Possible neuroprotective mechanisms of curcumin in attenuating 3-nitropropionic acid-induced neurotoxicity

Methods and Findings in Experimental and Clinical Pharmacology

Volumn 29, Issue 1, 2007, Pages 19-25

  Kumar, P ^a   Padi, S S V ^a   Naidu, P S ^a   Kumar, Anil ^a  

^a PANJAB UNIVERSITY   (India)

Author keywords

3 Nitropropionic acid; Cognitive impairment; Curcumin; Huntington's disease; Motor activity; Oxidative stress

Indexed keywords

3 NITROPROPIONIC ACID; CURCUMIN; GLUTATHIONE; NITRITE; SUCCINATE DEHYDROGENASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BODY WEIGHT; COGNITIVE DEFECT; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; IRON CHELATION; LIPID PEROXIDATION; MALE; MEMORY CONSOLIDATION; MOTOR PERFORMANCE; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; RAT;

ANIMALS; ANTIOXIDANTS; BODY WEIGHT; BRAIN; COGNITION DISORDERS; CURCUMA; CURCUMIN; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUTATHIONE; LIPID PEROXIDATION; MALE; MEMORY DISORDERS; MOTOR ACTIVITY; NEUROPROTECTIVE AGENTS; NEUROTOXICITY SYNDROMES; NEUROTOXINS; NITRITES; NITRO COMPOUNDS; OXIDATIVE STRESS; PHYTOTHERAPY; PLANT EXTRACTS; PLANTS, MEDICINAL; PROPIONIC ACIDS; RATS; RATS, WISTAR; SUCCINATE DEHYDROGENASE;

EID: 33947377439     PISSN: 03790355     EISSN: None     Source Type: Journal    
DOI: 10.1358/mf.2007.29.1.1063492     Document Type: Article

References (32)

