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Volumn 41, Issue 7, 2015, Pages 588-597

The hallmarks of castration-resistant prostate cancers

Author keywords

Androgen receptor; Castration resistant mechanisms; Hallmarks; Prostate cancer

Indexed keywords

ANDROGEN; ANDROGEN RECEPTOR; ANTIANDROGEN; ANTIAPOPTOTIC PROTEIN DERIVATIVE; MICRORNA; PROTEIN DERIVATIVE; UNCLASSIFIED DRUG;

EID: 84937639205     PISSN: 03057372     EISSN: 15321967     Source Type: Journal    
DOI: 10.1016/j.ctrv.2015.05.003     Document Type: Review
Times cited : (87)

References (167)
  • 4
    • 84866353706 scopus 로고    scopus 로고
    • Clinical development of novel therapeutics for castration-resistant prostate cancer: historic challenges and recent successes
    • Galsky M.D., Small A.C., Tsao C.K., Oh W.K. Clinical development of novel therapeutics for castration-resistant prostate cancer: historic challenges and recent successes. CA Cancer J Clin 2012, 62:299-308.
    • (2012) CA Cancer J Clin , vol.62 , pp. 299-308
    • Galsky, M.D.1    Small, A.C.2    Tsao, C.K.3    Oh, W.K.4
  • 6
    • 84904800824 scopus 로고    scopus 로고
    • Castration-resistant prostate cancer: latest evidence and therapeutic implications
    • Suzman D.L., Antonarakis E.S. Castration-resistant prostate cancer: latest evidence and therapeutic implications. Ther Adv Med Oncol 2014, 6:167-179.
    • (2014) Ther Adv Med Oncol , vol.6 , pp. 167-179
    • Suzman, D.L.1    Antonarakis, E.S.2
  • 7
    • 84876287522 scopus 로고    scopus 로고
    • Emerging therapies in metastatic castration-sensitive and castration-resistant prostate cancer
    • MacVicar G.R., Hussain M.H. Emerging therapies in metastatic castration-sensitive and castration-resistant prostate cancer. Curr Opin Oncol 2013, 25:252-260.
    • (2013) Curr Opin Oncol , vol.25 , pp. 252-260
    • MacVicar, G.R.1    Hussain, M.H.2
  • 8
    • 0029282743 scopus 로고
    • Prolonging survival in metastatic prostate cancer: the case for adrenal androgens-overview and summary of therapeutic controversies in prostatic cancer
    • Geller J. Prolonging survival in metastatic prostate cancer: the case for adrenal androgens-overview and summary of therapeutic controversies in prostatic cancer. J Clin Endocrinol Metab 1995, 80:1074-1078.
    • (1995) J Clin Endocrinol Metab , vol.80 , pp. 1074-1078
    • Geller, J.1
  • 9
    • 46749099444 scopus 로고    scopus 로고
    • Castration-recurrent prostate cancer is not androgen-independent
    • Mohler J.L. Castration-recurrent prostate cancer is not androgen-independent. Adv Exp Med Biol 2008, 617:223-234.
    • (2008) Adv Exp Med Biol , vol.617 , pp. 223-234
    • Mohler, J.L.1
  • 10
    • 0033215472 scopus 로고    scopus 로고
    • Evidence for clonal outgrowth of androgen-independent prostate cancer cells from androgen-dependent tumors through a two-step process
    • Craft N., Chhor C., Tran C., Belldegrun A., DeKernion J., Witte O.N., et al. Evidence for clonal outgrowth of androgen-independent prostate cancer cells from androgen-dependent tumors through a two-step process. Cancer Res 1999, 59:5030-5036.
    • (1999) Cancer Res , vol.59 , pp. 5030-5036
    • Craft, N.1    Chhor, C.2    Tran, C.3    Belldegrun, A.4    DeKernion, J.5    Witte, O.N.6
  • 11
    • 0037058653 scopus 로고    scopus 로고
    • The role of androgens and the androgen receptor in prostate cancer
    • Debes J.D., Tindall D.J. The role of androgens and the androgen receptor in prostate cancer. Cancer Lett 2002, 187:1-7.
    • (2002) Cancer Lett , vol.187 , pp. 1-7
    • Debes, J.D.1    Tindall, D.J.2
  • 12
    • 58149302446 scopus 로고    scopus 로고
    • Progression of prostate cancer: multiple pathways to androgen independence
    • Devlin H.L., Mudryj M. Progression of prostate cancer: multiple pathways to androgen independence. Cancer Lett 2009, 274:177-186.
    • (2009) Cancer Lett , vol.274 , pp. 177-186
    • Devlin, H.L.1    Mudryj, M.2
  • 13
    • 0035496220 scopus 로고    scopus 로고
    • The development of androgen-independent prostate cancer
    • Feldman B.J., Feldman D. The development of androgen-independent prostate cancer. Nat Rev Cancer 2001, 1:34-45.
    • (2001) Nat Rev Cancer , vol.1 , pp. 34-45
    • Feldman, B.J.1    Feldman, D.2
  • 14
    • 79957640371 scopus 로고    scopus 로고
    • Minireview: alternative activation pathways for the androgen receptor in prostate cancer
    • Lamont K.R., Tindall D.J. Minireview: alternative activation pathways for the androgen receptor in prostate cancer. Mol Endocrinol 2011, 25:897-907.
    • (2011) Mol Endocrinol , vol.25 , pp. 897-907
    • Lamont, K.R.1    Tindall, D.J.2
  • 15
    • 80053427621 scopus 로고    scopus 로고
    • Molecular alterations during progression of prostate cancer to androgen independence
    • Saraon P., Jarvi K., Diamandis E.P. Molecular alterations during progression of prostate cancer to androgen independence. Clin Chem 2011, 57:1366-1375.
    • (2011) Clin Chem , vol.57 , pp. 1366-1375
    • Saraon, P.1    Jarvi, K.2    Diamandis, E.P.3
  • 16
    • 10944221722 scopus 로고    scopus 로고
    • Molecular analysis integrating different pathways associated with androgen-independent progression in LuCaP 23.1 xenograft
    • Rocchi P., Muracciole X., Fina F., Mulholland D.J., Karsenty G., Palmari J., et al. Molecular analysis integrating different pathways associated with androgen-independent progression in LuCaP 23.1 xenograft. Oncogene 2004, 23:9111-9119.
    • (2004) Oncogene , vol.23 , pp. 9111-9119
    • Rocchi, P.1    Muracciole, X.2    Fina, F.3    Mulholland, D.J.4    Karsenty, G.5    Palmari, J.6
  • 17
    • 84934442185 scopus 로고    scopus 로고
    • Targeting the adaptive molecular landscape of castration-resistant prostate cancer
    • Wyatt A.W., Gleave M.E. Targeting the adaptive molecular landscape of castration-resistant prostate cancer. EMBO Mol Med 2015.
    • (2015) EMBO Mol Med
    • Wyatt, A.W.1    Gleave, M.E.2
  • 18
    • 0036219874 scopus 로고    scopus 로고
    • Mechanisms involved in the progression of androgen-independent prostate cancers: it is not only the cancer cell's fault
    • Arnold J.T., Isaacs J.T. Mechanisms involved in the progression of androgen-independent prostate cancers: it is not only the cancer cell's fault. Endocr Relat Cancer 2002, 9:61-73.
    • (2002) Endocr Relat Cancer , vol.9 , pp. 61-73
    • Arnold, J.T.1    Isaacs, J.T.2
  • 19
    • 33645690200 scopus 로고    scopus 로고
    • Mechanisms underlying the development of androgen-independent prostate cancer
    • Pienta K.J., Bradley D. Mechanisms underlying the development of androgen-independent prostate cancer. Clin Cancer Res 2006, 12:1665-1671.
    • (2006) Clin Cancer Res , vol.12 , pp. 1665-1671
    • Pienta, K.J.1    Bradley, D.2
  • 20
    • 0033557839 scopus 로고    scopus 로고
    • Survey of gene amplifications during prostate cancer progression by high-throughout fluorescence in situ hybridization on tissue microarrays
    • Bubendorf L., Kononen J., Koivisto P., Schraml P., Moch H., Gasser T.C., et al. Survey of gene amplifications during prostate cancer progression by high-throughout fluorescence in situ hybridization on tissue microarrays. Cancer Res 1999, 59:803-806.
    • (1999) Cancer Res , vol.59 , pp. 803-806
    • Bubendorf, L.1    Kononen, J.2    Koivisto, P.3    Schraml, P.4    Moch, H.5    Gasser, T.C.6
  • 21
    • 0242525635 scopus 로고    scopus 로고
    • Gene amplifications associated with the development of hormone-resistant prostate cancer
    • Edwards J., Krishna N.S., Witton C.J., Bartlett J.M. Gene amplifications associated with the development of hormone-resistant prostate cancer. Clin Cancer Res 2003, 9:5271-5281.
    • (2003) Clin Cancer Res , vol.9 , pp. 5271-5281
    • Edwards, J.1    Krishna, N.S.2    Witton, C.J.3    Bartlett, J.M.4
  • 22
    • 77952105685 scopus 로고    scopus 로고
    • Antitumour activity of MDV3100 in castration-resistant prostate cancer: a phase 1-2 study
    • Scher H.I., Beer T.M., Higano C.S., Anand A., Taplin M.E., Efstathiou E., et al. Antitumour activity of MDV3100 in castration-resistant prostate cancer: a phase 1-2 study. Lancet 2010, 375:1437-1446.
    • (2010) Lancet , vol.375 , pp. 1437-1446
    • Scher, H.I.1    Beer, T.M.2    Higano, C.S.3    Anand, A.4    Taplin, M.E.5    Efstathiou, E.6
  • 23
    • 84954386948 scopus 로고    scopus 로고
    • Enzalutamide: targeting the androgen signalling pathway in metastatic castration-resistant prostate cancer
    • Schalken J., Fitzpatrick J.M. Enzalutamide: targeting the androgen signalling pathway in metastatic castration-resistant prostate cancer. BJU Int 2015.
    • (2015) BJU Int
    • Schalken, J.1    Fitzpatrick, J.M.2
  • 24
    • 1542574202 scopus 로고    scopus 로고
    • Gene expression analysis of human prostate carcinoma during hormonal therapy identifies androgen-responsive genes and mechanisms of therapy resistance
    • Holzbeierlein J., Lal P., LaTulippe E., Smith A., Satagopan J., Zhang L., et al. Gene expression analysis of human prostate carcinoma during hormonal therapy identifies androgen-responsive genes and mechanisms of therapy resistance. Am J Pathol 2004, 164:217-227.
