메뉴 건너뛰기




Volumn 16, Issue 4, 2014, Pages 515-521

The role of mRNA splicing in prostate cancer

Author keywords

alternative splicing; androgen receptor; CRPC; neuroendocrine transdifferentiation; PI3K pathway; prostate cancer; REST repressor complex

Indexed keywords

ANDROGEN RECEPTOR; CYCLIN D1; FIBROBLAST GROWTH FACTOR RECEPTOR 2; KRUPPEL LIKE FACTOR 6; MESSENGER RNA PRECURSOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BCL X; RNA ISOFORM; VASCULOTROPIN;

EID: 84904731283     PISSN: 1008682X     EISSN: 17457262     Source Type: Journal    
DOI: 10.4103/1008-682X.127825     Document Type: Review
Times cited : (17)

References (108)
  • 1
    • 78049416081 scopus 로고    scopus 로고
    • Alternative pre-mRNA splicing regulation in cancer: Pathways and programs unhinged
    • David CJ, Manley JL. Alternative pre-mRNA splicing regulation in cancer: pathways and programs unhinged. Genes Dev 2010; 24: 2343-64.
    • (2010) Genes Dev , vol.24 , pp. 2343-2364
    • David, C.J.1    Manley, J.L.2
  • 2
    • 70350569286 scopus 로고    scopus 로고
    • Mechanisms of alternative splicing regulation: Insights from molecular and genomics approaches
    • Chen M, Manley JL. Mechanisms of alternative splicing regulation: insights from molecular and genomics approaches. Nat Rev Mol Cell Biol 2009; 10: 741-54.
    • (2009) Nat Rev Mol Cell Biol , vol.10 , pp. 741-754
    • Chen, M.1    Manley, J.L.2
  • 3
    • 56549101959 scopus 로고    scopus 로고
    • Alternative isoform regulation in human tissue transcriptomes
    • Wang ET, Sandberg R, Luo S, Khrebtukova I, Zhang L, et al. Alternative isoform regulation in human tissue transcriptomes. Nature 2008; 456: 470-6.
    • (2008) Nature , vol.456 , pp. 470-476
    • Wang, E.T.1    Sandberg, R.2    Luo, S.3    Khrebtukova, I.4    Zhang, L.5
  • 4
    • 56749098074 scopus 로고    scopus 로고
    • Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing
    • Pan Q, Shai O, Lee LJ, Frey BJ, Blencowe BJ. Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing. Nat Genet 2008; 40: 1413-5.
    • (2008) Nat Genet , vol.40 , pp. 1413-1415
    • Pan, Q.1    Shai, O.2    Lee, L.J.3    Frey, B.J.4    Blencowe, B.J.5
  • 5
    • 49949105213 scopus 로고    scopus 로고
    • The multiple lives of NMD factors: Balancing roles in gene and genome regulation
    • Isken O, Maquat LE. The multiple lives of NMD factors: balancing roles in gene and genome regulation. Nat Rev Genet 2008; 9: 699-712.
    • (2008) Nat Rev Genet , vol.9 , pp. 699-712
    • Isken, O.1    Maquat, L.E.2
  • 6
    • 72849106592 scopus 로고    scopus 로고
    • RNA processing and its regulation: Global insights into biological networks
    • Licatalosi DD, Darnell RB. RNA processing and its regulation: global insights into biological networks. Nat Rev Genet 2010; 11: 75-87.
    • (2010) Nat Rev Genet , vol.11 , pp. 75-87
    • Licatalosi, D.D.1    Darnell, R.B.2
  • 7
    • 75849145292 scopus 로고    scopus 로고
    • Expansion of the eukaryotic proteome by alternative splicing
    • Nilsen TW, Graveley BR. Expansion of the eukaryotic proteome by alternative splicing. Nature 2010; 463: 457-63.
    • (2010) Nature , vol.463 , pp. 457-463
    • Nilsen, T.W.1    Graveley, B.R.2
  • 8
    • 80455144530 scopus 로고    scopus 로고
    • Spliceosome structure and function
    • pii: a003707 Jul 1 doi: 10.1101/cshperspect.a003707
    • Will CL, Lührmann R. Spliceosome structure and function. Cold Spring Harb Perspect Biol. 2011 Jul 1;3(7). pii: a003707. doi: 10.1101/cshperspect. a003707.
    • (2011) Cold Spring Harb Perspect Biol. , vol.3 , Issue.7
    • Will, C.L.1    Lührmann, R.2
  • 9
    • 0037068447 scopus 로고    scopus 로고
    • Comprehensive proteomic analysis of the human spliceosome
    • Zhou Z, Licklider LJ, Gygi SP, Reed R. Comprehensive proteomic analysis of the human spliceosome. Nature 2002; 419: 182-5.
    • (2002) Nature , vol.419 , pp. 182-185
    • Zhou, Z.1    Licklider, L.J.2    Gygi, S.P.3    Reed, R.4
  • 12
    • 7444220147 scopus 로고    scopus 로고
    • Aberrant and alternative splicing in cancer
    • Venables JP. Aberrant and alternative splicing in cancer. Cancer Res 2004; 64: 7647-54.
    • (2004) Cancer Res , vol.64 , pp. 7647-7654
    • Venables, J.P.1
  • 13
    • 0036207384 scopus 로고    scopus 로고
    • Listening to silence and understanding nonsense: Exonic mutations that affect splicing
    • Cartegni L, Chew SL, Krainer AR. Listening to silence and understanding nonsense: exonic mutations that affect splicing. Nat Rev Genet 2002; 3: 285-98.
    • (2002) Nat Rev Genet , vol.3 , pp. 285-298
    • Cartegni, L.1    Chew, S.L.2    Krainer, A.R.3
  • 14
    • 33749993417 scopus 로고    scopus 로고
    • The consensus coding sequences of human breast and colorectal cancers
    • Sjöblom T, Jones S, Wood LD, Parsons DW, Lin J, et al. The consensus coding sequences of human breast and colorectal cancers. Science 2006; 314: 268-74.
    • (2006) Science , vol.314 , pp. 268-274
    • Sjöblom, T.1    Jones, S.2    Wood, L.D.3    Parsons, D.W.4    Lin, J.5
  • 15
    • 84870495530 scopus 로고    scopus 로고
    • Genome and transcriptome sequencing of lung cancers reveal diverse mutational and splicing events
    • Liu J, Lee W, Jiang Z, Chen Z, Jhunjhunwala S, et al. Genome and transcriptome sequencing of lung cancers reveal diverse mutational and splicing events. Genome Res 2012; 22: 2315-27.
