Androgen receptor mutations in prostate cancer

Cancer Research

Volumn 60, Issue 4, 2000, Pages 944-949

  Marcelli, Marco ^a,b   Ittmann, Michael ^a,b   Mariani, Stefania ^a   Sutherland, Richard ^a   Nigam, Rajni ^a   Murthy, Lata ^a   Zhao, Yali ^a   DiConcini, Dino ^a   Puxeddu, Efisio ^a   Esen, Adel ^a   Eastham, James ^a   Weigel, Nancy L ^a   Lamb, Dolores J ^a  

^a MICHAEL E DEBAKEY VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN RECEPTOR;

ARTICLE; CONTROLLED STUDY; EXON; GENE MUTATION; GENE SEQUENCE; HUMAN; HUMAN TISSUE; MALE; METASTASIS; MUTATION RATE; PRIORITY JOURNAL; PROSTATE CANCER; SEQUENCE ANALYSIS;

HUMANS; MALE; MUTATION; NEOPLASM METASTASIS; NEOPLASM STAGING; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; PROSTATIC NEOPLASMS; RECEPTORS, ANDROGEN;

EID: 0034652723     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (55)

1. Landis, S., Murray, T., Bolden, S., and Wingo, P. Cancer statistics 1999. CA Cancer J. Clin., 49: 8-31, 1999.
2. Tilley, W. D., Marcelli, M., Wilson, J. D., and McPhaul. J. M. Characterization and cloning of a cDNA encoding the human androgen receptor. Proc. Natl. Acad. Sci. USA, 86: 327-331, 1989.
3. McPhaul, M. Defects of androgen action. In: J. Jameson (ed.), Principles of Molecular Medicine, pp. 581-586. Totowa, NJ: Humana Press, 1998.
4. Kyprianou, N., English, H., and Isaacs, J. Programmed cell death during regression of PC-82 human prostate cancer following androgen ablation. Cancer Res., 50: 3748-3753, 1990.
5. Koivisto, P., Komer, M., Visakorpi, T., and Kallionemi, O-P. Androgen receptor gene and hormonal therapy failure of prostate cancer. Am. J. Pathol., 152: 1-9, 1998.
6. Isaacs, J., and Coffey, D. Adaptation vs. selection as the mechanism responsible for the relapse of prostatic cancer to androgen ablation as studied in the Dunning R-3327 H adenocarcinoma. Cancer Res., 41: 5070-5075, 1981.
7. Isaacs, J., Lundmo, P., Berges, R., Martikainen, P., Kyprianou, N., and English, H. Androgen regulation of programmed cell death of normal and malignant prostatic cells. J. Androl., 13: 457-464, 1992.
8. Van-der-Kwast, T., and Tetu, B. Androgen receptors in untreated and treated prostatic intraepithelial neoplasia. Eur. Urol., 30: 265-268, 1996.
9. Sadi, M. V., Walsh, P. C., and Barrack, E. R. Immunohistochemical study of androgen receptors in metastatic prostate cancer. Cancer (Phila.), 67: 3065-3071, 1991.
10. Tilley, W. D., Lim-Tio, S. S., Horsfall, D. J., Aspinall, J. O., Marshall, V. R., and Skinner, J. M. Detection of discrete androgen receptor epitopes in prostate cancer by immunostaining: measurement by color video image analysis. Cancer Res., 54: 4096-4102, 1994.
11. Hobisch, A., Culig, Z., Radmayr, C., Bartsch, G., Klocker, H., and Hittmair, A. Androgen receptor status of lymph node metastases from prostate cancer. Prostate, 28: 129-135, 1996.
12. Hobisch, A., Culig, Z., Radmayr, C., Bartsch, G., Klocker, H., and Hittmair, A. Distant metastases from prostatic carcinoma express androgen receptor protein. Cancer Res., 55: 3068-3072, 1995.
13. Van-der-Kwast, T. H., Schalken, J., Ruizeveld-de-Winter, J. A., Van-Vroonhoven, C. C. J., Mulder, E., Boersma, W., and Trapman, J. Androgen receptors in endocrinetherapy resistant human prostate cancer. Int. J. Cancer, 48: 189-193, 1991.
