γ-Secretase Inhibitors and Modulators Induce Distinct Conformational Changes in the Active Sites of γ-Secretase and Signal Peptide Peptidase

ACS Chemical Biology

Volumn 10, Issue 8, 2015, Pages 1925-1931

  Gertsik, Natalya ^a,b   Chau, De Ming ^a,b,c   Li, Yue Ming ^a,b  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b Weill Cornell Graduate School of Biomedical Sciences   (United States)

^c UNIVERSITY PUTRA MALAYSIA   (Malaysia)

Author keywords

[No Author keywords available]

Indexed keywords

CENTRAL NERVOUS SYSTEM AGENTS; GAMMA SECRETASE; GAMMA SECRETASE INHIBITOR; GAMMA SECRETASE MODULATOR; PEPTIDASE; SIGNAL PEPTIDE; UNCLASSIFIED DRUG; ASPARTIC PROTEINASE; BENZOPHENONE DERIVATIVE; MOLECULAR LIBRARY; SECRETASE; SIGNAL PEPTIDE PEPTIDASE;

ARTICLE; CONFORMATIONAL TRANSITION; ENZYME ACTIVITY; ENZYME SPECIFICITY; FEMALE; HUMAN; HUMAN CELL; OUTCOME ASSESSMENT; PRIORITY JOURNAL; ALZHEIMER DISEASE; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DRUG EFFECTS; ENZYME ACTIVE SITE; ENZYMOLOGY; HELA CELL LINE; MOLECULAR LIBRARY; PHARMACOLOGY; PROTEIN CONFORMATION; PROTEIN MULTIMERIZATION;

ALZHEIMER DISEASE; AMYLOID PRECURSOR PROTEIN SECRETASES; ASPARTIC ACID ENDOPEPTIDASES; BENZOPHENONES; CATALYTIC DOMAIN; HELA CELLS; HUMANS; PROTEIN CONFORMATION; PROTEIN MULTIMERIZATION; SMALL MOLECULE LIBRARIES;

EID: 84939804034     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/acschembio.5b00321     Document Type: Article

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