    • (2012) Genome Res , vol.22 , pp. 2315-2327
    • Liu, J.1    Lee, W.2    Jiang, Z.3    Chen, Z.4    Jhunjhunwala, S.5
  • 16
    • 84885735554 scopus 로고    scopus 로고
    • Mutational landscape and significance across 12 major cancer types
    • Kandoth C, McLellan MD, Vandin F, Ye K, Niu B, et al. Mutational landscape and significance across 12 major cancer types. Nature 2013; 502: 333-9.
    • (2013) Nature , vol.502 , pp. 333-339
    • Kandoth, C.1    McLellan, M.D.2    Vandin, F.3    Ye, K.4    Niu, B.5
  • 18
    • 80053900941 scopus 로고    scopus 로고
    • Frequent pathway mutations of splicing machinery in myelodysplasia
    • Yoshida K, Sanada M, Shiraishi Y, Nowak D, Nagata Y, et al. Frequent pathway mutations of splicing machinery in myelodysplasia. Nature 2011; 478: 64-9.
    • (2011) Nature , vol.478 , pp. 64-69
    • Yoshida, K.1    Sanada, M.2    Shiraishi, Y.3    Nowak, D.4    Nagata, Y.5
  • 19
    • 84857994411 scopus 로고    scopus 로고
    • SF3B1, a splicing factor is frequently mutated in refractory anemia with ring sideroblasts
    • Visconte V, Makishima H, Jankowska A, Szpurka H, Traina F, et al. SF3B1, a splicing factor is frequently mutated in refractory anemia with ring sideroblasts. Leukemia 2012; 26: 542-5.
    • (2012) Leukemia , vol.26 , pp. 542-545
    • Visconte, V.1    Makishima, H.2    Jankowska, A.3    Szpurka, H.4    Traina, F.5
  • 20
    • 84867852880 scopus 로고    scopus 로고
    • Alternative transcription and alternative splicing in cancer
    • Pal S, Gupta R, Davuluri RV. Alternative transcription and alternative splicing in cancer. Pharmacol Ther 2012; 136: 283-94.
    • (2012) Pharmacol Ther , vol.136 , pp. 283-294
    • Pal, S.1    Gupta, R.2    Davuluri, R.V.3
  • 21
    • 80053027909 scopus 로고    scopus 로고
    • Functional consequences of developmentally regulated alternative splicing
    • Kalsotra A, Cooper TA. Functional consequences of developmentally regulated alternative splicing. Nat Rev Genet 2011; 12: 715-29.
    • (2011) Nat Rev Genet , vol.12 , pp. 715-729
    • Kalsotra, A.1    Cooper, T.A.2
  • 22
    • 84878995293 scopus 로고    scopus 로고
    • MBNL proteins repress ES-cell-specific alternative splicing and reprogramming
    • Han H, Irimia M, Ross PJ, Sung HK, Alipanahi B, et al. MBNL proteins repress ES-cell-specific alternative splicing and reprogramming. Nature 2013; 498: 241-5.
    • (2013) Nature , vol.498 , pp. 241-245
    • Han, H.1    Irimia, M.2    Ross, P.J.3    Sung, H.K.4    Alipanahi, B.5
  • 23
    • 84899044116 scopus 로고    scopus 로고
    • MBNL1 and RBFOX2 cooperate to establish a splicing programme involved in pluripotent stem cell differentiation
    • Venables JP, Lapasset L, Gadea G, Fort P, Klinck R, et al. MBNL1 and RBFOX2 cooperate to establish a splicing programme involved in pluripotent stem cell differentiation. Nat Commun 2013; 4: 2480.
    • (2013) Nat Commun , vol.4 , pp. 2480
    • Venables, J.P.1    Lapasset, L.2    Gadea, G.3    Fort, P.4    Klinck, R.5
  • 24
    • 84884396659 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition: Focus on metastatic cascade, alternative splicing, non-coding RNAs and modulating compounds
    • Samatov TR, Tonevitsky AG, Schumacher U. Epithelial-mesenchymal transition: focus on metastatic cascade, alternative splicing, non-coding RNAs and modulating compounds. Mol Cancer 2013; 12: 107.
    • (2013) Mol Cancer , vol.12 , pp. 107
    • Samatov, T.R.1    Tonevitsky, A.G.2    Schumacher, U.3
  • 25
    • 84872491549 scopus 로고    scopus 로고
    • Developmental signaling pathways in cancer stem cells of solid tumors
    • Karamboulas C, Ailles L. Developmental signaling pathways in cancer stem cells of solid tumors. Biochim Biophys Acta 2013; 1830: 2481-95.
    • (2013) Biochim Biophys Acta , vol.1830 , pp. 2481-2495
    • Karamboulas, C.1    Ailles, L.2
  • 26
    • 63049123066 scopus 로고    scopus 로고
    • Transitions between epithelial and mesenchymal states: Acquisition of malignant and stem cell traits
    • Polyak K, Weinberg RA. Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. Nat Rev Cancer 2009; 9: 265-73.
    • (2009) Nat Rev Cancer , vol.9 , pp. 265-273
    • Polyak, K.1    Weinberg, R.A.2
  • 27
    • 80052322960 scopus 로고    scopus 로고
    • An EMT-driven alternative splicing program occurs in human breast cancer and modulates cellular phenotype
    • Shapiro IM, Cheng AW, Flytzanis NC, Balsamo M, Condeelis JS, et al. An EMT-driven alternative splicing program occurs in human breast cancer and modulates cellular phenotype. PLoS Genet 2011; 7: e1002218.
    • (2011) PLoS Genet , vol.7
    • Shapiro, I.M.1    Cheng, A.W.2    Flytzanis, N.C.3    Balsamo, M.4    Condeelis, J.S.5
  • 30
    • 3242672465 scopus 로고    scopus 로고
    • Whole genome scanning identifies genotypes associated with recurrence and metastasis in prostate tumors
    • Paris PL, Andaya A, Fridlyand J, Jain AN, Weinberg V, et al. Whole genome scanning identifies genotypes associated with recurrence and metastasis in prostate tumors. Hum Mol Genet 2004; 13: 1303-13.
    • (2004) Hum Mol Genet , vol.13 , pp. 1303-1313
    • Paris, P.L.1    Andaya, A.2    Fridlyand, J.3    Jain, A.N.4    Weinberg, V.5
  • 31
    • 27344451557 scopus 로고    scopus 로고
    • Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer
    • Tomlins SA, Rhodes DR, Perner S, Dhanasekaran SM, Mehra R, et al. Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer. Science 2005; 310: 644-8.
