-
1
-
-
66449106662
-
Generation of transgenic non-human primates with germline transmission
-
Sasaki E., et al. Generation of transgenic non-human primates with germline transmission. Nature 2009, 459:523-527.
-
(2009)
Nature
, vol.459
, pp. 523-527
-
-
Sasaki, E.1
-
2
-
-
84894081986
-
Generation of gene-modified cynomolgus monkey via Cas9/RNA-mediated gene targeting in one-cell embryos
-
Niu Y., et al. Generation of gene-modified cynomolgus monkey via Cas9/RNA-mediated gene targeting in one-cell embryos. Cell 2014, 156:836-843.
-
(2014)
Cell
, vol.156
, pp. 836-843
-
-
Niu, Y.1
-
3
-
-
84896142186
-
TALEN-mediated gene mutagenesis in rhesus and cynomolgus monkeys
-
Liu H., et al. TALEN-mediated gene mutagenesis in rhesus and cynomolgus monkeys. Cell Stem Cell 2014, 14:323-328.
-
(2014)
Cell Stem Cell
, vol.14
, pp. 323-328
-
-
Liu, H.1
-
4
-
-
84988553070
-
International regulatory landscape and integration of corrective genome editing into in vitro fertilization
-
Araki M., Ishii T. International regulatory landscape and integration of corrective genome editing into in vitro fertilization. Reprod. Biol. Endocrinol. 2014, 12:108.
-
(2014)
Reprod. Biol. Endocrinol.
, vol.12
, pp. 108
-
-
Araki, M.1
Ishii, T.2
-
6
-
-
84905481617
-
Potential impact of human mitochondrial replacement on global policy regarding germline gene modification
-
Ishii T. Potential impact of human mitochondrial replacement on global policy regarding germline gene modification. Reprod. Biomed. Online 2014, 29:150-155.
-
(2014)
Reprod. Biomed. Online
, vol.29
, pp. 150-155
-
-
Ishii, T.1
-
7
-
-
84928775204
-
Don't edit the human germ line
-
Lanphier E., et al. Don't edit the human germ line. Nature 2015, 519:410-411.
-
(2015)
Nature
, vol.519
, pp. 410-411
-
-
Lanphier, E.1
-
8
-
-
84928775846
-
A prudent path forward for genomic engineering and germline gene modification
-
Baltimore D., et al. A prudent path forward for genomic engineering and germline gene modification. Science 2015, 348:36-38.
-
(2015)
Science
, vol.348
, pp. 36-38
-
-
Baltimore, D.1
-
10
-
-
77955952561
-
Why the Medical Research Council refused Robert Edwards and Patrick Steptoe support for research on human conception in 1971
-
Johnson M.H., et al. Why the Medical Research Council refused Robert Edwards and Patrick Steptoe support for research on human conception in 1971. Hum. Reprod. 2010, 25:2157-2174.
-
(2010)
Hum. Reprod.
, vol.25
, pp. 2157-2174
-
-
Johnson, M.H.1
-
12
-
-
84898778301
-
A guide to genome engineering with programmable nucleases
-
Kim H., Kim J.S. A guide to genome engineering with programmable nucleases. Nat. Rev. Genet. 2014, 15:321-334.
-
(2014)
Nat. Rev. Genet.
, vol.15
, pp. 321-334
-
-
Kim, H.1
Kim, J.S.2
-
13
-
-
0029039226
-
Intracytoplasmic sperm injection: a novel treatment for all forms of male factor infertility
-
Palermo G.D., et al. Intracytoplasmic sperm injection: a novel treatment for all forms of male factor infertility. Fertil. Steril. 1995, 63:1231-1240.
-
(1995)
Fertil. Steril.
, vol.63
, pp. 1231-1240
-
-
Palermo, G.D.1
-
14
-
-
84872194963
-
Knockout mice created by TALEN-mediated gene targeting
-
Sung Y.H., et al. Knockout mice created by TALEN-mediated gene targeting. Nat. Biotechnol. 2013, 31:23-24.
