Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer

Science

Volumn 310, Issue 5748, 2005, Pages 644-648

  Tomlins, Scott A ^a   Rhodes, Daniel R ^a   Perner, Sven ^b,c   Dhanasekaran, Saravana M ^a   Mehra, Rohit ^a   Sun, Xiao Wei ^a   Varambally, Sooryanarayana ^a   Cao, Xuhong ^a   Tchinda, Joelle ^b   Kuefer, Rainer ^d   Lee, Charles ^b   Montie, James E ^a   Shah, Rajal B ^a   Pienta, Kenneth J ^a   Rubin, Mark A ^b,c   Chinnaiyan, Arul M ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d UNIVERSITY OF ULM   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ABERRATIONS; DIAGNOSIS; FLUORESCENCE; TUMORS;

CARCINOMAS; CHROMOSOMAL ABERRATIONS; GENE FUSIONS; MOLECULAR DIAGNOSIS;

GENES;

DNA; IMATINIB; TRANSCRIPTION FACTOR ETS;

CANCER;

ARTICLE; BREAST CANCER; CANCER CELL; CHROMOSOME REARRANGEMENT; CONTROLLED STUDY; DNA MICROARRAY; ERG GENE; ETV1 GENE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE; GENE EXPRESSION REGULATION; GENE FUSION; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HUMAN TISSUE; KIDNEY CANCER; LEUKEMIA; MALE; MYELOMA; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROSTATE CANCER; SARCOMA; TMPRSS2 GENE;

ANDROGENS; CELL LINE, TUMOR; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE REARRANGEMENT; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; MALE; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; NEOPLASM PROTEINS; ONCOGENE PROTEINS, FUSION; POLYMERASE CHAIN REACTION; PROSTATIC NEOPLASMS; SERINE ENDOPEPTIDASES; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TRANSLOCATION, GENETIC;

EID: 27344451557     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1117679     Document Type: Article

References (35)

1. J. D. Rowley, Nat. Rev. Cancer 1, 245 (2001).
2. T. H. Rabbitts, Nature 372, 143 (1994).
3. J. D. Rowley, Nature 243, 290 (1973).
4. A. de Klein et al., Nature 300, 765 (1982).
5. M. Deininger, E. Buchdunger, B. J. Druker, Blood 105, 2640 (2005).
6. F. Mitelman, Mutat. Res. 462, 247 (2000).
7. Materials and methods are available as supporting material on Science Online.
8. D. R. Rhodes et al., Neoplasia 6, 1 (2004).
9. P. A. Futreal et al., Nat. Rev. Cancer 4, 177 (2004).
10. Detailed results from the application of COPA to Oncomine data sets can be explored at www. oncomine.org.
11. T. Oikawa, T. Yamada, Gene 303, 11 (2003).
12. T. Hsu, M. Trojanowska, D. K. Watson, J. Cell. Biochem. 91, 896 (2004).
13. I. S. Jeon et al., Oncogene 10, 1229 (1995).
14. P. H. Sorensen et al., Nat. Genet. 6, 146 (1994).
15. J. Lapointe et al., Proc. Natl. Acad. Sci. U.S.A. 101, 811 (2004).
16. G. V. Glinsky, A. B. Glinskii, A. J. Stephenson, R. M. Hoffman, W. L. Gerald, J. Clin. Invest. 113, 913 (2004).
17. R. Fonseca et al., Cancer Res. 64, 1546 (2004).
18. B. Lin et al., Cancer Res. 59, 4180 (1999).
19. D. E. Afar et al., Cancer Res. 61, 1686 (2001).
20. E. Jacquinet et al., Eur. J. Biochem. 268, 2687 (2001).
21. G. Petrovics et al., Oncogene 24, 3847 (2005).
22. A. Jemal et al., CA Cancer J. Clin. 55, 10 (2005).
23. P. J. Valk et al., N. Engl. J. Med. 350, 1617 (2004).
24. J. R. Vasselli et al., Proc. Natl. Acad. Sci. U.S.A. 100, 6958 (2003).
25. M. E. Ross et al., Blood 102, 2951 (2003).
26. E. Tian et al., N. Engl. J. Med. 349, 2483 (2003).
27. S. M. Dhanasekaran et al., FASEB J. 19, 243 (2005).
28. J. B. Welsh et al., Cancer Res. 61, 5974 (2001).
29. F. Zhan et al., Blood 99, 1745 (2002).
30. S. M. Dhanasekaran et al., Nature 412, 822 (2001).
31. E. Huang et al., Lancet 361, 1590 (2003).
32. C. Sotiriou et al., Proc. Natl. Acad. Sci. U.S.A. 100, 10393 (2003).
33. T. O. Nielsen et al., Lancet 359, 1301 (2002).
34. Y. P. Yu et al., J. Clin. Oncol. 22, 2790 (2004).
35. We thank D. Roulston and E. Fearon for helpful discussions, D. Robins and K. Burnstein for the PC3+AR cells, and R. Desphande and C. Creighton for technical assistance. Supported by the Early Detection Research Network Biomarker Developmental Lab UO1 CA111275-01 (to A.M.C.); NIH Prostate specialized program of research excellence (SPORE) P50CA69568 (to K.J.P), RO1 CA97063 (to A.M.C.), and R01AC21404 (to M.A.R.); American Cancer Society RSC-02-179-MGO (to A.M.C.); Department of Defense (PC040517 to R.M. and PC020322 to A.M.C.); and the Cancer Center Bioinformatics Core (support grant 5P30 CA46592). D.R.R. is supported by the Cancer Biology Training Program. K.J.P. is an American Cancer Society Clinical Research Professor. A.M.C. is a Pew Biomedical Scholar, and S.A.T. and D.R.R. are Fellows of the Medical Scientist Training Program. Nucleotide sequences for the TMPRSS2:ETS fusions have been deposited at GenBank with accession numbers DQ204770 to DQ04773.