    • (2004) Am J Pathol , vol.164 , pp. 217-227
    • Holzbeierlein, J.1    Lal, P.2    LaTulippe, E.3    Smith, A.4    Satagopan, J.5    Zhang, L.6
  • 25
    • 49249119358 scopus 로고    scopus 로고
    • Maintenance of intratumoral androgens in metastatic prostate cancer: a mechanism for castration-resistant tumor growth
    • Montgomery R.B., Mostaghel E.A., Vessella R., Hess D.L., Kalhorn T.F., Higano C.S., et al. Maintenance of intratumoral androgens in metastatic prostate cancer: a mechanism for castration-resistant tumor growth. Cancer Res 2008, 68:4447-4454.
    • (2008) Cancer Res , vol.68 , pp. 4447-4454
    • Montgomery, R.B.1    Mostaghel, E.A.2    Vessella, R.3    Hess, D.L.4    Kalhorn, T.F.5    Higano, C.S.6
  • 26
    • 74949106995 scopus 로고    scopus 로고
    • Molecular mechanisms of castration-resistant prostate cancer progression
    • Dutt S.S., Gao A.C. Molecular mechanisms of castration-resistant prostate cancer progression. Future Oncol 2009, 5:1403-1413.
    • (2009) Future Oncol , vol.5 , pp. 1403-1413
    • Dutt, S.S.1    Gao, A.C.2
  • 27
    • 0030938257 scopus 로고    scopus 로고
    • A prevalent missense substitution that modulates activity of prostatic steroid 5alpha-reductase
    • Makridakis N., Ross R.K., Pike M.C., Chang L., Stanczyk F.Z., Kolonel L.N., et al. A prevalent missense substitution that modulates activity of prostatic steroid 5alpha-reductase. Cancer Res 1997, 57:1020-1022.
    • (1997) Cancer Res , vol.57 , pp. 1020-1022
    • Makridakis, N.1    Ross, R.K.2    Pike, M.C.3    Chang, L.4    Stanczyk, F.Z.5    Kolonel, L.N.6
  • 28
    • 51049098138 scopus 로고    scopus 로고
    • Androgen levels increase by intratumoral de novo steroidogenesis during progression of castration-resistant prostate cancer
    • Locke J.A., Guns E.S., Lubik A.A., Adomat H.H., Hendy S.C., Wood C.A., et al. Androgen levels increase by intratumoral de novo steroidogenesis during progression of castration-resistant prostate cancer. Cancer Res 2008, 68:6407-6415.
    • (2008) Cancer Res , vol.68 , pp. 6407-6415
    • Locke, J.A.1    Guns, E.S.2    Lubik, A.A.3    Adomat, H.H.4    Hendy, S.C.5    Wood, C.A.6
  • 29
    • 42949165515 scopus 로고    scopus 로고
    • A role for the androgen-receptor in clinically localized and advanced prostate cancer
    • Mohler J.L. A role for the androgen-receptor in clinically localized and advanced prostate cancer. Best Pract Res Clin Endocrinol Metab 2008, 22:357-372.
    • (2008) Best Pract Res Clin Endocrinol Metab , vol.22 , pp. 357-372
    • Mohler, J.L.1
  • 31
    • 0029011116 scopus 로고
    • Mutation of the androgen-receptor gene in metastatic androgen-independent prostate cancer
    • Taplin M.E., Bubley G.J., Shuster T.D., Frantz M.E., Spooner A.E., Ogata G.K., et al. Mutation of the androgen-receptor gene in metastatic androgen-independent prostate cancer. N Engl J Med 1995, 332:1393-1398.
    • (1995) N Engl J Med , vol.332 , pp. 1393-1398
    • Taplin, M.E.1    Bubley, G.J.2    Shuster, T.D.3    Frantz, M.E.4    Spooner, A.E.5    Ogata, G.K.6
  • 32
    • 0029915052 scopus 로고    scopus 로고
    • Mutations in the androgen receptor gene are associated with progression of human prostate cancer to androgen independence
    • Tilley W.D., Buchanan G., Hickey T.E., Bentel J.M. Mutations in the androgen receptor gene are associated with progression of human prostate cancer to androgen independence. Clin Cancer Res 1996, 2:277-285.
    • (1996) Clin Cancer Res , vol.2 , pp. 277-285
    • Tilley, W.D.1    Buchanan, G.2    Hickey, T.E.3    Bentel, J.M.4
  • 33
    • 65949113815 scopus 로고    scopus 로고
    • The role of androgen receptor mutations in prostate cancer progression
    • Brooke G.N., Bevan C.L. The role of androgen receptor mutations in prostate cancer progression. Curr Genomics 2009, 10:18-25.
    • (2009) Curr Genomics , vol.10 , pp. 18-25
    • Brooke, G.N.1    Bevan, C.L.2
  • 34
    • 0028113415 scopus 로고
    • Androgen receptor activation in prostatic tumor cell lines by insulin-like growth factor-I, keratinocyte growth factor, and epidermal growth factor
    • Culig Z., Hobisch A., Cronauer M.V., Radmayr C., Trapman J., Hittmair A., et al. Androgen receptor activation in prostatic tumor cell lines by insulin-like growth factor-I, keratinocyte growth factor, and epidermal growth factor. Cancer Res 1994, 54:5474-5478.
    • (1994) Cancer Res , vol.54 , pp. 5474-5478
    • Culig, Z.1    Hobisch, A.2    Cronauer, M.V.3    Radmayr, C.4    Trapman, J.5    Hittmair, A.6
  • 35
    • 34047181147 scopus 로고    scopus 로고
    • Drug insight: role of the androgen receptor in the development and progression of prostate cancer
    • Taplin M.E. Drug insight: role of the androgen receptor in the development and progression of prostate cancer. Nat Clin Pract Oncol 2007, 4:236-244.
    • (2007) Nat Clin Pract Oncol , vol.4 , pp. 236-244
    • Taplin, M.E.1
  • 36
    • 0026591729 scopus 로고
    • Anti-androgens and the mutated androgen receptor of LNCaP cells: differential effects on binding affinity, heat-shock protein interaction, and transcription activation
    • Veldscholte J., Berrevoets C.A., Brinkmann A.O., Grootegoed J.A., Mulder E. Anti-androgens and the mutated androgen receptor of LNCaP cells: differential effects on binding affinity, heat-shock protein interaction, and transcription activation. Biochemistry 1992, 31:2393-2399.
    • (1992) Biochemistry , vol.31 , pp. 2393-2399
    • Veldscholte, J.1    Berrevoets, C.A.2    Brinkmann, A.O.3    Grootegoed, J.A.4    Mulder, E.5
  • 37
    • 0034125195 scopus 로고    scopus 로고
    • Glucocorticoids can promote androgen-independent growth of prostate cancer cells through a mutated androgen receptor
    • Zhao X.Y., Malloy P.J., Krishnan A.V., Swami S., Navone N.M., Peehl D.M., et al. Glucocorticoids can promote androgen-independent growth of prostate cancer cells through a mutated androgen receptor. Nat Med 2000, 6:703-706.
    • (2000) Nat Med , vol.6 , pp. 703-706
    • Zhao, X.Y.1    Malloy, P.J.2    Krishnan, A.V.3    Swami, S.4    Navone, N.M.5    Peehl, D.M.6
  • 38
    • 59749095425 scopus 로고    scopus 로고
    • Pleiotropic functional properties of androgen receptor mutants in prostate cancer
    • Bergerat J.P., Ceraline J. Pleiotropic functional properties of androgen receptor mutants in prostate cancer. Hum Mutat 2009, 30:145-157.
    • (2009) Hum Mutat , vol.30 , pp. 145-157
    • Bergerat, J.P.1    Ceraline, J.2
  • 39
    • 0035552352 scopus 로고    scopus 로고
    • Androgen receptor mutations in carcinoma of the prostate: significance for endocrine therapy
    • Culig Z., Klocker H., Bartsch G., Hobisch A. Androgen receptor mutations in carcinoma of the prostate: significance for endocrine therapy. Am J Pharmacogenomics 2001, 1:241-249.
    • (2001) Am J Pharmacogenomics , vol.1 , pp. 241-249
    • Culig, Z.1    Klocker, H.2    Bartsch, G.3    Hobisch, A.4
  • 41
    • 0033152164 scopus 로고    scopus 로고
    • Selection for androgen receptor mutations in prostate cancers treated with androgen antagonist
    • Taplin M.E., Bubley G.J., Ko Y.J., Small E.J., Upton M., Rajeshkumar B., et al. Selection for androgen receptor mutations in prostate cancers treated with androgen antagonist. Cancer Res 1999, 59:2511-2515.
    • (1999) Cancer Res , vol.59 , pp. 2511-2515
    • Taplin, M.E.1    Bubley, G.J.2    Ko, Y.J.3    Small, E.J.4    Upton, M.5    Rajeshkumar, B.6
  • 42
    • 66249135684 scopus 로고    scopus 로고
    • Treatment-dependent androgen receptor mutations in prostate cancer exploit multiple mechanisms to evade therapy
    • Steinkamp M.P., O'Mahony O.A., Brogley M., Rehman H., Lapensee E.W., Dhanasekaran S., et al. Treatment-dependent androgen receptor mutations in prostate cancer exploit multiple mechanisms to evade therapy. Cancer Res 2009, 69:4434-4442.
    • (2009) Cancer Res , vol.69 , pp. 4434-4442
    • Steinkamp, M.P.1    O'Mahony, O.A.2    Brogley, M.3    Rehman, H.4    Lapensee, E.W.5    Dhanasekaran, S.6
  • 43
    • 1842531004 scopus 로고    scopus 로고
    • Transient, ligand-dependent arrest of the androgen receptor in subnuclear foci alters phosphorylation and coactivator interactions
    • Black B.E., Vitto M.J., Gioeli D., Spencer A., Afshar N., Conaway M.R., et al. Transient, ligand-dependent arrest of the androgen receptor in subnuclear foci alters phosphorylation and coactivator interactions. Mol Endocrinol 2004, 18:834-850.