-
(2013)
Nat. Biotechnol.
, vol.31
, pp. 23-24
-
-
Sung, Y.H.1
-
15
-
-
84877707375
-
One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering
-
Wang H., et al. One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering. Cell 2013, 153:910-918.
-
(2013)
Cell
, vol.153
, pp. 910-918
-
-
Wang, H.1
-
16
-
-
84884288934
-
Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity
-
Ran F.A., et al. Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity. Cell 2013, 154:1380-1389.
-
(2013)
Cell
, vol.154
, pp. 1380-1389
-
-
Ran, F.A.1
-
17
-
-
84874322004
-
Efficient gene targeting by TAL effector nucleases coinjected with exonucleases in zygotes
-
Mashimo T., et al. Efficient gene targeting by TAL effector nucleases coinjected with exonucleases in zygotes. Sci. Rep. 2013, 3:1253.
-
(2013)
Sci. Rep.
, vol.3
, pp. 1253
-
-
Mashimo, T.1
-
18
-
-
84904490723
-
Highly efficient targeted mutagenesis in one-cell mouse embryos mediated by the TALEN and CRISPR/Cas systems
-
Yasue A., et al. Highly efficient targeted mutagenesis in one-cell mouse embryos mediated by the TALEN and CRISPR/Cas systems. Sci. Rep. 2014, 4:5705.
-
(2014)
Sci. Rep.
, vol.4
, pp. 5705
-
-
Yasue, A.1
-
19
-
-
84905732049
-
Somatic mosaicism and allele complexity induced by CRISPR/Cas9 RNA injections in mouse zygotes
-
Yen S.T., et al. Somatic mosaicism and allele complexity induced by CRISPR/Cas9 RNA injections in mouse zygotes. Dev. Biol. 2014, 393:3-9.
-
(2014)
Dev. Biol.
, vol.393
, pp. 3-9
-
-
Yen, S.T.1
-
20
-
-
84897564599
-
Simultaneous gene editing by injection of mRNAs encoding transcription activator-like effector nucleases into mouse zygotes
-
Li C., et al. Simultaneous gene editing by injection of mRNAs encoding transcription activator-like effector nucleases into mouse zygotes. Mol. Cell. Biol. 2014, 34:1649-1658.
-
(2014)
Mol. Cell. Biol.
, vol.34
, pp. 1649-1658
-
-
Li, C.1
-
21
-
-
84884289608
-
One-step generation of mice carrying reporter and conditional alleles by CRISPR/Cas-mediated genome engineering
-
Yang H., et al. One-step generation of mice carrying reporter and conditional alleles by CRISPR/Cas-mediated genome engineering. Cell 2013, 154:1370-1379.
-
(2013)
Cell
, vol.154
, pp. 1370-1379
-
-
Yang, H.1
-
22
-
-
84890050551
-
Correction of a genetic disease in mouse via use of CRISPR-Cas9
-
Wu Y., et al. Correction of a genetic disease in mouse via use of CRISPR-Cas9. Cell Stem Cell 2013, 13:659-662.
-
(2013)
Cell Stem Cell
, vol.13
, pp. 659-662
-
-
Wu, Y.1
-
23
-
-
84902827660
-
-/-IL2RgammaC-null mouse by combining in vitro fertilization and CRISPR/Cas9 technology
-
-/-IL2RgammaC-null mouse by combining in vitro fertilization and CRISPR/Cas9 technology. Sci. Rep. 2014, 4:5290.
-
(2014)
Sci. Rep.
, vol.4
, pp. 5290
-
-
Li, F.1
-
24
-
-
84892689751
-
Correction of the Crb1rd8 allele and retinal phenotype in C57BL/6N mice via TALEN-mediated homology-directed repair
-
Low B.E., et al. Correction of the Crb1rd8 allele and retinal phenotype in C57BL/6N mice via TALEN-mediated homology-directed repair. Invest. Ophthalmol. Vis. Sci. 2014, 55:387-395.
