The inhibition of the highly expressed mir-221 and mir-222 impairs the growth of prostate carcinoma xenografts in mice

PLoS ONE

Volumn 3, Issue 12, 2008, Pages

  Mercatelli, Neri ^a,e   Coppola, Valeria ^b   Bonci, Desirée ^b   Miele, Francesca ^a   Costantini, Arianna ^a   Guadagnoli, Marco ^a   Bonanno, Elena ^a   Muto, Giovanni ^c   Frajese, Giovanni Vanni ^a,f   De Maria, Ruggero ^b,d   Spagnoli, Luigi Giusto ^a   Farace, Maria Giulia ^a   Ciafrè, Silvia Anna ^a  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

^b ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^c S GIOVANNI BOSCO HOSPITAL   (Italy)

^d Mediterranean Institute of Oncology   (Italy)

^e INSTITUT ANDRÉ LWOFF   (France)

^f UNIVERSITY OF CASSINO AND SOUTHERN LAZIO   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

MICRORNA; MICRORNA 221; MICRORNA 222; OLIGONUCLEOTIDE; PROTEIN P27; UNCLASSIFIED DRUG; CYCLINE; LOCKED NUCLEIC ACID; MIRN221 MICRORNA, HUMAN; MIRN222 MICRORNA, HUMAN; P27 ANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CANCER INHIBITION; CELL GROWTH; CELL PROLIFERATION; CELL STRAIN LNCAP; CONTROLLED STUDY; CORRELATION ANALYSIS; GENE FUNCTION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PROSTATE CARCINOMA; SCID MOUSE; TUMOR GROWTH; UPREGULATION; XENOGRAFT; AGED; ANIMAL; CARCINOMA; DISEASE COURSE; DOWN REGULATION; DRUG ANTAGONISM; DRUG EFFECT; DRUG SCREENING; GENE EXPRESSION REGULATION; GENE THERAPY; GENETICS; MIDDLE AGED; MOUSE MUTANT; NUCLEOTIDE SEQUENCE; PATHOLOGY; PHYSIOLOGY; PROSTATE TUMOR; TUMOR CELL CULTURE;

MUS;

AGED; ANIMALS; BASE SEQUENCE; CARCINOMA; CELL PROLIFERATION; DISEASE PROGRESSION; DOWN-REGULATION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE THERAPY; HUMANS; MALE; MICE; MICE, SCID; MICRORNAS; MIDDLE AGED; OLIGONUCLEOTIDES; PROLIFERATING CELL NUCLEAR ANTIGEN; PROSTATIC NEOPLASMS; TUMOR CELLS, CULTURED; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 58149240996     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0004029     Document Type: Article

References (32)