    • (2005) Science , vol.310 , pp. 644-648
    • Tomlins, S.A.1    Rhodes, D.R.2    Perner, S.3    Dhanasekaran, S.M.4    Mehra, R.5
  • 32
    • 84861581164 scopus 로고    scopus 로고
    • Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer
    • Barbieri CE, Baca SC, Lawrence MS, Demichelis F, Blattner M, et al. Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer. Nat Genet 2012; 44: 685-9.
    • (2012) Nat Genet , vol.44 , pp. 685-689
    • Barbieri, C.E.1    Baca, S.C.2    Lawrence, M.S.3    Demichelis, F.4    Blattner, M.5
  • 33
    • 84863723010 scopus 로고    scopus 로고
    • The mutational landscape of lethal castration-resistant prostate cancer
    • Grasso CS, Wu YM, Robinson DR, Cao X, Dhanasekaran SM, et al. The mutational landscape of lethal castration-resistant prostate cancer. Nature 2012; 487: 239-43.
    • (2012) Nature , vol.487 , pp. 239-243
    • Grasso, C.S.1    Wu, Y.M.2    Robinson, D.R.3    Cao, X.4    Dhanasekaran, S.M.5
  • 34
    • 44449139593 scopus 로고    scopus 로고
    • The role of SPINK1 in ETS rearrangement-negative prostate cancers
    • Tomlins SA, Rhodes DR, Yu J, Varambally S, Mehra R, et al. The role of SPINK1 in ETS rearrangement-negative prostate cancers. Cancer Cell 2008; 13: 519-28.
    • (2008) Cancer Cell , vol.13 , pp. 519-528
    • Tomlins, S.A.1    Rhodes, D.R.2    Yu, J.3    Varambally, S.4    Mehra, R.5
  • 35
    • 77954526989 scopus 로고    scopus 로고
    • Rearrangements of the RAF kinase pathway in prostate cancer, gastric cancer and melanoma
    • Palanisamy N, Ateeq B, Kalyana-Sundaram S, Pflueger D, Ramnarayanan K, et al. Rearrangements of the RAF kinase pathway in prostate cancer, gastric cancer and melanoma. Nat Med 2010; 16: 793-8.
    • (2010) Nat Med , vol.16 , pp. 793-798
    • Palanisamy, N.1    Ateeq, B.2    Kalyana-Sundaram, S.3    Pflueger, D.4    Ramnarayanan, K.5
  • 36
    • 79961222799 scopus 로고    scopus 로고
    • Urine TMPRSS2: ERG fusion transcript stratifies prostate cancer risk in men with elevated serum PSA
    • Tomlins SA, Aubin SM, Siddiqui J, Lonigro RJ, Sefton-Miller L, et al. Urine TMPRSS2: ERG fusion transcript stratifies prostate cancer risk in men with elevated serum PSA. Sci Transl Med 2011; 3: 94ra72.
    • (2011) Sci Transl Med , vol.3
    • Tomlins, S.A.1    Aubin, S.M.2    Siddiqui, J.3    Lonigro, R.J.4    Sefton-Miller, L.5
  • 37
    • 0242608654 scopus 로고    scopus 로고
    • Use of expression analysis to predict outcome after radical prostatectomy
    • Febbo PG, Sellers WR. Use of expression analysis to predict outcome after radical prostatectomy. J Urol 2003; 170: S11-9.
    • (2003) J Urol , vol.170
    • Febbo, P.G.1    Sellers, W.R.2
  • 39
    • 9144251970 scopus 로고    scopus 로고
    • Gene expression profiling identifies clinically relevant subtypes of prostate cancer
    • Lapointe J, Li C, Higgins JP, van de Rijn M, Bair E, et al. Gene expression profiling identifies clinically relevant subtypes of prostate cancer. Proc Natl Acad Sci USA 2004; 101: 811-6.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 811-816
    • Lapointe, J.1    Li, C.2    Higgins, J.P.3    Van De Rijn, M.4    Bair, E.5
  • 40
    • 84975685847 scopus 로고    scopus 로고
    • From sequence to molecular pathology, and a mechanism driving the neuroendocrine phenotype in prostate cancer
    • Lapuk AV, Wu C, Wyatt AW, McPherson A, McConeghy BJ, et al. From sequence to molecular pathology, and a mechanism driving the neuroendocrine phenotype in prostate cancer. J Pathol 2012; 227: 286-97.
    • (2012) J Pathol , vol.227 , pp. 286-297
    • Lapuk, A.V.1    Wu, C.2    Wyatt, A.W.3    McPherson, A.4    McConeghy, B.J.5
  • 41
    • 34250795169 scopus 로고    scopus 로고
    • Identification of differentially regulated splice variants and novel exons in glial brain tumors using exon expression arrays
    • French PJ, Peeters J, Horsman S, Duijm E, Siccama I, et al. Identification of differentially regulated splice variants and novel exons in glial brain tumors using exon expression arrays. Cancer Res 2007; 67: 5635-42.
    • (2007) Cancer Res , vol.67 , pp. 5635-5642
    • French, P.J.1    Peeters, J.2    Horsman, S.3    Duijm, E.4    Siccama, I.5
  • 42
    • 77955463831 scopus 로고    scopus 로고
    • Exon-level microarray analyses identify alternative splicing programs in breast cancer
    • Lapuk A, Marr H, Jakkula L, Pedro H, Bhattacharya S, et al. Exon-level microarray analyses identify alternative splicing programs in breast cancer. Mol Cancer Res 2010; 8: 961-74.
    • (2010) Mol Cancer Res , vol.8 , pp. 961-974
    • Lapuk, A.1    Marr, H.2    Jakkula, L.3    Pedro, H.4    Bhattacharya, S.5
  • 43
    • 33947541694 scopus 로고    scopus 로고
    • Alternative splicing: An emerging topic in molecular and clinical oncology
    • Pajares MJ, Ezponda T, Catena R, Calvo A, Pio R, et al. Alternative splicing: an emerging topic in molecular and clinical oncology. Lancet Oncol 2007; 8: 349-57.
    • (2007) Lancet Oncol , vol.8 , pp. 349-357
    • Pajares, M.J.1    Ezponda, T.2    Catena, R.3    Calvo, A.4    Pio, R.5
  • 44
    • 33646364024 scopus 로고    scopus 로고
    • Profiling alternatively spliced mRNA isoforms for prostate cancer classification
    • Zhang C, Li HR, Fan JB, Wang-Rodriguez J, Downs T, et al. Profiling alternatively spliced mRNA isoforms for prostate cancer classification. BMC Bioinformatics 2006; 7: 202.
