Development of clickable active site-directed photoaffinity probes for γ-secretase

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 8, 2012, Pages 2997-3000

  Crump, Christina J ^a,b   Am Ende, Christopher W ^c   Eric Ballard, T ^c   Pozdnyakov, Nikolay ^c   Pettersson, Martin ^c   Chau, De Ming ^a,b   Bales, Kelly R ^c   Li, Yue Ming ^a,b   Johnson, Douglas S ^c  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b Weill Graduate School of Medical Sciences of Cornell University   (United States)

^c PFIZER INC   (United States)

Author keywords

Secretase; Alzheimer's disease; Click chemistry; Clickable photoprobe; Photoaffinity labeling

Indexed keywords

ALKYNE; ASPARTIC PROTEINASE; AZIDE; BENZOPHENONE; BIOTIN; GAMMA SECRETASE; GAMMA SECRETASE INHIBITOR; L 505; L 646; PEPTIDASE; PRESENILIN 1; SIGNAL PEPTIDE PEPTIDASE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CLICK CHEMISTRY; COMPLEX FORMATION; CONJUGATION; DRUG POTENCY; DRUG SYNTHESIS; ENZYME ACTIVE SITE; FLUORESCENCE; GEL; HUMAN; HUMAN CELL; MOLECULAR PROBE; NONHUMAN; PHOTOAFFINITY LABELING; VALIDATION PROCESS; WESTERN BLOTTING;

ALKYNES; AMYLOID PRECURSOR PROTEIN SECRETASES; BENZOPHENONES; BLOTTING, WESTERN; CATALYTIC DOMAIN; CLICK CHEMISTRY; HELA CELLS; HUMANS; INHIBITORY CONCENTRATION 50; MOLECULAR STRUCTURE; PHOTOAFFINITY LABELS;

EID: 84862817371     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.02.027     Document Type: Article

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