcuminoids Chinese Medicine 2008 3, article 11
17. Motterlini R., Foresti R., Bassi R., Green C. J., Curcumin, an antioxidant and anti-inflammatory agent, induces heme oxygenase-1 and protects endothelial cells against oxidative stress Free Radical Biology and Medicine 2000 28 8 1303 1312 (Pubitemid 30417475)
18. Chen W. F., Deng S. L., Zhou B., Yang L., Liu Z. L., Curcumin and its analogues as potent inhibitors of low density lipoprotein oxidation: H-atom abstraction from the phenolic groups and possible involvement of the 4-hydroxy-3-methoxyphenyl groups Free Radical Biology and Medicine 2011 50 3 484
19. Barzegar A., Moosavi-Movahedi A. A., Intracellular ROS protection efficiency and free radical-scavenging activity of curcumin PLoS ONE 2011 6 10
20. Lim G. P., Chu T., Yang F., Beech W., Frautschy S. A., Cole G. M., The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse Journal of Neuroscience 2001 21 21 8370 8377 (Pubitemid 33051435)
21. Adams B. K., Cai J., Armstrong J., Herold M., Lu Y. J., Sun A., Snyder J. P., Liotta D. C., Jones D. P., Shoji M., EF24, a novel synthetic curcumin analog, induces apoptosis in cancer cells via a redox-dependent mechanism Anti-Cancer Drugs 2005 16 3 263 275 (Pubitemid 40283941)
22. Gu M., Owen A. D., Toffa S. E. K., Cooper J. M., Dexter D. T., Jenner P., Marsden C. D., Schapira A. H. V., Mitochondrial function, GSH and iron in neurodegeneration and Lewy body diseases Journal of the Neurological Sciences 1998 158 1 24 29 (Pubitemid 28277530)
23. Liu H., Harrell L. E., Shenvi S., Hagen T., Liu R. M., Gender differences in glutathione metabolism in Alzheimer's disease Journal of Neuroscience Research 2005 79 6 861 867 (Pubitemid 40476510)
24. Dickinson D. A., Iles K. E., Zhang H., Blank V., Forman H. J., Curcumin alters EpRE and AP-1 binding complexes and elevates glutamate-cysteine ligase gene expression FASEB Journal 2003 17 3 473 475
25. Rajeswari A., Curcumin protects mouse brain from oxidative stress caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydro pyridine European Review for Medical and Pharmacological Sciences 2006 10 4 157 161 (Pubitemid 44468939)
26. Zhang Y. J., Xu Y. F., Liu Y. H., Yin J., Li H. A., Wang Q., Wang J. Z., Peroxynitrite induces Alzheimer-like tau modifications and accumulation in rat brain and its underlying mechanisms FASEB Journal 2006 20 9 1431 1442 (Pubitemid 44943851)
27. Iwunze M. O., McEwan D., Peroxynitrite interaction with curcumin solubilized in ethanolic solution Cellular and Molecular Biology 2004 50 6 749 752
28. Smith D. G., Cappai R., Barnham K. J., The redox chemistry of the Alzheimer's disease amyloid peptide Biochimica et Biophysica Acta 2007 1768 8 1976 1990 (Pubitemid 47125850)
29. Parker W. D. Jr., Parks J., Filley C. M., Kleinschmidt-DeMasters B. K., Electron transport chain defects in Alzheimer's disease brain Neurology 1994 44 6 1090 1096 (Pubitemid 24188184)
30. Mutisya E. M., Bowling A. C., Beal M. F., Cortical cytochrome oxidase activity is reduced in Alzheimer's disease Journal of Neurochemistry 1994 63 6 2179 2184 (Pubitemid 24369993)
31. Atamna H., Boyle K., Amyloid- peptide binds with heme to form a peroxidase: relationship to the cytopathologies of Alzheimer's disease Proceedings of the National Academy of Sciences of the United States of America 2006 103 9 3381 3386 (Pubitemid 43346478)
