Nuclear genome transfer in human oocytes eliminates mitochondrial DNA variants

Nature

Volumn 493, Issue 7434, 2013, Pages 632-637

  Paull, Daniel ^a   Emmanuele, Valentina ^b   Weiss, Keren A ^a   Treff, Nathan ^c   Stewart, Latoya ^a   Hua, Haiqing ^a,d   Zimmer, Matthew ^a   Kahler, David J ^a   Goland, Robin S ^d   Noggle, Scott A ^a   Prosser, Robert ^d   Hirano, Michio ^b   Sauer, Mark V ^d   Egli, Dieter ^a  

^a New York Stem Cell Foundation Laboratory   (United States)

^b Och Spine at New York Presbyterian Hospitals   (United States)

^c REPRODUCTIVE MEDICINE ASSOCIATES OF NEW JERSEY   (United States)

^d NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MITOCHONDRIAL DNA;

BIOLOGICAL DEVELOPMENT; CHROMOSOME; CYTOPLASM; ENZYME ACTIVITY; GENOME; MITOCHONDRIAL DNA; OXYGEN CONSUMPTION; PUBLIC HEALTH; CELL ORGANELLE; MUTATION; OXYGEN;

ARTICLE; B LYMPHOCYTE; BLASTOCYST; CELL ACTIVATION; CELL ACTIVITY; CELL DIFFERENTIATION; CELL NUCLEUS TRANSPLANTATION; CHROMOSOME; DNA TRANSFER; ENZYME ACTIVITY; GENE MUTATION; GENETIC VARIABILITY; GENOME; GENOTYPE; HEART MUSCLE CELL; HUMAN; HUMAN CELL; MITOCHONDRIAL RESPIRATION; NUCLEOTIDE SEQUENCE; OOCYTE; OXYGEN CONSUMPTION; PRIORITY JOURNAL; STEM CELL; CELL EXPANSION; DEPOLYMERIZATION; DNA SEQUENCE; GENE TRANSFER; NERVE CELL; NONHUMAN; NUCLEAR REPROGRAMMING; SPINDLE CELL;

CELL LINE; CELLS, CULTURED; CRYOPRESERVATION; DNA, MITOCHONDRIAL; EMBRYONIC DEVELOPMENT; EMBRYONIC STEM CELLS; GENOTYPE; HUMANS; MITOCHONDRIA; NUCLEAR TRANSFER TECHNIQUES; OOCYTES;

EID: 84873099821     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature11800     Document Type: Article

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