14. McGuire, W., Chamness, G., and Fuqua, S. Estrogen receptor variants in clinical breast cancer. Mol. Endocrinol., 5: 1571-1577, 1991.
15. Newmark, J. R., Hardy, D. O., Tonb, D. C., Carter, B. S., Epstein, J. I., Isaacs, W. B., Brown, T. R., and Barrack, E. R. Androgen receptor gene mutations in human prostate cancer. Proc. Natl. Acad. Sci. USA, 89: 6319-6323, 1992.
16. Suzuki, H., Sato, N., Watabe, Y., Masai, M., Seino, S., and Shimazaki, J. Androgen receptor gene mutations in human prostate cancer. J. Steroid Biochem. Mol. Biol., 46: 759-765, 1993.
17. Suzuki, H., Akakura, K., Komiya, A., Aida, S., Akimoto, S., and Shimazaki, J. Codon 877 mutation in the androgen receptor gene in advanced prostate cancer: relation to antiandrogen withdrawal syndrome. Prostate, 29: 153-158, 1996.
18. Castagnaro, M., Yandell, D. W., Dockhorn-Dworniczak, B., Wolfe, H. J., and Poremba, C. Androgen receptor gene mutations and p53 gene analysis in advanced prostate cancer (in German). Verh. Dtsch. Ges. Pathol., 77: 119-123, 1993.
19. Culig, Z., Hobisch, A., Cronauer, M. V., Calo, A. C. B., Hittmair, A., Radmayr, C., Eberle, J., Bartsch, G., and Klocker, H. Mutant androgen receptor detected in an advanced stage prostatic carcinoma is activated by adrenal androgens and progesterone. Mol. Endocrinol., 7: 1541-1550, 1993.
20. Culig, Z., Klocker, H., Eberle, J., Kaspar, F., Hobisch, A., Cronauer, M. V., and Bartsch, G. DNA sequence of the androgen receptor in prostatic tumor cell lines and tissue specimens assessed by means of the polymerase chain reaction. Prostate, 22: 11-22, 1993.
21. Gaddipati, J. P., McLeod, D. G., Heidenberg, H. B., Sesterhenn, I. A., Finger, M. J., Moul, J. W., and Srivastava, S. Frequent detection of codon 877 mutation in the androgen receptor gene in advanced prostate cancers. Cancer Res., 54: 2861-2864, 1994.
22. Shoenberg, M. P., Hakimi, J. M., Wang, S. P., Bova, G. S., Fischbeck, K. H., Isaacs, W. B., Walsh, P. C., and Barrack, E. R. Microsalellite mutation (Cag(24→18)1 in the androgen receptor gene in human prostate cancer. Biochem. Biophys. Res. Commun., 198: 74-80, 1994.
23. Ruizeveld-de-Winter, J. A., Janssen, P. J. A., Sleddens, H. M. E. B., Verleun-Moojman, M. C. T., Trapman, J., Brinkmann, A. O., Santerse, A. B., Schröder, F. H., and Van-der-Kwast, T. D. Androgen receptor status in localized and locally progressive hormone refractory human prostate cancer. Am. J. Pathol., 144: 735-746, 1994.
24. Elo, J. P., Kvist, L., Leinonen, K., Isomaa, V., Henttu, P., Lukkarinen, O., and Vihko, P. Mutated human undrogen receptor gene detected in a prostatic cancer patient is also activated by estradiol. J. Clin. Endocrinol. Metab., 80: 3494-3500, 1995.
25. Takahashi, H., Furusato, M., Allsbrook, W. C., Jr., Nishii, H., Wakui, S., Barrett, J. C., and Boyd, J. Prevalence of androgen receptor gene mutations in latent prostatic carcinomas from Japanese men. Cancer Res. 55: 1621-1624, 1995.
26. Taplin, M-E., Bubley, G. J., Shuster, T., Frantz, M., Spooner, A., Ogata, G., Keer, H., and Balk, S. Mutation of the androgen-receptor gene in metastatic androgen-independent prostate cancer. N. Engl. J. Med., 332: 1393-1398, 1995.