32. Seo J. S., Leem Y. H., Lee K. W., Kim S. W., Lee J. K., Han P. L., Severe motor neuron degeneration in the spinal cord of the Tg2576 mouse model of Alzheimer disease Journal of Alzheimer's Disease 2010 21 1 263 276
33. Zhu Y. G., Chen X. C., Chen Z. Z., Zeng Y. Q., Shi G. B., Su Y. H., Peng X., Curcumin protects mitochondria from oxidative damage and attenuates apoptosis in cortical neurons Acta Pharmacologica Sinica 2004 25 12 1606 1612 (Pubitemid 39628027)
34. Raza H., John A., Brown E. M., Benedict S., Kambal A., Alterations in mitochondrial respiratory functions, redox metabolism and apoptosis by oxidant 4-hydroxynonenal and antioxidants curcumin and melatonin in PC12 cells Toxicology and Applied Pharmacology 2008 226 2 161 168
35. Baum L., Ng A., Curcumin interaction with copper and iron suggests one possible mechanism of action in Alzheimer's disease animal models Journal of Alzheimer's Disease 2004 6 4 367 377 (Pubitemid 39287248)
36. Jiao Y. IV, Wilkinson J., Christine Pietsch E., Buss J. L., Wang W., Planalp R., Torti F. M., Torti S. V., Iron chelation in the biological activity of curcumin Free Radical Biology and Medicine 2006 40 7 1152 1160
37. Bush A. I., Pettingell W. H., Multhaup G., Paradis D. M., Vonsattel J. P., Gusella J. F., Beyreuther K., Masters C. L., Tanzi R. E., Rapid induction of Alzheimer A amyloid formation by zinc Science 1994 265 5177 1464 1467 (Pubitemid 24306803)
38. Stoltenberg M., Bush A. I., Bach G., Smidt K., Larsen A., Rungby J., Lund S., Doering P., Danscher G., Amyloid plaques arise from zinc-enriched cortical layers in APP/PS1 transgenic mice and are paradoxically enlarged with dietary zinc deficiency Neuroscience 2007 150 2 357 369 (Pubitemid 350198720)
39. Davinelli S., Intrieri M., Russo C., Di Costanzo A., Zella D., Bosco P., Scapagnini G., The Alzheimer's disease signature: potential perspectives for novel biomarkers Immunity and Ageing 2011 8 7
40. Jin C. Y., Lee J. D., Park C., Choi Y. H., Kim G. Y., Curcumin attenuates the release of pro-inflammatory cytokines in lipopolysaccharide-stimulated BV2 microglia Acta Pharmacologica Sinica 2007 28 10 1645 1651 (Pubitemid 47493297)
41. Bharti A. C., Donato N., Aggarwal B. B., Curcumin (diferuloylmethane) inhibits constitutive and IL-6-inducible STAT3 phosphorylation in human multiple myeloma cells Journal of Immunology 2003 171 7 3863 3871 (Pubitemid 37254592)
42. Bierhaus A., Zhang Y., Quehenberger P., Luther T., Haase M., Mller M., Mackman N., Ziegler R., Nawroth P. P., The dietary pigment curcumin reduces endothelial tissue factor gene expression by inhibiting binding of AP-1 to the DNA and activation of NF- B Thrombosis and Haemostasis 1997 77 4 772 782 (Pubitemid 27182979)
43. Xu Y. X., Pindolia K. R., Janakiraman N., Chapman R. A., Gautam S. C., Curcumin inhibits IL1 and TNF induction of AP-1 and NF-kB DNA-binding activity in bone marrow stromal cells Hematopathology and Molecular Hematology 1997-1998 11 1 49 62
44. Kang G., Kong P. J., Yuh Y. J., Lim S. Y., Yim S. V., Chun W., Kim S. S., Curcumin suppresses lipopolysaccharide-induced cyclooxygenase-2 expression by inhibiting activator protein 1 and nuclear factor B bindings in BV2 microglial cells Journal of Pharmacological Sciences 2004 94 3 325 328 (Pubitemid 38470742)
45. Brouet I., Ohshima H., Curcumin, an anti-tumour promoter and anti-inflammatory agent, inhibits induction of nitric oxide synthase in activated macrophages Biochemical and Biophysical Research Communications 1995 206 2 533 540
