Lipid regulation of cardiac ion channels in heart disease

Cardiovascular Diseases: Nutritional and Therapeutic Interventions

Volumn , Issue , 2013, Pages 77-100

  Yue, Lixia ^a   Yue, Zhichao ^a   Xie, Jia ^a  

^a UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

Author keywords

[No Author keywords available]

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EID: 84936929015     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (229)

1. Abi-Char, J., A. Maguy, A. Coulombe, E. Balse, P. Ratajczak, J. L. Samuel et al. 2007. Membrane cholesterol modulates Kv1.5 potassium channel distribution and function in rat cardiomyocytes. J Physiol 582 (Pt 3): 1205-1217.
2. Alberts, B., A. Jihnson, J. Lewis, M. Raff, K. Roberts, and P. Walter. 2002. Membrane structure. In Molecular Biology of The Cell, Alberts, B., Jihnson, A., Lewis, J., Raff, M., Roberts, K., and Walter, P. (Eds), p. 583. New York: Garland Science.
3. Alioua, A., R. Lu, Y. Kumar, M. Eghbali, P. Kundu, L. Toro et al. 2008. Slo1 caveolin-binding motif, a mechanism of caveolin-1-Slo1 interaction regulating Slo1 surface expression. J Biol Chem 283 (8): 4808-4817.
4. Andersson, D. A., M. Nash, and S. Bevan. 2007. Modulation of the cold-activated channel TRPM8 by lysophospholipids and polyunsaturated fatty acids. J Neurosci 27 (12): 3347-3355.
5. Aravamudan, B., D. Volonte, R. Ramani, E. Gursoy, M. P. Lisanti, B. London et al. 2003. Transgenic overexpression of caveolin-3 in the heart induces a cardiomyopathic phenotype. Hum Mol Genet 12 (21): 2777-2788.
6. Backx, P. H. and E. Marban. 1993. Background potassium current active during the plateau of the action potential in guinea pig ventricular myocytes. Circ Res 72 (4): 890-900.
7. Balijepalli, R. C., J. D. Foell, D. D. Hall, J. W. Hell, and T. J. Kamp. 2006. Localization of cardiac L-type Ca(2+) channels to a caveolar macromolecular signaling complex is required for beta(2)-adrenergic regulation. Proc Natl Acad Sci USA 103 (19): 7500-7505.
8. Bandell, M., G. M. Story, S. W. Hwang, V. Viswanath, S. R. Eid, M. J. Petrus et al. 2004. Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin. Neuron 41 (6): 849-857.
9. Barbuti, A., B. Gravante, M. Riolfo, R. Milanesi, B. Terragni, and D. DiFrancesco. 2004. Localization of pacemaker channels in lipid rafts regulates channel kinetics. Circ Res 94 (10): 1325-1331.
10. Barenholz, Y. 2000. Liposomology. Prog Lipid Res 39 (1): 1-2.
11. Barhanin, J., F. Lesage, E. Guillemare, M. Fink, M. Lazdunski, and G. Romey. 1996. K(V)LQT1 and lsK (minK) proteins associate to form the I(Ks) cardiac potassium current. Nature 384 (6604): 78-80.
12. Barrett, C. F., L. Liu, and A. R. Rittenhouse. 2001. Arachidonic acid reversibly enhances N-type calcium current at an extracellular site. Am J Physiol Cell Physiol 280 (5): C1306-C1318.
13. Basora, N., G. Boulay, L. Bilodeau, E. Rousseau, and M. D. Payet. 2003. 20-Hydroxyeicosatetraenoic acid (20-HETE) activates mouse TRPC6 channels expressed in HEK293 cells. J Biol Chem 278 (34): 31709-31716.
14. Baukrowitz, T., U. Schulte, D. Oliver, S. Herlitze, T. Krauter, S. J. Tucker et al. 1998. PIP2 and PIP as determinants for ATP inhibition of KATP channels. Science 282 (5391): 1141-1144.
15. Benoit, C., B. Renaudon, D. Salvail, and E. Rousseau. 2001. EETs relax airway smooth muscle via an EpDHF effect: BKCa channel activation and hyperpolarization. Am J Physiol - Lung Cell Mol Physiol 280 (5): L965-L973.
16. Bian, J., J. Cui, and T. V. McDonald. 2001. HERG K(+) channel activity is regulated by changes in phosphatidyl inositol 4,5-bisphosphate. Circ Res 89 (12): 1168-1176.
17. Bian, J. S., A. Kagan, and T. V. McDonald. 2004. Molecular analysis of PIP2 regulation of HERG and IKr. Am J Physiol Heart Circ Physiol 287 (5): H2154-H2163.
18. Bian, J. S. and T. V. McDonald. 2007. Phosphatidylinositol 4,5-bisphosphate interactions with the HERG K(+) channel. Pflugers Arch 455 (1): 105-113.
19. Brainard, A. M., V. P. Korovkina, and S. K. England. 2009. Disruption of the maxi-K-caveolin-1 interaction alters current expression in human myometrial cells. Reprod Biol Endocrinol 7: 131.
20. Brash, A. R. 2001. Arachidonic acid as a bioactive molecule. J Clin Invest 107 (11): 1339-1345.
21. Burtis, C. A., E. R. Ashwood, and D. E. Bruns (Eds). 2005. Tietz Textbook of Clinical Chemistry and Molecular Diagnostics. New York: Elsevier Health Sciences.
22. Bush, E. W., D. B. Hood, P. J. Papst, J. A. Chapo, W. Minobe, M. R. Bristow et al. 2006. Canonical transient receptor potential channels promote cardiomyocyte hypertrophy through activation of calcineurin signaling. J Biol Chem 281 (44): 33487-33496.
23. Cahalan, M. D., S. L. Zhang, A. V. Yeromin, K. Ohlsen, J. Roos, and K. A. Stauderman. 2007. Molecular basis of the CRAC channel. Cell Calcium 42 (2): 133-144.
24. Calaghan, S. and E. White. 2006. Caveolae modulate excitation-contraction coupling and beta2-adrenergic signalling in adult rat ventricular myocytes. Cardiovasc Res 69 (4): 816-824.
25. Catterall, W. A. 2010. Ion channel voltage sensors: Structure, function, and pathophysiology. Neuron 67 (6): 915-928.
26. Catterall, W. A. 2011. Voltage-gated calcium channels. Cold Spring Harb Perspect Biol 3 (8): a003947.
27. Catterall, W. A. 2012. Voltage-gated sodium channels at 60: Structure, function, and pathophysiology. J Physiol 590 (Pt 11): 2577-2589.
28. Chilton, L., S. Ohya, D. Freed, E. George, V. Drobic, Y. Shibukawa et al. 2005. K+ currents regulate the resting membrane potential, proliferation, and contractile responses in ventricular fibroblasts and myofibroblasts. Am J Physiol Heart Circ Physiol 288 (6): H2931-H2939.
