Green tea polyphenol (-)-epigallocatechin-3-gallate induces neurorescue of long-term serum-deprived PC12 cells and promotes neurite outgrowth

Journal of Neurochemistry

Volumn 93, Issue 5, 2005, Pages 1157-1167

  Reznichenko, L ^a   Amit, T ^a   Youdim, M B H ^a   Mandel, S ^a  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

Author keywords

( ) epigallocatechin 3 gallate; Differentiation; Neurodegenerative diseases; Neurorescue; Polyphenol; Protein kinase C

Indexed keywords

EPIGALLOCATECHIN GALLATE; POLYPHENOL; PROTEIN KINASE C ALPHA;

ANIMAL CELL; ARTICLE; CELL STRAIN; CONTROLLED STUDY; IMMUNOCYTOCHEMISTRY; NERVE CELL CULTURE; NERVE CELL NECROSIS; NERVE FIBER GROWTH; NONHUMAN; PRIORITY JOURNAL; RAT; TEA; WESTERN BLOTTING;

ANIMALS; BIOLOGICAL TRANSPORT; CATECHIN; CELL DEATH; CELL DIFFERENTIATION; CELL MEMBRANE; CULTURE MEDIA, SERUM-FREE; ENZYME ACTIVATION; FLAVONOIDS; NEURITES; NEUROPROTECTIVE AGENTS; PC12 CELLS; PHENOLS; PROTEIN KINASE C; PROTEIN KINASE C-ALPHA; RATS;

EID: 20144371838     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2005.03085.x     Document Type: Article

References (59)

