Efficient generation of genome-modified mice via offset-nicking by CRISPR/Cas system

Biochemical and Biophysical Research Communications

Volumn 445, Issue 4, 2014, Pages 791-794

  Fujii, Wataru ^a   Onuma, Asuka ^a   Sugiura, Koji ^a   Naito, Kunihiko ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

CRISPR Cas9; Genome modified animals; Nickase; Off target

Indexed keywords

CAS9 NICKASE; CELLULAR APOPTOSIS SUSCEPTIBILITY PROTEIN; GUIDE RNA; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CRISPR CAS SYSTEM; DNA MODIFICATION; EMBRYO; FEMALE; GENE DELETION; GENE MUTATION; GENE TARGETING; GENOME; MOUSE; NONHUMAN; PRIORITY JOURNAL; ZYGOTE;

ANIMALIA; MAMMALIA; MUS;

CRISPR/CAS9; GENOME-MODIFIED ANIMALS; NICKASE; OFF-TARGET;

ANIMALS; BASE SEQUENCE; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEATS; DEOXYRIBONUCLEASE I; GENE DELETION; GENE KNOCK-IN TECHNIQUES; GENOME; MICE; MICE, MUTANT STRAINS; MOLECULAR SEQUENCE DATA; RNA, GUIDE;

EID: 84897413441     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2014.01.141     Document Type: Article

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