46. Nanji A. A., Jokelainen K., Tipoe G. L., Rahemtulla A., Thomas P., Dannenberg A. J., Curcumin prevents alcohol-induced liver disease in rats by inhibiting the expression of NF- B-dependent genes American Journal of Physiology 2003 284 2 321 327
47. Rahman I., Marwick J., Kirkham P., Redox modulation of chromatin remodeling: impact on histone acetylation and deacetylation, NF- B and pro-inflammatory gene expression Biochemical Pharmacology 2004 68 6 1255 1267 (Pubitemid 39094292)
48. Bengmark S., Curcumin, an atoxic antioxidant and natural NF B, cyclooxygenase-2, lipooxygenase, and inducible nitric oxide synthase inhibitor: a shield against acute and chronic diseases Journal of Parenteral and Enteral Nutrition 2006 30 1 45 51 (Pubitemid 43102234)
49. Hae S. L., Jung K. K., Cho J. Y., Rhee M. H., Hong S., Kwon M., Kim S. H., Kang S. Y., Neuroprotective effect of curcumin is mainly mediated by blockade of microglial cell activation Pharmazie 2007 62 12 937 942
50. Cole G. M., Teter B., Frautschy S. A., Neuroprotective effects of curcumin Advances in Experimental Medicine and Biology 2007 595 197 212
51. Garcia-Alloza M., Borrelli L. A., Rozkalne A., Hyman B. T., Bacskai B. J., Curcumin labels amyloid pathology in vivo, disrupts existing plaques, and partially restores distorted neurites in an Alzheimer mouse model Journal of Neurochemistry 2007 102 4 1095 1104 (Pubitemid 47174225)
52. Frautschy S. A., Hu W., Kim P., Miller S. A., Chu T., Harris-White M. E., Cole G. M., Phenolic anti-inflammatory antioxidant reversal of A -induced cognitive deficits and neuropathology Neurobiology of Aging 2001 22 6 993 1005 (Pubitemid 34070638)
53. Ohtsuka K., Suzuki T., Roles of molecular chaperones in the nervous system Brain Research Bulletin 2000 53 2 141 146
54. Yanagisawa D., Shirai N., Amatsubo T., Taguchi H., Hirao K., Urushitani M., Morikawa S., Inubushi T., Kato M., Kato F., Morino K., Kimura H., Nakano I., Yoshida C., Okada T., Sano M., Wada Y., Wada K. N., Yamamoto A., Tooyama I., Relationship between the tautomeric structures of curcumin derivatives and their A -binding activities in the context of therapies for Alzheimer's disease Biomaterials 2010 31 14 4179 4185
55. Dadhaniya P., Patel C., Muchhara J., Bhadja N., Mathuria N., Vachhani K., Soni M. G., Safety assessment of a solid lipid curcumin particle preparation: acute and subchronic toxicity studies Food and Chemical Toxicology 2011 49 8 1834 1842
56. Weinreb O., Amit T., Youdim M. B. H., The application of proteomics for studying the neurorescue activity of the polyphenol (-) -epigallocatechin-3- gallate Archives of Biochemistry and Biophysics 2008 476 2 152 160
57. Faria A., Pestana D., Teixeira D., Couraud P. O., Romero I., Weksler B., De Freitas V., Mateus N., Calhau C., Insights into the putative catechin and epicatechin transport across blood-brain barrier Food and Function 2011 2 1 39 44
58. Lin L. C., Wang M. N., Tseng T. Y., Sung J. S., Tsai T. H., Pharmacokinetics of (-) -epigallocatechin-3-gallate in conscious and freely moving rats and its brain regional distribution Journal of Agricultural and Food Chemistry 2007 55 4 1517 1524
59. Yin S. T., Tang M. L., Deng H. M., Xing T. R., Chen J. T., Wang H. L., Ruan D. Y., Epigallocatechin-3-gallate induced primary cultures of rat hippocampal neurons death linked to calcium overload and oxidative stress Naunyn-Schmiedeberg's Archives of Pharmacology 2009 379 6 551 564