-
(2014)
Invest. Ophthalmol. Vis. Sci.
, vol.55
, pp. 387-395
-
-
Low, B.E.1
-
25
-
-
84907200149
-
Prevention of muscular dystrophy in mice by CRISPR/Cas9-mediated editing of germline DNA
-
Long C., et al. Prevention of muscular dystrophy in mice by CRISPR/Cas9-mediated editing of germline DNA. Science 2014, 345:1184-1188.
-
(2014)
Science
, vol.345
, pp. 1184-1188
-
-
Long, C.1
-
26
-
-
84905594309
-
Simple generation of albino C57BL/6J mice with G291T mutation in the tyrosinase gene by the CRISPR/Cas9 system
-
Mizuno S., et al. Simple generation of albino C57BL/6J mice with G291T mutation in the tyrosinase gene by the CRISPR/Cas9 system. Mamm. Genome 2014, 25:327-334.
-
(2014)
Mamm. Genome
, vol.25
, pp. 327-334
-
-
Mizuno, S.1
-
27
-
-
84892659943
-
Feasibility for a large scale mouse mutagenesis by injecting CRISPR/Cas plasmid into zygotes
-
Mashiko D., et al. Feasibility for a large scale mouse mutagenesis by injecting CRISPR/Cas plasmid into zygotes. Dev. Growth Differ. 2014, 56:122-129.
-
(2014)
Dev. Growth Differ.
, vol.56
, pp. 122-129
-
-
Mashiko, D.1
-
28
-
-
84908225939
-
Efficient gene targeting of the Rosa26 locus in mouse zygotes using TALE nucleases
-
Kasparek P., et al. Efficient gene targeting of the Rosa26 locus in mouse zygotes using TALE nucleases. FEBS Lett. 2014, 588:3982-3988.
-
(2014)
FEBS Lett.
, vol.588
, pp. 3982-3988
-
-
Kasparek, P.1
-
29
-
-
84897413441
-
Efficient generation of genome-modified mice via offset-nicking by CRISPR/Cas system
-
Fujii W., et al. Efficient generation of genome-modified mice via offset-nicking by CRISPR/Cas system. Biochem. Biophys. Res. Commun. 2014, 445:791-794.
-
(2014)
Biochem. Biophys. Res. Commun.
, vol.445
, pp. 791-794
-
-
Fujii, W.1
-
30
-
-
79961196358
-
Knockout rats generated by embryo microinjection of TALENs
-
Tesson L., et al. Knockout rats generated by embryo microinjection of TALENs. Nat. Biotechnol. 2011, 29:695-696.
-
(2011)
Nat. Biotechnol.
, vol.29
, pp. 695-696
-
-
Tesson, L.1
-
31
-
-
84883779087
-
Simultaneous generation and germline transmission of multiple gene mutations in rat using CRISPR-Cas systems
-
Li W., et al. Simultaneous generation and germline transmission of multiple gene mutations in rat using CRISPR-Cas systems. Nat. Biotechnol. 2013, 31:684-686.
-
(2013)
Nat. Biotechnol.
, vol.31
, pp. 684-686
-
-
Li, W.1
-
32
-
-
84903555108
-
Allele-specific genome editing and correction of disease-associated phenotypes in rats using the CRISPR-Cas platform
-
Yoshimi K., et al. Allele-specific genome editing and correction of disease-associated phenotypes in rats using the CRISPR-Cas platform. Nat. Commun. 2014, 5:4240.
-
(2014)
Nat. Commun.
, vol.5
, pp. 4240
-
-
Yoshimi, K.1
-
33
-
-
84867911474
-
Efficient TALEN-mediated gene knockout in livestock
-
Carlson D.F., et al. Efficient TALEN-mediated gene knockout in livestock. Proc. Natl. Acad. Sci. U.S.A. 2012, 109:17382-17387.
