EETs relax airway smooth muscle via an EpDHF effect: BKCa channel activation and hyperpolarization

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 280, Issue 5 25-5, 2001, Pages

  Benoit, Catherine ^a   Renaudon, Barbara ^a   Salvail, Dany ^a   Rousseau, Eric ^a  

^a UNIVERSITY OF SHERBROOKE   (Canada)

Author keywords

Bronchorelaxation; Eicosanoids; Epithelium derived hyperpolarizing factors; Epoxyeicosatrienoic acids; Large conductance calcium activated potassium channel; Membrane potential; Planar lipid bilayers; Potassium conductance

Indexed keywords

14,15 EPOXY 5,8,11 ICOSATRIENOIC ACID; 8,9 EPOXYICOSATRIENOIC ACID; CALCIUM ION; CARBACHOL; CYTOCHROME P450; EPOXYICOSATRIENOIC ACID; IBERIOTOXIN; POTASSIUM CHANNEL; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CALCIUM CONDUCTANCE; CONTROLLED STUDY; GUINEA PIG; HYPERPOLARIZATION; MALE; MEMBRANE POTENTIAL; NONHUMAN; POTASSIUM CONDUCTANCE; PRIORITY JOURNAL; RABBIT; SMOOTH MUSCLE RELAXATION; TRACHEA MUSCLE;

EID: 0035034125     PISSN: 10400605     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajplung.2001.280.5.l965     Document Type: Article

References (44)

