Allele-specific genome editing and correction of disease-associated phenotypes in rats using the CRISPR-Cas platform

Nature Communications

Volumn 5, Issue , 2014, Pages

  Yoshimi, K ^a   Kaneko, T ^a   Voigt, B ^a   Mashimo, T ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DNA FRAGMENT; GUIDE RNA; OLIGODEOXYNUCLEOTIDE; AGOUTI PROTEIN; ASIP PROTEIN, RAT; MONOPHENOL MONOOXYGENASE; STEM CELL FACTOR RECEPTOR;

ALLELE; BACTERIUM; CHROMOSOME; DISEASE PREVALENCE; FRAGMENTATION; GENETIC ENGINEERING; GENOME; PHENOTYPE; RODENT;

ALLELE; ANIMAL CELL; ANIMAL CELL CULTURE; ARTICLE; CONTROLLED STUDY; CRISPR CAS SYSTEM; DNA SEQUENCE; ELECTROPORATION; EMBRYO; EXON; FIBROBLAST; GENE CONVERSION; GENE MUTATION; GENOME; INDEL MUTATION; LONG TERMINAL REPEAT; MISSENSE MUTATION; NONHUMAN; PHENOTYPE; POLYMERASE CHAIN REACTION; RAT; SEQUENCE ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM; ANIMAL; GENE THERAPY; GENETIC ENGINEERING; GENETICS; PROCEDURES; RNA EDITING;

AGOUTI SIGNALING PROTEIN; ALLELES; ANIMALS; CRISPR-CAS SYSTEMS; GENETIC ENGINEERING; GENETIC THERAPY; MONOPHENOL MONOOXYGENASE; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTO-ONCOGENE PROTEINS C-KIT; RATS; RNA EDITING; RNA, GUIDE;

EID: 84903555108     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms5240     Document Type: Article

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