27. Taplin, M. E., Bubley, G. J., Ko, Y. J., Small, E. J., Upton, M., Rajeshkumar, B., and Balk, S. P. Selection for androgen receptor mutations in prostate cancers treated with androgen antagonist. Cancer Res., 59: 2511-2515, 1999.
28. Visakorpi, T., Hyytinen, E., Koivisto, P., Tanner, M., Keinanen, R., Palmberg, C., Palotie, A., Tammela, T., Isola, J., and Kallioniemi, O. P. In vivo amplification of the androgen receptor gene and progression of human prostate cancer. Nat. Genet., 9: 401-406, 1995.
29. Evans, B. A., Harper, M. E., Daniells, C. E., Watts, C. E., Matenhelia, S., Green, J., and Griffiths, K. Low incidence of androgen receptor gene mutations in human prostatic tumors using single strand conformation polymorphism analysis. Prostate, 28: 162-171, 1996.
30. Koivisto, P., Kononen, J., Palmberg, C., Tammela, T., Hyytinen, E., Isola, J., Trapman, J., Cleutjens, K., Noordzij, A., Visakorpi, T., and Kallioniemi, O. P. Androgen receptor gene amplification: a possible molecular mechanism for androgen deprivation therapy failure in prostate cancer. Cancer Res., 57: 314-319, 1997.
31. de Vere White, R., Meyers, F., Chi, S. G., Chamberlain, S., Siders, D., Lee, F., Stewart, S., and Gumerlock, P. H. Human androgen receptor expression in prostate cancer following androgen ablation. Eur. Urol., 31: 1-6, 1997.
32. Paz, A., Lindner, A., Zisman, A., and Siegel, Y. A genetic sequence change in the 3′-noncoding region of the androgen receptor gene in prostate carcinoma. Eur. Urol., 31: 209-215, 1997.
33. Watanabe, M., Ushijima, T., Shiraishi, T., Yatani, R., Shimazaki, J., Kotake, T., Sugimura, T., and Nagao, M. Genetic alterations of androgen receptor gene in Japanese human prostate cancer. Jpn. J. Clin. Oncol., 27: 389-393, 1997.
34. Tilley, W., Buchanan, G., Hickey, T., and Bentel, J. Mutations of the androgen receptor gene are associated with progression of human prostate cancer to androgen independence. Clin. Cancer Res., 2: 277-285, 1996.
35. Wang, C., and Uchida, T. Androgen receptor gene mutations in prostate cancer (in Japanese). Nippon Hinyokika Gakkai Zasshi, 88: 550-556, 1997.
36. Hakimi, J., Ahmed, R., Isaacs, W., Bova, W., and Barrack, E. Mutational analysis of the androgen receptor gene in hormone refractory metastases of prostate cancer. Proc. Am. Assoc. Cancer Res., 39: 552, 1998.
37. Marcelli, M., Weigel, N. L., and Lamb, D. J. Steroid receptor in prostate cancer development. In: S. P. Ethier (ed.), Endocrine Oncology, in press. Totowa, NJ: Humana Press, 2000.
38. Shiao, Y-H., Buzard, G., Weghorst, C., and Rice, J. DNA template as a source of artifact in the detection of p53 gene mutations using archived tissue. Biotechniques, 22: 608-612, 1997.
39. Wheeler, T. M., and Lebovitz, R. M. Fresh tissue harvest for research from prostatectomy specimens. Prostate, 25: 274-279, 1994.
40. Ittmann, M., Wieczorek, R., Heller, P., Dave, A., Provet, J., and Krolewski, J. Alterations of the p53 and MDM-2 genes are infrequent in clinically localized stage B prostate adenocarcinoma. Am. J. Pathol., 145: 287-293, 1994.
41. Marcelli, M., Tilley, W. D., Wilson, C. M., Griffin, J. E., Wilson, J. D., and McPhaul, M. J. Definition of the human androgen receptor gene permits the identification of mutations that cause androgen resistance: premature termination codon of the receptor protein at amino acid residue 588 causes complete androgen resistance. Mol. Endocrinol., 4: 1105-1116, 1990.