60. Wang J. H., Cheng J., Li C. R., Ye M., Ma Z., Cai F., Modulation of Ca 2+ signals by epigallocatechin-3-gallate(EGCG) in cultured rat hippocampal neurons International Journal of Molecular Sciences 2011 12 1 742 754
61. Dragicevic N., Smith A., Lin X., Yuan F., Copes N., Delic V., Tan J., Cao C., Shytle R. D., Bradshaw P. C., Green tea epigallocatechin-3-gallate (EGCG) and other flavonoids reduce Alzheimer's amyloid-induced mitochondrial dysfunction Journal Alzheimer Disease 2011 26 3 507 521
62. Mandel S., Youdim M. B. H., Catechin polyphenols: neurodegeneration and neuroprotection in neurodegenerative diseases Free Radical Biology and Medicine 2004 37 3 304 317 (Pubitemid 38833997)
63. Lee S. J., Lee K. W., Protective effect of (-) -epigallocatechin gallate against advanced glycation endproducts-induced injury in neuronal cells Biological and Pharmaceutical Bulletin 2007 30 8 1369 1373
64. Kim C. Y., Lee C., Park G. H., Jang J. H., Neuroprotective effect of epigallocatechin-3-gallate against -amyloid-induced oxidative and nitrosative cell death via augmentation of antioxidant defense capacity Archives of Pharmacal Research 2009 32 6 869 881
65. He M., Zhao L., Wei M. J., Yao W. F., Zhao H. S., Chen F. J., Neuroprotective effects of (-) -epigallocatechin-3-gallate on aging mice induced by D-galactose Biological and Pharmaceutical Bulletin 2009 32 1 55 60
66. Lin S. M., Wang S. W., Ho S. C., Tang Y. L., Protective effect of green tea (-) -epigallocatechin-3-gallate against the monoamine oxidase B enzyme activity increase in adult rat brains Nutrition 2010 26 11-12 1195 1200
67. Nagai K., Jiang M. H., Hada J., Nagata T., Yajima Y., Yamamoto S., Nishizaki T., (-) -Epigallocatechin gallate protects against NO stress-induced neuronal damage after ischemia by acting as an anti-oxidant Brain Research 2002 956 2 319 322 (Pubitemid 35351399)
68. Perron N. R., Hodges J. N., Jenkins M., Brumaghim J. L., Predicting how polyphenol antioxidants prevent DNA damage by binding to iron Inorganic Chemistry 2008 47 14 6153 6161
69. Levites Y., Amit T., Mandel S., Youdim M. B. H., Neuroprotection and neurorescue against Abeta toxicity and PKC-dependent release of nonamyloidogenic soluble precursor protein by green tea polyphenol (-) -epigallocatechin-3- gallate FASEB Journal 2003 17 8 952 954
70. Levites Y., Amit T., Youdim M. B. H., Mandel S., Involvement of protein kinase C activation and cell survival/cell cycle genes in green tea polyphenol (-) -epigallocatechin 3-gallate neuroprotective action Journal of Biological Chemistry 2002 277 34 30574 30580 (Pubitemid 34970751)
71. Kim S. J., Jeong H. J., Lee K. M., Myung N. Y., An N. H., Mo Yang W., Kyu Park S., Lee H. J., Hong S. H., Kim H. M., Um J. Y., Epigallocatechin-3-gallate suppresses NF- B activation and phosphorylation of p38 MAPK and JNK in human astrocytoma U373MG cells Journal of Nutritional Biochemistry 2007 18 9 587 596 (Pubitemid 47212709)
72. Spencer J. P. E., Flavonoids: modulators of brain function? British Journal of Nutrition 2008 99 1 ES60 ES77
73. Lee Y. K., Yuk D. Y., Lee J. W., Lee S. Y., Ha T. Y., Oh K. W., Yun Y. P., Hong J. T., (-) -Epigallocatechin-3-gallate prevents lipopolysaccharide- induced elevation of beta-amyloid generation and memory deficiency Brain Research 2009 1250 164 174