29. Cho, H., J. Shin, C. Y. Shin, S. Y. Lee, and U. Oh. 2002. Mechanosensitive ion channels in cultured sensory neurons of neonatal rats. J Neurosci 22 (4): 1238-1247.
30. Chuang, H. H., E. D. Prescott, H. Kong, S. Shields, S. E. Jordt, A. I. Basbaum et al. 2001. Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition. Nature 411 (6840): 957-962.
31. Clapham, D. E. 2003. TRP channels as cellular sensors. Nature 426 (6966): 517-524.
32. Clapham, D. E. and D. Kim. 1989. G protein activation mechanisms of the cardiac K+ channel, iK.ACh. Soc Gen Physiol Ser 44: 55-68.
33. Cloutier, M., S. Campbell, N. Basora, S. Proteau, M. D. Payet, and E. Rousseau. 2003. 20-HETE inotropic effects involve the activation of a nonselective cationic current in airway smooth muscle. Am J Physiol Lung Cell Mol Physiol 285 (3): L560-L568.
34. Cohen, A. W., D. S. Park, S. E. Woodman, T. M. Williams, M. Chandra, J. Shirani et al. 2003. Caveolin-1 null mice develop cardiac hypertrophy with hyperactivation of p42/44 MAP kinase in cardiac fibroblasts. Am J Physiol Cell Physiol 284 (2): C457-C474.
35. Colbert, C. M. and E. Pan. 1999. Arachidonic acid reciprocally alters the availability of transient and sustained dendritic K(+) channels in hippocampal CA1 pyramidal neurons. J Neurosci 19 (19): 8163-8171.
36. Coste, B., J. Mathur, M. Schmidt, T. J. Earley, S. Ranade, M. J. Petrus et al. 2010. Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels. Science 330 (6000): 55-60.
37. Coste, B., B. Xiao, J. S. Santos, R. Syeda, J. Grandl, K. S. Spencer et al. 2012. Piezo proteins are pore-forming subunits of mechanically activated channels. Nature 483 (7388): 176-181.
38. Danthi, S., J. A. Enyeart, and J. J. Enyeart. 2003. Modulation of native TREK-1 and Kv1.4 K+ channels by polyunsaturated fatty acids and lysophospholipids. J Membr Biol 195 (3): 147-164.
39. Dart, C. 2011. Lipid microdomains and the regulation of ion channel function. J Physiol 588 (Pt 17): 3169-3178.
40. Delmas, P., B. Coste, N. Gamper, and M. S. Shapiro. 2005. Phosphoinositide lipid second messengers: New paradigms for calcium channel modulation. Neuron 47 (2): 179-182.
41. Dhalla, N. S., V. Elimban, and H. Rupp. 1992. Paradoxical role of lipid metabolism in heart function and dysfunction. Mol Cell Biochem 116 (1-2): 3-9.
42. Dietrich, A., H. Kalwa, B. Fuchs, F. Grimminger, N. Weissmann, and T. Gudermann. 2007. In vivo TRPC functions in the cardiopulmonary vasculature. Cell Calcium 42 (2): 233-244.
43. Doerner, J. F., H. Hatt, and I. S. Ramsey. 2011. Voltage- and temperature-dependent activation of TRPV3 channels is potentiated by receptor-mediated PI(4,5)P2 hydrolysis. J Gen Physiol 137 (3): 271-288.
44. Dong, X. P., D. Shen, X. Wang, T. Dawson, X. Li, Q. Zhang et al. 2010a. PI(3,5)P(2) controls membrane trafficking by direct activation of mucolipin Ca(2+) release channels in the endolysosome. Nat Commun 1: 38.
45. Dong, X. P., X. Wang, and H. Xu. 2010b. TRP channels of intracellular membranes. J Neurochem 113 (2): 313-328.
46. Du, J., J. Xie, Z. Zhang, H. Tsujikawa, D. Fusco, D. Silverman et al. 2010. TRPM7-mediated Ca2+ signals confer fibrogenesis in human atrial fibrillation. Circ Res 106 (5): 992-1003.
47. Eddlestone, G. T. 1995. ATP-sensitive K channel modulation by products of PLA2 action in the insulin-secreting HIT cell line. Am J Physiol 268 (1 Pt 1): C181-C190.
48. Eder, P. and J. D. Molkentin. 2011. TRPC channels as effectors of cardiac hypertrophy. Circ Res 108 (2): 265-272.
49. El Chemaly, A., R. Guinamard, M. Demion, N. Fares, V. Jebara, J. F. Faivre et al. 2006. A voltage-activated proton current in human cardiac fibroblasts. Biochem Biophys Res Commun 340 (2): 512-516.
50. England, S., S. Bevan, and R. J. Docherty. 1996. PGE2 modulates the tetrodotoxin-resistant sodium current in neonatal rat dorsal root ganglion neurones via the cyclic AMP-protein kinase A cascade. J Physiol 495 (Pt 2): 429-440.
51. Fang, X., T. L. Kaduce, N. L. Weintraub, S. Harmon, L. M. Teesch, C. Morisseau et al. 2001. Pathways of epoxyeicosatrienoic acid metabolism in endothelial cells. Implications for the vascular effects of soluble epoxide hydrolase inhibition. J Biol Chem 276 (18): 14867-14874.
52. Gamper, N., V. Reznikov, Y. Yamada, J. Yang, and M. S. Shapiro. 2004. Phosphatidylinositol [correction] 4,5-bisphosphate signals underlie receptor-specific Gq/11-mediated modulation of N-type Ca2+ channels. J Neurosci 24 (48): 10980-10992.
53. Gavrilova-Ruch, O., R. Schonherr, and S. H. Heinemann. 2007. Activation of hEAG1 potassium channels by arachidonic acid. Pflugers Arch 453 (6): 891-903.
54. Goldstein, S. A., D. Bockenhauer, I. O’Kelly, and N. Zilberberg. 2001. Potassium leak channels and the KCNK family of two-P-domain subunits. Nat Rev Neurosci 2 (3): 175-184.
55. Gurney, A. and B. Manoury. 2009. Two-pore potassium channels in the cardiovascular system. Eur Biophys J 38 (3): 305-318.
56. Han, J., J. Truell, C. Gnatenco, and D. Kim. 2002. Characterization of four types of background potassium channels in rat cerebellar granule neurons. J Physiol 542 (Pt 2): 431-444.
57. Hansen, S. B., X. Tao, and R. Mackinnon. 2011. Structural basis of PIP(2) activation of the classical inward rectifier K(+) channel Kir2.2. Nature 477: 495-498.
58. Hara, Y., M. Wakamori, M. Ishii, E. Maeno, M. Nishida, T. Yoshida et al. 2002. LTRPC2 Ca2+-permeable channel activated by changes in redox status confers susceptibility to cell death. Mol Cell 9 (1): 163-173.