    • (2004) Mol Endocrinol , vol.18 , pp. 834-850
    • Black, B.E.1    Vitto, M.J.2    Gioeli, D.3    Spencer, A.4    Afshar, N.5    Conaway, M.R.6
  • 44
    • 33846603663 scopus 로고    scopus 로고
    • Androgen receptor coregulators and their involvement in the development and progression of prostate cancer
    • Chmelar R., Buchanan G., Need E.F., Tilley W., Greenberg N.M. Androgen receptor coregulators and their involvement in the development and progression of prostate cancer. Int J Cancer 2007, 120:719-733.
    • (2007) Int J Cancer , vol.120 , pp. 719-733
    • Chmelar, R.1    Buchanan, G.2    Need, E.F.3    Tilley, W.4    Greenberg, N.M.5
  • 45
    • 24344508481 scopus 로고    scopus 로고
    • Androgen receptor mutations identified in prostate cancer and androgen insensitivity syndrome display aberrant ART-27 coactivator function
    • Li W., Cavasotto C.N., Cardozo T., Ha S., Dang T., Taneja S.S., et al. Androgen receptor mutations identified in prostate cancer and androgen insensitivity syndrome display aberrant ART-27 coactivator function. Mol Endocrinol 2005, 19:2273-2282.
    • (2005) Mol Endocrinol , vol.19 , pp. 2273-2282
    • Li, W.1    Cavasotto, C.N.2    Cardozo, T.3    Ha, S.4    Dang, T.5    Taneja, S.S.6
  • 46
    • 0345256383 scopus 로고    scopus 로고
    • Constitutive activation of the androgen receptor by a point mutation in the hinge region: a new mechanism for androgen-independent growth in prostate cancer
    • Ceraline J., Cruchant M.D., Erdmann E., Erbs P., Kurtz J.E., Duclos B., et al. Constitutive activation of the androgen receptor by a point mutation in the hinge region: a new mechanism for androgen-independent growth in prostate cancer. Int J Cancer 2004, 108:152-157.
    • (2004) Int J Cancer , vol.108 , pp. 152-157
    • Ceraline, J.1    Cruchant, M.D.2    Erdmann, E.3    Erbs, P.4    Kurtz, J.E.5    Duclos, B.6
  • 47
    • 84861728843 scopus 로고    scopus 로고
    • Androgen receptor splice variants activate androgen receptor target genes and support aberrant prostate cancer cell growth independent of canonical androgen receptor nuclear localization signal
    • Chan S.C., Li Y., Dehm S.M. Androgen receptor splice variants activate androgen receptor target genes and support aberrant prostate cancer cell growth independent of canonical androgen receptor nuclear localization signal. J Biol Chem 2012, 287:19736-19749.
    • (2012) J Biol Chem , vol.287 , pp. 19736-19749
    • Chan, S.C.1    Li, Y.2    Dehm, S.M.3
  • 48
    • 65549168746 scopus 로고    scopus 로고
    • A novel androgen receptor splice variant is up-regulated during prostate cancer progression and promotes androgen depletion-resistant growth
    • Guo Z., Yang X., Sun F., Jiang R., Linn D.E., Chen H., et al. A novel androgen receptor splice variant is up-regulated during prostate cancer progression and promotes androgen depletion-resistant growth. Cancer Res 2009, 69:2305-2313.
    • (2009) Cancer Res , vol.69 , pp. 2305-2313
    • Guo, Z.1    Yang, X.2    Sun, F.3    Jiang, R.4    Linn, D.E.5    Chen, H.6
  • 49
    • 74049109753 scopus 로고    scopus 로고
    • Identification of novel truncated androgen receptor (AR) mutants including unreported pre-mRNA splicing variants in the 22Rv1 hormone-refractory prostate cancer (PCa) cell line
    • Marcias G., Erdmann E., Lapouge G., Siebert C., Barthelemy P., Duclos B., et al. Identification of novel truncated androgen receptor (AR) mutants including unreported pre-mRNA splicing variants in the 22Rv1 hormone-refractory prostate cancer (PCa) cell line. Hum Mutat 2009, 31:74-80.
    • (2009) Hum Mutat , vol.31 , pp. 74-80
    • Marcias, G.1    Erdmann, E.2    Lapouge, G.3    Siebert, C.4    Barthelemy, P.5    Duclos, B.6
  • 50
    • 58249110391 scopus 로고    scopus 로고
    • Ligand-independent androgen receptor variants derived from splicing of cryptic exons signify hormone-refractory prostate cancer
    • Hu R., Dunn T.A., Wei S., Isharwal S., Veltri R.W., Humphreys E., et al. Ligand-independent androgen receptor variants derived from splicing of cryptic exons signify hormone-refractory prostate cancer. Cancer Res 2009, 69:16-22.
    • (2009) Cancer Res , vol.69 , pp. 16-22
    • Hu, R.1    Dunn, T.A.2    Wei, S.3    Isharwal, S.4    Veltri, R.W.5    Humphreys, E.6
  • 51
    • 77955296562 scopus 로고    scopus 로고
    • Castration resistance in human prostate cancer is conferred by a frequently occurring androgen receptor splice variant
    • Sun S., Sprenger C.C., Vessella R.L., Haugk K., Soriano K., Mostaghel E.A., et al. Castration resistance in human prostate cancer is conferred by a frequently occurring androgen receptor splice variant. J Clin Invest 2010, 120:2715-2730.
    • (2010) J Clin Invest , vol.120 , pp. 2715-2730
    • Sun, S.1    Sprenger, C.C.2    Vessella, R.L.3    Haugk, K.4    Soriano, K.5    Mostaghel, E.A.6
  • 52
    • 79955719838 scopus 로고    scopus 로고
    • Expression of androgen receptor splice variants in prostate cancer bone metastases is associated with castration-resistance and short survival
    • Hornberg E., Ylitalo E.B., Crnalic S., Antti H., Stattin P., Widmark A., et al. Expression of androgen receptor splice variants in prostate cancer bone metastases is associated with castration-resistance and short survival. PLoS ONE 2011, 6:e19059.
    • (2011) PLoS ONE , vol.6 , pp. e19059
    • Hornberg, E.1    Ylitalo, E.B.2    Crnalic, S.3    Antti, H.4    Stattin, P.5    Widmark, A.6
  • 53
    • 84872534568 scopus 로고    scopus 로고
    • Androgen receptor splice variants mediate enzalutamide resistance in castration-resistant prostate cancer cell lines
    • Li Y., Chan S.C., Brand L.J., Hwang T.H., Silverstein K.A., Dehm S.M. Androgen receptor splice variants mediate enzalutamide resistance in castration-resistant prostate cancer cell lines. Cancer Res 2013, 73:483-489.
    • (2013) Cancer Res , vol.73 , pp. 483-489
    • Li, Y.1    Chan, S.C.2    Brand, L.J.3    Hwang, T.H.4    Silverstein, K.A.5    Dehm, S.M.6
  • 54
    • 77953280591 scopus 로고    scopus 로고
    • Regression of castrate-recurrent prostate cancer by a small-molecule inhibitor of the amino-terminus domain of the androgen receptor
    • Andersen R.J., Mawji N.R., Wang J., Wang G., Haile S., Myung J.K., et al. Regression of castrate-recurrent prostate cancer by a small-molecule inhibitor of the amino-terminus domain of the androgen receptor. Cancer Cell 2010, 17:535-546.
    • (2010) Cancer Cell , vol.17 , pp. 535-546
    • Andersen, R.J.1    Mawji, N.R.2    Wang, J.3    Wang, G.4    Haile, S.5    Myung, J.K.6
  • 55
    • 58949101975 scopus 로고    scopus 로고
    • In vivo knockdown of the androgen receptor results in growth inhibition and regression of well-established, castration-resistant prostate tumors
    • Snoek R., Cheng H., Margiotti K., Wafa L.A., Wong C.A., Wong E.C., et al. In vivo knockdown of the androgen receptor results in growth inhibition and regression of well-established, castration-resistant prostate tumors. Clin Cancer Res 2009, 15:39-47.
    • (2009) Clin Cancer Res , vol.15 , pp. 39-47
    • Snoek, R.1    Cheng, H.2    Margiotti, K.3    Wafa, L.A.4    Wong, C.A.5    Wong, E.C.6
  • 56
    • 41549141749 scopus 로고    scopus 로고
    • SIRNA-directed in vivo silencing of androgen receptor inhibits the growth of castration-resistant prostate carcinomas
    • Compagno D., Merle C., Morin A., Gilbert C., Mathieu J.R., Bozec A., et al. SIRNA-directed in vivo silencing of androgen receptor inhibits the growth of castration-resistant prostate carcinomas. PLoS ONE 2007, 2:e1006.
    • (2007) PLoS ONE , vol.2 , pp. e1006
    • Compagno, D.1    Merle, C.2    Morin, A.3    Gilbert, C.4    Mathieu, J.R.5    Bozec, A.6
  • 57
    • 0033812827 scopus 로고    scopus 로고
    • Acquisition of androgen-mediated expression of mouse vas deferens protein (MVDP) gene in cultured epithelial cells and in vas deferens during postnatal development
    • Manin M., Martinez A., Van Der Schueren B., Reynaert I., Jean C. Acquisition of androgen-mediated expression of mouse vas deferens protein (MVDP) gene in cultured epithelial cells and in vas deferens during postnatal development. J Androl 2000, 21:641-650.
    • (2000) J Androl , vol.21 , pp. 641-650
    • Manin, M.1    Martinez, A.2    Van Der Schueren, B.3    Reynaert, I.4    Jean, C.5
  • 58
    • 33748927940 scopus 로고    scopus 로고
    • Interaction of IGF signaling and the androgen receptor in prostate cancer progression
    • Wu J.D., Haugk K., Woodke L., Nelson P., Coleman I., Plymate S.R. Interaction of IGF signaling and the androgen receptor in prostate cancer progression. J Cell Biochem 2006, 99:392-401.
    • (2006) J Cell Biochem , vol.99 , pp. 392-401
    • Wu, J.D.1    Haugk, K.2    Woodke, L.3    Nelson, P.4    Coleman, I.5    Plymate, S.R.6
  • 59
    • 20444368837 scopus 로고    scopus 로고
    • The androgen receptor and signal-transduction pathways in hormone-refractory prostate cancer. Part 2: Androgen-receptor cofactors and bypass pathways
    • Edwards J., Bartlett J.M. The androgen receptor and signal-transduction pathways in hormone-refractory prostate cancer. Part 2: Androgen-receptor cofactors and bypass pathways. BJU Int 2005, 95:1327-1335.
