Piperidine acetic acid based γ-secretase modulators directly bind to presenilin-1

ACS Chemical Neuroscience

Volumn 2, Issue 12, 2011, Pages 705-710

  Crump, Christina J ^a,b   Fish, Benjamin A ^c   Castro, Suita V ^a   Chau, De Ming ^a,b   Gertsik, Natalya ^a,d   Ahn, Kwangwook ^a,e   Stiff, Cory ^c   Pozdnyakov, Nikolay ^c   Bales, Kelly R ^c   Johnson, Douglas S ^c   Li, Yue Ming ^a,b  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b Department of Pharmacology ^*  (United States)

^c PFIZER INC   (United States)

^d Weill Cornell Graduate School of Biomedical Sciences   (United States)

^e TissueGene Inc   (United States)

Author keywords

secretase modulator; Alzheimer's disease; click chemistry; GSM 1; photoaffinity labeling; presenilin

Indexed keywords

GAMMA SECRETASE; PRESENILIN 1; RITALINIC ACID;

ARTICLE; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; HELA CELL; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; PHOTOAFFINITY LABELING; PRIORITY JOURNAL;

EID: 82455172862     PISSN: None     EISSN: 19487193     Source Type: Journal    
DOI: 10.1021/cn200098p     Document Type: Article

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