59. Harada, M., A. Maguy, B. Ordog, K. Dawson, T. Murohara, K. Kamiya et al. 2010. Role of TRP channels in cardiac fibroblast proliferation-New target for AF preventation? Heart Rhythm 7: S52 (Abstract).
60. Heineke, J. and J. D. Molkentin. 2006. Regulation of cardiac hypertrophy by intracellular signalling pathways. Nat Rev Mol Cell Biol 7 (8): 589-600.
61. Hilgemann, D. W. and R. Ball. 1996. Regulation of cardiac Na+, Ca2+ exchange and KATP potassium channels by PIP2. Science 273 (5277): 956-959.
62. Hille, B. 2003. Ion Channels of Excitable Membranes. Sunderland, MA: Sinauer Associates, Inc.
63. Hofmann, T., A. G. Obukhov, M. Schaefer, C. Harteneck, T. Gudermann, and G. Schultz. 1999. Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol. Nature 397 (6716): 259-263.
64. Honore, E., J. Barhanin, B. Attali, F. Lesage, and M. Lazdunski. 1994. External blockade of the major cardiac delayed-rectifier K+ channel (Kv1.5) by polyunsaturated fatty acids. Proc Natl Acad Sci USA 91 (5): 1937-1941.
65. Hu, H. Z., R. Xiao, C. Wang, N. Gao, C. K. Colton, J. D. Wood et al. 2006. Potentiation of TRPV3 channel function by unsaturated fatty acids. J Cell Physiol 208 (1): 201-212.
66. Huang, C. L., S. Feng, and D. W. Hilgemann. 1998. Direct activation of inward rectifier potassium channels by PIP2 and its stabilization by Gbetagamma. Nature 391 (6669): 803-806.
67. Hwang, S. W., H. Cho, J. Kwak, S. Y. Lee, C. J. Kang, J. Jung et al. 2000. Direct activation of capsaicin receptors by products of lipoxygenases: Endogenous capsaicin-like substances. Proc Natl Acad Sci USA 97 (11): 6155-6160.
68. Jenkins, C. M., A. Cedars, and R. W. Gross. 2009. Eicosanoid signalling pathways in the heart. Cardiovasc Res 82 (2): 240-249.
69. Jors, S., V. Kazanski, A. Foik, D. Krautwurst, and C. Harteneck. 2006. Receptor-induced activation of Drosophila TRP gamma by polyunsaturated fatty acids. J Biol Chem 281 (40): 29693-29702.
70. Kamkin, A., I. Kiseleva, K. D. Wagner, A. Lammerich, J. Bohm, P. B. Persson et al. 1999. Mechanically induced potentials in fibroblasts from human right atrium. Exp Physiol 84 (2): 347-356.
71. Kamkin, A., I. Kiseleva, K. D. Wagner, A. Pylaev, K. P. Leiterer, H. Theres et al. 2002. A possible role for atrial fibroblasts in postinfarction bradycardia. Am J Physiol Heart Circ Physiol 282 (3): H842-H849.
72. Karashima, Y., J. Prenen, V. Meseguer, G. Owsianik, T. Voets, and B. Nilius. 2008. Modulation of the transient receptor potential channel TRPA1 by phosphatidylinositol 4,5-biphosphate manipulators. Pflugers Arch 457 (1): 77-89.
73. Katzung, B. G., S. B. Masters, and A. J. Trevor (Eds). 2009. Basic & Clinical Pharmacology, New York: McGraw-Hill Medical.
74. Keros, S. and C. J. McBain. 1997. Arachidonic acid inhibits transient potassium currents and broadens action potentials during electrographic seizures in hippocampal pyramidal and inhibitory interneurons. J Neurosci 17 (10): 3476-3487.
75. Kim, D. and D. E. Clapham. 1989. Potassium channels in cardiac cells activated by arachidonic acid and phospholipids. Science 244 (4909): 1174-1176.
76. Kim, D., D. L. Lewis, L. Graziadei, E. J. Neer, D. Bar-Sagi, and D. E. Clapham. 1989. G-protein beta gamma-subunits activate the cardiac muscarinic K+-channel via phospholipase A2. Nature 337 (6207): 557-560.
77. Kim, D. and A. Pleumsamran. 2000. Cytoplasmic unsaturated free fatty acids inhibit ATP-dependent gating of the G protein-gated K(+) channel. J Gen Physiol 115 (3): 287-304.
78. Kiseleva, I. S., A. G. Kamkin, R. Kirkheis, and G. I. Kositskii. 1987. Intercellular electronic interactions in the cardiac sinus node in the frog. Dokl Akad Nauk SSSR 292 (6): 1502-1505.
79. Klein, R. M., C. A. Ufret-Vincenty, L. Hua, and S. E. Gordon. 2008. Determinants of molecular specificity in phosphoinositide regulation. J Biol Chem 283 (38): 26208-26216.
80. Kuwahara, K., Y. Wang, J. McAnally, J. A. Richardson, R. Bassel-Duby, J. A. Hill et al. 2006. TRPC6 fulfills a calcineurin signaling circuit during pathologic cardiac remodeling. J Clin Invest 116 (12): 3114-3126.
81. Kwiatek, A. M., R. D. Minshall, D. R. Cool, R. A. Skidgel, A. B. Malik, and C. Tiruppathi. 2006. Caveolin-1 regulates store-operated Ca2+ influx by binding of its scaffolding domain to transient receptor potential channel-1 in endothelial cells. Mol Pharmacol 70 (4): 1174-1183.
82. Lai, J., F. Porreca, J. C. Hunter, and M. S. Gold. 2004. Voltage-gated sodium channels and hyperalgesia. Annu Rev Pharmacol Toxicol 44: 371-397.
83. Large, W. A., S. N. Saleh, and A. P. Albert. 2009. Role of phosphoinositol 4,5-bisphosphate and diacylglycerol in regulating native TRPC channel proteins in vascular smooth muscle. Cell Calcium 45 (6): 574-582.
84. Ledesma, M. D., M. G. Martin, and C. G. Dotti. 2012. Lipid changes in the aged brain: Effect on synaptic function and neuronal survival. Prog Lipid Res 51 (1): 23-35.
85. Lee, J., S. K. Cha, T. J. Sun, and C. L. Huang. 2005. PIP2 activates TRPV5 and releases its inhibition by intracellular Mg2+. J Gen Physiol 126 (5): 439-451.
86. Lee, H. C., T. Lu, N. L. Weintraub, M. VanRollins, A. A. Spector, and E. F. Shibata. 1999. Effects of epoxyeicosatrienoic acids on the cardiac sodium channels in isolated rat ventricular myocytes. J Physiol 519 (Pt 1): 153-168.
87. Lesage, F., F. Maingret, and M. Lazdunski. 2000a. Cloning and expression of human TRAAK, a polyunsaturated fatty acids-activated and mechano-sensitive K(+) channel. FEBS Lett 471 (2-3): 137-140.