    • (2005) BJU Int , vol.95 , pp. 1327-1335
    • Edwards, J.1    Bartlett, J.M.2
  • 60
    • 1842668004 scopus 로고    scopus 로고
    • Interleukin-6 promotes androgen-independent growth in LNCaP human prostate cancer cells
    • Lee S.O., Lou W., Hou M., de Miguel F., Gerber L., Gao A.C. Interleukin-6 promotes androgen-independent growth in LNCaP human prostate cancer cells. Clin Cancer Res 2003, 9:370-376.
    • (2003) Clin Cancer Res , vol.9 , pp. 370-376
    • Lee, S.O.1    Lou, W.2    Hou, M.3    de Miguel, F.4    Gerber, L.5    Gao, A.C.6
  • 61
    • 0345549484 scopus 로고    scopus 로고
    • Interleukin-4 enhances prostate-specific antigen expression by activation of the androgen receptor and Akt pathway
    • Lee S.O., Lou W., Hou M., Onate S.A., Gao A.C. Interleukin-4 enhances prostate-specific antigen expression by activation of the androgen receptor and Akt pathway. Oncogene 2003, 22:7981-7988.
    • (2003) Oncogene , vol.22 , pp. 7981-7988
    • Lee, S.O.1    Lou, W.2    Hou, M.3    Onate, S.A.4    Gao, A.C.5
  • 62
    • 0036510548 scopus 로고    scopus 로고
    • Activation of the androgen receptor N-terminal domain by interleukin-6 via MAPK and STAT3 signal transduction pathways
    • Ueda T., Bruchovsky N., Sadar M.D. Activation of the androgen receptor N-terminal domain by interleukin-6 via MAPK and STAT3 signal transduction pathways. J Biol Chem 2002, 277:7076-7085.
    • (2002) J Biol Chem , vol.277 , pp. 7076-7085
    • Ueda, T.1    Bruchovsky, N.2    Sadar, M.D.3
  • 63
    • 77953896432 scopus 로고    scopus 로고
    • Cell signaling by receptor tyrosine kinases
    • Lemmon M.A., Schlessinger J. Cell signaling by receptor tyrosine kinases. Cell 2010, 141:1117-1134.
    • (2010) Cell , vol.141 , pp. 1117-1134
    • Lemmon, M.A.1    Schlessinger, J.2
  • 64
    • 0034671668 scopus 로고    scopus 로고
    • HER-2/neu promotes androgen-independent survival and growth of prostate cancer cells through the Akt pathway
    • Wen Y., Hu M.C., Makino K., Spohn B., Bartholomeusz G., Yan D.H., et al. HER-2/neu promotes androgen-independent survival and growth of prostate cancer cells through the Akt pathway. Cancer Res 2000, 60:6841-6845.
    • (2000) Cancer Res , vol.60 , pp. 6841-6845
    • Wen, Y.1    Hu, M.C.2    Makino, K.3    Spohn, B.4    Bartholomeusz, G.5    Yan, D.H.6
  • 65
    • 0037106457 scopus 로고    scopus 로고
    • Androgen receptor expression is regulated by the phosphoinositide 3-kinase/Akt pathway in normal and tumoral epithelial cells
    • Manin M., Baron S., Goossens K., Beaudoin C., Jean C., Veyssiere G., et al. Androgen receptor expression is regulated by the phosphoinositide 3-kinase/Akt pathway in normal and tumoral epithelial cells. Biochem J 2002, 366:729-736.
    • (2002) Biochem J , vol.366 , pp. 729-736
    • Manin, M.1    Baron, S.2    Goossens, K.3    Beaudoin, C.4    Jean, C.5    Veyssiere, G.6
  • 66
    • 0033545848 scopus 로고    scopus 로고
    • From HER2/Neu signal cascade to androgen receptor and its coactivators: a novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells
    • Yeh S., Lin H.K., Kang H.Y., Thin T.H., Lin M.F., Chang C. From HER2/Neu signal cascade to androgen receptor and its coactivators: a novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells. Proc Natl Acad Sci USA 1999, 96:5458-5463.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 5458-5463
    • Yeh, S.1    Lin, H.K.2    Kang, H.Y.3    Thin, T.H.4    Lin, M.F.5    Chang, C.6
  • 67
    • 1342325380 scopus 로고    scopus 로고
    • Epidermal growth factor increases coactivation of the androgen receptor in recurrent prostate cancer
    • Gregory C.W., Fei X., Ponguta L.A., He B., Bill H.M., French F.S., et al. Epidermal growth factor increases coactivation of the androgen receptor in recurrent prostate cancer. J Biol Chem 2004, 279:7119-7130.
    • (2004) J Biol Chem , vol.279 , pp. 7119-7130
    • Gregory, C.W.1    Fei, X.2    Ponguta, L.A.3    He, B.4    Bill, H.M.5    French, F.S.6
  • 68
    • 77951036849 scopus 로고    scopus 로고
    • Aberrant activation of the androgen receptor by NF-kappaB2/p52 in prostate cancer cells
    • Nadiminty N., Lou W., Sun M., Chen J., Yue J., Kung H.J., et al. Aberrant activation of the androgen receptor by NF-kappaB2/p52 in prostate cancer cells. Cancer Res 2010, 70:3309-3319.
    • (2010) Cancer Res , vol.70 , pp. 3309-3319
    • Nadiminty, N.1    Lou, W.2    Sun, M.3    Chen, J.4    Yue, J.5    Kung, H.J.6
  • 69
    • 84868591659 scopus 로고    scopus 로고
    • Safety and preliminary efficacy analysis of the mTOR inhibitor ridaforolimus in patients with taxane-treated, castration-resistant prostate cancer
    • Amato R.J., Wilding G., Bubley G., Loewy J., Haluska F., Gross M.E. Safety and preliminary efficacy analysis of the mTOR inhibitor ridaforolimus in patients with taxane-treated, castration-resistant prostate cancer. Clin Genitourin Cancer 2012, 10:232-238.
    • (2012) Clin Genitourin Cancer , vol.10 , pp. 232-238
    • Amato, R.J.1    Wilding, G.2    Bubley, G.3    Loewy, J.4    Haluska, F.5    Gross, M.E.6
  • 70
    • 84878889486 scopus 로고    scopus 로고
    • Phase 2 trial of single-agent everolimus in chemotherapy-naive patients with castration-resistant prostate cancer (SAKK 08/08)
    • Templeton A.J., Dutoit V., Cathomas R., Rothermundt C., Bartschi D., Droge C., et al. Phase 2 trial of single-agent everolimus in chemotherapy-naive patients with castration-resistant prostate cancer (SAKK 08/08). Eur Urol 2013, 64:150-158.
    • (2013) Eur Urol , vol.64 , pp. 150-158
    • Templeton, A.J.1    Dutoit, V.2    Cathomas, R.3    Rothermundt, C.4    Bartschi, D.5    Droge, C.6
  • 71
    • 84885175489 scopus 로고    scopus 로고
    • A phase II study evaluating the toxicity and efficacy of single-agent temsirolimus in chemotherapy-naive castration-resistant prostate cancer
    • Kruczek K., Ratterman M., Tolzien K., Sulo S., Lestingi T.M., Nabhan C. A phase II study evaluating the toxicity and efficacy of single-agent temsirolimus in chemotherapy-naive castration-resistant prostate cancer. Br J Cancer 2013, 109:1711-1716.
    • (2013) Br J Cancer , vol.109 , pp. 1711-1716
    • Kruczek, K.1    Ratterman, M.2    Tolzien, K.3    Sulo, S.4    Lestingi, T.M.5    Nabhan, C.6
  • 72
    • 84887499254 scopus 로고    scopus 로고
    • Synergistic targeting of PI3K/AKT pathway and androgen receptor axis significantly delays castration-resistant prostate cancer progression in vivo
    • Thomas C., Lamoureux F., Crafter C., Davies B.R., Beraldi E., Fazli L., et al. Synergistic targeting of PI3K/AKT pathway and androgen receptor axis significantly delays castration-resistant prostate cancer progression in vivo. Mol Cancer Ther 2013, 12:2342-2355.
    • (2013) Mol Cancer Ther , vol.12 , pp. 2342-2355
    • Thomas, C.1    Lamoureux, F.2    Crafter, C.3    Davies, B.R.4    Beraldi, E.5    Fazli, L.6
  • 73
    • 14244254699 scopus 로고    scopus 로고
    • Regulation of androgen receptor signaling in prostate cancer
    • Dehm S.M., Tindall D.J. Regulation of androgen receptor signaling in prostate cancer. Expert Rev Anticancer Ther 2005, 5:63-74.
    • (2005) Expert Rev Anticancer Ther , vol.5 , pp. 63-74
    • Dehm, S.M.1    Tindall, D.J.2
  • 74
    • 0035361340 scopus 로고    scopus 로고
    • A mechanism for androgen receptor-mediated prostate cancer recurrence after androgen deprivation therapy
    • Gregory C.W., He B., Johnson R.T., Ford O.H., Mohler J.L., French F.S., et al. A mechanism for androgen receptor-mediated prostate cancer recurrence after androgen deprivation therapy. Cancer Res 2001, 61:4315-4319.
    • (2001) Cancer Res , vol.61 , pp. 4315-4319
    • Gregory, C.W.1    He, B.2    Johnson, R.T.3    Ford, O.H.4    Mohler, J.L.5    French, F.S.6
  • 75
    • 0037693192 scopus 로고    scopus 로고
    • Expression of Tip60, an androgen receptor coactivator, and its role in prostate cancer development
    • Halkidou K., Gnanapragasam V.J., Mehta P.B., Logan I.R., Brady M.E., Cook S., et al. Expression of Tip60, an androgen receptor coactivator, and its role in prostate cancer development. Oncogene 2003, 22:2466-2477.
    • (2003) Oncogene , vol.22 , pp. 2466-2477
    • Halkidou, K.1    Gnanapragasam, V.J.2    Mehta, P.B.3    Logan, I.R.4    Brady, M.E.5    Cook, S.6
  • 76
    • 37349118115 scopus 로고    scopus 로고
    • Androgen receptor (AR) coregulators: a diversity of functions converging on and regulating the AR transcriptional complex
    • Heemers H.V., Tindall D.J. Androgen receptor (AR) coregulators: a diversity of functions converging on and regulating the AR transcriptional complex. Endocr Rev 2007, 28:778-808.