    • (2006) BMC Bioinformatics , vol.7 , pp. 202
    • Zhang, C.1    Li, H.R.2    Fan, J.B.3    Wang-Rodriguez, J.4    Downs, T.5
  • 45
    • 84866252932 scopus 로고    scopus 로고
    • Transcriptome-wide detection of differentially expressed coding and non-coding transcripts and their clinical significance in prostate cancer
    • Erho N, Buerki C, Triche TJ, Davicioni E, Vergara IA. Transcriptome-wide detection of differentially expressed coding and non-coding transcripts and their clinical significance in prostate cancer. J Oncol 2012; 2012: 541353.
    • (2012) J Oncol , vol.2012 , pp. 541353
    • Erho, N.1    Buerki, C.2    Triche, T.J.3    Davicioni, E.4    Vergara, I.A.5
  • 46
    • 22244447065 scopus 로고    scopus 로고
    • Integration of gene expression profiling and clinical variables to predict prostate carcinoma recurrence after radical prostatectomy
    • Stephenson AJ, Smith A, Kattan MW, Satagopan J, Reuter VE, et al. Integration of gene expression profiling and clinical variables to predict prostate carcinoma recurrence after radical prostatectomy. Cancer 2005; 104: 290-8.
    • (2005) Cancer , vol.104 , pp. 290-298
    • Stephenson, A.J.1    Smith, A.2    Kattan, M.W.3    Satagopan, J.4    Reuter, V.E.5
  • 48
    • 84862777104 scopus 로고    scopus 로고
    • RNA-seq analysis of prostate cancer in the Chinese population identifies recurrent gene fusions, cancer-associated long noncoding RNAs and aberrant alternative splicings
    • Ren S, Peng Z, Mao JH, Yu Y, Yin C, et al. RNA-seq analysis of prostate cancer in the Chinese population identifies recurrent gene fusions, cancer-associated long noncoding RNAs and aberrant alternative splicings. Cell Res 2012; 22: 806-21.
    • (2012) Cell Res , vol.22 , pp. 806-821
    • Ren, S.1    Peng, Z.2    Mao, J.H.3    Yu, Y.4    Yin, C.5
  • 49
    • 70349395222 scopus 로고    scopus 로고
    • Anti-androgens and androgen-depleting therapies in prostate cancer: New agents for an established target
    • Chen Y, Clegg NJ, Scher HI. Anti-androgens and androgen-depleting therapies in prostate cancer: new agents for an established target. Lancet Oncol 2009; 10: 981-91.
    • (2009) Lancet Oncol , vol.10 , pp. 981-991
    • Chen, Y.1    Clegg, N.J.2    Scher, H.I.3
  • 50
    • 80054931284 scopus 로고    scopus 로고
    • Alternatively spliced androgen receptor variants
    • Dehm SM, Tindall DJ. Alternatively spliced androgen receptor variants. Endocr Relat Cancer 2011; 18: R183-96.
    • (2011) Endocr Relat Cancer , vol.18
    • Dehm, S.M.1    Tindall, D.J.2
  • 51
    • 65549168746 scopus 로고    scopus 로고
    • A novel androgen receptor splice variant is up-regulated during prostate cancer progression and promotes androgen depletion-resistant growth
    • Guo Z, Yang X, Sun F, Jiang R, Linn DE, et al. A novel androgen receptor splice variant is up-regulated during prostate cancer progression and promotes androgen depletion-resistant growth. Cancer Res 2009; 69: 2305-13.
    • (2009) Cancer Res , vol.69 , pp. 2305-2313
    • Guo, Z.1    Yang, X.2    Sun, F.3    Jiang, R.4    Linn, D.E.5
  • 52
    • 58249110391 scopus 로고    scopus 로고
    • Ligand-independent androgen receptor variants derived from splicing of cryptic exons signify hormone-refractory prostate cancer
    • Hu R, Dunn TA, Wei S, Isharwal S, Veltri RW, et al. Ligand-independent androgen receptor variants derived from splicing of cryptic exons signify hormone-refractory prostate cancer. Cancer Res 2009; 69: 16-22.
    • (2009) Cancer Res , vol.69 , pp. 16-22
    • Hu, R.1    Dunn, T.A.2    Wei, S.3    Isharwal, S.4    Veltri, R.W.5
  • 53
    • 79959312739 scopus 로고    scopus 로고
    • A snapshot of the expression signature of androgen receptor splicing variants and their distinctive transcriptional activities
    • Hu R, Isaacs WB, Luo J. A snapshot of the expression signature of androgen receptor splicing variants and their distinctive transcriptional activities. Prostate 2011;71:1656-67.
    • (2011) Prostate , vol.71 , pp. 1656-1667
    • Hu, R.1    Isaacs, W.B.2    Luo, J.3
  • 54
    • 79955719838 scopus 로고    scopus 로고
    • Expression of androgen receptor splice variants in prostate cancer bone metastases is associated with castration-resistance and short survival
    • Hörnberg E, Ylitalo EB, Crnalic S, Antti H, Stattin P, et al. Expression of androgen receptor splice variants in prostate cancer bone metastases is associated with castration-resistance and short survival. PLoS One 2011; 6: e19059.
    • (2011) PLoS One , vol.6
    • Hörnberg, E.1    Ylitalo, E.B.2    Crnalic, S.3    Antti, H.4    Stattin, P.5
  • 55
    • 84863979005 scopus 로고    scopus 로고
    • Distinct transcriptional programs mediated by the ligand-dependent full-length androgen receptor and its splice variants in castration-resistant prostate cancer
    • Hu R, Lu C, Mostaghel EA, Yegnasubramanian S, Gurel M, et al. Distinct transcriptional programs mediated by the ligand-dependent full-length androgen receptor and its splice variants in castration-resistant prostate cancer. Cancer Res 2012; 72: 3457-62.
    • (2012) Cancer Res , vol.72 , pp. 3457-3462
    • Hu, R.1    Lu, C.2    Mostaghel, E.A.3    Yegnasubramanian, S.4    Gurel, M.5
  • 56
    • 84872534568 scopus 로고    scopus 로고
    • Androgen receptor splice variants mediate enzalutamide resistance in castration-resistant prostate cancer cell lines
    • Li Y, Chan SC, Brand LJ, Hwang TH, Silverstein KA, et al. Androgen receptor splice variants mediate enzalutamide resistance in castration-resistant prostate cancer cell lines. Cancer Res 2013; 73: 483-9.