88. Lesage, F., C. Terrenoire, G. Romey, and M. Lazdunski. 2000b. Human TREK2, a 2P domain mechano-sensitive K+ channel with multiple regulations by polyunsaturated fatty acids, lysophospholipids, and Gs, Gi, and Gq protein-coupled receptors. J Biol Chem 275 (37): 28398-28405.
89. Li, N., J. Y. Liu, H. Qiu, T. R. Harris, P. Sirish, B. D. Hammock et al. 2011a. Use of metabolomic profiling in the study of arachidonic acid metabolism in cardiovascular disease. Congest Heart Fail 17 (1): 42-46.
90. Li, G. R., H. Y. Sun, J. B. Chen, Y. Zhou, H. F. Tse, and C. P. Lau. 2009. Characterization of multiple ion channels in cultured human cardiac fibroblasts. PLoS One 4 (10): e7307.
91. Li, Y., M. A. Zaydman, D. Wu, J. Shi, M. Guan, B. Virgin-Downey et al. 2011b. KCNE1 enhances phosphatidylinositol 4,5-bisphosphate (PIP2) sensitivity of IKs to modulate channel activity. Proc Natl Acad Sci USA 108 (22): 9095-9100.
92. Lim, H. Y. and R. Bodmer. 2011. Phospholipid homeostasis and lipotoxic cardiomyopathy: A matter of balance. Fly (Austin) 5 (3): 234-236.
93. Lim, H. Y., W. Wang, R. J. Wessells, K. Ocorr, and R. Bodmer. 2011. Phospholipid homeostasis regulates lipid metabolism and cardiac function through SREBP signaling in Drosophila. Genes Dev 25 (2): 189-200.
94. Liu, S. J. 2007. Inhibition of L-type Ca2+ channel current and negative inotropy induced by arachidonic acid in adult rat ventricular myocytes. Am J Physiol Cell Physiol 293 (5): C1594-C1604.
95. Liu, L., C. F. Barrett, and A. R. Rittenhouse. 2001a. Arachidonic acid both inhibits and enhances whole cell calcium currents in rat sympathetic neurons. Am J Physiol Cell Physiol 280 (5): C1293-C1305.
96. Liu, L., J. F. Heneghan, T. Mitra-Ganguli, M. L. Roberts-Crowley, and A. R. Rittenhouse. 2007. Role of PIP2 in regulating versus modulating Ca2+ channel activity. J Physiol 583 (Pt 3): 1165-1166; author reply 67.
97. Liu, M., W. Huang, D. Wu, and J. V. Priestley. 2006b. TRPV1, but not P2X, requires cholesterol for its function and membrane expression in rat nociceptors. Eur J Neurosci 24 (1): 1-6.
98. Liu, J. Y., N. Li, J. Yang, H. Qiu, D. Ai, N. Chiamvimonvat et al. 2010. Metabolic profiling of murine plasma reveals an unexpected biomarker in rofecoxib-mediated cardiovascular events. Proc Natl Acad Sci USA 107 (39): 17017-17022.
99. Liu, D. and E. R. Liman. 2003. Intracellular Ca2+ and the phospholipid PIP2 regulate the taste transduction ion channel TRPM5. Proc Natl Acad Sci USA 100 (25): 15160-15165.
100. Liu, Y., D. Liu, L. Heath, D. M. Meyers, D. S. Krafte, P. K. Wagoner et al. 2001b. Direct activation of an inwardly rectifying potassium channel by arachidonic acid. Mol Pharmacol 59 (5): 1061-1068.
101. Liu, Y., D. Liu, and D. S. Krafte. 2002. Decrease of inward rectification as a mechanism for arachidonic acid-induced potentiation of hKir2.3. Eur Biophys J 31 (7): 497-503.
102. Liu, D., Z. Zhang, and E. R. Liman. 2005b. Extracellular acid block and acid-enhanced inactivation of the Ca2+-activated cation channel TRPM5 involve residues in the S3-S4 and S5-S6 extracellular domains. J Biol Chem 280 (21): 20691-20699.
103. Liu, B., C. Zhang, and F. Qin. 2005a. Functional recovery from desensitization of vanilloid receptor TRPV1 requires resynthesis of phosphatidylinositol 4,5-bisphosphate. J Neurosci 25 (19): 4835-4843.
104. Liu, L., R. Zhao, Y. Bai, L. F. Stanish, J. E. Evans, M. J. Sanderson et al. 2006a. M1 muscarinic receptors inhibit L-type Ca2+ current and M-current by divergent signal transduction cascades. J Neurosci 26 (45): 11588-11598.
105. Lopes, C. M. B., T. Rohács, G. Czirják, T. Balla, P. Enyedi, and D. E. Logothetis. 2005. PIP2 hydrolysis underlies agonist-induced inhibition and regulates voltage gating of two-pore domain K+ channels. J Physiol 564 (1): 117-129.
106. Loussouarn, G., K. H. Park, C. Bellocq, I. Baro, F. Charpentier, and D. Escande. 2003. Phosphatidylinositol-4,5-bisphosphate, PIP2, controls KCNQ1/KCNE1 voltage-gated potassium channels: A functional homology between voltage-gated and inward rectifier K+ channels. EMBO J 22 (20): 5412-5421.
107. Lu, T., T. Hoshi, N. L. Weintraub, A. A. Spector, and H. C. Lee. 2001. Activation of ATP-sensitive K(+) channels by epoxyeicosatrienoic acids in rat cardiac ventricular myocytes. J Physiol 537 (Pt 3): 811-827.
108. Lu, T., M. VanRollins, and H. C. Lee. 2002. Stereospecific activation of cardiac ATP-sensitive K(+) channels by epoxyeicosatrienoic acids: A structural determinant study. Mol Pharmacol 62 (5): 1076-1083.
109. Lukacs, V., B. Thyagarajan, P. Varnai, A. Balla, T. Balla, and T. Rohacs. 2007. Dual regulation of TRPV1 by phosphoinositides. J Neurosci 27 (26): 7070-7080.
110. Lvov, A., S. D. Gage, V. M. Berrios, and W. R. Kobertz. 2010. Identification of a protein-protein interaction between KCNE1 and the activation gate machinery of KCNQ1. J Gen Physiol 135 (6): 607-618.
111. Maguy, A., T. E. Hebert, and S. Nattel. 2006. Involvement of lipid rafts and caveolae in cardiac ion channel function. Cardiovasc Res 69 (4): 798-807.
112. Martens, J. R., K. O’Connell, and M. Tamkun. 2004. Targeting of ion channels to membrane microdomains: Localization of KV channels to lipid rafts. Trends Pharmacol Sci 25 (1): 16-21.
113. Mercado, J., A. Gordon-Shaag, W. N. Zagotta, and S. E. Gordon. 2010. Ca2+-dependent desensitization of TRPV2 channels is mediated by hydrolysis of phosphatidylinositol 4,5-bisphosphate. J Neurosci 30 (40): 13338-13347.
