Interfocal heterogeneity of PTEN/MMAC1 gene alterations in multiple metastatic prostate cancer tissues

Cancer Research

Volumn 58, Issue 2, 1998, Pages 204-209

  Suzuki, Hiroyoshi ^a   Freije, Diha ^a   Nusskern, Deborah R ^a   Okami, Kenji ^a   Cairns, Paul ^a   Sidransky, David ^a   Isaacs, William B ^a,b   Bova, G Steven ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CHROMOSOME 10Q; CLINICAL ARTICLE; CONTROLLED STUDY; FLUORESCENCE IN SITU HYBRIDIZATION; GENE DELETION; GENE LOSS; HUMAN; HUMAN TISSUE; MALE; POINT MUTATION; PRIORITY JOURNAL; PROSTATE CANCER; SINGLE STRAND CONFORMATION POLYMORPHISM; TUMOR SUPPRESSOR GENE;

AGED; AGED, 80 AND OVER; DNA PRIMERS; DNA, NEOPLASM; GENE DELETION; GENES, TUMOR SUPPRESSOR; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; LOSS OF HETEROZYGOSITY; MALE; MICROSATELLITE REPEATS; MIDDLE AGED; PHOSPHORIC MONOESTER HYDROLASES; POINT MUTATION; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; PROSTATIC NEOPLASMS; PROTEIN-TYROSINE-PHOSPHATASE; PTEN PHOSPHOHYDROLASE; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEINS;