1. Bastianetto S., Ramassamy C., Dore S., Christen Y., Poirier J. and Quirion R. (2000) The Ginkgo biloba extract (EGb 761) protects hippocampal neurons against cell death induced by beta-amyloid. Eur. J. Neurosci. 12, 1882-1890.
2. Batistatou A. and Greene L. A. (1993) Internucleosomal DNA cleavage and neuronal cell survival/death. J. Cell Biol. 122, 523-532.
3. Brodie C., Bogi K., Acs P., Lazarovici P., Petrovics G., Anderson W. B. and Blumberg P. M. (1999) Protein kinase C-e plays a role in neurite outgrowth in response to epidermal growth factor and nerve growth factor. Cell Growth Differ. 10, 183-191.
4. Butterfield D., Castegna A., Pocernich C., Drake J., Scapagnini G. and Calabrese V. (2002) Nutritional approaches to combat oxidative stress in Alzheimer's disease. J. Nutr. Biochem. 13, 444-461.
5. Checkoway H., Powers K., Smith-Weller T., Franklin G. M., Longstreth W. T. Jr and Swanson P. D. (2002) Parkinson's disease risks associated with cigarette smoking, alcohol consumption, and caffeine intake. Am. J. Epidemiol. 155, 732-738.
6. Choi Y. B., Kim Y. I., Lee K. S., Kim B. S. and Kim D. J. (2004) Protective effect of epigallocatechin gallate on brain damage after transient middle cerebral artery occlusion in rats. Brain Res. 1019, 47-54.
7. Choi Y. T., Jung C. H., Lee S. R., Bae J. H., Baek W. K., Suh M. H., Park J., Park C. W. and Suh S. I. (2001) The green tea polyphenol (-)-epigallocatechin gallate attenuates beta-amyloid-induced neurotoxicity in cultured hippocampal neurons. Life Sci. 70, 603-614.
8. Cordey M., Gundimeda U., Gopalakrishna R. and Pike C. J. (2003) Estrogen activates protein kinase C in neurons: role in neuroprotection. J. Neurochem. 84, 1340-1348.
9. Das K. P., Freudenrichb T. M. and William R. (2004) Assessment of PC12 cell differentiation and neurite growth: a comparison of morphological and neurochemical measures. Neurotoxicol. Teratol. 26, 397-406.
10. Dauer W. and Przedborski S. (2003) Parkinson's disease: mechanisms and models. Neuron 39, 889-909.
11. Dempsey E. C., Newton A. C., Mochly-Rosen D., Fields A. P., Reyland M. E., Insel P. A. and Messing R. O. (2000) Protein kinase C isozimes and the regulation of diverse cell responses. Am. J. Physiol. Lung Cell. Mol. Physiol. 279, L429-L438.
12. Dupont J. L., Janoshazi A., Bellahcene M., Mykita S. and de Barry J. (2000) Reversible protein kinase C activation in PC12 cells: effect of NGF treatment. Eur. J. Neurosci. 12, 215-226.
13. Duriez P. J. and Shah G. M. (1997) Cleavage of poly (ADP-ribose) polymerase: a sensitive parameter to study cell death. Biochem. Cell Biol. 75, 337-349.
14. Durkin J. P., Tremblay R., Chakravarthy B., Mealing G., Morley P., Small D. and Song D. (1997) Evidence that the early loss of membrane protein kinase C is a necessary step in the excitatory amino acid-induced death of primary cortical neurons. J. Neurochem. 68, 1400-1412.
15. Gallo G. and Letourneau P. C. (2004) Regulation of growth cone actin filaments by guidance cues. J. Neurobiol. 58, 92-102.
16. Gatti A. and Robinson P. J. (1996) Unique phosphorylation of protein kinase C-alpha in PC12 cells induces resistance to translocation and down-regulation. J. Biol. Chem. 271, 31 718-31 722.
17. Greene L. A. (1978) Nerve growth factor prevents the death and stimulates the neuronal differentiation of clonal PC12 pheochromocytoma cells in serum-free medium. J. Cell Biol. 78, 747-755.
18. Greene L. A. and Tischler A. S. (1976) Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. Proc. Natl Acad. Sci. USA 73, 2424-2428.
19. Grunblatt E., Mandel S., Hirsch J. J. et al. (2004) Gene expression profiling of parkinsonian substantia nigra pars compacta; alterations in ubiquitin-proteasome, heat shock protein, iron and oxidative stress regulated proteins, cell adhesion/cellular matrix and vesicle trafficking genes. J. Neural Transm. 111, 1543-1573.
20. Han Y, S., Zheng W. H., Bastianetto S., Chabot J. G. and Quirion R. (2004) Neuroprotective effects of resveratrol against beta-amyloid-induced neurotoxicity in rat hippocampal neurons: involvement of protein kinase. Br. J. Pharmacol. 141, 997-1005.
21. Higdon J. V. and Frei B. (2003) Tea catechins and polyphenols: health effects, metabolism, and antioxidant functions. Crit. Rev. Food Sci. Nutr. 43, 89-143.