114. Meves, H. 2006. The action of prostaglandins on ion channels. Curr Neuropharmacol 4 (1): 41-57.
115. Meves, H. 2008. Arachidonic acid and ion channels: An update. Br J Pharmacol 155 (1): 4-16.
116. Michailidis, I. E., Y. Zhang, and J. Yang. 2007. The lipid connection-regulation of voltage-gated Ca(2+) channels by phosphoinositides. Pflugers Arch 455 (1): 147-155.
117. Mignen, O., J. L. Thompson, and T. J. Shuttleworth. 2008. Both Orai1 and Orai3 are essential components of the arachidonate-regulated Ca2+-selective (ARC) channels. J Physiol 586 (1): 185-195.
118. Mignen, O., J. L. Thompson, and T. J. Shuttleworth. 2009. The molecular architecture of the arachidonate-regulated Ca2+-selective ARC channel is a pentameric assembly of Orai1 and Orai3 subunits. J Physiol 587 (Pt 17): 4181-4197.
119. Miyachi, E., C. Kato, and T. Nakaki. 1994. Arachidonic acid blocks gap junctions between retinal horizontal cells. Neuroreport 5 (4): 485-488.
120. Moffat, M. P., C. A. Ward, J. R. Bend, T. Mock, P. Farhangkhoee, and M. Karmazyn. 1993. Effects of epoxyeicosatrienoic acids on isolated hearts and ventricular myocytes. Am J Physiol 264 (4 Pt 2): H1154-H1160.
121. Montell, C. 2005. The TRP superfamily of cation channels. Sci STKE 2005 (272): 1-24.
122. Montell, C. and G. M. Rubin. 1989. Molecular characterization of the Drosophila trp locus: A putative integral membrane protein required for phototransduction. Neuron 2 (4): 1313-1323.
123. Moreau, R., A. M. Hurst, J. Y. Lapointe, and D. Lajeunesse. 1996. Activation of maxi-K channels by parathyroid hormone and prostaglandin E2 in human osteoblast bone cells. J Membr Biol 150 (2): 175-184.
124. Morenilla-Palao, C., M. Pertusa, V. Meseguer, H. Cabedo, and F. Viana. 2009. Lipid raft segregation modulates TRPM8 channel activity. J Biol Chem 284 (14): 9215-9224.
125. Morin, C., M. Sirois, V. Echave, M. M. Gomes, and E. Rousseau. 2007. Functional effects of 20-HETE on human bronchi: Hyperpolarization and relaxation due to BKCa channel activation. Am J Physiol Lung Cell Mol Physiol 293 (4): L1037-L1044.
126. Morisseau, C. and B. D. Hammock. 2005. Epoxide hydrolases: Mechanisms, inhibitor designs, and biological roles. Annu Rev Pharmacol Toxicol 45: 311-333.
127. Murata, Y., H. Iwasaki, M. Sasaki, K. Inaba, and Y. Okamura. 2005. Phosphoinositide phosphatase activity coupled to an intrinsic voltage sensor. Nature 435 (7046): 1239-1243.
128. Murata, Y. and Y. Okamura. 2007. Depolarization activates the phosphoinositide phosphatase Ci-VSP, as detected in Xenopus oocytes coexpressing sensors of PIP2. J Physiol 583 (Pt 3): 875-889.
129. Muzzio, I. A., C. C. Gandhi, U. Manyam, A. Pesnell, and L. D. Matzel. 2001. Receptor-stimulated phospholipase A(2) liberates arachidonic acid and regulates neuronal excitability through protein kinase C. J Neurophysiol 85 (4): 1639-1647.
130. Nattel, S., A. Maguy, S. Le Bouter, and Y. H. Yeh. 2007. Arrhythmogenic ion-channel remodeling in the heart: Heart failure, myocardial infarction, and atrial fibrillation. Physiol Rev 87 (2): 425-456.
131. Nerbonne, J. M. and R. S. Kass. 2005. Molecular physiology of cardiac repolarization. Physiol Rev 85 (4): 1205-1253.
132. Nicol, G. D. and M. Cui. 1994. Enhancement by prostaglandin E2 of bradykinin activation of embryonic rat sensory neurones. J Physiol 480 (Pt 3): 485-492.
133. Nicol, G. D., M. R. Vasko, and A. R. Evans. 1997. Prostaglandins suppress an outward potassium current in embryonic rat sensory neurons. J Neurophysiol 77 (1): 167-176.
134. Nilius, B. 2007. TRP channels in disease. Biochim Biophys Acta 1772 (8): 805-812.
135. Nilius, B., F. Mahieu, J. Prenen, A. Janssens, G. Owsianik, R. Vennekens et al. 2006. The Ca2+-activated cation channel TRPM4 is regulated by phosphatidylinositol 4,5-biphosphate. EMBO J 25 (3): 467-478.
136. Nilius, B., G. Owsianik, and T. Voets. 2008. Transient receptor potential channels meet phosphoinositides. EMBO J 27 (21): 2809-2816.
137. Nishida, M., N. Onohara, Y. Sato, R. Suda, M. Ogushi, S. Tanabe et al. 2007. Galpha12/13-mediated up-regulation of TRPC6 negatively regulates endothelin-1-induced cardiac myofibroblast formation and collagen synthesis through nuclear factor of activated T cells activation. J Biol Chem 282 (32): 23117-23128.
138. Nithipatikom, K., E. R. Gross, M. P. Endsley, J. M. Moore, M. A. Isbell, J. R. Falck et al. 2004. Inhibition of cytochrome P450 omega-hydroxylase: A novel endogenous cardioprotective pathway. Circ Res 95 (8): e65-e71.
139. O’Connell, K. M., J. R. Martens, and M. M. Tamkun. 2004. Localization of ion channels to lipid Raft domains within the cardiovascular system. Trends Cardiovasc Med 14 (2): 37-42.
140. Ohba, T., H. Watanabe, M. Murakami, Y. Takahashi, K. Iino, S. Kuromitsu et al. 2007. Upregulation of TRPC1 in the development of cardiac hypertrophy. J Mol Cell Cardiol 42 (3): 498-507.
141. Oike, H., M. Wakamori, Y. Mori, H. Nakanishi, R. Taguchi, T. Misaka et al. 2006. Arachidonic acid can function as a signaling modulator by activating the TRPM5 cation channel in taste receptor cells. Biochim Biophys Acta 1761 (9): 1078-1084.
142. Oliver, D., C. C. Lien, M. Soom, T. Baukrowitz, P. Jonas, and B. Fakler. 2004. Functional conversion between A-type and delayed rectifier K+ channels by membrane lipids. Science 304 (5668): 265-270.
143. Onohara, N., M. Nishida, R. Inoue, H. Kobayashi, H. Sumimoto, Y. Sato et al. 2006. TRPC3 and TRPC6 are essential for angiotensin II-induced cardiac hypertrophy. EMBO J 25 (22): 5305-5316.