EID: 0031964511     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Rarker, S. L., Tong, T., Bolden, S., and Wingo, P. A. Cancer statistics, 1997. CA Cancer J. Clin., 47: 5-27, 1997.
2. Cher, M. L., Bova, G. S., Moore, D. H., Small, E. J., Carroll, P. R., Pin, S. P., Epstein, J. I., Isaacs, W. B., and Jensen, R. H. Genetic alterations in untreated metastases and androgen-independent prostate cancer detected by comparative genomic hybridization and allelotyping. Cancer Res., 56: 3091-3102, 1996.
3. Carter, B. S., Ewing, C. M., Ward, W. S., Treiger, B. F., Aalders, T. W., Schalken, J. A., Epstein, J. I., and Isaacs, W. B. Allelic loss of chromosomes 16q and 10q in human prostate cancer. Proc. Natl. Acad. Sci. USA, 87: 8751-8755, 1990.
4. Bergerheim, U. S., Kunimi, K., Collins, V. P., and Ekman, P. Deletion mapping of chromosomes 8, 10, and 16 in human prostatic carcinoma. Genes Chromosomes Cancer, 3: 215-220, 1991.
5. Visakorpi, T., Kallioniemi, A. H., Syvänen, A-C., Hyytinen, E. R., Karhu, R., Tammela, T., Isola, J. J., and Kallioniemi, O-P. Genetic changes in primary and recurrent prostate cancer by comparative genomic hybridization. Cancer Res., 55: 342-347, 1995.
6. Zenklusen, J. C., Thompson, J. C., Troncoso, P., Kagan, J., and Conti, C. J. Loss of heterozygosity in human primary prostate carcinomas: a possible tumor suppressor gene at 7q31.1. Cancer Res., 54: 6370-6373, 1994.
7. Bova, G. S., Carter, B. S., Bussemarkers, M. J. G., Emi, M., Fujiwara, Y., Kyprianou, N., Jacobs, S. C., Robinson, J. C., Epstein, J. I., Walsh, P. C., and Isaacs, W. B. Homozygous deletion and frequent allelic loss of chromosome 8p22 loci in human prostate cancer. Cancer Res., 53: 3869-3873, 1993.
8. Suzuki, H., Emi, M., Komiya, A., Fujiwara, Y., Yatani, R., Nakamura, Y., and Shimazaki, J. Localization of a tumor suppressor gene associated with progression of human prostate cancer within a 1.2-Mb region of 8p22-21.3. Genes Chromosomes Cancer, 13: 168-174, 1995.
9. Komiya, A., Suzuki, H., Ueda, T., Yatani, R., Emi, M., Ito, H., and Shimazaki, J. Allelic losses at loci on chromosome 10 are associated with metastasis and progression of human prostate cancer. Genes Chromosomes Cancer, 17: 245-253, 1996.
10. Gray, I. C., Phillips, S. M. A., Lee, S. J., Neoptolemos, J. P., Weissenbach, J., and Spurr, N. K. Loss of the chromosomal region 10q23-25 in prostate cancer. Cancer Res., 55: 4800-4803, 1995.
11. Trybus, T. M., Burgess, A. C., Wojno, K. J., Glover, T. W., and Makoska, J. Distinct areas of allelic loss on chromosomal regions 10p and 10q in human prostate cancer. Cancer Res., 56: 2263-2267, 1996.
12. Ittmann M. Allelic loss on chromosome 10 in prostate adenocarcinoma. Cancer Res., 56: 2143-2147, 1996.
13. Suzuki, H., Komiya, A., Emi, M., Kuramochi, H., Shiraishi, T., Yatani, R., and Shimazaki, J. Three distinct commonly deleted regions of chromosome arm 16q in human primary and metastatic prostate cancers. Genes Chromosomes Cancer, 17: 225-233, 1996.
14. Gao, X., Zacharek, A., Salkowski, A., Grignon, D. J., Sakr, W., Porter, A. T., and Honn, K. V. Loss of heterozygosity of the BRCA1 and other loci on chromosome 17q in human prostate cancer. Cancer Res., 55: 1002-1005, 1995.
15. Ueda, T., Komiya, A., Emi, M., Suzuki, H., Shiraishi, T., Yatani, R., Masai, M., Yasuda, K., and Ito, H. Allelic losses on 18q21 are associated with progression and metastasis in human prostate cancer. Genes Chromosomes Cancer, 20: 140-147, 1997.
16. Li, J., Yen, C., Liaw, D., Podsypanina, K., Bose, S., Wang, S. I., Puc, J., Miliaresis, C., Rodgers, L., McCombie, R., Bigner, S. H., Giovanella, B. C., Ittmann, M., Tycko, B., Hibshoosh, H., Wigler, M. H., and Parsons, R. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate Science (Washington DC), 275: 1943-1947, 1997.
17. Steck, P. A., Pershouse, M. A., Jasser, S. A., Yung, W. K. A., Lin, H., Ligon, A. H., Langford, L. A., Baumgard, M. L., Hattier, T., Davis, T., Frye, C., Hu, R., Swedlund, B., Teng, D. H. F., and Tavtigian, S. V. Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat. Genet., 15: 356-362, 1997.
18. Cairns, P., Okami, K., Halachmi, S., Halachmi, N., Esteller, M., Herman, J. G., Jen, J., Isaacs, W. B., Bova, G. S., and Sidransky, D. Frequent inactivation of PTEN/ MMAC1 in primary prostate cancer. Cancer Res., 57: 4997-5000, 1997.