-
(2012)
Proc. Natl. Acad. Sci. U.S.A.
, vol.109
, pp. 17382-17387
-
-
Carlson, D.F.1
-
34
-
-
84941208123
-
Efficient generation of gene-modified pigs via injection of zygote with Cas9/sgRNA
-
Wang Y., et al. Efficient generation of gene-modified pigs via injection of zygote with Cas9/sgRNA. Sci. Rep. 2015, 5:8256.
-
(2015)
Sci. Rep.
, vol.5
, pp. 8256
-
-
Wang, Y.1
-
35
-
-
84897594300
-
One-step generation of knockout pigs by zygote injection of CRISPR/Cas system
-
Hai T., et al. One-step generation of knockout pigs by zygote injection of CRISPR/Cas system. Cell Res. 2014, 24:372-375.
-
(2014)
Cell Res.
, vol.24
, pp. 372-375
-
-
Hai, T.1
-
36
-
-
84919951002
-
Genome edited sheep and cattle
-
Proudfoot C., et al. Genome edited sheep and cattle. Transgenic Res. 2015, 24:147-153.
-
(2015)
Transgenic Res.
, vol.24
, pp. 147-153
-
-
Proudfoot, C.1
-
37
-
-
84902361082
-
Generation of a monkey with MECP2 mutations by TALEN-based gene targeting
-
Liu Z., et al. Generation of a monkey with MECP2 mutations by TALEN-based gene targeting. Neurosci. Bull. 2014, 30:381-386.
-
(2014)
Neurosci. Bull.
, vol.30
, pp. 381-386
-
-
Liu, Z.1
-
38
-
-
84920269807
-
Correction of a genetic disease by CRISPR-Cas9-mediated gene editing in mouse spermatogonial stem cells
-
Wu Y., et al. Correction of a genetic disease by CRISPR-Cas9-mediated gene editing in mouse spermatogonial stem cells. Cell Res. 2015, 25:67-79.
-
(2015)
Cell Res.
, vol.25
, pp. 67-79
-
-
Wu, Y.1
-
39
-
-
84925662286
-
Targeted germline modifications in rats ising CRISPR/Cas9 and spermatogonial stem cells
-
Chapman K.M., et al. Targeted germline modifications in rats ising CRISPR/Cas9 and spermatogonial stem cells. Cell Rep. 2015, 10:1828-1835.
-
(2015)
Cell Rep.
, vol.10
, pp. 1828-1835
-
-
Chapman, K.M.1
-
40
-
-
84928395483
-
Selective elimination of mitochondrial mutations in the germline by genome editing
-
Reddy P., et al. Selective elimination of mitochondrial mutations in the germline by genome editing. Cell 2015, 161:459-469.
-
(2015)
Cell
, vol.161
, pp. 459-469
-
-
Reddy, P.1
-
41
-
-
84930618439
-
CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes
-
Liang P., et al. CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes. Protein Cell 2015, 6:363-372.
-
(2015)
Protein Cell
, vol.6
, pp. 363-372
-
-
Liang, P.1
-
42
-
-
84864439768
-
Targeted gene knockout by direct delivery of zinc-finger nuclease proteins
-
Gaj T., et al. Targeted gene knockout by direct delivery of zinc-finger nuclease proteins. Nat. Methods 2012, 9:805-807.
-
(2012)
Nat. Methods
, vol.9
, pp. 805-807
-
-
Gaj, T.1
-
43
-
-
84901834420
-
Highly efficient RNA-guided genome editing in human cells via delivery of purified Cas9 ribonucleoproteins
-
Kim S., et al. Highly efficient RNA-guided genome editing in human cells via delivery of purified Cas9 ribonucleoproteins. Genome Res. 2014, 24:1012-1019.
-
(2014)
Genome Res.
