Distinct pharmacological effects of inhibitors of signal peptide peptidase and γ-secretase

Journal of Biological Chemistry

Volumn 283, Issue 48, 2008, Pages 33287-33295

  Sato, Toru ^a   Ananda, Kuppanna ^a   Cheng, Cathy I ^a   Suh, Eric J ^a   Narayanan, Saravanakumar ^a   Wolfe, Michael S ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINES; BINDING ENERGY; BINDING SITES; DOCKING; KETONES; LABELING; ORGANIC COMPOUNDS; PROTEINS; SUBSTRATES;

ACTIVE SITES; ASPARTYL PROTEASES; BLOCK LABELING; CLEAVAGE MECHANISMS; DOCKING SITES; HELICAL PEPTIDES; INFLAMMATORY DRUGS; MEMBRANE TOPOLOGIES; PHARMACOLOGICAL EFFECTS; SECRETASE; SIGNAL PEPTIDES;

SURFACE PLASMON RESONANCE;

ACETYLSALICYLIC ACID; ENZYME INHIBITOR; GAMMA SECRETASE; GAMMA SECRETASE INHIBITOR; IBUPROFEN; INDOMETACIN; NONSTEROID ANTIINFLAMMATORY AGENT; PEPTIDASE; SIGNAL PEPTIDE PEPTIDASE; SIGNAL PEPTIDE PEPTIDASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG BINDING SITE; DRUG EFFECT; DRUG MECHANISM; ENZYME INHIBITION; ENZYME SUBSTRATE; NONHUMAN; PHOTOAFFINITY LABELING; PRIORITY JOURNAL;

AMINO ACID MOTIFS; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; BINDING SITES; CELL MEMBRANE; ENZYME ACTIVATION; HUMANS; MEMBRANE PROTEINS; PEPTIDES; PROTEASE INHIBITORS; SERINE ENDOPEPTIDASES;

EID: 57749120456     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M805670200     Document Type: Article

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