    • (2007) Endocr Rev , vol.28 , pp. 778-808
    • Heemers, H.V.1    Tindall, D.J.2
  • 77
    • 0042671452 scopus 로고    scopus 로고
    • Expression of androgen receptor coactivators in normal and cancer prostate tissues and cultured cell lines
    • Mestayer C., Blanchere M., Jaubert F., Dufour B., Mowszowicz I. Expression of androgen receptor coactivators in normal and cancer prostate tissues and cultured cell lines. Prostate 2003, 56:192-200.
    • (2003) Prostate , vol.56 , pp. 192-200
    • Mestayer, C.1    Blanchere, M.2    Jaubert, F.3    Dufour, B.4    Mowszowicz, I.5
  • 78
    • 42949086905 scopus 로고    scopus 로고
    • Influence of nucleophosmin/B23 on DNA binding and transcriptional activity of the androgen receptor in prostate cancer cell
    • Leotoing L., Meunier L., Manin M., Mauduit C., Decaussin M., Verrijdt G., et al. Influence of nucleophosmin/B23 on DNA binding and transcriptional activity of the androgen receptor in prostate cancer cell. Oncogene 2008, 27:2858-2867.
    • (2008) Oncogene , vol.27 , pp. 2858-2867
    • Leotoing, L.1    Meunier, L.2    Manin, M.3    Mauduit, C.4    Decaussin, M.5    Verrijdt, G.6
  • 80
    • 84911487876 scopus 로고    scopus 로고
    • Identification of a potent antiandrogen that targets the BF3 site of the androgen receptor and inhibits enzalutamide-resistant prostate cancer
    • Munuganti R.S., Hassona M.D., Leblanc E., Frewin K., Singh K., Ma D., et al. Identification of a potent antiandrogen that targets the BF3 site of the androgen receptor and inhibits enzalutamide-resistant prostate cancer. Chem Biol 2014, 21:1476-1485.
    • (2014) Chem Biol , vol.21 , pp. 1476-1485
    • Munuganti, R.S.1    Hassona, M.D.2    Leblanc, E.3    Frewin, K.4    Singh, K.5    Ma, D.6
  • 81
    • 84878645503 scopus 로고    scopus 로고
    • Peptidomimetic targeting of critical androgen receptor-coregulator interactions in prostate cancer
    • Ravindranathan P., Lee T.K., Yang L., Centenera M.M., Butler L., Tilley W.D., et al. Peptidomimetic targeting of critical androgen receptor-coregulator interactions in prostate cancer. Nat Commun. 2013, 4:1923.
    • (2013) Nat Commun. , vol.4 , pp. 1923
    • Ravindranathan, P.1    Lee, T.K.2    Yang, L.3    Centenera, M.M.4    Butler, L.5    Tilley, W.D.6
  • 82
    • 0032584160 scopus 로고    scopus 로고
    • Etk/Bmx, a tyrosine kinase with a pleckstrin-homology domain, is an effector of phosphatidylinositol 3'-kinase and is involved in interleukin 6-induced neuroendocrine differentiation of prostate cancer cells
    • Qiu Y., Robinson D., Pretlow T.G., Kung H.J. Etk/Bmx, a tyrosine kinase with a pleckstrin-homology domain, is an effector of phosphatidylinositol 3'-kinase and is involved in interleukin 6-induced neuroendocrine differentiation of prostate cancer cells. Proc Natl Acad Sci USA 1998, 95:3644-3649.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 3644-3649
    • Qiu, Y.1    Robinson, D.2    Pretlow, T.G.3    Kung, H.J.4
  • 83
    • 0027319765 scopus 로고
    • Characterization of neuroendocrine differentiation in human benign prostate and prostatic adenocarcinoma
    • Aprikian A.G., Cordon-Cardo C., Fair W.R., Reuter V.E. Characterization of neuroendocrine differentiation in human benign prostate and prostatic adenocarcinoma. Cancer 1993, 71:3952-3965.
    • (1993) Cancer , vol.71 , pp. 3952-3965
    • Aprikian, A.G.1    Cordon-Cardo, C.2    Fair, W.R.3    Reuter, V.E.4
  • 84
    • 1842788109 scopus 로고    scopus 로고
    • Neuroendocrine differentiation in hormone refractory prostate cancer following androgen deprivation therapy
    • discussion 92
    • Hirano D., Okada Y., Minei S., Takimoto Y., Nemoto N. Neuroendocrine differentiation in hormone refractory prostate cancer following androgen deprivation therapy. Eur Urol 2004, 45:586-592. discussion 92.
    • (2004) Eur Urol , vol.45 , pp. 586-592
    • Hirano, D.1    Okada, Y.2    Minei, S.3    Takimoto, Y.4    Nemoto, N.5
  • 85
    • 58149191580 scopus 로고    scopus 로고
    • Neuroendocrine differentiation in the progression of prostate cancer
    • Komiya A., Suzuki H., Imamoto T., Kamiya N., Nihei N., Naya Y., et al. Neuroendocrine differentiation in the progression of prostate cancer. Int J Urol 2009, 16:37-44.
    • (2009) Int J Urol , vol.16 , pp. 37-44
    • Komiya, A.1    Suzuki, H.2    Imamoto, T.3    Kamiya, N.4    Nihei, N.5    Naya, Y.6
  • 86
    • 0035117130 scopus 로고    scopus 로고
    • Expression of adrenomedullin and peptide amidation activity in human prostate cancer and in human prostate cancer cell lines
    • Rocchi P., Boudouresque F., Zamora A.J., Muracciole X., Lechevallier E., Martin P.M., et al. Expression of adrenomedullin and peptide amidation activity in human prostate cancer and in human prostate cancer cell lines. Cancer Res 2001, 61:1196-1206.
    • (2001) Cancer Res , vol.61 , pp. 1196-1206
    • Rocchi, P.1    Boudouresque, F.2    Zamora, A.J.3    Muracciole, X.4    Lechevallier, E.5    Martin, P.M.6
  • 87
    • 3442881895 scopus 로고    scopus 로고
    • NE-10 neuroendocrine cancer promotes the LNCaP xenograft growth in castrated mice
    • Jin R.J., Wang Y., Masumori N., Ishii K., Tsukamoto T., Shappell S.B., et al. NE-10 neuroendocrine cancer promotes the LNCaP xenograft growth in castrated mice. Cancer Res 2004, 64:5489-5495.
    • (2004) Cancer Res , vol.64 , pp. 5489-5495
    • Jin, R.J.1    Wang, Y.2    Masumori, N.3    Ishii, K.4    Tsukamoto, T.5    Shappell, S.B.6
  • 88
    • 84860168795 scopus 로고    scopus 로고
    • Molecular characterization of neuroendocrine prostate cancer and identification of new drug targets
    • Beltran H., Rickman D.S., Park K., Chae S.S., Sboner A., MacDonald T.Y., et al. Molecular characterization of neuroendocrine prostate cancer and identification of new drug targets. Cancer Discov 2011, 1:487-495.
    • (2011) Cancer Discov , vol.1 , pp. 487-495
    • Beltran, H.1    Rickman, D.S.2    Park, K.3    Chae, S.S.4    Sboner, A.5    MacDonald, T.Y.6
  • 89
    • 84894275509 scopus 로고    scopus 로고
    • High fidelity patient-derived xenografts for accelerating prostate cancer discovery and drug development
    • Lin D., Wyatt A.W., Xue H., Wang Y., Dong X., Haegert A., et al. High fidelity patient-derived xenografts for accelerating prostate cancer discovery and drug development. Cancer Res 2014, 74:1272-1283.
    • (2014) Cancer Res , vol.74 , pp. 1272-1283
    • Lin, D.1    Wyatt, A.W.2    Xue, H.3    Wang, Y.4    Dong, X.5    Haegert, A.6
  • 90
    • 0027773015 scopus 로고
    • Detection of the apoptosis-suppressing oncoprotein bc1-2 in hormone-refractory human prostate cancers
    • Colombel M., Symmans F., Gil S., O'Toole K.M., Chopin D., Benson M., et al. Detection of the apoptosis-suppressing oncoprotein bc1-2 in hormone-refractory human prostate cancers. Am J Pathol 1993, 143:390-400.
    • (1993) Am J Pathol , vol.143 , pp. 390-400
    • Colombel, M.1    Symmans, F.2    Gil, S.3    O'Toole, K.M.4    Chopin, D.5    Benson, M.6
  • 91
    • 0032785072 scopus 로고    scopus 로고
    • Targeting bcl-2 gene to delay androgen-independent progression and enhance chemosensitivity in prostate cancer using antisense bcl-2 oligodeoxynucleotides
    • Gleave M.E., Miayake H., Goldie J., Nelson C., Tolcher A. Targeting bcl-2 gene to delay androgen-independent progression and enhance chemosensitivity in prostate cancer using antisense bcl-2 oligodeoxynucleotides. Urology 1999, 54:36-46.
    • (1999) Urology , vol.54 , pp. 36-46
    • Gleave, M.E.1    Miayake, H.2    Goldie, J.3    Nelson, C.4    Tolcher, A.5
  • 92
    • 0027093255 scopus 로고
    • Expression of the protooncogene bcl-2 in the prostate and its association with emergence of androgen-independent prostate cancer
    • McDonnell T.J., Troncoso P., Brisbay S.M., Logothetis C., Chung L.W., Hsieh J.T., et al. Expression of the protooncogene bcl-2 in the prostate and its association with emergence of androgen-independent prostate cancer. Cancer Res 1992, 52:6940-6944.
    • (1992) Cancer Res , vol.52 , pp. 6940-6944
    • McDonnell, T.J.1    Troncoso, P.2    Brisbay, S.M.3    Logothetis, C.4    Chung, L.W.5    Hsieh, J.T.6
  • 93
    • 0037083472 scopus 로고    scopus 로고
    • Clusterin expression is significantly enhanced in prostate cancer cells following androgen withdrawal therapy
    • July L.V., Akbari M., Zellweger T., Jones E.C., Goldenberg S.L., Gleave M.E. Clusterin expression is significantly enhanced in prostate cancer cells following androgen withdrawal therapy. Prostate 2002, 50:179-188.
    • (2002) Prostate , vol.50 , pp. 179-188
    • July, L.V.1    Akbari, M.2    Zellweger, T.3    Jones, E.C.4    Goldenberg, S.L.5    Gleave, M.E.6
  • 94
    • 28244456529 scopus 로고    scopus 로고
    • Increased Hsp27 after androgen ablation facilitates androgen-independent progression in prostate cancer via signal transducers and activators of transcription 3-mediated suppression of apoptosis
    • Rocchi P., Beraldi E., Ettinger S., Fazli L., Vessella R.L., Nelson C., et al. Increased Hsp27 after androgen ablation facilitates androgen-independent progression in prostate cancer via signal transducers and activators of transcription 3-mediated suppression of apoptosis. Cancer Res 2005, 65:11083-11093.