    • (2013) Cancer Res , vol.73 , pp. 483-489
    • Li, Y.1    Chan, S.C.2    Brand, L.J.3    Hwang, T.H.4    Silverstein, K.A.5
  • 57
    • 81255150464 scopus 로고    scopus 로고
    • Androgen receptor variants occur frequently in castration resistant prostate cancer metastases
    • Zhang X, Morrissey C, Sun S, Ketchandji M, Nelson PS, et al. Androgen receptor variants occur frequently in castration resistant prostate cancer metastases. PLoS One 2011; 6: e27970.
    • (2011) PLoS One , vol.6
    • Zhang, X.1    Morrissey, C.2    Sun, S.3    Ketchandji, M.4    Nelson, P.S.5
  • 58
    • 80052827038 scopus 로고    scopus 로고
    • Resistance to CYP17A1 inhibition with abiraterone in castration-resistant prostate cancer: INDUCTION of steroidogenesis and androgen receptor splice variants
    • Mostaghel EA, Marck BT, Plymate SR, Vessella RL, Balk S, et al. Resistance to CYP17A1 inhibition with abiraterone in castration-resistant prostate cancer: INDUCTION of steroidogenesis and androgen receptor splice variants. Clin Cancer Res 2011; 17: 5913-25.
    • (2011) Clin Cancer Res , vol.17 , pp. 5913-5925
    • Mostaghel, E.A.1    Marck, B.T.2    Plymate, S.R.3    Vessella, R.L.4    Balk, S.5
  • 59
    • 79951825699 scopus 로고    scopus 로고
    • Small molecule inhibitors targeting the "achilles' heel" of androgen receptor activity
    • Sadar MD. Small molecule inhibitors targeting the "achilles' heel" of androgen receptor activity. Cancer Res 2011; 71: 1208-13.
    • (2011) Cancer Res , vol.71 , pp. 1208-1213
    • Sadar, M.D.1
  • 60
    • 79952772097 scopus 로고    scopus 로고
    • Intragenic rearrangement and altered RNA splicing of the androgen receptor in a cell-based model of prostate cancer progression
    • Li Y, Alsagabi M, Fan D, Bova GS, Tewfik AH, et al. Intragenic rearrangement and altered RNA splicing of the androgen receptor in a cell-based model of prostate cancer progression. Cancer Res 2011; 71: 2108-17.
    • (2011) Cancer Res , vol.71 , pp. 2108-2117
    • Li, Y.1    Alsagabi, M.2    Fan, D.3    Bova, G.S.4    Tewfik, A.H.5
  • 61
    • 84886447413 scopus 로고    scopus 로고
    • TALEN-engineered AR gene rearrangements reveal endocrine uncoupling of androgen receptor in prostate cancer
    • Nyquist MD, Li Y, Hwang TH, Manlove LS, Vessella RL, et al. TALEN-engineered AR gene rearrangements reveal endocrine uncoupling of androgen receptor in prostate cancer. Proc Natl Acad Sci USA 2013; 110: 17492-7.
    • (2013) Proc Natl Acad Sci USA , vol.110 , pp. 17492-17497
    • Nyquist, M.D.1    Li, Y.2    Hwang, T.H.3    Manlove, L.S.4    Vessella, R.L.5
  • 62
    • 84869094406 scopus 로고    scopus 로고
    • AR intragenic deletions linked to androgen receptor splice variant expression and activity in models of prostate cancer progression
    • Li Y, Hwang TH, Oseth LA, Hauge A, Vessella RL, et al. AR intragenic deletions linked to androgen receptor splice variant expression and activity in models of prostate cancer progression. Oncogene 2012; 31: 4759-67.
    • (2012) Oncogene , vol.31 , pp. 4759-4767
    • Li, Y.1    Hwang, T.H.2    Oseth, L.A.3    Hauge, A.4    Vessella, R.L.5
  • 63
    • 84902471998 scopus 로고    scopus 로고
    • Mechanisms of the androgen receptor splicing in prostate cancer cells
    • Jul doi: 10.1038/onc.2013.284
    • Liu LL, Xie N, Sun S, Plymate S, Mostaghel E, et al. Mechanisms of the androgen receptor splicing in prostate cancer cells. Oncogene. 2013 Jul 15. doi: 10.1038/onc.2013.284.
    • (2013) Oncogene. , vol.15
    • Liu, L.L.1    Xie, N.2    Sun, S.3    Plymate, S.4    Mostaghel, E.5
  • 64
    • 0345829926 scopus 로고    scopus 로고
    • Cellular response to an antisense-mediated shift of Bcl-x pre-mRNA splicing and antineoplastic agents
    • Mercatante DR, Mohler JL, Kole R. Cellular response to an antisense-mediated shift of Bcl-x pre-mRNA splicing and antineoplastic agents. J Biol Chem 2002; 277: 49374-82.
    • (2002) J Biol Chem , vol.277 , pp. 49374-49382
    • Mercatante, D.R.1    Mohler, J.L.2    Kole, R.3
  • 65
    • 0027992204 scopus 로고
    • Alternative splicing in fibroblast growth factor receptor 2 is associated with induced epithelial-mesenchymal transition in rat bladder carcinoma cells
    • Savagner P, Vallés AM, Jouanneau J, Yamada KM, Thiery JP. Alternative splicing in fibroblast growth factor receptor 2 is associated with induced epithelial-mesenchymal transition in rat bladder carcinoma cells. Mol Biol Cell 1994; 5: 851-62.
    • (1994) Mol Biol Cell , vol.5 , pp. 851-862
    • Savagner, P.1    Vallés, A.M.2    Jouanneau, J.3    Yamada, K.M.4    Thiery, J.P.5
  • 66
    • 0031577732 scopus 로고    scopus 로고
    • Alternative splicing of fibroblast growth factor receptor 2 (FGF-R2) in human prostate cancer
    • Carstens RP, Eaton JV, Krigman HR, Walther PJ, Garcia-Blanco MA. Alternative splicing of fibroblast growth factor receptor 2 (FGF-R2) in human prostate cancer. Oncogene 1997; 15: 3059-65.
    • (1997) Oncogene , vol.15 , pp. 3059-3065
    • Carstens, R.P.1    Eaton, J.V.2    Krigman, H.R.3    Walther, P.J.4    Garcia-Blanco, M.A.5
  • 68
    • 0242526150 scopus 로고    scopus 로고
    • An alternatively spliced cyclin D1 isoform, cyclin D1b, is a nuclear oncogene
    • Lu F, Gladden AB, Diehl JA. An alternatively spliced cyclin D1 isoform, cyclin D1b, is a nuclear oncogene. Cancer Res 2003; 63: 7056-61.