22. Jenner P. and Olanow C. W. (1996) Oxidative stress and the pathogenesis of Parkinson's disease. Neurology 47, S161-S170.
23. Jiffar T., Kurinna S., Suck G., Carlson-Bremer D., Ricciardi M. R., Konopleva M., Andreeff M. and Ruvolo P. P. (2004) PKC alpha mediates chemoresistance in acute lymphoblastic leukemia through effects on Bcl2 phosphorylation. Leukemia 18, 505-512.
24. Joseph J. A., Shukitt-Hale B., Denisova N. A., Bielinski D., Martin A., McEwen J. J. and Bickford P. C. (1999) Reversals of age-related declines in neuronal signal transduction, cognitive, and motor behavioral deficits with blueberry, spinach, or strawberry dietary supplementation. J. Neurosci. 19, 8114-8121.
25. Joseph J. A., Denisova N. A., Arendash G., Gordon M., Diamond D., Shukitt-Hale B. and Morgan D. (2003) Blueberry supplementation enhances signaling and prevents behavioral deficits in an Alzheimer disease model. Nat. Neurosci. 6, 153-162.
26. Kim S. Y., Ahn B. H., Kim J. et al. (2004) Phospholipase C, protein kinase C, Ca2+/calmodulin-dependent protein kinase II, and redox state are involved in epigallocatechin gallate-induced phospholipase D activation in human astroglioma cells. Eur. J. Biochem. 271, 3470-3480.
27. Lee H., Bae J. H. and Lee S. R. (2004a) Protective effect of green tea polyphenol EGCG against neuronal damage and brain edema after unilateral cerebral ischemia in gerbils. J. Neurosci. Res. 77, 892-900.
28. Lee J. H., Song D. K., Jung C. H. et al. (2004b) (-)-epigallocatechin gallate attenuates glutamate-induced cytotoxicity via intracellular ca modulation in PC12 cells. Clin. Exp. Pharmacol. Physiol. 31, 530-536.
29. Lee S., Suh S. and Kim S. (2000) Protective effects of the green tea polyphenol. (-)-epigallocatechin gallate against hippocampal neuronal damage after transient global ischemia in gerbils. Neurosci. Lett. 287, 191-194.
30. Levites Y., Weinreb O., Maor G., Youdim M. B. and Mandel S. (2001) Green tea polyphenol (-)-epigallocatechin-3-gallate prevents N-methyl-4-phenyl-1,2,3,6 tetrahydropyridine-induced dopaminergic neurodegeneration. J. Neurochem. 78, 1073-1082.
31. Levites Y., Amit T., Youdim M. B. and Mandel S. (2002) Involvement of protein kinase C activation and cell survival/cell cycle genes in green tea polyphenol (-)-epigallocatechin-3-gallate neuroprotective action. J. Biol. Chem. 277, 30 574-30 580.
32. Levites Y., Amit T., Mandel S. and Youdim M. B. (2003) Neuroprotection and neurorescue against Abeta toxicity and PKC-dependent release of nonamyloidogenic soluble precursor protein by green tea polyphenol (-)-epigallocatechin-3-gallate. Faseb J. 17, 952-954.
33. Li S. C., Schoenberg B. S., Wang C. C., Cheng X. M., Rui D. Y., Bolis C. L. and Schoenberg D. G. (1985) A prevalence survey of Parkinson's disease and other movement disorders in the People's Republic of China. Arch. Neurol. 42, 655-657.
34. Liu J. P. (1996) Protein kinase C and its substrates. Mol. Cell Endocrinol. 116, 1-29.
35. Maher P. (2001) How protein kinase C activation protects nerve cells from oxidative stress-induced cell death. J. Neurosci. 21, 2929-2938.
36. Mandel S. and Youdim M. B. (2004) Catechin polyphenols: neurodegeneration and neuroprotection in neurodegenerative diseases. Free Radic. Biol. Med. 37, 304-317.
37. Mandel S., Reznichenko L., Amit T. and Youdim M. B. (2003) Green tea polyphenol (-)-epigallocatechin-3-gallate protects rat PC12 cells from apoptosis induced by serum withdrawal. Neurotox. Res. 5, 419-424.
38. Mandel S., Maor G. and Youdim M. B. (2004a) Iron and alpha synuclein in the substantia nigra of MPTP-treated mice: effect of neuroprotective drugs r-apomorphine and green tea polyphenol epigallocatechin-3-gallate. J. Mol. Neuro. 24, 401-416.
39. Mandel S., Weinreb O., Amit T. and Youdim M. B. H. (2004b) Cell signaling pathways in the neuroprotective actions of the green tea polyphenol (-)-epigallocatechin-3-gallate: implications for neurodegenerative diseases. J. Neurochem. 88, 1555-1569.
40. Matsuoka Y., Hasegawa H., Okuda S., Muraki T., Uruno T. and Kubota K. (1995) Ameliorative effects of tea catechins on active oxygen-related nerve cell injuries. J. Pharmacol. Exp. Ther. 274, 602-608.