144. Pani, B., H. L. Ong, S. C. Brazer, X. Liu, K. Rauser, B. B. Singh et al. 2009. Activation of TRPC1 by STIM1 in ER-PM microdomains involves release of the channel from its scaffold caveolin-1. Proc Natl Acad Sci USA 106 (47): 20087-20092.
145. Park, D. S., A. W. Cohen, P. G. Frank, B. Razani, H. Lee, T. M. Williams et al. 2003. Caveolin-1 null (-/-) mice show dramatic reductions in life span. Biochemistry 42 (51): 15124-15131.
146. Park, K. H., J. Piron, S. Dahimene, J. Merot, I. Baro, D. Escande et al. 2005. Impaired KCNQ1-KCNE1 and phosphatidylinositol-4,5-bisphosphate interaction underlies the long QT syndrome. Circ Res 96 (7): 730-739.
147. Patel, A. J., E. Honore, F. Maingret, F. Lesage, M. Fink, F. Duprat et al. 1998a. A mammalian two pore domain mechano-gated S-like K+ channel. EMBO J 17 (15): 4283-4290.
148. Patel, A. J., I. Lauritzen, M. Lazdunski, and E. Honore. 1998b. Disruption of mitochondrial respiration inhibits volume-regulated anion channels and provokes neuronal cell swelling. J Neurosci 18 (9): 3117-3123.
149. Payandeh, J., T. Scheuer, N. Zheng, and W. A. Catterall. 2011. The crystal structure of a voltage-gated sodium channel. Nature 475 (7356): 353-358.
150. Pian, P., A. Bucchi, R. B. Robinson, and S. A. Siegelbaum. 2006. Regulation of gating and rundown of HCN hyperpolarization-activated channels by exogenous and endogenous PIP2. J Gen Physiol 128 (5): 593-604.
151. Piechotta, P. L., M. Rapedius, P. J. Stansfeld, M. K. Bollepalli, G. Ehrlich, I. Andres-Enguix et al. 2011. The pore structure and gating mechanism of K2P channels. EMBO J 30 (17): 3607-3619.
152. Pike, L. J. 2003. Lipid rafts: Bringing order to chaos. J Lipid Res 44 (4): 655-667.
153. Prakriya, M., S. Feske, Y. Gwack, S. Srikanth, A. Rao, and P. G. Hogan. 2006. Orai1 is an essential pore subunit of the CRAC channel. Nature 443 (7108): 230-233.
154. Pristera, A. and K. Okuse. 2011. Building excitable membranes: Lipid rafts and multiple controls on trafficking of electrogenic molecules. Neuroscientist 18 (1): 70-81.
155. Putzke, C., K. Wemhoner, F. B. Sachse, S. Rinne, G. Schlichthorl, X. T. Li et al. 2007. The acid-sensitive potassium channel TASK-1 in rat cardiac muscle. Cardiovasc Res 75 (1): 59-68.
156. Ramsey, I. S., M. M. Moran, J. A. Chong, and D. E. Clapham. 2006. A voltage-gated proton-selective channel lacking the pore domain. Nature 440 (7088): 1213-1216.
157. Rapoport, S. I. 2003. In vivo approaches to quantifying and imaging brain arachidonic and docosahexaenoic acid metabolism. J Pediatr 143 (4 Suppl): S26-S34.
158. Ratajczak, P., T. Damy, C. Heymes, P. Oliviero, F. Marotte, E. Robidel et al. 2003. Caveolin-1 and -3 dissociations from caveolae to cytosol in the heart during aging and after myocardial infarction in rat. Cardiovasc Res 57 (2): 358-369.
159. Reichling, D. B. and J. D. Levine. 1997. Heat transduction in rat sensory neurons by calcium-dependent activation of a cation channel. Proc Natl Acad Sci USA 94 (13): 7006-7011.
160. Ren, J., E. Karpinski, and C. G. Benishin. 1995. Prostaglandin E2 contracts vascular smooth muscle and inhibits potassium currents in vascular smooth muscle cells of rat tail artery. J Pharmacol Exp Ther 275 (2): 710-719.
161. Ren, D., B. Navarro, H. Xu, L. Yue, Q. Shi, and D. E. Clapham. 2001. A prokaryotic voltage-gated sodium channel. Science 294 (5550): 2372-2375.
162. Roberts-Crowley, M. L., T. Mitra-Ganguli, L. Liu, and A. R. Rittenhouse. 2009. Regulation of voltage-gated Ca2+ channels by lipids. Cell Calcium 45 (6): 589-601.
163. Roberts-Crowley, M. L. and A. R. Rittenhouse. 2009. Arachidonic acid inhibition of L-type calcium (CaV1.3b) channels varies with accessory CaVbeta subunits. J Gen Physiol 133 (4): 387-403.
164. Rohacs, T. 2007. Regulation of TRP channels by PIP(2). Pflugers Arch 453 (6): 753-762.
165. Rohacs, T., C. M. Lopes, I. Michailidis and D. E. Logothetis. 2005. PI(4,5)P(2) regulates the activation and desensitization of TRPM8 channels through the TRP domain. Nat Neurosci 8 (5): 626-634.
166. Romanenko, V. G., G. H. Rothblat, and I. Levitan. 2002. Modulation of endothelial inward-rectifier K+ current by optical isomers of cholesterol. Biophys J 83 (6): 3211-3222.
167. Rose, R. A., N. Hatano, S. Ohya, Y. Imaizumi, and W. R. Giles. 2007. C-type natriuretic peptide activates a non-selective cation current in acutely isolated rat cardiac fibroblasts via natriuretic peptide C receptor-mediated signalling. J Physiol 580 (Pt 1): 255-274.
168. Ruiz-Velasco, V. and S. R. Ikeda. 1998. Heterologous expression and coupling of G protein-gated inwardly rectifying K+ channels in adult rat sympathetic neurons. J Physiol 513 (Pt 3): 761-773.
169. Runnels, L. W., L. Yue, and D. E. Clapham. 2002. The TRPM7 channel is inactivated by PIP(2) hydrolysis. Nat Cell Biol 4 (5): 329-336.
170. Saleh, S. N., A. P. Albert, and W. A. Large. 2009. Activation of native TRPC1/C5/C6 channels by endothelin-1 is mediated by both PIP3 and PIP2 in rabbit coronary artery myocytes. J Physiol 587 (Pt 22): 5361-5375.
171. Sampson, L. J., L. M. Davies, R. Barrett-Jolley, N. B. Standen, and C. Dart. 2007. Angiotensin II-activated protein kinase C targets caveolae to inhibit aortic ATP-sensitive potassium channels. Cardiovasc Res 76 (1): 61-70.
172. Sampson, L. J., Y. Hayabuchi, N. B. Standen, and C. Dart. 2004. Caveolae localize protein kinase A signaling to arterial ATP-sensitive potassium channels. Circ Res 95 (10): 1012-1018.
173. Sanguinetti, M. C., M. E. Curran, A. Zou, J. Shen, P. S. Spector, D. L. Atkinson et al. 1996. Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channel. Nature 384 (6604): 80-83.