19. Nihei, N., Ichikawa, T., Kawana, Y., Kuramochi, H., Kugo, H., Oshimura, M., Killary, A. M., Rinker-Schaeffer, C. W., Barrett, J. C., Isaacs, J. T., and Shimazaki, J. Localization of metastasis suppressor gene(s) for rat prostate cancer to the long arm of human chromosome 10. Genes Chromosomes Cancer, 14: 112-119, 1995.
20. Mirchandani, D., Zheng, J., Miller, G. J., Ghosh, A. K., Shibata, D. K., Cote, R. J., and Roy-Burman, P. Heterogeneity in intratumor distribution of p53 mutations in human prostate cancer. Am. J. Pathol., 147: 92-101, 1995.
21. Konishi, N., Hiasa, Y., Matsuda, H., Tao, M., Tsuzuki, T., Hayashi, I., Kitahori, Y., Shiraishi, T., Yatani, R., Shimazaki, J., and Lin, J-C. Intratumor cellular heterogeneity and alterations in ras oncogenes and p53 tumor suppressor gene in human prostate carcinoma. Am. J. Pathol., 147: 1112-1122, 1995.
22. O'Malley, F. P., Grignon, D. J., Keeney, M., Kerkvliet, N., and McLean, C. DNA heterogeneity in prostatic adenocarcinoma: a DNA flow cytometric mapping study with whole organ sections of prostate. Cancer (Phila.), 71: 2797-2802, 1993.
23. Sakr, W. A., Makoska, J. A., Benson, P., Grignon, D. J., Wolman, S. R., Pontes, J. E., and Crissman, J. D. Allelic loss in locally metastatic, multisampled prostate cancer. Cancer Res., 54: 3273-3277, 1994.
24. Stapleton, A. M., Timme, T. L., Gousse, A. E., Li, Q-F., Tonbon, A. A., Kattan, M. W., Slawin, K. M., Wheeler, T. M., Scardino, P. T., and Thompson, T. C. Primary human prostate cancer cells harboring p53 mutations are clonally expanded in metastases. Clin. Cancer Res., 3: 1389-1397, 1997.
25. Geburek, B. M., Kollmorgen, T. A., Qian, J., D'Souza-Gburek, S. M., Lieber, M. M., and Jenkin, R. B. Chromosomal anomalies in stage D1 prostate adenocarcinoma primary tumors and lymph node metastases detected by fluorescence in situ hybridization. J. Urol., 151: 223-227, 1994.
26. Rasheed, B. K. A., Stenzel, T. T., McLendon, R. E., Parsons, R., Friedman, A. H., Friedman, H. S., Bigner, D. D., and Bigner, S. H. PTEN gene mutations are seen in high-grade but not in low-grade gliomas. Cancer Res., 57: 4187-4190, 1997.
27. Risinger, J. I., Hayes, A. K., Berchuck, A., and Barrett, J. C. PTEN/MMAC1 mutations in endometrial cancers. Cancer Res., 57: 4736-4738, 1997.
28. Tashiro, H., Blazes, M. S., Wu, R., Cho, K. R., Bose, S., Wang, S. I., Li, J., Parsons, R., and Ellenson, L. H. Mutations in PTEN are frequent in endometorial carcinoma but rare in other common gynecological malignancies. Cancer Res., 57: 3935-3940, 1997.
29. Kong, D., Suzuki, A., Zou, T. T., Sakurada, A., Kemp, L. W., Wakatsuki, S., Yokoyama, T., Yamakawa, H., Furukawa, T., Sato, M., Ohuchi, N., Sato, S., Yin, J., Wang, S., Abraham, J. M., Souza, R. F., Smolinski, K. N., Meltzer, S. J., and Horii, A. PTEN1 is frequently mutated in primary endometrial carcinomas. Nat. Genet., 17: 143-144, 1997.
30. Rhei, E., Kang, L., Bogomolniy, F., Federici, M. G., Borgan, P. I., and Boyd, J. Mutation analysis of the putative tumor suppressor gene PTEN/MMAC1 in primary breast carcinomas. Cancer Res., 57: 3657-3659, 1997.
31. Guldberg, P., thor Straten, P., Birck, A., Ahrenkiel, V., Kirkin, A. F., and Zeuthen, J. Disruption of the MMAC1/PTEN gene by deletion or mutation is a frequent event in malignant melanoma. Cancer Res., 57: 3660-3663, 1997.
32. Liaw, D., Marsh, D. J., Li, J., Dahia, P. L. M., Wang, S. I., Zheng, Z., Bose, S., Call, K. M., Tsou, H. C., Peacocke, M. P., Eng, C., and Parsons, R. Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome. Nat. Genet., 16: 64-67, 1997.
33. Marsh, D. J., Dahia, P. L. M., Zheng, Z., Liaw, D., Parsons, R., Gorlin, R. J., and Eng, C. Germline mutations in PTEN are present in Bannayan-Zonana syndrome. Nat. Genet., 16: 333-334, 1997.
34. Suzuki, H., Komiya, A., Aida, S., Akimoto, S., Shiraishi, T., Yatani, R., Igarashi, T., and Shimazaki, J. Microsatellite instability and other molecular abnormalities in human prostate cancer. Jpn. J. Cancer Res., 86: 956-961, 1995.
35. Egawa, S., Uchida, T., Suyama, K., Wang, C., Ohori, M., Irie, S., Iwamura, M., and Koshiba, K. Genomic instability of microsatellite repeats in prostate cancer: relationship to clinicopathological variables. Cancer Res., 55: 2418-2421, 1995.
36. Watanabe, M., Imai, H., Shiraishi, T., Shimazaki, J., Kotake, T., and Yatani, R. Microsatellite instability in human prostate cancer. Br. J. Cancer, 72: 562-564, 1995.