74. Rezai-Zadeh K., Shytle D., Sun N., Mori T., Hou H., Jeanniton D., Ehrhart J., Townsend K., Zeng J., Morgan D., Hardy J., Town T., Tan J., Green tea epigallocatechin-3-gallate (EGCG) modulates amyloid precursor protein cleavage and reduces cerebral amyloidosis in Alzheimer transgenic mice Journal of Neuroscience 2005 25 38 8807 8814 (Pubitemid 41362059)
75. Rezai-Zadeh K., Arendash G. W., Hou H., Fernandez F., Jensen M., Runfeldt M., Shytle R. D., Tan J., Green tea epigallocatechin-3-gallate (EGCG) reduces -amyloid mediated cognitive impairment and modulates tau pathology in Alzheimer transgenic mice Brain Research 2008 1214 177 187
76. Ehrnhoefer D. E., Bieschke J., Boeddrich A., Herbst M., Masino L., Lurz R., Engemann S., Pastore A., Wanker E. E., EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers Nature Structural and Molecular Biology 2008 15 6 558 566 (Pubitemid 351799141)
77. Ono K., Yoshiike Y., Takashima A., Hasegawa K., Naiki H., Yamada M., Potent anti-amyloidogenic and fibril-destabilizing effects of polyphenols in vitro: implications for the prevention and therapeutics of Alzheimer's disease Journal of Neurochemistry 2003 87 1 172 181 (Pubitemid 37210651)
78. Jeon S. Y., Bae K., Seong Y. H., Song K. S., Green tea catechins as a BACE1 ( -secretase) inhibitor Bioorganic and Medicinal Chemistry Letters 2003 13 22 3905 3908 (Pubitemid 37338416)
79. Obregon D. F., Rezai-Zadeh K., Bai Y., Sun N., Hou H., Ehrhart J., Zeng J., Mori T., Arendash G. W., Shytle D., Town T., Tan J., ADAM10 activation is required for green tea (-) -epigallocatechin-3-gallate- induced -secretase cleavage of amyloid precursor protein Journal of Biological Chemistry 2006 281 24 16419 16427
80. Lee J. W., Lee Y. K., Ban J. O., Ha T. Y., Yun Y. P., Han S. B., Oh K. W., Hong J. T., Green tea (-) -epigallocatechin-3-gallate inhibits -amyloid-induced cognitive dysfunction through modification of secretase activity via inhibition of ERK and NF- B pathways in mice Journal of Nutrition 2009 139 10 1987 1993
81. Giunta B., Hou H., Zhu Y., Salemi J., Ruscin A., Shytle R. D., Tan J., Fish oil enhances anti-amyloidogenic properties of green tea EGCG in Tg2576 mice Neuroscience Letters 2010 471 3 134 138
82. Li Q., Zhao H. F., Zhang Z. F., Liu Z. G., Pei X. R., Wang J. B., Li Y., Long-term green tea catechin administration prevents spatial learning and memory impairment in senescence-accelerated mouse prone-8 mice by decreasing A 1-42 oligomers and upregulating synaptic plasticity-related proteins in the hippocampus Neuroscience 2009 163 3 741 749
83. Baur J. A., Pearson K. J., Price N. L., Jamieson H. A., Lerin C., Kalra A., Prabhu V. V., Allard J. S., Lopez-Lluch G., Lewis K., Pistell P. J., Poosala S., Becker K. G., Boss O., Gwinn D., Wang M., Ramaswamy S., Fishbein K. W., Spencer R. G., Lakatta E. G., Le Couteur D., Shaw R. J., Navas P., Puigserver P., Ingram D. K., De Cabo R., Sinclair D. A., Resveratrol improves health and survival of mice on a high-calorie diet Nature 2006 444 7117 337 342 (Pubitemid 44764104)
84. Baur J. A., Sinclair D. A., Therapeutic potential of resveratrol: the in vivo evidence Nature Reviews Drug Discovery 2006 5 6 493 506 (Pubitemid 44136961)
85. Caruso F., Tanski J., Villegas-Estrada A., Rossi M., Structural basis for antioxidant activity of trans-resveratrol: Ab initio calculations and crystal and molecular structure Journal of Agricultural and Food Chemistry 2004 52 24 7279 7285
86. Mokni M., Elkahoui S., Limam F., Amri M., Aouani E., Effect of resveratrol on antioxidant enzyme activities in the brain of healthy rat Neurochemical Research 2007 32 6 981 987 (Pubitemid 46726017)