, vol.24
, pp. 1012-1019
-
-
Kim, S.1
-
44
-
-
84902204289
-
Dimeric CRISPR RNA-guided FokI nucleases for highly specific genome editing
-
Tsai S.Q., et al. Dimeric CRISPR RNA-guided FokI nucleases for highly specific genome editing. Nat. Biotechnol. 2014, 32:569-576.
-
(2014)
Nat. Biotechnol.
, vol.32
, pp. 569-576
-
-
Tsai, S.Q.1
-
45
-
-
84896929630
-
Improving CRISPR-Cas nuclease specificity using truncated guide RNAs
-
Fu Y., et al. Improving CRISPR-Cas nuclease specificity using truncated guide RNAs. Nat. Biotechnol. 2014, 32:279-284.
-
(2014)
Nat. Biotechnol.
, vol.32
, pp. 279-284
-
-
Fu, Y.1
-
46
-
-
84923846574
-
Digenome-seq: genome-wide profiling of CRISPR-Cas9 off-target effects in human cells
-
Kim D., et al. Digenome-seq: genome-wide profiling of CRISPR-Cas9 off-target effects in human cells. Nat. Methods 2015, 12:237-243.
-
(2015)
Nat. Methods
, vol.12
, pp. 237-243
-
-
Kim, D.1
-
47
-
-
84923266604
-
GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases
-
Tsai S.Q., Zheng Z. GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases. Nat. Biotechnol. 2015, 33:187-197.
-
(2015)
Nat. Biotechnol.
, vol.33
, pp. 187-197
-
-
Tsai, S.Q.1
Zheng, Z.2
-
48
-
-
84873088209
-
Towards germline gene therapy of inherited mitochondrial diseases
-
Tachibana M., et al. Towards germline gene therapy of inherited mitochondrial diseases. Nature 2013, 493:627-631.
-
(2013)
Nature
, vol.493
, pp. 627-631
-
-
Tachibana, M.1
-
49
-
-
84873099821
-
Nuclear genome transfer in human oocytes eliminates mitochondrial DNA variants
-
Paull D., et al. Nuclear genome transfer in human oocytes eliminates mitochondrial DNA variants. Nature 2013, 493:632-637.
-
(2013)
Nature
, vol.493
, pp. 632-637
-
-
Paull, D.1
-
50
-
-
77952096877
-
Pronuclear transfer in human embryos to prevent transmission of mitochondrial DNA disease
-
Craven L., et al. Pronuclear transfer in human embryos to prevent transmission of mitochondrial DNA disease. Nature 2010, 465:82-85.
-
(2010)
Nature
, vol.465
, pp. 82-85
-
-
Craven, L.1
-
51
-
-
84881125741
-
Ethical and legal issues arising in research on inducing human germ cells from pluripotent stem cells
-
Ishii T., et al. Ethical and legal issues arising in research on inducing human germ cells from pluripotent stem cells. Cell Stem Cell 2013, 13:145-148.
-
(2013)
Cell Stem Cell
, vol.13
, pp. 145-148
-
-
Ishii, T.1
-
52
-
-
84973394822
-
Preimplantation genetic diagnosis: prenatal testing for embryos finally achieving its potential
-
Stern H.J. Preimplantation genetic diagnosis: prenatal testing for embryos finally achieving its potential. J. Clin. Med. 2014, 3:280-309.
-
(2014)
J. Clin. Med.
, vol.3
, pp. 280-309
-
-
Stern, H.J.1
-
53
-
-
84893594630
-
Genome analyses of single human oocytes
-
Hou Y., et al. Genome analyses of single human oocytes. Cell 2013, 155:1492-1506.
-
(2013)
Cell
, vol.155
, pp. 1492-1506
-
-
Hou, Y.1
-
54
-
-
84938556431
-
Apparent homozygosity of p.Phe508del in CFTR due to a large gene deletion of exons 4-11
-
Neocleous V., et al. Apparent homozygosity of p.Phe508del in CFTR due to a large gene deletion of exons 4-11. Case Rep. Genet. 2014, 2014:613863.