1. Ludolph, A.C., He, F., Spencer, P.S., Hammerstad, J., Sabri, M. 3-Nitropropionic acid-exogenous animal neurotoxin and possible human striatal toxin. Can J Neurol Sci 1991, 18: 492-8.
2. Beal, M.F., Brouillet, E., Jenkins, B.G. et al. Neurochemical and histologic characterization of striatal excitotoxic lesions produced by the mitochondrial toxin 3-nitropropionic acid. J Neurosci 1993, 13: 4181-92.
3. Butterfield, D.A., Howard, B.J., LaFontaine, M.A. Brain oxidative stress in animal models of accelerated aging and the age-related neurodegenerative disorders, Alzheimer's disease and Huntington's disease. Curr Med Chem 2001, 8: 815-28.
4. Browne, S.E., Ferrante, R.J., Beal, M.F. Oxidative stress in Huntington's disease. Brain Pathol 1999, 9: 147-63.
5. Fukui, K., Onodera, K., Shinkai, T., Suzuki, S., Urano, S. Impairment of learning and memory in rats caused by oxidative stress and aging, and changes in antioxidative defense systems. Ann NY Acad Sci 2001, 928: 168-75.
6. Liu, R., Liu, I.Y., Bi, X. et al. Reversal of age-related learning deficits and brain oxidative stress in mice with superoxide dismutase/catalase mimetics. Proc Natl Acad Sci U S A 2003, 100: 8526-31.
7. Beal, M.F., Ferrante, R.J., Henshaw, R. et al. 3-Nitropropionic acid neurotoxicity is attenuated in copper/zinc superoxide dismutase transgenic mice. J Neurochem 1995, 65: 919-22.
8. Fontaine, M.A., Geddes, J.W., Banks, A., Butterfield, D.A. Effect of exogenous and endogenous antioxidants on 3-nitropionic acid-induced in vivo oxidative stress and striatal lesions: insights into Huntington's disease. J Neurochem 2000, 75: 1709-15.
9. Schulz, J.B., Henshaw, D.R., MacGarvey, U., Beal, M.F. Involvement of oxidative stress in 3-nitropropionic acid neurotoxicity. Neurochem Int 1996b, 29: 167-71.
10. Ganguli, M., Chandra, V., Kamboli, M.I. et al. Apolipoprotein E polymorphism and Alzheimer disease: The Indo-US Cross National Dementia study. Arch Neurol 2000, 57: 824-30.
11. Sreejayan, N., Rao, M.N.A. Free radical scavenging activity of curcuminoids. Arzneii Forsch 1996, 46: 838-43.
12. Sreejayan, N., Rao, M.N.A. Nitric oxide scavenging by curcuminoids. J Pharm Pharmacol 1997, 49: 105-7.
13. Daniel, S., Lemon, J.L., Dairam, A., Watkins, G.M., Daya, S. Through metal binding, curcumin protects against lead- and cadmium-induced lipid peroxidation in rat brain homogenates and against lead-induced tissue damage in rat brain. J Inorg Biochem 2004, 98: 266-75.
14. Thiyagarajan, M., Sharma, SS. Neuroprotective effect of curcumin in middle cerebral artery occlusion induced focal cerebral ischemia in rats. Life Sci 2004, 74: 969-85.
15. Frautschy, S.A., Hu, W., Kim, P. et al. Phenolic antiinflammatory antioxidant reversal of A beta-induced cognitive deficits and neuropathology. Neurobiol Aging 2001, 22: 993-1005.
16. Naidu, P.S., Singh, A., Kulkarni, S.K. Quercetin, a bioflavonoid, attenuates haloperidol-induced orofacial dyskinesia. Neuropharmacology 2003, 44: 1100-6.
17. Verma, A., Kulkarni, S.K. Evaluation of learning and memory mechanisms employing plus maze in rats and mice. Prog Neuropsychopharmacol Biol Psychiatry 1992, 16: 117-25.
18. Wills, E.D. Mechanism of lipid peroxide formation in animal. Biochem J 1966, 99: 667-676.
19. Ellman, G.L. Tissue sulfhydryl groups. Arch Biochem Biophys 1959, 82: 70-7.
20. 15N] nitrate in biological fluids. Ann Biochem 1982, 126: 131-8.
21. Gornall, A.G., Bardawill, C.J., David, M.M. Determination of serum proteins by means of the biuret reaction. J Biol Chem 1949, 177: 751-66.
22. Hamilton, J.M., Wolfson, T., Peavy, G.M., Jacobson, M.W., Corey-Bloom, J. Huntington Study Group. Rate and correlates of weight change in Huntington's disease. J Neurol Neurosurg Psychiatry 2004, 75: 209-12.
23. Keene, C.D., Rodrigues, C.M., Eich, T. et al. A bile acid protects against motor and cognitive deficits and reduces striatal degeneration in the 3-nitropropionic acid model of Huntington's disease. Exp Neurol 2001, 171: 351-60.
24. Teunissen, C.E., Steinbusch, H.W., Angevaren, M., Appels, M., Bruijn, C., Prickaerts, J., De-Vente, J. Behavioural correlates of striatal glial fibrillary acidic protein in the 3-nitropropionic acid rat model: disturbed walking pattern and spatial orientation. Neuroscience 2001, 105: 153-67.
25. Sugino, T., Nozaki, K., Takagi, Y., Hattori, I., Hashimoto, N., Yodoi, J. Expression and distribution of redox regulatory protein, thioredoxin after metabolic impairment by 3-nitropropionic acid in rat brain. Neurosci Lett 1999, 275: 145-8.
26. Giassom, B.I., Ischiropoulos, H., Lee, V.M.-Y., Trojanowski, J.Q. Causes and consequences of oxidative stress in Alzheimer's disease. Free Radical Biol Med 2002, 12: 1264-75.
27. Ghoneim, A.I., Abdel-Naim, A.B., Khalifa, A.E., El-Denshary, E.S. Protective effects of curcumin against ischaemia/reperfusion insult in rat forebrain. Pharmacol Res 2002, 46: 273-9.
28. Montilla, P., Tunez, I., Munoz, MC. et al. Effect of glucocorticoids on 3-nitropropionic acid-induced oxidative stress in synaptosomes. Eur J Pharmacol 2004, 488: 19-25.
29. Kunchandy, F., Rao, M.N.A. Oxygen radical scavenging activity of curcumin. Int J Pharm 1990, 58: 237-40.
30. Wallis, R.A., Panizzon, K.L., Henry, D., Wasterlain, C.G. Neuroprotection against nitric oxide injury with inhibitors of ADP-ribosylation. Neuro Report 1993, 5: 245-48.
31. Tunez, I., Montilla, P., Munoz, M.D.C., Feijoo, M., Salcedo, M. Protective effect of nicotine on 3-nitropropionic acid-induced oxidative stress in synaptosomes in an animal model of Huntington's disease. Eur J Pharmacol 2004, 504: 169-75.
32. Tunez, I., Montilla, P., Munoz, M.D.C., Feijoo, M., Salcedo, M. Protective effect of melatonin on 3-nitropropionic acid-induced oxidative stress in synaptosomes in an animal model of Huntington's disease. J Pineal Res 2004, 37: 252-6.