    • (2003) Cancer Res , vol.63 , pp. 7056-7061
    • Lu, F.1    Gladden, A.B.2    Diehl, J.A.3
  • 69
    • 84873872188 scopus 로고    scopus 로고
    • Convergence of oncogenic and hormone receptor pathways promotes metastatic phenotypes
    • Augello MA, Burd CJ, Birbe R, McNair C, Ertel A, et al. Convergence of oncogenic and hormone receptor pathways promotes metastatic phenotypes. J Clin Invest 2013; 123: 493-508.
    • (2013) J Clin Invest , vol.123 , pp. 493-508
    • Augello, M.A.1    Burd, C.J.2    Birbe, R.3    McNair, C.4    Ertel, A.5
  • 70
    • 34347358573 scopus 로고    scopus 로고
    • In vivo regulation of p21 by the Kruppel-like factor 6 tumor-suppressor gene in mouse liver and human hepatocellular carcinoma
    • Narla G, Kremer-Tal S, Matsumoto N, Zhao X, Yao S, et al. In vivo regulation of p21 by the Kruppel-like factor 6 tumor-suppressor gene in mouse liver and human hepatocellular carcinoma. Oncogene 2007; 26: 4428-34.
    • (2007) Oncogene , vol.26 , pp. 4428-4434
    • Narla, G.1    Kremer-Tal, S.2    Matsumoto, N.3    Zhao, X.4    Yao, S.5
  • 71
    • 21344473196 scopus 로고    scopus 로고
    • Targeted inhibition of the KLF6 splice variant, KLF6 SV1, suppresses prostate cancer cell growth and spread
    • Narla G, DiFeo A, Yao S, Banno A, Hod E, et al. Targeted inhibition of the KLF6 splice variant, KLF6 SV1, suppresses prostate cancer cell growth and spread. Cancer Res 2005; 65: 5761-8.
    • (2005) Cancer Res , vol.65 , pp. 5761-5768
    • Narla, G.1    Difeo, A.2    Yao, S.3    Banno, A.4    Hod, E.5
  • 72
    • 13944252065 scopus 로고    scopus 로고
    • A germline DNA polymorphism enhances alternative splicing of the KLF6 tumor suppressor gene and is associated with increased prostate cancer risk
    • Narla G, Difeo A, Reeves HL, Schaid DJ, Hirshfeld J, et al. A germline DNA polymorphism enhances alternative splicing of the KLF6 tumor suppressor gene and is associated with increased prostate cancer risk. Cancer Res 2005; 65: 1213-22.
    • (2005) Cancer Res , vol.65 , pp. 1213-1222
    • Narla, G.1    Difeo, A.2    Reeves, H.L.3    Schaid, D.J.4    Hirshfeld, J.5
  • 73
    • 62949123360 scopus 로고    scopus 로고
    • The role of KLF6 and its splice variants in cancer therapy
    • DiFeo A, Martignetti JA, Narla G. The role of KLF6 and its splice variants in cancer therapy. Drug Resist Updat 2009; 12: 1-7.
    • (2009) Drug Resist Updat , vol.12 , pp. 1-7
    • Difeo, A.1    Martignetti, J.A.2    Narla, G.3
  • 74
    • 7444240909 scopus 로고    scopus 로고
    • VEGF165b, an inhibitory vascular endothelial growth factor splice variant: Mechanism of action, in vivo effect on angiogenesis and endogenous protein expression
    • Woolard J, Wang WY, Bevan HS, Qiu Y, Morbidelli L, et al. VEGF165b, an inhibitory vascular endothelial growth factor splice variant: mechanism of action, in vivo effect on angiogenesis and endogenous protein expression. Cancer Res 2004; 64: 7822-35.
    • (2004) Cancer Res , vol.64 , pp. 7822-7835
    • Woolard, J.1    Wang, W.Y.2    Bevan, H.S.3    Qiu, Y.4    Morbidelli, L.5
  • 75
    • 54549123309 scopus 로고    scopus 로고
    • VEGF-A splicing: The key to anti-angiogenic therapeutics?
    • Harper SJ, Bates DO. VEGF-A splicing: the key to anti-angiogenic therapeutics? Nat Rev Cancer 2008; 8: 880-7.
    • (2008) Nat Rev Cancer , vol.8 , pp. 880-887
    • Harper, S.J.1    Bates, D.O.2
  • 76
    • 41649101428 scopus 로고    scopus 로고
    • The endogenous anti-angiogenic VEGF isoform, VEGF165b inhibits human tumour growth in mice
    • Rennel E, Waine E, Guan H, Schüler Y, Leenders W, et al. The endogenous anti-angiogenic VEGF isoform, VEGF165b inhibits human tumour growth in mice. Br J Cancer 2008; 98: 1250-7.
    • (2008) Br J Cancer , vol.98 , pp. 1250-1257
    • Rennel, E.1    Waine, E.2    Guan, H.3    Schüler, Y.4    Leenders, W.5
  • 77
    • 75949107937 scopus 로고    scopus 로고
    • VEGF inhibitors and prostate cancer therapy
    • Aragon-Ching JB, Dahut WL. VEGF inhibitors and prostate cancer therapy. Curr Mol Pharmacol 2009; 2: 161-8.
    • (2009) Curr Mol Pharmacol , vol.2 , pp. 161-168
    • Aragon-Ching, J.B.1    Dahut, W.L.2
  • 78
    • 80054751998 scopus 로고    scopus 로고
    • Exome sequencing identifies a spectrum of mutation frequencies in advanced and lethal prostate cancers
    • Kumar A, White TA, MacKenzie AP, Clegg N, Lee C, et al. Exome sequencing identifies a spectrum of mutation frequencies in advanced and lethal prostate cancers. Proc Natl Acad Sci USA 2011; 108: 17087-92.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 17087-17092
    • Kumar, A.1    White, T.A.2    Mackenzie, A.P.3    Clegg, N.4    Lee, C.5
  • 79
    • 55549143293 scopus 로고    scopus 로고
    • The emerging role of splicing factors in cancer
    • Grosso AR, Martins S, Carmo-Fonseca M. The emerging role of splicing factors in cancer. EMBO Rep 2008; 9: 1087-93.
    • (2008) EMBO Rep , vol.9 , pp. 1087-1093
    • Grosso, A.R.1    Martins, S.2    Carmo-Fonseca, M.3
  • 81
    • 75149187424 scopus 로고    scopus 로고
    • Alternative splicing of the cyclin D1 proto-oncogene is regulated by the RNA-binding protein Sam68
    • Paronetto MP, Cappellari M, Busà R, Pedrotti S, Vitali R, et al. Alternative splicing of the cyclin D1 proto-oncogene is regulated by the RNA-binding protein Sam68. Cancer Res 2010; 70: 229-39.