87. Kumar A., Naidu P. S., Seghal N., Padi S. S. V., Neuroprotective effects of resveratrol against intracerebroventricular colchicine-induced cognitive impairment and oxidative stress in rats Pharmacology 2007 79 1 17 26 (Pubitemid 46034173)
88. de la Lastra C. A., Villegas I., Resveratrol as an antioxidant and pro-oxidant agent: mechanisms and clinical implications Biochemical Society Transactions 2007 35 5 1156 1160 (Pubitemid 350206449)
89. Alcan F. J., Villalba J. M., Sirtuin activators Expert Opinion on Therapeutic Patents 2009 19 4 403 414
90. Saiko P., Szakmary A., Jaeger W., Szekeres T., Resveratrol and its analogs: defense against cancer, coronary disease and neurodegenerative maladies or just a fad? Mutation Research 2008 658 1-2 68 94 (Pubitemid 351172881)
91. Wang J., Ho L., Qin W., Rocher A. B., Seror I., Humala N., Maniar K., Dolios G., Wang R., Hof P. R., Pasinetti G. M., Caloric restriction attenuates -amyloid neuropathology in a mouse model of Alzheimer's disease FASEB Journal 2005 19 6 659 661 (Pubitemid 40471277)
92. Patel N. V., Gordon M. N., Connor K. E., Good R. A., Engelman R. W., Mason J., Morgan D. G., Morgan T. E., Finch C. E., Caloric restriction attenuates A -deposition in Alzheimer transgenic models Neurobiology of Aging 2005 26 7 995 1000 (Pubitemid 40312661)
93. Kim D., Nguyen M. D., Dobbin M. M., Fischer A., Sananbenesi F., Rodgers J. T., Delalle I., Baur J. A., Sui G., Armour S. M., Puigserver P., Sinclair D. A., Tsai L. H., SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis EMBO Journal 2007 26 13 3169 3179 (Pubitemid 47057498)
94. Kelsey N. A., Wilkins H. M., Linseman D. A., Nutraceutical antioxidants as novel neuroprotective agents Molecules 2010 15 11 7792 7814
95. Rivire C., Richard T., Quentin L., Krisa S., Mérillon J. M., Monti J. P., Inhibitory activity of stilbenes on Alzheimer's -amyloid fibrils in vitro Bioorganic and Medicinal Chemistry 2007 15 2 1160 1167 (Pubitemid 44880692)
96. Marambaud P., Zhao H., Davies P., Resveratrol promotes clearance of Alzheimer's disease amyloid- peptides Journal of Biological Chemistry 2005 280 45 37377 37382 (Pubitemid 41642343)
97. Tang B. L., Chua C. E. L., SIRT1 and neuronal diseases Molecular Aspects of Medicine 2008 29 3 187 200 (Pubitemid 351615154)
98. Feng Y., Wang X. P., Yang S. G., Wang Y. J., Zhang X., Du X. T., Sun X. X., Zhao M., Huang L., Liu R. T., Resveratrol inhibits beta-amyloid oligomeric cytotoxicity but does not prevent oligomer formation NeuroToxicology 2009 30 6 986 995
99. Han Y. S., Zheng W. H., Bastianetto S., Chabot J. G., Quirion R., Neuroprotective effects of resveratrol against -amyloid-induced neurotoxicity in rat hippocampal neurons: involvement of protein kinase C British Journal of Pharmacology 2004 141 6 997 1005 (Pubitemid 38510083)
100. Candelario-Jalil E., de Oliveira A. C. P., Grf S., Bhatia H. S., Hll M., Muoz E., Fiebich B. L., Resveratrol potently reduces prostaglandin E 2 production and free radical formation in lipopolysaccharide-activated primary rat microglia Journal of Neuroinflammation 2007 4, article 25
101. Kim Y. A., Lim S. Y., Rhee S. H., Park K. Y., Kim C. H., Choi B. T., Lee S. J., Park Y. M., Choi Y. H., Resveratrol inhibits inducible nitric oxide synthase and cyclooxygenase-2 expression in -amyloid-treated C6 glioma cells International Journal of Molecular Medicine 2006 17 6 1069 1075
