-
1
-
-
6944250259
-
Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies
-
COI: 1:CAS:528:DC%2BD2cXhtVSjsLrK, PID: 15517885
-
Aggarwal BB, Bhardwaj A, Aggarwal RS, Seeram NP, Shishodia S, Takada Y (2004) Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies. Anticancer Res 24(5A):2783–2840
-
(2004)
Anticancer Res
, vol.24
, Issue.5A
, pp. 2783-2840
-
-
Aggarwal, B.B.1
Bhardwaj, A.2
Aggarwal, R.S.3
Seeram, N.P.4
Shishodia, S.5
Takada, Y.6
-
2
-
-
0029804116
-
Mechanism of activation of protein kinase B by insulin and IGF-1
-
COI: 1:CAS:528:DyaK2sXht1Oqs7o%3D, PID: 8978681
-
Alessi DR, Andjelkovic M, Caudwell B, Cron P, Morrice N, Cohen P et al (1996) Mechanism of activation of protein kinase B by insulin and IGF-1. EMBO J 15(23):6541–6551
-
(1996)
EMBO J
, vol.15
, Issue.23
, pp. 6541-6551
-
-
Alessi, D.R.1
Andjelkovic, M.2
Caudwell, B.3
Cron, P.4
Morrice, N.5
Cohen, P.6
-
3
-
-
0031127305
-
Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha
-
COI: 1:CAS:528:DyaK2sXjsFOjtb8%3D, PID: 9094314
-
Alessi DR, James SR, Downes CP, Holmes AB, Gaffney PR, Reese CB et al (1997) Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha. Curr Biol 7(4):261–269
-
(1997)
Curr Biol
, vol.7
, Issue.4
, pp. 261-269
-
-
Alessi, D.R.1
James, S.R.2
Downes, C.P.3
Holmes, A.B.4
Gaffney, P.R.5
Reese, C.B.6
-
4
-
-
33750293584
-
Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling
-
COI: 1:CAS:528:DC%2BD28XhtFCjtLbI, PID: 17028174
-
Baba M, Hong SB, Sharma N, Warren MB, Nickerson ML, Iwamatsu A et al (2006) Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling. Proc Natl Acad Sci USA 103(42):15552–15557
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, Issue.42
, pp. 15552-15557
-
-
Baba, M.1
Hong, S.B.2
Sharma, N.3
Warren, M.B.4
Nickerson, M.L.5
Iwamatsu, A.6
-
5
-
-
59149091041
-
Curcumin disrupts the mammalian target of rapamycin–raptor complex
-
COI: 1:CAS:528:DC%2BD1MXhtFOltLY%3D, PID: 19176385
-
Beevers CS, Chen L, Liu L, Luo Y, Webster NJ, Huang S (2009) Curcumin disrupts the mammalian target of rapamycin–raptor complex. Cancer Res 69(3):1000–1008
-
(2009)
Cancer Res
, vol.69
, Issue.3
, pp. 1000-1008
-
-
Beevers, C.S.1
Chen, L.2
Liu, L.3
Luo, Y.4
Webster, N.J.5
Huang, S.6
-
6
-
-
33745918631
-
Curcumin inhibits the mammalian target of rapamycin-mediated signaling pathways in cancer cells
-
COI: 1:CAS:528:DC%2BD28XntVeqtrs%3D, PID: 16550606
-
Beevers CS, Li F, Liu L, Huang S (2006) Curcumin inhibits the mammalian target of rapamycin-mediated signaling pathways in cancer cells. Int J Cancer 119(4):757–764
-
(2006)
Int J Cancer
, vol.119
, Issue.4
, pp. 757-764
-
-
Beevers, C.S.1
Li, F.2
Liu, L.3
Huang, S.4
-
7
-
-
84874251703
-
AKTivation of PI3K/AKT/mTOR signaling pathway by KSHV
-
PID: 23316192
-
Bhatt AP, Damania B (2012) AKTivation of PI3K/AKT/mTOR signaling pathway by KSHV. Front Immunol 3:401
-
(2012)
Front Immunol
, vol.3
, pp. 401
-
-
Bhatt, A.P.1
Damania, B.2
-
8
-
-
79955627038
-
Resveratrol modulates the malignant properties of cutaneous melanoma through changes in the activation and attenuation of the antiapoptotic protooncogenic protein Akt/PKB