1. Ambros V (2001) microRNAs: tiny regulators with great potential. Cell 107(7): 823-6.
2. Filipowicz W, Bhattacharyya SN, Sonenberg N (2008) Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? Nat Rev Genet 9(2): 102-14.
3. He L, He X, Lowe SW, Hannon GJ (2007) microRNAs join the p53 network-another piece in the tumor-suppression puzzle. Nat Rev Cancer 7(11): 819-22.
4. Cho WC (2007) OncomiRs: the discovery and progress of microRNAs in cancers. Mol Cancer 6: 60.
5. Ciafré SA, Galardi S, Mangiola A, Ferracin M, Liu CG, et al. (2005) Extensive modulation of a set of microRNAs in primary glioblastoma. Biochem Biophys Res Commun 334(4): 1351-8.
6. kip1 by miRNA 221/222 in glioblastoma. Cell Cycle 6 (16): 2005-9.
7. Le Sage C, Nagel R, Egan DA, Schrier M, Mesman E, et al. (2007) Regulation of the p27(Kip1) tumor suppressor by miR-221 and miR-222 promotes cancer cell proliferation. EMBO J 26(15): 3699-708.
8. Medina R, Zaidi SK, Liu CG, Stein JL, van Wijnen AJ, et al. (2008) MicroRNAs 221 and 222 bypass quiescence and compromise cell survival. Cancer Res 68(8): 2773-80.
9. Galardi S, Mercatelli N, Giorda E, Massalini S, Frajese GV, et al. (2007) miR-221 and miR-222 expression affects the proliferation potential of human prostate carcinoma cell lines by targeting p27Kip1. J Biol Chem 282(32): 23716-24.
10. Yu SL, Chen HY, Chang GC, Chen CY, Chen HW, et al. (2008) MicroRNA signature predicts survival and relapse in lung cancer. Cancer Cell 13(1): 48-57.
11. Garofalo M, Quintavalle C, Di Leva G, Zanca C, Romano G, et al. (2008) MicroRNA signatures of TRAIL resistance in human non-small cell lung cancer. Oncogene 27(27): 3845-55.
12. Meng F, Henson R, Wehbe-Janek H, Ghoshal K, Jacob ST, Patel T (2007) MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer. Gastroenterology 133(2): 647-58.
13. Fornari F, Gramantieri L, Ferracin M, Veronese A, Sabbioni S, et al. (2008) MiR-221 controls CDKN1C/p57 and CDKN1B/p27 expression in human hepatocellular carcinoma. Oncogene 27(43): 5651-61.
14. Lee EJ, Gusev Y, Jiang J, Nuovo GJ, Lerner MR, et al. (2007) Expression profiling identifies microRNA signature in pancreatic cancer. Int J Cancer 120(5): 1046-54.
15. Visone R, Russo L, Pallante P, De Martino I, Ferraro A, et al. (2007) MicroRNAs (miR)-221 and miR-222, both overexpressed in human thyroid papillary carcinomas, regulate p27Kip1 protein levels and cell cycle. Endocr Relat Cancer 14(3): 791-8.
16. Jemal A, Siegel R, Ward E, Hao Y, Xu J, et al. (2008) Cancer statistics, 2008. CA Cancer J Clin 58(2): 71-96.
17. Jiang J, Lee EJ, Gusev Y, Schmittgen TD (2005) Real-time expression profiling of microRNA precursors in human cancer cell lines. Nucleic Acids Res 33(17): 5394-403.
18. Sylvestre Y, De Guire V, Querido E, Mukhopadhyay UK, Bourdeau V, et al. (2007) An E2F/miR-20a autoregulatory feedback loop. J Biol Chem 282(4): 2135-43.
19. Shi XB, Xue L, Yang J, Ma AH, Zhao J, et al. (2007) An androgen-regulated miRNA suppresses Bak1 expression and induces androgen-independent growth of prostate cancer cells. Proc Natl Acad Sci U S A 104(50): 19983-8.
20. Musiyenko A, Bitko V, Barik S (2008) Ectopic expression of miR-126*, an intronic product of the vascular endothelial EGF-like 7 gene, regulates prostein translation and invasiveness of prostate cancer LNCaP cells. J Mol Med 86(3): 313-22.
21. Lu Z, Liu M, Stribinskis V, Klinge CM, Ramos KS, et al. (2008) MicroRNA-21 promotes cell transformation by targeting the programmed cell death 4 gene. Oncogene 27(31): 4373-9.
22. Mattie MD, Benz CC, Bowers J, Sensinger K, Wong L, et al. (2006) Optimized high-throughput microRNA expression profiling provides novel biomarker assessment of clinical prostate and breast cancer biopsies. Mol Cancer 5: 24.
23. Prueitt RL, Yi M, Hudson RS, Wallace TA, Howe TM, et al. (2008) Expression of microRNAs and protein-coding genes associated with perineural invasion in prostate cancer. Prostate 68(11): 1152-64.
24. Porkka KP, Pfeiffer MJ, Waltering KK, Vessella RL, Tammela TL, Visakorpi T (2007) MicroRNA expression profiling in prostate cancer. Cancer Res 67(13): 6130-5.
25. Krützfeld J, Rajewsky N, Braich R, Rajeev KG, Tuschl T, et al. (2005) Silencing of microRNAs in vivo with 'antagomirs'. Nature 438(7068): 685-9.
26. Krützfeld J, Kuwajima S, Braich R, Rajeev KG, Pena J, et al. (2007) Specificity, duplex degradation and subcellular localization of antagomirs. Nucleic Acids Res 35(9): 2885-92.
27. Dalmay T (2008) MicroRNAs and cancer. J Intern Med 263(4): 366-75.
28. Carè A, Catalucci D, Felicetti F, Bonci D, Addario A, et al. (2007) MicroRNA-133 controls cardiac hypertrophy. Nat Med 13(5): 613-8.
29. Felicetti F, Errico MC, Bottero L, Segnalini P, Stoppacciaro A, et al. (2008) The promyelocytic leukemia zinc finger-microRNA-221/-222 pathway controls melanoma progression through multiple oncogenic mechanisms. Cancer Res 68(8): 2745-54.
30. Fontana L, Fiori ME, Albini S, Cifaldi L, Giovinazzi S, et al. (2008) Antagomir-17-5p abolishes the growth of therapy resistant neuroblastoma through p21 and BIM. PloS ONE 3(5): e2236.
31. Fernandez PL, Hernandez L, Farré X, Campo E, Cardesa A (2002) Alterations of cell cycle-regulatory genes in prostate cancer. Pathobiol 70(1): 1-10.
32. Said J (2005) Biomarker discovery in urogenital cancer. Biomarkers 10 Suppl 1: S83-6.