    • (2005) Cancer Res , vol.65 , pp. 11083-11093
    • Rocchi, P.1    Beraldi, E.2    Ettinger, S.3    Fazli, L.4    Vessella, R.L.5    Nelson, C.6
  • 95
    • 4644237335 scopus 로고    scopus 로고
    • Heat shock protein 27 increases after androgen ablation and plays a cytoprotective role in hormone-refractory prostate cancer
    • Rocchi P., So A., Kojima S., Signaevsky M., Beraldi E., Fazli L., et al. Heat shock protein 27 increases after androgen ablation and plays a cytoprotective role in hormone-refractory prostate cancer. Cancer Res 2004, 64:6595-6602.
    • (2004) Cancer Res , vol.64 , pp. 6595-6602
    • Rocchi, P.1    So, A.2    Kojima, S.3    Signaevsky, M.4    Beraldi, E.5    Fazli, L.6
  • 96
    • 84864280130 scopus 로고    scopus 로고
    • TP53INP1 as new therapeutic target in castration-resistant prostate cancer
    • Giusiano S., Baylot V., Andrieu C., Fazli L., Gleave M., Iovanna J.L., et al. TP53INP1 as new therapeutic target in castration-resistant prostate cancer. Prostate 2012, 72:1286-1294.
    • (2012) Prostate , vol.72 , pp. 1286-1294
    • Giusiano, S.1    Baylot, V.2    Andrieu, C.3    Fazli, L.4    Gleave, M.5    Iovanna, J.L.6
  • 98
    • 84919889898 scopus 로고    scopus 로고
    • The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets
    • Katsogiannou M., Andrieu C., Baylot V., Baudot A., Dusetti N.J., Gayet O., et al. The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets. Mol Cell Proteomics 2014, 13:3585-3601.
    • (2014) Mol Cell Proteomics , vol.13 , pp. 3585-3601
    • Katsogiannou, M.1    Andrieu, C.2    Baylot, V.3    Baudot, A.4    Dusetti, N.J.5    Gayet, O.6
  • 99
    • 84870580756 scopus 로고    scopus 로고
    • Targeting TCTP as a new therapeutic strategy in castration-resistant prostate cancer
    • Baylot V., Katsogiannou M., Andrieu C., Taieb D., Acunzo J., Giusiano S., et al. Targeting TCTP as a new therapeutic strategy in castration-resistant prostate cancer. Mol Ther 2012, 20:2244-2256.
    • (2012) Mol Ther , vol.20 , pp. 2244-2256
    • Baylot, V.1    Katsogiannou, M.2    Andrieu, C.3    Taieb, D.4    Acunzo, J.5    Giusiano, S.6
  • 101
    • 77950518207 scopus 로고    scopus 로고
    • Heat shock protein 27 confers resistance to androgen ablation and chemotherapy in prostate cancer cells through eIF4E
    • Andrieu C., Taieb D., Baylot V., Ettinger S., Soubeyran P., De-Thonel A., et al. Heat shock protein 27 confers resistance to androgen ablation and chemotherapy in prostate cancer cells through eIF4E. Oncogene 2010, 29:1883-1896.
    • (2010) Oncogene , vol.29 , pp. 1883-1896
    • Andrieu, C.1    Taieb, D.2    Baylot, V.3    Ettinger, S.4    Soubeyran, P.5    De-Thonel, A.6
  • 102
    • 0031964511 scopus 로고    scopus 로고
    • Interfocal heterogeneity of PTEN/MMAC1 gene alterations in multiple metastatic prostate cancer tissues
    • Suzuki H., Freije D., Nusskern D.R., Okami K., Cairns P., Sidransky D., et al. Interfocal heterogeneity of PTEN/MMAC1 gene alterations in multiple metastatic prostate cancer tissues. Cancer Res 1998, 58:204-209.
    • (1998) Cancer Res , vol.58 , pp. 204-209
    • Suzuki, H.1    Freije, D.2    Nusskern, D.R.3    Okami, K.4    Cairns, P.5    Sidransky, D.6
  • 103
    • 0030936323 scopus 로고    scopus 로고
    • PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer
    • Li J., Yen C., Liaw D., Podsypanina K., Bose S., Wang S.I., et al. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science 1997, 275:1943-1947.
    • (1997) Science , vol.275 , pp. 1943-1947
    • Li, J.1    Yen, C.2    Liaw, D.3    Podsypanina, K.4    Bose, S.5    Wang, S.I.6
  • 104
    • 58649114084 scopus 로고    scopus 로고
    • MTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice
    • Guertin D.A., Stevens D.M., Saitoh M., Kinkel S., Crosby K., Sheen J.H., et al. MTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice. Cancer Cell 2009, 15:148-159.
    • (2009) Cancer Cell , vol.15 , pp. 148-159
    • Guertin, D.A.1    Stevens, D.M.2    Saitoh, M.3    Kinkel, S.4    Crosby, K.5    Sheen, J.H.6
  • 105
    • 68049137909 scopus 로고    scopus 로고
    • Targeting the PI3K/AKT pathway for the treatment of prostate cancer
    • Sarker D., Reid A.H., Yap T.A., de Bono J.S. Targeting the PI3K/AKT pathway for the treatment of prostate cancer. Clin Cancer Res 2009, 15:4799-4805.
    • (2009) Clin Cancer Res , vol.15 , pp. 4799-4805
    • Sarker, D.1    Reid, A.H.2    Yap, T.A.3    de Bono, J.S.4
  • 106
    • 0034637524 scopus 로고    scopus 로고
    • Increased AKT activity contributes to prostate cancer progression by dramatically accelerating prostate tumor growth and diminishing p27Kip1 expression
    • Graff J.R., Konicek B.W., McNulty A.M., Wang Z., Houck K., Allen S., et al. Increased AKT activity contributes to prostate cancer progression by dramatically accelerating prostate tumor growth and diminishing p27Kip1 expression. J Biol Chem 2000, 275:24500-24505.
    • (2000) J Biol Chem , vol.275 , pp. 24500-24505
    • Graff, J.R.1    Konicek, B.W.2    McNulty, A.M.3    Wang, Z.4    Houck, K.5    Allen, S.6
  • 107
    • 0037216526 scopus 로고    scopus 로고
    • AKT-independent protection of prostate cancer cells from apoptosis mediated through complex formation between the androgen receptor and FKHR
    • Li P., Lee H., Guo S., Unterman T.G., Jenster G., Bai W. AKT-independent protection of prostate cancer cells from apoptosis mediated through complex formation between the androgen receptor and FKHR. Mol Cell Biol 2003, 23:104-118.
    • (2003) Mol Cell Biol , vol.23 , pp. 104-118
    • Li, P.1    Lee, H.2    Guo, S.3    Unterman, T.G.4    Jenster, G.5    Bai, W.6
  • 108
    • 0034643331 scopus 로고    scopus 로고
    • AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1
    • Medema R.H., Kops G.J., Bos J.L., Burgering B.M. AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1. Nature 2000, 404:782-787.
    • (2000) Nature , vol.404 , pp. 782-787
    • Medema, R.H.1    Kops, G.J.2    Bos, J.L.3    Burgering, B.M.4
  • 109
    • 57749083377 scopus 로고    scopus 로고
    • A transcription-independent function of FOXO1 in inhibition of androgen-independent activation of the androgen receptor in prostate cancer cells
    • Liu P., Li S., Gan L., Kao T.P., Huang H. A transcription-independent function of FOXO1 in inhibition of androgen-independent activation of the androgen receptor in prostate cancer cells. Cancer Res 2008, 68:10290-10299.
    • (2008) Cancer Res , vol.68 , pp. 10290-10299
    • Liu, P.1    Li, S.2    Gan, L.3    Kao, T.P.4    Huang, H.5
  • 110
    • 0028823416 scopus 로고
    • In vivo gene therapy with p53 or p21 adenovirus for prostate cancer
    • Eastham J.A., Hall S.J., Sehgal I., Wang J., Timme T.L., Yang G., et al. In vivo gene therapy with p53 or p21 adenovirus for prostate cancer. Cancer Res 1995, 55:5151-5155.
    • (1995) Cancer Res , vol.55 , pp. 5151-5155
    • Eastham, J.A.1    Hall, S.J.2    Sehgal, I.3    Wang, J.4    Timme, T.L.5    Yang, G.6
  • 112
    • 0032876470 scopus 로고    scopus 로고
    • P53 mutations in prostate cancer bone metastases suggest that selected p53 mutants in the primary site define foci with metastatic potential
    • Navone N.M., Labate M.E., Troncoso P., Pisters L.L., Conti C.J., von Eschenbach A.C., et al. P53 mutations in prostate cancer bone metastases suggest that selected p53 mutants in the primary site define foci with metastatic potential. J Urol 1999, 161:304-308.
    • (1999) J Urol , vol.161 , pp. 304-308
    • Navone, N.M.1    Labate, M.E.2    Troncoso, P.3    Pisters, L.L.4    Conti, C.J.5    von Eschenbach, A.C.6
  • 113
    • 0035450742 scopus 로고    scopus 로고
    • Reduction of wild type p53 function confers a hormone resistant phenotype on LNCaP prostate cancer cells
    • Burchardt M., Burchardt T., Shabsigh A., Ghafar M., Chen M.W., Anastasiadis A., et al. Reduction of wild type p53 function confers a hormone resistant phenotype on LNCaP prostate cancer cells. Prostate 2001, 48:225-230.
    • (2001) Prostate , vol.48 , pp. 225-230
    • Burchardt, M.1    Burchardt, T.2    Shabsigh, A.3    Ghafar, M.4    Chen, M.W.5    Anastasiadis, A.6
  • 114
    • 2442693040 scopus 로고    scopus 로고
    • Inhibition of p53 function diminishes androgen receptor-mediated signaling in prostate cancer cell lines
    • Cronauer M.V., Schulz W.A., Burchardt T., Ackermann R., Burchardt M. Inhibition of p53 function diminishes androgen receptor-mediated signaling in prostate cancer cell lines. Oncogene 2004, 23:3541-3549.