-
(2014)
Case Rep. Genet.
, vol.2014
, pp. 613863
-
-
Neocleous, V.1
-
55
-
-
0037379416
-
Homozygosity for CAG mutation in Huntington disease is associated with a more severe clinical course
-
Squitieri F., et al. Homozygosity for CAG mutation in Huntington disease is associated with a more severe clinical course. Brain 2003, 126:946-955.
-
(2003)
Brain
, vol.126
, pp. 946-955
-
-
Squitieri, F.1
-
56
-
-
84867116289
-
Regulation of male fertility by CFTR and implications in male infertility
-
Chen H., et al. Regulation of male fertility by CFTR and implications in male infertility. Hum. Reprod. Update 2012, 18:703-713.
-
(2012)
Hum. Reprod. Update
, vol.18
, pp. 703-713
-
-
Chen, H.1
-
57
-
-
0014675706
-
Early stages of fertilization in vitro of human oocytes matured in vitro
-
Edwards R.G., et al. Early stages of fertilization in vitro of human oocytes matured in vitro. Nature 1969, 221:632-635.
-
(1969)
Nature
, vol.221
, pp. 632-635
-
-
Edwards, R.G.1
-
58
-
-
0015222881
-
Social values and research in human embryology
-
Edwards R.G., Sharpe D.J. Social values and research in human embryology. Nature 1971, 231:87-91.
-
(1971)
Nature
, vol.231
, pp. 87-91
-
-
Edwards, R.G.1
Sharpe, D.J.2
-
59
-
-
0025288823
-
Ooplasmic transfusion: prophase germinal vesicle oocytes made developmentally competent by microinjection of metaphase II egg cytoplasm
-
Flood J.T., et al. Ooplasmic transfusion: prophase germinal vesicle oocytes made developmentally competent by microinjection of metaphase II egg cytoplasm. Fertil. Steril. 1990, 53:1049-1054.
-
(1990)
Fertil. Steril.
, vol.53
, pp. 1049-1054
-
-
Flood, J.T.1
-
60
-
-
0030055790
-
The development of mouse zygotes after fusion with synchronous and asynchronous cytoplasm
-
Levron J., et al. The development of mouse zygotes after fusion with synchronous and asynchronous cytoplasm. Hum. Reprod. 1996, 11:1287-1292.
-
(1996)
Hum. Reprod.
, vol.11
, pp. 1287-1292
-
-
Levron, J.1
-
61
-
-
0030790458
-
Birth of infant after transfer of anucleate donor oocyte cytoplasm into recipient eggs
-
Cohen J., et al. Birth of infant after transfer of anucleate donor oocyte cytoplasm into recipient eggs. Lancet 1997, 350:186-187.
-
(1997)
Lancet
, vol.350
, pp. 186-187
-
-
Cohen, J.1
-
62
-
-
0035104763
-
Mitochondria in human offspring derived from ooplasmic transplantation
-
Barritt J.A., et al. Mitochondria in human offspring derived from ooplasmic transplantation. Hum. Reprod. 2001, 16:513-516.
-
(2001)
Hum. Reprod.
, vol.16
, pp. 513-516
-
-
Barritt, J.A.1
-
63
-
-
85006309679
-
Rebuttal: interooplasmic transfers in humans
-
Barritt J.A., et al. Rebuttal: interooplasmic transfers in humans. Reprod. Biomed. Online 2001, 3:47-48.
-
(2001)
Reprod. Biomed. Online
, vol.3
, pp. 47-48
-
-
Barritt, J.A.1
-
64
-
-
2342603701
-
Pregnancy derived from human nuclear transfer
-
Zhang J., et al. Pregnancy derived from human nuclear transfer. Fertil. Steril. 2003, 80:56.
-
(2003)
Fertil. Steril.
, vol.80
, pp. 56
-
-
Zhang, J.1
|