174. Seth, M., C. Sumbilla, S. P. Mullen, D. Lewis, M. G. Klein, A. Hussain et al. 2004. Sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA) gene silencing and remodeling of the Ca2+ signaling mechanism in cardiac myocytes. Proc Natl Acad Sci USA 101 (47): 16683-16688.
175. Seth, M., Z.-S. Zhang, L. Mao, V. Graham, J. Burch, J. Stiber et al. 2009. TRPC1 channels are critical for hypertrophic signaling in the heart. Circ Res 105 (10): 1023-1030.
176. Seubert, J., B. Yang, J. A. Bradbury, J. Graves, L. M. Degraff, S. Gabel et al. 2004. Enhanced postischemic functional recovery in CYP2J2 transgenic hearts involves mitochondrial ATP-sensitive K+ channels and p42/p44 MAPK pathway. Circ Res 95 (5): 506-514.
177. Seubert, J. M., D. C. Zeldin, K. Nithipatikom, and G. J. Gross. 2007. Role of epoxyeicosatrienoic acids in protecting the myocardium following ischemia/reperfusion injury. Prostaglandins Other Lipid Mediat 82 (1-4): 50-59.
178. Shibukawa, Y., E. L. Chilton, K. A. Maccannell, R. B. Clark, and W. R. Giles. 2005. K+ currents activated by depolarization in cardiac fibroblasts. Biophys J 88 (6): 3924-3935.
179. Shuttleworth, T. J. 2010. Arachidonic acid-regulated Ca2+ channel. In Bradshaw, R.A. and E.A. Dennis (eds.). Handbook of Cell Signaling, pp. 915-920. Amsterdam, the Netherlands: Elsevier Inc.
180. Shuttleworth, T. J., J. L. Thompson, and O. Mignen. 2007. STIM1 and the noncapacitative ARC channels. Cell Calcium 42 (2): 183-191.
181. Shyng, S. L. and C. G. Nichols. 1998. Membrane phospholipid control of nucleotide sensitivity of KATP channels. Science 282 (5391): 1138-1141.
182. Simons, K. and E. Ikonen. 1997. Functional rafts in cell membranes. Nature 387 (6633): 569-572.
183. Simons, K. and D. Toomre. 2000. Lipid rafts and signal transduction. Nat Rev Mol Cell Biol 1 (1): 31-39.
184. Smirnov, S. V. and P. I. Aaronson. 1996. Modulatory effects of arachidonic acid on the delayed rectifier K+ current in rat pulmonary arterial myocytes. Structural aspects and involvement of protein kinase C. Circ Res 79 (1): 20-31.
185. Sohn, J. W., A. Lim, S. H. Lee, and W. K. Ho. 2007. Decrease in PIP(2) channel interactions is the final common mechanism involved in PKC- and arachidonic acid-mediated inhibitions of GABA(B)-activated K+ current. J Physiol 582 (Pt 3): 1037-1046.
186. Stables, M. J. and D. W. Gilroy. 2011. Old and new generation lipid mediators in acute inflammation and resolution. Prog Lipid Res 50 (1): 35-51.
187. Stockbridge, L. L. and A. S. French. 1988. Stretch-activated cation channels in human fibroblasts. Biophys J 54 (1): 187-190.
188. Suh, B. C. and B. Hille. 2008. PIP2 is a necessary cofactor for ion channel function: How and why? Annu Rev Biophys 37 175-195.
189. Suh, B. C., T. Inoue, T. Meyer, and B. Hille. 2006. Rapid chemically induced changes of PtdIns(4,5)P2 gate KCNQ ion channels. Science 314 (5804): 1454-1457.
190. Suh, B. C., D. I. Kim, B. H. Falkenburger, and B. Hille. 2012. Membrane-localized beta-subunits alter the PIP2 regulation of high-voltage activated Ca2+ channels. Proc Natl Acad Sci USA 109 (8): 3161-3166.
191. Suh, B. C., K. Leal, and B. Hille. 2010. Modulation of high-voltage activated Ca(2+) channels by membrane phosphatidylinositol 4,5-bisphosphate. Neuron 67 (2): 224-238.
192. Szoke, E., R. Borzsei, D. M. Toth, O. Lengl, Z. Helyes, Z. Sandor et al. 2010. Effect of lipid raft disruption on TRPV1 receptor activation of trigeminal sensory neurons and transfected cell line. Eur J Pharmacol 628 (1-3): 67-74.
193. Talavera, K., M. Staes, A. Janssens, G. Droogmans, and B. Nilius. 2004. Mechanism of arachidonic acid modulation of the T-type Ca2+ channel alpha1G. J Gen Physiol 124 (3): 225-238.
194. Thomas, A. M., S. C. Harmer, T. Khambra, and A. Tinker. 2011. Characterization of a binding site for anionic phospholipids on KCNQ1. J Biol Chem 286 (3): 2088-2100.
195. Thyagarajan, B., V. Lukacs, and T. Rohacs. 2008. Hydrolysis of phosphatidylinositol 4,5-bisphosphate mediates calcium-induced inactivation of TRPV6 channels. J Biol Chem 283 (22): 14980-14987.
196. Togashi, K., Y. Hara, T. Tominaga, T. Higashi, Y. Konishi, Y. Mori et al. 2006. TRPM2 activation by cyclic ADP-ribose at body temperature is involved in insulin secretion. EMBO J 25 (9): 1804-1815.
197. Tombola, F., M. H. Ulbrich, S. C. Kohout, and E. Y. Isacoff. 2010. The opening of the two pores of the Hv1 voltage-gated proton channel is tuned by cooperativity. Nat Struct Mol Biol 17 (1): 44-50.
198. Vaithianathan, T., A. Bukiya, J. Liu, P. Liu, M. Asuncion-Chin, Z. Fan et al. 2008. Direct regulation of BK channels by phosphatidylinositol 4,5-bisphosphate as a novel signaling pathway. J Gen Physiol 132 (1): 13-28.
199. Varnai, P., B. Thyagarajan, T. Rohacs, and T. Balla. 2006. Rapidly inducible changes in phosphatidylinositol 4,5-bisphosphate levels influence multiple regulatory functions of the lipid in intact living cells. J Cell Biol 175 (3): 377-382.
200. Vatta, M., M. J. Ackerman, B. Ye, J. C. Makielski, E. E. Ughanze, E. W. Taylor et al. 2006. Mutant caveolin-3 induces persistent late sodium current and is associated with long-QT syndrome. Circulation 114 (20): 2104-2112.
201. Vig, M., C. Peinelt, A. Beck, D. L. Koomoa, D. Rabah, M. Koblan-Huberson et al. 2006. CRACM1 is a plasma membrane protein essential for store-operated Ca2+ entry. Science 312 (5777): 1220-1223.