    • (2004) Oncogene , vol.23 , pp. 3541-3549
    • Cronauer, M.V.1    Schulz, W.A.2    Burchardt, T.3    Ackermann, R.4    Burchardt, M.5
  • 117
    • 84863723010 scopus 로고    scopus 로고
    • The mutational landscape of lethal castration-resistant prostate cancer
    • Grasso C.S., Wu Y.M., Robinson D.R., Cao X., Dhanasekaran S.M., Khan A.P., et al. The mutational landscape of lethal castration-resistant prostate cancer. Nature 2012, 487:239-243.
    • (2012) Nature , vol.487 , pp. 239-243
    • Grasso, C.S.1    Wu, Y.M.2    Robinson, D.R.3    Cao, X.4    Dhanasekaran, S.M.5    Khan, A.P.6
  • 119
    • 84862186491 scopus 로고    scopus 로고
    • MicroRNAs and prostate cancer: from preclinical research to translational oncology
    • Maugeri-Sacca M., Coppola V., Bonci D., De Maria R. MicroRNAs and prostate cancer: from preclinical research to translational oncology. Cancer J 2012, 18:253-261.
    • (2012) Cancer J , vol.18 , pp. 253-261
    • Maugeri-Sacca, M.1    Coppola, V.2    Bonci, D.3    De Maria, R.4
  • 120
    • 84904469607 scopus 로고    scopus 로고
    • Uncovering the roles of miRNAs and their relationship with androgen receptor in prostate cancer
    • ChunJiao S., Huan C., ChaoYang X., GuoMei R. Uncovering the roles of miRNAs and their relationship with androgen receptor in prostate cancer. IUBMB Life 2014, 66:379-386.
    • (2014) IUBMB Life , vol.66 , pp. 379-386
    • ChunJiao, S.1    Huan, C.2    ChaoYang, X.3    GuoMei, R.4
  • 121
    • 58149240996 scopus 로고    scopus 로고
    • The inhibition of the highly expressed miR-221 and miR-222 impairs the growth of prostate carcinoma xenografts in mice
    • Mercatelli N., Coppola V., Bonci D., Miele F., Costantini A., Guadagnoli M., et al. The inhibition of the highly expressed miR-221 and miR-222 impairs the growth of prostate carcinoma xenografts in mice. PLoS ONE 2008, 3:e4029.
    • (2008) PLoS ONE , vol.3 , pp. e4029
    • Mercatelli, N.1    Coppola, V.2    Bonci, D.3    Miele, F.4    Costantini, A.5    Guadagnoli, M.6
  • 122
    • 34548168073 scopus 로고    scopus 로고
    • MiR-221 and miR-222 expression affects the proliferation potential of human prostate carcinoma cell lines by targeting p27Kip1
    • Galardi S., Mercatelli N., Giorda E., Massalini S., Frajese G.V., Ciafre S.A., et al. MiR-221 and miR-222 expression affects the proliferation potential of human prostate carcinoma cell lines by targeting p27Kip1. J Biol Chem 2007, 282:23716-23724.
    • (2007) J Biol Chem , vol.282 , pp. 23716-23724
    • Galardi, S.1    Mercatelli, N.2    Giorda, E.3    Massalini, S.4    Frajese, G.V.5    Ciafre, S.A.6
  • 123
    • 15444362131 scopus 로고    scopus 로고
    • Glucose deprivation increases mRNA stability of vascular endothelial growth factor through activation of AMP-activated protein kinase in DU145 prostate carcinoma
    • Yun H., Lee M., Kim S.S., Ha J. Glucose deprivation increases mRNA stability of vascular endothelial growth factor through activation of AMP-activated protein kinase in DU145 prostate carcinoma. J Biol Chem 2005, 280:9963-9972.
    • (2005) J Biol Chem , vol.280 , pp. 9963-9972
    • Yun, H.1    Lee, M.2    Kim, S.S.3    Ha, J.4
  • 124
    • 34250851115 scopus 로고    scopus 로고
    • A microRNA component of the p53 tumour suppressor network
    • He L., He X., Lim L.P., de Stanchina E., Xuan Z., Liang Y., et al. A microRNA component of the p53 tumour suppressor network. Nature 2007, 447:1130-1134.
    • (2007) Nature , vol.447 , pp. 1130-1134
    • He, L.1    He, X.2    Lim, L.P.3    de Stanchina, E.4    Xuan, Z.5    Liang, Y.6
  • 125
  • 126
    • 34249817549 scopus 로고    scopus 로고
    • Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis
    • Chang T.C., Wentzel E.A., Kent O.A., Ramachandran K., Mullendore M., Lee K.H., et al. Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis. Mol Cell 2007, 26:745-752.
    • (2007) Mol Cell , vol.26 , pp. 745-752
    • Chang, T.C.1    Wentzel, E.A.2    Kent, O.A.3    Ramachandran, K.4    Mullendore, M.5    Lee, K.H.6
  • 127
    • 79751473114 scopus 로고    scopus 로고
    • The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44
    • Liu C., Kelnar K., Liu B., Chen X., Calhoun-Davis T., Li H., et al. The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44. Nat Med 2011, 17:211-215.
    • (2011) Nat Med , vol.17 , pp. 211-215
    • Liu, C.1    Kelnar, K.2    Liu, B.3    Chen, X.4    Calhoun-Davis, T.5    Li, H.6
  • 131
    • 0037599536 scopus 로고    scopus 로고
    • Androgen receptor involvement in the progression of prostate cancer
    • Suzuki H., Ueda T., Ichikawa T., Ito H. Androgen receptor involvement in the progression of prostate cancer. Endocr Relat Cancer 2003, 10:209-216.
    • (2003) Endocr Relat Cancer , vol.10 , pp. 209-216
    • Suzuki, H.1    Ueda, T.2    Ichikawa, T.3    Ito, H.4
  • 132
    • 84856530618 scopus 로고    scopus 로고
    • Common structural and epigenetic changes in the genome of castration-resistant prostate cancer
    • Friedlander T.W., Roy R., Tomlins S.A., Ngo V.T., Kobayashi Y., Azameera A., et al. Common structural and epigenetic changes in the genome of castration-resistant prostate cancer. Cancer Res 2012, 72:616-625.
    • (2012) Cancer Res , vol.72 , pp. 616-625
    • Friedlander, T.W.1    Roy, R.2    Tomlins, S.A.3    Ngo, V.T.4    Kobayashi, Y.5    Azameera, A.6
  • 134
    • 42449158952 scopus 로고    scopus 로고
    • Spliceosome assembly and composition
    • Matlin A.J., Moore M.J. Spliceosome assembly and composition. Adv Exp Med Biol 2007, 623:14-35.
    • (2007) Adv Exp Med Biol , vol.623 , pp. 14-35
    • Matlin, A.J.1    Moore, M.J.2
  • 135
    • 84883187664 scopus 로고    scopus 로고
    • Alternative splicing programs in prostate cancer
    • Sette C. Alternative splicing programs in prostate cancer. Int J Cell Biol 2013, 2013:458727.
    • (2013) Int J Cell Biol , vol.2013 , pp. 458727
    • Sette, C.1
  • 136
    • 48549089747 scopus 로고    scopus 로고
    • Splicing of a novel androgen receptor exon generates a constitutively active androgen receptor that mediates prostate cancer therapy resistance
    • Dehm S.M., Schmidt L.J., Heemers H.V., Vessella R.L., Tindall D.J. Splicing of a novel androgen receptor exon generates a constitutively active androgen receptor that mediates prostate cancer therapy resistance. Cancer Res 2008, 68:5469-5477.
    • (2008) Cancer Res , vol.68 , pp. 5469-5477
    • Dehm, S.M.1    Schmidt, L.J.2    Heemers, H.V.3    Vessella, R.L.4    Tindall, D.J.5
  • 139
    • 77950524790 scopus 로고    scopus 로고
    • The splicing regulator Sam68 binds to a novel exonic splicing silencer and functions in SMN2 alternative splicing in spinal muscular atrophy
    • Pedrotti S., Bielli P., Paronetto M.P., Ciccosanti F., Fimia G.M., Stamm S., et al. The splicing regulator Sam68 binds to a novel exonic splicing silencer and functions in SMN2 alternative splicing in spinal muscular atrophy. EMBO J 2010, 29:1235-1247.
    • (2010) EMBO J , vol.29 , pp. 1235-1247
    • Pedrotti, S.1    Bielli, P.2    Paronetto, M.P.3    Ciccosanti, F.4    Fimia, G.M.5    Stamm, S.6
  • 140
    • 84868355027 scopus 로고    scopus 로고
    • The spliceosome as a target of novel antitumour drugs
    • Bonnal S., Vigevani L., Valcarcel J. The spliceosome as a target of novel antitumour drugs. Nat Rev Drug Discov 2012, 11:847-859.
    • (2012) Nat Rev Drug Discov , vol.11 , pp. 847-859
    • Bonnal, S.1    Vigevani, L.2    Valcarcel, J.3
  • 141
    • 80355141485 scopus 로고    scopus 로고
    • Potential molecular targeting of splice variants for cancer treatment
    • Blair C.A., Zi X. Potential molecular targeting of splice variants for cancer treatment. Indian J Exp Biol 2011, 49:836-839.
    • (2011) Indian J Exp Biol , vol.49 , pp. 836-839
    • Blair, C.A.1    Zi, X.2
  • 142
    • 79959331609 scopus 로고    scopus 로고
    • Recurrent chimeric RNAs enriched in human prostate cancer identified by deep sequencing
    • Kannan K., Wang L., Wang J., Ittmann M.M., Li W., Yen L. Recurrent chimeric RNAs enriched in human prostate cancer identified by deep sequencing. Proc Natl Acad Sci USA 2011, 108:9172-9177.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 9172-9177
    • Kannan, K.1    Wang, L.2    Wang, J.3    Ittmann, M.M.4    Li, W.5    Yen, L.6
  • 143
    • 84927171105 scopus 로고    scopus 로고
    • Next-generation sequencing reveals novel rare fusion events with functional implication in prostate cancer
    • Teles Alves I., Hartjes T., McClellan E., Hiltemann S., Bottcher R., Dits N., et al. Next-generation sequencing reveals novel rare fusion events with functional implication in prostate cancer. Oncogene 2014.