102. Lu X., Ma L., Ruan L., Kong Y., Mou H., Zhang Z., Wang Z., Wang J. M., Le Y., Resveratrol differentially modulates inflammatory responses of microglia and astrocytes Journal of Neuroinflammation 2010 7, article 46
103. Inoue H., Jiang X. F., Katayama T., Osada S., Umesono K., Namura S., Brain protection by resveratrol and fenofibrate against stroke requires peroxisome proliferator-activated receptor in mice Neuroscience Letters 2003 352 3 203 206 (Pubitemid 38367603)
104. Wang Y. J., He F., Li X. L., The neuroprotection of resveratrol in the experimental cerebral ischemia Zhonghua Yi Xue Za Zhi 2003 83 7 534 536
105. Karuppagounder S. S., Pinto J. T., Xu H., Chen H. L., Beal M. F., Gibson G. E., Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer's disease Neurochemistry International 2009 54 2 111 118
106. Manczak M., Mao P., Calkins M. J., Cornea A., Reddy A. P., Murphy M. P., Szeto H. H., Park B., Reddy P. H., Mitochondria-targeted antioxidants protect against amyloid- toxicity in Alzheimer's disease neurons Journal of Alzheimer's Disease 2010 20 supplement 2 S609 S631
107. Chen C. Y., Jang J. H., Li M. H., Surh Y. J., Resveratrol upregulates heme oxygenase-1 expression via activation of NF-E2-related factor 2 in PC12 cells Biochemical and Biophysical Research Communications 2005 331 4 993 1000
108. Zhuang H., Kim Y. S., Koehler R. C., Doré S., Potential mechanism by which resveratrol, a red wine constituent, protects neurons Annals of the New York Academy of Sciences 2003 993 276 288
109. Scapagnini G., Colombrita C., Amadio M., D'Agata V., Arcelli E., Sapienza M., Quattrone A., Calabrese V., Curcumin activates defensive genes and protects neurons against oxidative stress Antioxidants and Redox Signaling 2006 8 3-4 395 403 (Pubitemid 43741311)
110. Nishinaka T., Ichijo Y., Ito M., Kimura M., Katsuyama M., Iwata K., Miura T., Terada T., Yabe-Nishimura C., Curcumin activates human glutathione S -transferase P1 expression through antioxidant response element Toxicology Letters 2007 170 3 238 247 (Pubitemid 46710275)
111. Ishrat T., Hoda M. N., Khan M. B., Yousuf S., Ahmad M., Khan M. M., Ahmad A., Islam F., Amelioration of cognitive deficits and neurodegeneration by curcumin in rat model of sporadic dementia of Alzheimer's type (SDAT) European Neuropsychopharmacology 2009 19 9 636 647
112. Jiang H., Tian X., Guo Y., Duan W., Bu H., Li C., Activation of nuclear factor erythroid 2-related factor 2 cytoprotective signaling by curcumin protect primary spinal cord astrocytes against oxidative toxicity Biological Pharmaceutical Bulletin 2011 34 8 1194 1197
113. Romeo L., Intrieri M., D'Agata V., Mangano N. G., Oriani G., Ontario M. L., Scapagnini G., The major green tea polyphenol, (-) -epigallocatechin-3- gallate, induces heme oxygenase in rat neurons and acts as an effective neuroprotective agent against oxidative stress Journal of the American College of Nutrition 2009 28 supplement 492S 499S
114. Shah Z. A., Li R. C., Ahmad A. S., Kensler T. W., Yamamoto M., Biswal S., Doré S., The flavanol (-) -epicatechin prevents stroke damage through the Nrf2/HO1 pathway Journal of Cerebral Blood Flow and Metabolism 2010 30 12 1951 1961
115. Weinreb O., Mandel S., Youdim M. B. H., cDNA gene expression profile homology of antioxidants and their antiapoptotic and proapoptotic activities in human neuroblastoma cells FASEB Journal 2003 17 8 935 937