42. Misrahi, M., Venencie, P. Y., Saugier-Veber, P., Sar, S., Dessen, P., and Milgrom, E. Structure of the human progesterone receptor gene. Biochim. Biophys. Acta, 1216: 289-292, 1993.
43. Orita, M., Suzuki, Y., Sekiya, T., and Hayashi, K. Rapid and sensitive detection of point mutations and DNA polymorphisms using the polymerase chain reaction. Genomics, 5: 874-879, 1989.
44. Orita, M., Iwahana, H., Kanazawa, H., Hayashi, K., and Sekiya, T. Detection of polymorphisms of human DNA by gel electrophoresis as single-strand conformation polymorphisms. Proc. Natl. Acad. Sci. USA, 86: 2766-2770, 1989.
45. Thigpen, A. E., Davis, D. L., Milatovich, A., Mendonca, B. B., Imperato-McGinley, J., Griffin, J. E., Francke, U., Wilson, J. D., and Russell, D. W. Molecular genetics of steroid 5α-reductase 2 deficiency. J. Clin. Investig., 90: 799-809, 1992.
46. Marcelli, M., Tilley, W. D., Wilson, C. M., Wilson, J. D., Griffin, J. E., and McPhaul, M. J. A single nucleotide substitution introduces a premature termination codon into the androgen receptor gene of a patient with receptor-negative androgen resistance. J. Clin. Inves., 85: 1522-1528, 1990.
47. Marcelli, M., Tilley, W. D., Zoppi, S., Griffin, J. E., Wilson, J. D., and McPhaul, M. J. Androgen resistance associated with a mutation of the androgen receptor at amino acid 772 (Arg→Cys) results from a combination of decreased messenger ribonucleic acid levels and impairment of receptor function. J. Clin. Endocrinol. Metab., 73: 318-325, 1991.
48. Marcelli, M., Zoppi, S., Griffin, J. E., Wilson, J. D., and McPhaul, M. J. A mutation of the DNA-binding domain of the androgen receptor gene causes receptor positive androgen resistance. J. Clin. Inves., 87: 1123-1126, 1991.
49. Marcelli, M., Zoppi, S., Wilson, C. M., Griffin, J. E., and McPhaul, M. J. Amino acid substitutions in the hormone binding domain of the human androgen receptor alter the stability of the hormone-receptor complex. J. Clin. Inves., 94: 1642-1650, 1994.
50. McPhaul, M. J., Marcelli, M., Tilley, W. D., Griffin, J. E., and Wilson, J. D. Androgen receptor mutations causing androgen resistance. FASEB J., 5: 2910-2915, 1991.
51. McPhaul, M. J., Marcelli, M., Zoppi, S., Griffin, J. E., and Wilson, J. D. Mutations in the ligand binding domain of the human androgen receptor gene cluster in two regions of the gene. J. Clin. Inves., 90: 2097-2101, 1992.
52. Zoppi, S., Marcelli, M., Deslypere, J-P., Griffin, J. E., Wilson, J. D., and McPhaul, M. J. Amino acid substitution in the DNA binding domain of the human androgen receptor are a frequent cause of receptor-binding positive androgen resistance. Mol. Endocrinol., 6: 409-415, 1992.
53. Wilson, C. M., Griffin, J. E., Wilson, J. D., Marcelli, M., Zoppi, S., and McPhaul, M. J. Immunoreactive androgen receptor expression in subjects with androgen resistance. J. Clin. Endocrinol. Metab., 75: 1474-1478, 1992.
54. Sanger, F., Nicklen, S., and Coulson, A. R. DNA sequencing with chain-terminating inhibitors. Proc. Natl. Acad. Sci. USA, 74: 5463-5467, 1977.
55. Melamed, J., Einhorn, J., and Ittmann, M. Allelic loss on chromosome 13q in human prostate carcinoma. Clin. Can. Res., 3: 1867-1872, 1997.