    • (2010) Cancer Res , vol.70 , pp. 229-239
    • Paronetto, M.P.1    Cappellari, M.2    Busà, R.3    Pedrotti, S.4    Vitali, R.5
  • 82
    • 34347348168 scopus 로고    scopus 로고
    • The RNA-binding protein Sam68 contributes to proliferation and survival of human prostate cancer cells
    • Busà R, Paronetto MP, Farini D, Pierantozzi E, Botti F, et al. The RNA-binding protein Sam68 contributes to proliferation and survival of human prostate cancer cells. Oncogene 2007; 26: 4372-82.
    • (2007) Oncogene , vol.26 , pp. 4372-4382
    • Busà, R.1    Paronetto, M.P.2    Farini, D.3    Pierantozzi, E.4    Botti, F.5
  • 83
    • 84904665882 scopus 로고    scopus 로고
    • The transcriptional co-activator SND1 is a novel regulator of alternative splicing in prostate cancer cells
    • Sep 2. doi: 10.1038/onc.2013.360
    • Cappellari M, Bielli P, Paronetto MP, Ciccosanti F, Fimia GM, et al. The transcriptional co-activator SND1 is a novel regulator of alternative splicing in prostate cancer cells. Oncogene. 2013 Sep 2. doi: 10.1038/onc.2013.360.
    • (2013) Oncogene.
    • Cappellari, M.1    Bielli, P.2    Paronetto, M.P.3    Ciccosanti, F.4    Fimia, G.M.5
  • 85
    • 77955737984 scopus 로고    scopus 로고
    • The oncoprotein SF2/ASF promotes non-small cell lung cancer survival by enhancing survivin expression
    • Ezponda T, Pajares MJ, Agorreta J, Echeveste JI, López-Picazo JM, et al. The oncoprotein SF2/ASF promotes non-small cell lung cancer survival by enhancing survivin expression. Clin Cancer Res 2010; 16: 4113-25.
    • (2010) Clin Cancer Res , vol.16 , pp. 4113-4125
    • Ezponda, T.1    Pajares, M.J.2    Agorreta, J.3    Echeveste, J.I.4    López-Picazo, J.M.5
  • 86
    • 77952796886 scopus 로고    scopus 로고
    • Identification of ASF/SF2 as a critical, allele-specific effector of the cyclin D1b oncogene
    • Olshavsky NA, Comstock CE, Schiewer MJ, Augello MA, Hyslop T, et al. Identification of ASF/SF2 as a critical, allele-specific effector of the cyclin D1b oncogene. Cancer Res 2010; 70: 3975-84.
    • (2010) Cancer Res , vol.70 , pp. 3975-3984
    • Olshavsky, N.A.1    Comstock, C.E.2    Schiewer, M.J.3    Augello, M.A.4    Hyslop, T.5
  • 87
    • 84883187664 scopus 로고    scopus 로고
    • Alternative splicing programs in prostate cancer
    • Sette C. Alternative splicing programs in prostate cancer. Int J Cell Biol 2013; 2013: 458727.
    • (2013) Int J Cell Biol , vol.2013 , pp. 458727
    • Sette, C.1
  • 88
    • 84881403991 scopus 로고    scopus 로고
    • A road map to comprehensive androgen receptor axis targeting for castration-resistant prostate cancer
    • Mitsiades N. A road map to comprehensive androgen receptor axis targeting for castration-resistant prostate cancer. Cancer Res 2013; 73: 4599-605.
    • (2013) Cancer Res , vol.73 , pp. 4599-4605
    • Mitsiades, N.1
  • 89
    • 84879478480 scopus 로고    scopus 로고
    • Targeting the PI3K/Akt/mTOR pathway in castration-resistant prostate cancer
    • Bitting RL, Armstrong AJ. Targeting the PI3K/Akt/mTOR pathway in castration-resistant prostate cancer. Endocr Relat Cancer 2013; 20: R83-99.
    • (2013) Endocr Relat Cancer , vol.20
    • Bitting, R.L.1    Armstrong, A.J.2
  • 90
    • 79955975429 scopus 로고    scopus 로고
    • Reciprocal feedback regulation of PI3K and androgen receptor signaling in PTEN-deficient prostate cancer
    • Carver BS, Chapinski C, Wongvipat J, Hieronymus H, Chen Y, et al. Reciprocal feedback regulation of PI3K and androgen receptor signaling in PTEN-deficient prostate cancer. Cancer Cell 2011; 19: 575-86.
    • (2011) Cancer Cell , vol.19 , pp. 575-586
    • Carver, B.S.1    Chapinski, C.2    Wongvipat, J.3    Hieronymus, H.4    Chen, Y.5
  • 91
    • 83355176377 scopus 로고    scopus 로고
    • Identification of novel androgen-regulated pathways and mRNA isoforms through genome-wide exon-specific profiling of the LNCaP transcriptome
    • Rajan P, Dalgliesh C, Carling PJ, Buist T, Zhang C, et al. Identification of novel androgen-regulated pathways and mRNA isoforms through genome-wide exon-specific profiling of the LNCaP transcriptome. PLoS One 2011; 6: e29088.
    • (2011) PLoS One , vol.6
    • Rajan, P.1    Dalgliesh, C.2    Carling, P.J.3    Buist, T.4    Zhang, C.5
  • 92
    • 80051951015 scopus 로고    scopus 로고
    • The RNA-binding protein Sam68 is a multifunctional player in human cancer
    • Bielli P, Busà R, Paronetto MP, Sette C. The RNA-binding protein Sam68 is a multifunctional player in human cancer. Endocr Relat Cancer 2011; 18: R91-102.
    • (2011) Endocr Relat Cancer , vol.18
    • Bielli, P.1    Busà, R.2    Paronetto, M.P.3    Sette, C.4
  • 93
    • 28544450763 scopus 로고    scopus 로고
    • Concerted regulation of nuclear and cytoplasmic activities of SR proteins by AKT
    • Blaustein M, Pelisch F, Tanos T, Muñoz MJ, Wengier D, et al. Concerted regulation of nuclear and cytoplasmic activities of SR proteins by AKT. Nat Struct Mol Biol 2005; 12: 1037-44.