1. Ca channels from tracheal smooth muscle. Am J Physiol Lung Cell Mol Physiol 268: L1057-L1063, 1995.
2. + channel on pig coronary artery endothelial cells. J Physiol (Lond) 504: 537-543, 1997.
3. Bauersachs J, Hecker M, and Busse R. Display of the characteristics of endothelium-derived hyperpolarizing factor by a cytochrome P450-derived arachidonic acid metabolite in the coronary microcirculation. Br J Pharmacol 113: 1548-1553, 1994.
4. Bertrand C and Tschirhart E. Epithelial factors: modulation of the airway smooth muscle tone. Fundam Clin Pharmacol 7: 261-273, 1993.
5. Cadieux A, Lanoue C, Sirois P, and Barabe J. Carbamylcholine- and 5-hydroxytryptamine-induced contraction in rat isolated airways: inhibition by calcitonin gene-related peptide. Br J Pharmacol 101: 193-199, 1990.
6. Campbell WB, Gebremedhin D, Pratt PF, and Harder DR. Identification of epoxyeicosatrienoic acids as endothelium-derived hyperpolarizing factors. Circ Res 78: 415-423, 1996.
7. Campbell WB and Harder DR. Endothelium-derived hyperpolarizing factors and vascular cytochrome P450 metabolites of arachidonic acid in the regulation of tone. Circ Res 84: 484-488, 1999.
8. Capdevila JH, Falck JR, and Estabrook RW. Cytochrome P450 and the arachidonate cascade. FASEB J 6: 731-736, 1992.
9. Capdevila JH, Karara A, Waxman DJ, Martin MV, Falck JR, and Guengerich FP. Cytochrome P-450 enzyme-specific control of the regio- and enantiofacial selectivity of the microsomal arachidonic acid epoxygenase. J Biol Chem 265: 10865-10871, 1990.
10. Chen J, Capdevila JH, Zeldin DC, and Rosemberg RL. Inhibition of cardiac L-type calcium channels by epoxyeicosatrienoic acids. Mol Pharmacol 55: 288-295, 1999.
11. Devereux TR, Serabjit-Singh CJ, Slaughter SR, Wolf CR, Philpot RM, and Fouts JR. Identification of cytochrome P-450 isozymes in nonciliated bronchiolar epithelial (Clara) and alveolar type II cells isolated from rabbit lung. Exp Lung Res 2: 221-230, 1981.
12. Ca channels. Am J Physiol Lung Cell Mol Physiol 275: L423-L431, 1998.
13. Eckman DM, Hopkins N, McBride C, and Keef KD. Endothelium-dependent relaxation and hyperpolarization in guinea-pig coronary artery: role of epoxyeicosatrienoic acid. Br J Pharmacol 124: 181-189, 1998.
14. Fang X, Kaduce TL, Weintraub NL, VanRollins M, and Spector AA. Functional implications of a newly characterized pathway of 11,12-epoxyeicosatrienoic acid metabolism in arterial smooth muscle. Circ Res 79: 784-793, 1996.
15. Gebremedhin D, Harder DR, Pratt PF, and Campbell WB. Bioassay of an endothelium-derived hyperpolarizing factor from bovine coronary arteries: role of a cytochrome P450 metabolite. J Vase Res 35: 274-284, 1998.
16. Gebremedhin D, Ma YH, Falck JR, Roman RJ, VanRollins M, and Harder DR. Mechanism of action of cerebral epoxyeicosatrienoic acids on cerebral arterial smooth muscle. Am J Physiol Heart Circ Physiol 263: H519-H525, 1992.
17. + channels in porcine coronary artery smooth muscle cells. J Cardiovasc Pharmacol 32: 642-649, 1998.
18. Hecker M. Endothelium-derived hyperpolarizing factor: fact or fiction? News Physiol Sci 15: 1-5, 2000.
19. Holtzman MJ. Arachidonic acid metabolism in airway epithelial cells. Annu Rev Physiol 54: 303-329, 1992.
20. Imig JD, Inscho EW, Deichmann PC, Reddy KM, and Falck JR. Afferent arteriolar vasodilation to the sulfonimide analog of 11,12-epoxyeicosatrienoic acid involves protein kinase A. Hypertension 33: 408-413, 1999.
21. Karara A, Dishman E, Blair I, Falck JR, and Capdevila JH. Endogenous epoxyeicosatrienoic acids: cytochrome P-450 controlled stereoselectivity of the hepatic arachidonic acid epoxygenase. J Biol Chem 264: 19822-19827, 1989.
22. Katoh T, Takahashi K, Capdevila J, Karara A, Falck JR, Jacobson HR, and Badr KF. Glomerular stereospecific synthesis and hemodynamic actions of 8,9-epoxyeicosatrienoic acid in rat kidney. Am J Physiol Renal Fluid Electrolyte Physiol 261: F578-F586, 1991.
23. Knickle LC and Bend JR. Bioactivation of arachidonic acid by the cytochrome P450 monooxygenases of guinea pig lung: the orthologue of cytochrome P450 2B4 is solely responsible for formation of epoxyeicosatrienoic acids. Mol Pharmacol 45: 1273-1280, 1994.
24. Kume H, Graziano MP, and Kotlikoff MI. Stimulatory and inhibitory regulation of calcium-activated potassium channels by guanine nucleotide-binding proteins. Proc Natl Acad Sci USA 89: 11051-11055, 1992.
25. + channels in coronary smooth muscle through a guanine nucleotide binding protein. Circ Res 80: 877-884, 1997.
26. Li PL, Zou AP, and Campbell WB. Regulation of potassium channels in coronary arterial smooth muscle by endothelium-derived vasodilators. Hypertension 29: 1-7, 1997.
27. Miura H, Liu Y, and Gutterman DD. Human coronary arteriolar dilation to bradykinin depends on membrane hyperpolarization: contribution of nitric oxide and calcium-activated potassium channels. Circulation 99: 3132-3138, 1999.
28. Needleman P, Turk J, Jakschik BA, Morrison AR, and Lefkowith JB. Arachidonic acid metabolism. Annu Rev Biochem 55: 69-102, 1986.
29. Pfister SL, Spitzbarth N, Edgemond W, and Campbell WB. Vasorelaxation by an endothelium-derived metabolite of arachidonic acid. Am J Physiol Heart Circ Physiol 270: H1021-H1030, 1996.
30. Proctor KG, Falck JR, and Capdevila J. Intestinal vasodilation by epoxyeicosatrienoic acids: arachidonic acid metabolites produced by a cytochrome P450 monooxygenase. Circ Res 60: 50-59, 1987.
31. Roman RJ and Alonso-Galicia M. P-450 eicosanoids: a novel signaling pathway regulating renal function. News Physiol Sci 14: 238-242, 1999.
32. 2 and epoxyeicosatrienoic acids in relaxation of bovine coronary arteries to arachidonic acid. Am J Physiol Heart Circ Physiol 264: H327-H335, 1993.
33. --channel activity by 5,6- and 11,12-EET. Am J Physiol Lung Cell Mol Physiol 275: L432-L441, 1998.
34. Savaria D, Lanoue C, Cadieux A, and Rousseau E. Large conducting potassium channel reconstituted from airway smooth muscle. Am J Physiol Lung Cell Mol Physiol 262: L327-L336, 1992.
35. Scarborough PE, Ma J, Qu W, and Zeldin DC. P450 subfamily CYP2J and their role in the bioactivation of arachidonic acid in extrahepatic tissues. Drug Metab Rev 31: 205-234, 1999.
36. Shimizu T and Wolfe LS. Arachidonic acid cascade and signal transduction. J Neurochem 55: 1-15, 1990.
37. Silverman E, In KH, Yandava C, and Drazen JM. Pharmacogenetics of the 5-lipoxygenase pathway in asthma. Clin Exp Allergy 28, Suppl 5: 164-170, 1998.
38. Valverde MA, Rojas P, Amigo J, Cosmelli D, Orio P, Bahamonde MI, Mann GE, Vergara C, and Latorre R. Acute activation of Maxi-K channels (hSlo) by estradiol binding to the β subunit. Science 285: 1929-1931, 1999.
39. Watkins PB. Drug metabolism by cytochromes P450 in the liver and small bowel. Gastroenterol Clin North Am 21: 511-526, 1992.
40. Weintraub NL, Fang X, Kaduce TL, VanRollins M, Chatterjee P, and Spector AA. Potentiation of endothelium-dependent relaxation by epoxyeicosatrienoic acids. Circ Res 81: 258-267, 1997.
41. Wong PY, Lin KT, Yan YT, Ahern D, Iles J, Shen SY, Bhatt RK, and Falck JR. 14(R),15(S)-epoxyeicosatrienoic acid [14(A),15(S)-EET] receptor in guinea pig mononuclear cell membranes. J Lipid Mediat 6: 199-208, 1993.
42. Zeldin DC, Moomaw CR, Jesse N, Tomer KB, Beetham J, Hammock BD, and Wu S. Biochemical characterization of the human liver cytochrome P450 arachidonic acid epoxygenase pathway. Arch Biochem Biophys 330: 87-96, 1996.
43. Zeldin DC, Plitman JD, Kobayashi J, Miller RF, Snapper JR, Falck JR, Szarek JL, Philpot RM, and Capdevila JH. The rabbit pulmonary cytochrome P450 arachidonic acid metabolic pathway: characterization and significance. J Clin Invest 95: 2150-2160, 1995.
44. + channel activity. Am J Physiol Renal Fluid Electrolyte Physiol 270: F822-F832, 1996.