Potential impact of human mitochondrial replacement on global policy regarding germline gene modification

Reproductive BioMedicine Online

Volumn 29, Issue 2, 2014, Pages 150-155

  Ishii, Tetsuya ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

Author keywords

enhancement; ethics; eugenics; genome editing technology; international harmonization; IVF

Indexed keywords

CELL THERAPY; DNA MODIFICATION; GENOME; HEALTH CARE POLICY; HUMAN; LEGAL ASPECT; MEDICAL ETHICS; MEDICAL TECHNOLOGY; MITOCHONDRIAL REPLACEMENT; MITOCHONDRION; NONHUMAN; REVIEW; SAFETY; UNITED KINGDOM; GENETIC ENGINEERING; GENETICS; GERM CELL; MITOCHONDRIAL DISEASES;

MITOCHONDRIAL DNA;

DNA, MITOCHONDRIAL; GENETIC ENGINEERING; GERM CELLS; HUMANS; MITOCHONDRIAL DISEASES;

EID: 84905481617     PISSN: 14726483     EISSN: 14726491     Source Type: Journal    
DOI: 10.1016/j.rbmo.2014.04.001     Document Type: Note

References (23)

1. Anderson S., Bankier A.T., Barrell B.G., de Bruijn M.H.L., Coulson A.R., Drouin J., Eperon I.C., Nierlich D.P., Roe B.A., Sanger F., Schreier P.H., Smith A.J.H., Staden R., and Young I.G. Sequence and organization of the human mitochondrial genome Nature 290 1981 57 65
2. Baylis F. The ethics of creating children with three genetic parents Reprod. Biomed. Online 26 2013 531 534
3. Brown D.T., Herbert M., Lamb V.K., Chinnery P.F., Taylor R.W., Lightowlers R.N., Craven L., Cree L., Gardner J.L., and Turnbull D.M. Transmission of mitochondrial DNA disorders: possibilities for the future Lancet 368 2006 87 89
4. Bredenoord A., and Braude P. Ethics of mitochondrial gene replacement: from bench to bedside BMJ 341 2010 c6021
5. ClinicalTrials.gov, 2013. Autologous T-Cells Genetically Modified at the CCR5 Gene by Zinc Finger Nucleases SB-728 for HIV (Zinc-Finger). < http://clinicaltrials.gov/ct2/show/NCT00842634 > (Accessed in the ClinicalTrials.gov. November 14, 2013).
6. Cohen J., and Alikani M. The biological basis for defining bi-parental or tri-parental origin of offspring from cytoplasmic and spindle transfer Reprod. Biomed. Online 26 2013 535 537
7. Craven L., Tuppen H.A., Greggains G.D., Harbottle S.J., Murphy J.L., Cree L.M., Murdoch A.P., Chinnery P.F., Taylor R.W., Lightowlers R.N., Herbert M., and Turnbull D.M. Pronuclear transfer in human embryos to prevent transmission of mitochondrial DNA disease Nature 465 2010 82 85
8. Darnovsky M.A. A slippery slope to human germline modification Nature 499 2013 127
9. Department of Health, 2014. Mitochondrial Donation. A Consultation on Draft Regulations to Permit the Use of New Treatment Techniques to Prevent the Transmission of a Serious Mitochondrial Disease from Mother to Child. < https://www.gov.uk/government/consultations/serious-mitochondrial-disease-new- techniques-to-prevent-transmission >.
10. FDA, 2014. Meeting Materials, Cellular, Tissue and Gene Therapies Advisory Committee. < http://www.FDA.gov/AdvisoryCommittees/ CommitteesMeetingMaterials/BloodVaccinesandOtherBiologics/ CellularTissueandGeneTherapiesAdvisoryCommittee/ucm380047.htm >.
11. Frankel, M.S., Chapman, A.R., 2000. Human Inheritable Genetic Modifications. Assessing Scientific, Ethical, Religious, and Policy Issues. American Association for the Advancement of Science. < http://shr.aaas.org/ projects/human-enhance/reports/germline.pdf >.
12. Gaj T., Gersbach C.A., and Barbas C.F. 3rd ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering Trends Biotechnol 31 2013 397 405
13. HFEA, 2013a. Authority Paper: Mitochondria replacement Consultation: Advice to Government. < http://www.hfea.gov.uk/7796.html >.
14. HFEA, 2013b. HFEA Statement Regarding the Klaus Reinhardt et al. Science Paper 'Mitochondrial Replacement, Evolution, and the Clinic'. < http://www.hfea.gov.uk/8178.html >.
15. ICH, International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use web site. < http://www.ich.org/ >.
16. Ishii T., Reijo Pera R.A., and Greely H.G. Ethical and legal issues arising in research on inducing human germ cells from pluripotent stem cells Cell Stem Cell 13 2013 145 148
17. Johnson M.H. Tri-parenthood - a simply misleading term or an ethically misguided approach? Reprod. Biomed. Online 26 2013 516 519
18. Koopman W.J., Willems P.H., and Smeitink J.A. Monogenic mitochondrial disorders N. Engl. J. Med 366 2012 1132 1141
19. Niu Y., Shen B., Cui Y., Chen Y., Wang J., Wang L., Kang Y., Zhao X., Si W., Li W., Xiang A.P., Zhou J., Guo X., Bi Y., Si C., Hu B., Dong G., Wang H., Zhou Z., Li T., Tan T., Pu X., Wang F., Ji S., Zhou Q., Huang X., Ji W., and Sha J. Generation of gene-modified cynomolgus monkey via Cas9/RNA-mediated gene targeting in one-cell embryos Cell 156 2014 836 843
20. Paull D., Emmanuele V., Weiss K.A., Treff N., Stewart L., Hua H., Zimmer M., Kahler D.J., Goland R.S., Noggle S.A., Prosser R., Hirano M., Sauer M.V., and Egli D. Nuclear genome transfer in human oocytes eliminates mitochondrial DNA variants Nature 493 2013 632 637
21. Reinhardt K., Dowling D.K., and Morrow E.H. Mitochondrial replacement, evolution, and the clinic Science 341 2013 1345 1346
22. St John J.C., and Campbell K.H. The battle to prevent the transmission of mitochondrial DNA disease: is karyoplast transfer the answer? Gene Ther 17 2010 147 149
23. Tachibana M., Amato P., Sparman M., Woodward J., Sanchis D.M., Ma H., Gutierrez N.M., Tippner-Hedges R., Kang E., Lee H.S., Ramsey C., Masterson K., Battaglia D., Lee D., Wu D., Jensen J., Patton P., Gokhale S., Stouffer R., and Mitalipov S. Towards germline gene therapy of inherited mitochondrial diseases Nature 493 2013 627 631