41. Meiri K. F. and Gordon-Weeks P. R. (1990) GAP-43 in growth cones is associated with areas of membrane that are tightly attached to the substrate and is a component of a membrane skeleton subcellular fraction. J. Neurosci. 10, 256-266.
42. Mills J. C., Kim L. H. and Pittman R. N. (1997) Differentiation to an NGF-dependent state and apoptosis following NGF removal both occur asynchronously in cultures of PC12 cells. Exp. Cell Res. 231, 337-345.
43. Min D. S., Ahn B. H., Rhie D. J., Yoon S. H., Hahn S. J., Kim M. S. and Jo Y.H. (2001) Expression and regulation of phospholipase D during neuronal differentiation of PC12 cells. Neuropharmacology 41, 384-391.
44. Nobre Junior H. V., Cunha G. M., Maia F. D., Oliveira R. A., Moraes M. O. and Rao V. S. (2003) Catechin attenuates 6-hydroxydopamine (6-OHDA)-induced cell death in primary cultures of mesencephalic cells. Comp. Biochem. Physiol. C Toxicol. Pharmacol. 136, 175-180.
45. Pappas T. C., Decorti F., Macdonald N. J., Neet K. E. and Taglialatela G. (2003) Tumour necrosis factor-alpha- vs. growth factor deprivation-promoted cell death: different receptor requirements for mediating nerve growth factor-promoted rescue. Aging Cell 2, 83-92.
46. Pa'rrizas M., Saltiel A. R. and LeRoith D. (1997) Insulin-like growth factor 1 inhibits apoptosis using the phosphatidylinositol 3′-kinase and mitogen-activated protein kinase pathways. J. Biol. Chem. 272, 154-161.
47. Riederer P., Sofic E., Rausch W. D., Schmidt B., Reynolds G. P., Jellinger K. and Youdim M. B. (1989) Transition metals, ferritin, glutathione, and ascorbic acid in parkinsonian brains. J. Neurochem. 52, 515-520.
48. Ruvolo P. P., Deng X., Carr B. K. and May W. S. (1998) A functional role for mitochondrial protein kinase C alpha in Bcl-2 phosphorylation and suppression of apoptosis. J. Biol. Chem. 273, 25 436-25 442.
49. Sagara Y., Vanhnasy J. and Maher P. (2004) Induction of PC12 cell differentiation by flavonoids is dependent upon extracellular signal-regulated kinase activation. J. Neurochem. 90, 1144-1155.
50. Stackman R. W., Eckenstein F., Frei B., Kulhánek D., Nowlin J. and Quinn J. F. (2003) Prevention of age-related spatial memory deficits in a transgenic mouse model of Alzheimer's disease by chronic Ginkgo biloba treatment. Exp. Neurol. 184, 510-520.
51. Tan E. K., Tan C., Fook-Chong S. M. et al. (2003) Dose-dependent protective effect of coffee, tea, and smoking in Parkinson's disease: a study in ethnic Chinese. J. Neurol. Sci. 216, 163-167.
52. de la Torre J. C., Mallory M., Brot M., Gold L., Koob G., Oldstone M. B. and Masliah F. (1996) Viral persistence in neurons alters synaptic plasticity and cognitive functions without destruction of brain cells. Virology 220, 508-515.
53. Troy C. M., Rabacchi S. A., Hohl J. B., Angelastro J. M., Greene L. A. and Shelanski M. L. (2001) Death in the balance: alternative participation of the caspase-2 and -9 pathways in neuronal death induced by nerve growth factor deprivation. J. Neurosci. 21, 5007-5016.
54. Vianna M. R., Barros D. M., Silvia T., Choi H., Madche C., Rodrigues C., Medina J. H. and Izquierdo I. (2000) Pharmacological demonstration of the differential involvement of protein kinase C isoforms in short- and long-term memory formation and retrieval of one-trial avoidance in rats. Psychopharmacology (Berl) 150, 77-84.
55. Weinreb O., Mandel S. and Youdim M. B. (2003) CDNA gene expression profile homology of antioxidants and their anti-apoptotic and proapoptotic activities in human neuroblastoma cells. Ann. NY Acad. Sci. 993, 351-361.
56. Weinreb O., Mandel S., Amit T. and Youdim M. B. (2004) Neurological mechanisms of green tea polyphenols in Alzheimer's and Parkinson's diseases. J. Nutr. Biochem. 15, 506-516.
57. Wiseman S. A., Balentine D. A. and Frei B. (1997) Antioxidants in tea. Crit. Rev. Food Sci. Nutr. 37, 705-718.
58. Wooten M. W., Zhou G., Seibenhener M. L. and Coleman E. S. (1994) A role for zeta protein kinase C in nerve growth factor-induced differentiation of PC12 cells. Cell Growth Differ. 5, 395-403.
59. Yao R. and Cooper G. M. (1995) Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor. Science 267, 2003-2006.