202. Villarroel, A. 1996. Progression of M-current inhibition after agonist removal. J Neurophysiol 75 (1): 518-521.
203. Villarroel, A. and T. L. Schwarz. 1996. Inhibition of the Kv4 (Shal) family of transient K+ currents by arachidonic acid. J Neurosci 16 (8): 2522-2532.
204. van der Vusse, G. J., T. H. Roemen, F. W. Prinzen, W. A. Coumans, and R. S. Reneman. 1982. Uptake and tissue content of fatty acids in dog myocardium under normoxic and ischemic conditions. Circ Res 50 (4): 538-546.
205. Walsh, K. B. and J. Zhang. 2008. Neonatal rat cardiac fibroblasts express three types of voltage-gated K+ channels: Regulation of a transient outward current by protein kinase C. Am J Physiol Heart Circ Physiol 294 (2): H1010-H1017.
206. Wang, C., U. L. Mirshahi, B. Liu, Z. Jia, T. Mirshahi, and H. Zhang. 2008. Arachidonic acid activates Kir2.3 channels by enhancing channel-phosphatidyl-inositol 4,5-bisphosphate interactions. Mol Pharmacol 73 (4): 1185-1194.
207. Wang, X. L., D. Ye, T. E. Peterson, S. Cao, V. H. Shah, Z. S. Katusic et al. 2005. Caveolae targeting and regulation of large conductance Ca(2+)-activated K+ channels in vascular endothelial cells. J Biol Chem 280 (12): 11656-11664.
208. Watanabe, H., J. Vriens, J. Prenen, G. Droogmans, T. Voets, and B. Nilius. 2003. Anandamide and arachidonic acid use epoxyeicosatrienoic acids to activate TRPV4 channels. Nature 424 (6947): 434-438.
209. Weinreich, D. and W. F. Wonderlin. 1987. Inhibition of calcium-dependent spike after-hyperpolarization increases excitability of rabbit visceral sensory neurones. J Physiol 394: 415-427.
210. Whorton, M. R. and R. MacKinnon. 2011. Crystal structure of the mammalian GIRK2 K+ channel and gating regulation by G proteins, PIP2, and sodium. Cell 147 (1): 199-208.
211. Williams, T. M., M. W. Cheung, D. S. Park, B. Razani, A. W. Cohen, W. J. Muller et al. 2003. Loss of caveolin-1 gene expression accelerates the development of dysplastic mammary lesions in tumor-prone transgenic mice. Mol Biol Cell 14 (3): 1027-1042.
212. Wong, W. and L. C. Schlichter. 2004. Differential recruitment of Kv1.4 and Kv4.2 to lipid rafts by PSD-95. J Biol Chem 279 (1): 444-452.
213. Wood, J. N., J. P. Boorman, K. Okuse, and M. D. Baker. 2004. Voltage-gated sodium channels and pain pathways. J Neurobiol 61 (1): 55-71.
214. Woodcock, E. A., P. M. Kistler, and Y. K. Ju. 2009. Phosphoinositide signalling and cardiac arrhythmias. Cardiovasc Res 82 (2): 286-295.
215. Woodman, S. E., D. S. Park, A. W. Cohen, M. W. Cheung, M. Chandra, J. Shirani et al. 2002. Caveolin-3 knock-out mice develop a progressive cardiomyopathy and show hyperactivation of the p42/44 MAPK cascade. J Biol Chem 277 (41): 38988-38997.
216. Wu, L., C. S. Bauer, X. G. Zhen, C. Xie, and J. Yang. 2002. Dual regulation of voltage-gated calcium channels by PtdIns(4,5)P2. Nature 419 (6910): 947-952.
217. Wu, X., P. Eder, B. Chang, and J. D. Molkentin. 2010. TRPC channels are necessary mediators of pathologic cardiac hypertrophy. Proc Nat Acad Sci 107 (15): 7000-7005.
218. Wu, L. J., G. Wu, M. R. Akhavan Sharif, A. Baker, Y. Jia, F. H. Fahey et al. 2012. The voltage-gated proton channel Hv1 enhances brain damage from ischemic stroke. Nat Neurosci 15 (4): 565-573.
219. Xia, F., X. Gao, E. Kwan, P. P. Lam, L. Chan, K. Sy et al. 2004. Disruption of pancreatic beta-cell lipid rafts modifies Kv2.1 channel gating and insulin exocytosis. J Biol Chem 279 (23): 24685-24691.
220. Xian Tao, L., V. Dyachenko, M. Zuzarte, C. Putzke, R. Preisig-Muller, G. Isenberg et al. 2006. The stretch-activated potassium channel TREK-1 in rat cardiac ventricular muscle. Cardiovasc Res 69 (1): 86-97.
221. Xiao, Y. F., L. Huang, and J. P. Morgan. 1998. Cytochrome P450: A novel system modulating Ca2+ channels and contraction in mammalian heart cells. J Physiol 508 (Pt 3): 777-792.
222. Xie, J., B. Sun, J. Du, W. Yang, H.-C. Chen, J. D. Overton et al. 2011. Phosphatidylinositol 4,5-bisphosphate (PIP2) controls magnesium gatekeeper TRPM6 activity. Sci Rep 1: 12.
223. Yaguchi, T., S. Yamamoto, T. Nagata, T. Kanno, A. Tanaka, and T. Nishizaki. 2005. Effects of cis-unsaturated free fatty acids on PKC-epsilon activation and nicotinic ACh receptor responses. Brain Res Mol Brain Res 133 (2): 320-324.
224. Yao, J. and F. Qin. 2009. Interaction with phosphoinositides confers adaptation onto the TRPV1 pain receptor. PLoS Biol 7 (2): e46.
225. Ye, B., R. C. Balijepalli, J. D. Foell, S. Kroboth, Q. Ye, Y. H. Luo et al. 2008. Caveolin-3 associates with and affects the function of hyperpolarization-activated cyclic nucleotide-gated channel 4. Biochemistry 47 (47): 12312-12318.
226. Yeromin, A. V., S. L. Zhang, W. Jiang, Y. Yu, O. Safrina, and M. D. Cahalan. 2006. Molecular identification of the CRAC channel by altered ion selectivity in a mutant of Orai. Nature 443 (7108): 226-229.
227. Zhen, X. G., C. Xie, A. Fitzmaurice, C. E. Schoonover, E. T. Orenstein, and J. Yang. 2005. Functional architecture of the inner pore of a voltage-gated Ca2+ channel. J Gen Physiol 126 (3): 193-204.
228. Zhen, X. G., C. Xie, Y. Yamada, Y. Zhang, C. Doyle, and J. Yang. 2006. A single amino acid mutation attenuates rundown of voltage-gated calcium channels. FEBS Lett 580 (24): 5733-5738.
229. Zolles, G., N. Klocker, D. Wenzel, J. Weisser-Thomas, B. K. Fleischmann, J. Roeper et al. 2006. Pacemaking by HCN channels requires interaction with phosphoinositides. Neuron 52 (6): 1027-1036.