-
COI: 1:CAS:528:DC%2BC3MXlsV2ls74%3D, PID: 21407133
-
Bhattacharya S, Darjatmoko SR, Polans AS (2011) Resveratrol modulates the malignant properties of cutaneous melanoma through changes in the activation and attenuation of the antiapoptotic protooncogenic protein Akt/PKB. Melanoma Res 21(3):180–187
-
(2011)
Melanoma Res
, vol.21
, Issue.3
, pp. 180-187
-
-
Bhattacharya, S.1
Darjatmoko, S.R.2
Polans, A.S.3
-
9
-
-
0029103330
-
Control of p70 s6 kinase by kinase activity of FRAP in vivo
-
COI: 1:CAS:528:DyaK2MXos1Slsro%3D, PID: 7566123
-
Brown EJ, Beal PA, Keith CT, Chen J, Shin TB, Schreiber SL (1995) Control of p70 s6 kinase by kinase activity of FRAP in vivo. Nature 377(6548):441–446
-
(1995)
Nature
, vol.377
, Issue.6548
, pp. 441-446
-
-
Brown, E.J.1
Beal, P.A.2
Keith, C.T.3
Chen, J.4
Shin, T.B.5
Schreiber, S.L.6
-
10
-
-
0030881836
-
Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin
-
COI: 1:CAS:528:DyaK2sXksVygsLw%3D, PID: 9204908
-
Brunn GJ, Hudson CC, Sekulic A, Williams JM, Hosoi H, Houghton PJ et al (1997) Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin. Science 277(5322):99–101
-
(1997)
Science
, vol.277
, Issue.5322
, pp. 99-101
-
-
Brunn, G.J.1
Hudson, C.C.2
Sekulic, A.3
Williams, J.M.4
Hosoi, H.5
Houghton, P.J.6
-
11
-
-
84879955291
-
Mammalian target of rapamycin and its downstream signalling components are activated in psoriatic skin
-
COI: 1:CAS:528:DC%2BC3sXhtV2mtLzK, PID: 23398394
-
Buerger C, Malisiewicz B, Eiser A, Hardt K, Boehncke WH (2013) Mammalian target of rapamycin and its downstream signalling components are activated in psoriatic skin. Br J Dermatol 169(1):156–159
-
(2013)
Br J Dermatol
, vol.169
, Issue.1
, pp. 156-159
-
-
Buerger, C.1
Malisiewicz, B.2
Eiser, A.3
Hardt, K.4
Boehncke, W.H.5
-
12
-
-
84870710500
-
Inhibition of mTOR suppresses UVB-induced keratinocyte proliferation and survival
-
COI: 1:CAS:528:DC%2BC38XhvVSmtb7P
-
Carr TD, DiGiovanni J, Lynch CJ, Shantz LM (2012) Inhibition of mTOR suppresses UVB-induced keratinocyte proliferation and survival. Cancer Prev Res (Phila) 5(12):1394–1404
-
(2012)
Cancer Prev Res (Phila)
, vol.5
, Issue.12
, pp. 1394-1404
-
-
Carr, T.D.1
DiGiovanni, J.2
Lynch, C.J.3
Shantz, L.M.4
-
13
-
-
48049083079
-
Dynamic frequency of CD4 + CD25 + Foxp3 + Treg cells in psoriasis vulgaris
-
COI: 1:CAS:528:DC%2BD1cXpsVCrsbY%3D, PID: 18562180
-
Chen L, Shen Z, Wang G, Fan P, Liu Y (2008) Dynamic frequency of CD4 + CD25 + Foxp3 + Treg cells in psoriasis vulgaris. J Dermatol Sci 51(3):200–203
-
(2008)
J Dermatol Sci
, vol.51
, Issue.3
, pp. 200-203
-
-
Chen, L.1
Shen, Z.2
Wang, G.3
Fan, P.4
Liu, Y.5
-
14
-
-
84872613658
-
mTORC2-PKBalpha/Akt1 Serine 473 phosphorylation axis is essential for regulation of FOXP3 stability by chemokine CCL3 in psoriasis
-
COI: 1:CAS:528:DC%2BC38XhslymsLfJ, PID: 23223135
-
Chen L, Wu J, Pier E, Zhao Y, Shen Z (2013) mTORC2-PKBalpha/Akt1 Serine 473 phosphorylation axis is essential for regulation of FOXP3 stability by chemokine CCL3 in psoriasis. J Invest Dermatol 133(2):418–428