    • (2014) Oncogene
    • Teles Alves, I.1    Hartjes, T.2    McClellan, E.3    Hiltemann, S.4    Bottcher, R.5    Dits, N.6
  • 144
    • 84876234101 scopus 로고    scopus 로고
    • High-resolution ERG-expression profiling on GeneChip exon 1.0 ST arrays in primary and castration-resistant prostate cancer
    • Smit F.P., Salagierski M., Jannink S., Schalken J.A. High-resolution ERG-expression profiling on GeneChip exon 1.0 ST arrays in primary and castration-resistant prostate cancer. BJU Int 2013, 111:836-842.
    • (2013) BJU Int , vol.111 , pp. 836-842
    • Smit, F.P.1    Salagierski, M.2    Jannink, S.3    Schalken, J.A.4
  • 145
    • 84921718196 scopus 로고    scopus 로고
    • Whole transcriptome sequencing reveals extensive unspliced mRNA in metastatic castration-resistant prostate cancer
    • Sowalsky A.G., Xia Z., Wang L., Zhao H., Chen S., Bubley G.J., et al. Whole transcriptome sequencing reveals extensive unspliced mRNA in metastatic castration-resistant prostate cancer. Mol Cancer Res 2014.
    • (2014) Mol Cancer Res
    • Sowalsky, A.G.1    Xia, Z.2    Wang, L.3    Zhao, H.4    Chen, S.5    Bubley, G.J.6
  • 147
    • 27344451557 scopus 로고    scopus 로고
    • Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer
    • Tomlins S.A., Rhodes D.R., Perner S., Dhanasekaran S.M., Mehra R., Sun X.W., et al. Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer. Science 2005, 310:644-648.
    • (2005) Science , vol.310 , pp. 644-648
    • Tomlins, S.A.1    Rhodes, D.R.2    Perner, S.3    Dhanasekaran, S.M.4    Mehra, R.5    Sun, X.W.6
  • 148
    • 70350231922 scopus 로고    scopus 로고
    • Overexpression of prostate-specific TMPRSS2(exon 0)-ERG fusion transcripts corresponds with favorable prognosis of prostate cancer
    • Hermans K.G., Boormans J.L., Gasi D., van Leenders G.J., Jenster G., Verhagen P.C., et al. Overexpression of prostate-specific TMPRSS2(exon 0)-ERG fusion transcripts corresponds with favorable prognosis of prostate cancer. Clin Cancer Res 2009, 15:6398-6403.
    • (2009) Clin Cancer Res , vol.15 , pp. 6398-6403
    • Hermans, K.G.1    Boormans, J.L.2    Gasi, D.3    van Leenders, G.J.4    Jenster, G.5    Verhagen, P.C.6
  • 149
    • 79952846687 scopus 로고    scopus 로고
    • The ETS gene ETV4 is required for anchorage-independent growth and a cell proliferation gene expression program in PC3 prostate cells
    • Hollenhorst P.C., Paul L., Ferris M.W., Graves B.J. The ETS gene ETV4 is required for anchorage-independent growth and a cell proliferation gene expression program in PC3 prostate cells. Genes Cancer 2011, 1:1044-1052.
    • (2011) Genes Cancer , vol.1 , pp. 1044-1052
    • Hollenhorst, P.C.1    Paul, L.2    Ferris, M.W.3    Graves, B.J.4
  • 150
    • 33749029695 scopus 로고    scopus 로고
    • TMPRSS2:ERG fusion-associated deletions provide insight into the heterogeneity of prostate cancer
    • Perner S., Demichelis F., Beroukhim R., Schmidt F.H., Mosquera J.M., Setlur S., et al. TMPRSS2:ERG fusion-associated deletions provide insight into the heterogeneity of prostate cancer. Cancer Res 2006, 66:8337-8341.
    • (2006) Cancer Res , vol.66 , pp. 8337-8341
    • Perner, S.1    Demichelis, F.2    Beroukhim, R.3    Schmidt, F.H.4    Mosquera, J.M.5    Setlur, S.6
  • 151
    • 77954997528 scopus 로고    scopus 로고
    • Antibody-based detection of ERG rearrangement-positive prostate cancer
    • Park K., Tomlins S.A., Mudaliar K.M., Chiu Y.L., Esgueva R., Mehra R., et al. Antibody-based detection of ERG rearrangement-positive prostate cancer. Neoplasia 2010, 12:590-598.
    • (2010) Neoplasia , vol.12 , pp. 590-598
    • Park, K.1    Tomlins, S.A.2    Mudaliar, K.M.3    Chiu, Y.L.4    Esgueva, R.5    Mehra, R.6
  • 152
    • 79961031183 scopus 로고    scopus 로고
    • Antibody EPR3864 is specific for ERG genomic fusions in prostate cancer: implications for pathological practice
    • van Leenders G.J., Boormans J.L., Vissers C.J., Hoogland A.M., Bressers A.A., Furusato B., et al. Antibody EPR3864 is specific for ERG genomic fusions in prostate cancer: implications for pathological practice. Mod Pathol 2011, 24:1128-1138.
    • (2011) Mod Pathol , vol.24 , pp. 1128-1138
    • van Leenders, G.J.1    Boormans, J.L.2    Vissers, C.J.3    Hoogland, A.M.4    Bressers, A.A.5    Furusato, B.6
  • 153
    • 34248510706 scopus 로고    scopus 로고
    • TMPRSS2:ERG gene fusion associated with lethal prostate cancer in a watchful waiting cohort
    • Demichelis F., Fall K., Perner S., Andren O., Schmidt F., Setlur S.R., et al. TMPRSS2:ERG gene fusion associated with lethal prostate cancer in a watchful waiting cohort. Oncogene 2007, 26:4596-4599.
    • (2007) Oncogene , vol.26 , pp. 4596-4599
    • Demichelis, F.1    Fall, K.2    Perner, S.3    Andren, O.4    Schmidt, F.5    Setlur, S.R.6
  • 155
    • 77950518687 scopus 로고    scopus 로고
    • Prevalence of TMPRSS2-ERG and SLC45A3-ERG gene fusions in a large prostatectomy cohort
    • Esgueva R., Perner S., J LaFargue C., Scheble V., Stephan C., Lein M., et al. Prevalence of TMPRSS2-ERG and SLC45A3-ERG gene fusions in a large prostatectomy cohort. Mod Pathol 2010, 23:539-546.
    • (2010) Mod Pathol , vol.23 , pp. 539-546
    • Esgueva, R.1    Perner, S.J.2    LaFargue, C.3    Scheble, V.4    Stephan, C.5    Lein, M.6
  • 157
    • 84866313567 scopus 로고    scopus 로고
    • Chimeric transcript generated by cis-splicing of adjacent genes regulates prostate cancer cell proliferation
    • Zhang Y., Gong M., Yuan H., Park H.G., Frierson H.F., Li H. Chimeric transcript generated by cis-splicing of adjacent genes regulates prostate cancer cell proliferation. Cancer Discov 2012, 2:598-607.
    • (2012) Cancer Discov , vol.2 , pp. 598-607
    • Zhang, Y.1    Gong, M.2    Yuan, H.3    Park, H.G.4    Frierson, H.F.5    Li, H.6
  • 158
    • 66149150235 scopus 로고    scopus 로고
    • SLC45A3-ELK4 is a novel and frequent erythroblast transformation-specific fusion transcript in prostate cancer
    • Rickman D.S., Pflueger D., Moss B., VanDoren V.E., Chen C.X., de la Taille A., et al. SLC45A3-ELK4 is a novel and frequent erythroblast transformation-specific fusion transcript in prostate cancer. Cancer Res 2009, 69:2734-2738.
    • (2009) Cancer Res , vol.69 , pp. 2734-2738
    • Rickman, D.S.1    Pflueger, D.2    Moss, B.3    VanDoren, V.E.4    Chen, C.X.5    de la Taille, A.6
  • 159
    • 45549090259 scopus 로고    scopus 로고
    • Characterization of TMPRSS2-ETS gene aberrations in androgen-independent metastatic prostate cancer
    • Mehra R., Tomlins S.A., Yu J., Cao X., Wang L., Menon A., et al. Characterization of TMPRSS2-ETS gene aberrations in androgen-independent metastatic prostate cancer. Cancer Res 2008, 68:3584-3590.
    • (2008) Cancer Res , vol.68 , pp. 3584-3590
    • Mehra, R.1    Tomlins, S.A.2    Yu, J.3    Cao, X.4    Wang, L.5    Menon, A.6
  • 161
    • 84864449290 scopus 로고    scopus 로고
    • TMPRSS2-driven ERG expression in vivo increases self-renewal and maintains expression in a castration resistant subpopulation
    • Casey O.M., Fang L., Hynes P.G., Abou-Kheir W.G., Martin P.L., Tillman H.S., et al. TMPRSS2-driven ERG expression in vivo increases self-renewal and maintains expression in a castration resistant subpopulation. PLoS ONE 2012, 7:e41668.
    • (2012) PLoS ONE , vol.7 , pp. e41668
    • Casey, O.M.1    Fang, L.2    Hynes, P.G.3    Abou-Kheir, W.G.4    Martin, P.L.5    Tillman, H.S.6
  • 162
    • 33751260934 scopus 로고    scopus 로고
    • TMPRSS2 fusions with oncogenic ETS factors in prostate cancer involve unbalanced genomic rearrangements and are associated with HDAC1 and epigenetic reprogramming
    • Iljin K., Wolf M., Edgren H., Gupta S., Kilpinen S., Skotheim R.I., et al. TMPRSS2 fusions with oncogenic ETS factors in prostate cancer involve unbalanced genomic rearrangements and are associated with HDAC1 and epigenetic reprogramming. Cancer Res 2006, 66:10242-10246.
    • (2006) Cancer Res , vol.66 , pp. 10242-10246
    • Iljin, K.1    Wolf, M.2    Edgren, H.3    Gupta, S.4    Kilpinen, S.5    Skotheim, R.I.6
  • 164
    • 82655183787 scopus 로고    scopus 로고
    • TMPRSS2-ERG-specific transcriptional modulation is associated with prostate cancer biomarkers and TGF-beta signaling
    • Brase J.C., Johannes M., Mannsperger H., Falth M., Metzger J., Kacprzyk L.A., et al. TMPRSS2-ERG-specific transcriptional modulation is associated with prostate cancer biomarkers and TGF-beta signaling. BMC Cancer 2011, 11:507.
    • (2011) BMC Cancer , vol.11 , pp. 507
    • Brase, J.C.1    Johannes, M.2    Mannsperger, H.3    Falth, M.4    Metzger, J.5    Kacprzyk, L.A.6


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