    • (2005) Nat Struct Mol Biol , vol.12 , pp. 1037-1044
    • Blaustein, M.1    Pelisch, F.2    Tanos, T.3    Muñoz, M.J.4    Wengier, D.5
  • 94
    • 79959863480 scopus 로고    scopus 로고
    • C-Myc regulates RNA splicing of the A-Raf kinase and its activation of the ERK pathway
    • Rauch J, Moran-Jones K, Albrecht V, Schwarzl T, Hunter K, et al. c-Myc regulates RNA splicing of the A-Raf kinase and its activation of the ERK pathway. Cancer Res 2011; 71: 4664-74.
    • (2011) Cancer Res , vol.71 , pp. 4664-4674
    • Rauch, J.1    Moran-Jones, K.2    Albrecht, V.3    Schwarzl, T.4    Hunter, K.5
  • 97
    • 84864910082 scopus 로고    scopus 로고
    • The Akt-SRPK-SR axis constitutes a major pathway in transducing EGF signaling to regulate alternative splicing in the nucleus
    • Zhou Z, Qiu J, Liu W, Zhou Y, Plocinik RM, et al. The Akt-SRPK-SR axis constitutes a major pathway in transducing EGF signaling to regulate alternative splicing in the nucleus. Mol Cell 2012; 47: 422-33.
    • (2012) Mol Cell , vol.47 , pp. 422-433
    • Zhou, Z.1    Qiu, J.2    Liu, W.3    Zhou, Y.4    Plocinik, R.M.5
  • 98
    • 4143095430 scopus 로고    scopus 로고
    • Altered Hsp90 function in cancer: A unique therapeutic opportunity
    • Bagatell R, Whitesell L. Altered Hsp90 function in cancer: a unique therapeutic opportunity. Mol Cancer Ther 2004; 3: 1021-30.
    • (2004) Mol Cancer Ther , vol.3 , pp. 1021-1030
    • Bagatell, R.1    Whitesell, L.2
  • 99
    • 84878964181 scopus 로고    scopus 로고
    • The HSP70 family and cancer
    • Murphy ME. The HSP70 family and cancer. Carcinogenesis 2013; 34: 1181-8.
    • (2013) Carcinogenesis , vol.34 , pp. 1181-1188
    • Murphy, M.E.1
  • 100
  • 101
    • 12344252767 scopus 로고    scopus 로고
    • Neuroendocrine differentiation in prostate cancer: Implications for new treatment modalities
    • Vashchenko N, Abrahamsson PA. Neuroendocrine differentiation in prostate cancer: implications for new treatment modalities. Eur Urol 2005; 47: 147-55.
    • (2005) Eur Urol , vol.47 , pp. 147-155
    • Vashchenko, N.1    Abrahamsson, P.A.2
  • 102
    • 79953701350 scopus 로고    scopus 로고
    • Neuroendocrine prostate cancer xenografts with large-cell and small-cell features derived from a single patient's tumor: Morphological, immunohistochemical, and gene expression profiles
    • Aparicio A, Tzelepi V, Araujo JC, Guo CC, Liang S, et al. Neuroendocrine prostate cancer xenografts with large-cell and small-cell features derived from a single patient's tumor: morphological, immunohistochemical, and gene expression profiles. Prostate 2011; 71: 846-56.
    • (2011) Prostate , vol.71 , pp. 846-856
    • Aparicio, A.1    Tzelepi, V.2    Araujo, J.C.3    Guo, C.C.4    Liang, S.5
  • 103
    • 0028968802 scopus 로고
    • The neuron-restrictive silencer factor (NRSF): A coordinate repressor of multiple neuron-specific genes
    • Schoenherr CJ, Anderson DJ. The neuron-restrictive silencer factor (NRSF): a coordinate repressor of multiple neuron-specific genes. Science 1995; 267: 1360-3.
    • (1995) Science , vol.267 , pp. 1360-1363
    • Schoenherr, C.J.1    Anderson, D.J.2
  • 104
    • 84893296911 scopus 로고    scopus 로고
    • REST mediates androgen receptor actions on gene repression and predicts early recurrence of prostate cancer
    • Svensson C, Ceder J, Iglesias-Gato D, Chuan YC, Pang ST, et al. REST mediates androgen receptor actions on gene repression and predicts early recurrence of prostate cancer. Nucleic Acids Res 2014; 42: 999-1015.
    • (2014) Nucleic Acids Res , vol.42 , pp. 999-1015
    • Svensson, C.1    Ceder, J.2    Iglesias-Gato, D.3    Chuan, Y.C.4    Pang, S.T.5
  • 105
    • 84876171528 scopus 로고    scopus 로고
    • Extensive alternative splicing of the repressor element silencing transcription factor linked to cancer
    • Chen GL, Miller GM. Extensive alternative splicing of the repressor element silencing transcription factor linked to cancer. PLoS One 2013; 8: e62217.
    • (2013) PLoS One , vol.8
    • Chen, G.L.1    Miller, G.M.2
  • 106
    • 84886398684 scopus 로고    scopus 로고
    • The small cell lung cancer-specific isoform of RE1-silencing transcription factor (REST) is regulated by neural-specific Ser/Arg repeat-related protein of 100 kDa (nSR100)
    • Shimojo M, Shudo Y, Ikeda M, Kobashi T, Ito S. The small cell lung cancer-specific isoform of RE1-silencing transcription factor (REST) is regulated by neural-specific Ser/Arg repeat-related protein of 100 kDa (nSR100). Mol Cancer Res 2013; 11: 1258-68.
    • (2013) Mol Cancer Res , vol.11 , pp. 1258-1268
    • Shimojo, M.1    Shudo, Y.2    Ikeda, M.3    Kobashi, T.4    Ito, S.5
  • 107
    • 80052238639 scopus 로고    scopus 로고
    • Cross-regulation between an alternative splicing activator and a transcription repressor controls neurogenesis
    • Raj B, O'Hanlon D, Vessey JP, Pan Q, Ray D, et al. Cross-regulation between an alternative splicing activator and a transcription repressor controls neurogenesis. Mol Cell 2011; 43: 843-50.
    • (2011) Mol Cell , vol.43 , pp. 843-850
    • Raj, B.1    O'Hanlon, D.2    Vessey, J.P.3    Pan, Q.4    Ray, D.5
  • 108
    • 84883483017 scopus 로고    scopus 로고
    • MRNA splicing variants: Exploiting modularity to outwit cancer therapy
    • Dehm SM. mRNA splicing variants: exploiting modularity to outwit cancer therapy. Cancer Res 2013; 73: 5309-14.
    • (2013) Cancer Res , vol.73 , pp. 5309-5314
    • Dehm, S.M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.