-
(2013)
J Invest Dermatol
, vol.133
, Issue.2
, pp. 418-428
-
-
Chen, L.1
Wu, J.2
Pier, E.3
Zhao, Y.4
Shen, Z.5
-
15
-
-
58349122896
-
Activation of the mammalian target of rapamycin signalling pathway in epidermal tumours and its correlation with cyclin-dependent kinase 2
-
PID: 19016696
-
Chen SJ, Nakahara T, Takahara M, Kido M, Dugu L, Uchi H et al (2009) Activation of the mammalian target of rapamycin signalling pathway in epidermal tumours and its correlation with cyclin-dependent kinase 2. Br J Dermatol 160(2):442–445
-
(2009)
Br J Dermatol
, vol.160
, Issue.2
, pp. 442-445
-
-
Chen, S.J.1
Nakahara, T.2
Takahara, M.3
Kido, M.4
Dugu, L.5
Uchi, H.6
-
16
-
-
84878963619
-
Peracetylated (−)-epigallocatechin-3-gallate (AcEGCG) potently prevents skin carcinogenesis by suppressing the PKD1-dependent signaling pathway in CD34+ skin stem cells and skin tumors
-
COI: 1:CAS:528:DC%2BC3sXptFCnt74%3D, PID: 23385063
-
Chiou YS, Sang S, Cheng KH, Ho CT, Wang YJ, Pan MH (2013) Peracetylated (−)-epigallocatechin-3-gallate (AcEGCG) potently prevents skin carcinogenesis by suppressing the PKD1-dependent signaling pathway in CD34+ skin stem cells and skin tumors. Carcinogenesis 34(6):1315–1322
-
(2013)
Carcinogenesis
, vol.34
, Issue.6
, pp. 1315-1322
-
-
Chiou, Y.S.1
Sang, S.2
Cheng, K.H.3
Ho, C.T.4
Wang, Y.J.5
Pan, M.H.6
-
17
-
-
0347335785
-
Dual mechanisms of green tea extract (EGCG)-induced cell survival in human epidermal keratinocytes
-
COI: 1:CAS:528:DC%2BD3sXot1Kitrk%3D, PID: 12897059
-
Chung JH, Han JH, Hwang EJ, Seo JY, Cho KH, Kim KH et al (2003) Dual mechanisms of green tea extract (EGCG)-induced cell survival in human epidermal keratinocytes. FASEB J 17(13):1913–1915
-
(2003)
FASEB J
, vol.17
, Issue.13
, pp. 1913-1915
-
-
Chung, J.H.1
Han, J.H.2
Hwang, E.J.3
Seo, J.Y.4
Cho, K.H.5
Kim, K.H.6
-
18
-
-
84874849789
-
mTOR inhibitors in tuberous sclerosis complex
-
COI: 1:CAS:528:DC%2BC3sXlt1OltA%3D%3D, PID: 23730262
-
Curatolo P, Moavero R (2012) mTOR inhibitors in tuberous sclerosis complex. Curr Neuropharmacol 10(4):404–415
-
(2012)
Curr Neuropharmacol
, vol.10
, Issue.4
, pp. 404-415
-
-
Curatolo, P.1
Moavero, R.2
-
19
-
-
67649867447
-
mTOR complex 2 in adipose tissue negatively controls whole-body growth
-
COI: 1:CAS:528:DC%2BD1MXotFaju7k%3D, PID: 19497867
-
Cybulski N, Polak P, Auwerx J, Ruegg MA, Hall MN (2009) mTOR complex 2 in adipose tissue negatively controls whole-body growth. Proc Natl Acad Sci USA 106(24):9902–9907
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, Issue.24
, pp. 9902-9907
-
-
Cybulski, N.1
Polak, P.2
Auwerx, J.3
Ruegg, M.A.4
Hall, M.N.5
-
20
-
-
84878545765
-
1alpha,25-dihydroxyvitamin-D3-3-bromoacetate regulates AKT/mTOR signaling cascades: a therapeutic agent for psoriasis
-
PID: 23314787
-
Datta Mitra A, Raychaudhuri SP, Abria CJ, Mitra A, Wright R, Ray R et al (2013) 1alpha,25-dihydroxyvitamin-D3-3-bromoacetate regulates AKT/mTOR signaling cascades: a therapeutic agent for psoriasis. J Invest Dermatol 133(6):1556–1564
