Efficient genetic manipulation of the NOD-Rag1-/-IL2RgammaC-null mouse by combining in vitro fertilization and CRISPR/Cas9 technology

Scientific Reports

Volumn 4, Issue , 2014, Pages

  Li, Feng ^a   Cowley, Dale O ^b,c   Banner, Debra ^c   Holle, Eric ^b   Zhang, Liguo ^d   Su, Lishan ^a,d,e  

^a UNIVERSITY OF NORTH CAROLINA HOSPITALS   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

^c Trans Viragen Inc   (United States)

^d INSTITUTE OF BIOPHYSICS   (China)

^e JILIN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CRISPR ASSOCIATED PROTEIN; FUMARYLACETOACETASE; GUIDE RNA; HYDROLASE; IL2RG PROTEIN, MOUSE; INTERLEUKIN 2 RECEPTOR GAMMA;

ANIMAL; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT; CRISPR CAS SYSTEM; DEFICIENCY; EXON; FEMALE; GENETIC PROCEDURES; GENETICS; HUMAN; IN VITRO STUDY; KNOCKOUT MOUSE; MALE; MAMMALIAN EMBRYO; METABOLISM; MOLECULAR GENETICS; MOUSE; NEWBORN; NONOBESE DIABETIC MOUSE; NUCLEOTIDE SEQUENCE; PREGNANCY; PROCEDURES; SCID MOUSE;

ANIMALS; ANIMALS, NEWBORN; BASE SEQUENCE; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEATS; CRISPR-ASSOCIATED PROTEINS; CRISPR-CAS SYSTEMS; EMBRYO, MAMMALIAN; EXONS; FEMALE; GENETIC TECHNIQUES; HUMANS; HYDROLASES; IN VITRO TECHNIQUES; INTERLEUKIN RECEPTOR COMMON GAMMA SUBUNIT; MALE; MICE; MICE, INBRED NOD; MICE, KNOCKOUT; MICE, SCID; MOLECULAR SEQUENCE DATA; PREGNANCY; RNA, GUIDE;

EID: 84902827660     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep05290     Document Type: Article

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