-
(2013)
J Invest Dermatol
, vol.133
, Issue.6
, pp. 1556-1564
-
-
Datta Mitra, A.1
Raychaudhuri, S.P.2
Abria, C.J.3
Mitra, A.4
Wright, R.5
Ray, R.6
-
21
-
-
34447572751
-
Low concentrations of curcumin induce growth arrest and apoptosis in skin keratinocytes only in combination with UVA or visible light
-
COI: 1:CAS:528:DC%2BD2sXns1ymu74%3D, PID: 17410200
-
Dujic J, Kippenberger S, Hoffmann S, Ramirez-Bosca A, Miquel J, Diaz-Alperi J et al (2007) Low concentrations of curcumin induce growth arrest and apoptosis in skin keratinocytes only in combination with UVA or visible light. J Invest Dermatol 127(8):1992–2000
-
(2007)
J Invest Dermatol
, vol.127
, Issue.8
, pp. 1992-2000
-
-
Dujic, J.1
Kippenberger, S.2
Hoffmann, S.3
Ramirez-Bosca, A.4
Miquel, J.5
Diaz-Alperi, J.6
-
22
-
-
84859447655
-
Functional protein pathway activation mapping of the progression of normal skin to squamous cell carcinoma
-
COI: 1:CAS:528:DC%2BC38XlvFGmt7g%3D
-
Einspahr JG, Calvert V, Alberts DS, Curiel-Lewandrowski C, Warneke J, Krouse R et al (2012) Functional protein pathway activation mapping of the progression of normal skin to squamous cell carcinoma. Cancer Prev Res (Phila) 5(3):403–413
-
(2012)
Cancer Prev Res (Phila)
, vol.5
, Issue.3
, pp. 403-413
-
-
Einspahr, J.G.1
Calvert, V.2
Alberts, D.S.3
Curiel-Lewandrowski, C.4
Warneke, J.5
Krouse, R.6
-
23
-
-
84873183133
-
Neural nitric oxide synthase participates in pemphigus vulgaris acantholysis through upregulation of Rous sarcoma, mammalian target of rapamycin and focal adhesion kinase
-
COI: 1:CAS:528:DC%2BC3sXjsFGltL0%3D, PID: 23362871
-
Espana A, Modol T, Gil MP, Lopez-Zabalza MJ (2013) Neural nitric oxide synthase participates in pemphigus vulgaris acantholysis through upregulation of Rous sarcoma, mammalian target of rapamycin and focal adhesion kinase. Exp Dermatol 22(2):125–130
-
(2013)
Exp Dermatol
, vol.22
, Issue.2
, pp. 125-130
-
-
Espana, A.1
Modol, T.2
Gil, M.P.3
Lopez-Zabalza, M.J.4
-
24
-
-
84856228512
-
Mammalian target of rapamycin (mTOR) inhibitors slow skin carcinogenesis, but impair wound healing
-
COI: 1:CAS:528:DC%2BC38XkvVSjtb0%3D, PID: 21895616
-
Feldmeyer L, Hofbauer GF, Boni T, French LE, Hafner J (2012) Mammalian target of rapamycin (mTOR) inhibitors slow skin carcinogenesis, but impair wound healing. Br J Dermatol 166(2):422–424
-
(2012)
Br J Dermatol
, vol.166
, Issue.2
, pp. 422-424
-
-
Feldmeyer, L.1
Hofbauer, G.F.2
Boni, T.3
French, L.E.4
Hafner, J.5
-
25
-
-
58649092475
-
mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)
-
COI: 1:CAS:528:DC%2BD1cXhsVentrjI, PID: 18925875
-
Garcia-Martinez JM, Alessi DR (2008) mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1). Biochem J 416(3):375–385
-
(2008)
Biochem J
, vol.416
, Issue.3
, pp. 375-385
-
-
Garcia-Martinez, J.M.1
Alessi, D.R.2
-
27
-
-
68149096799
-
The pharmacology of mTOR inhibition
-
PID: 19383975
-
Guertin DA, Sabatini DM (2009) The pharmacology of mTOR inhibition. Sci Signal 2((67)):pe24
-
(2009)
Sci Signal
, vol.2
, Issue.67
, pp. pe24
-
-
Guertin, D.A.1
Sabatini, D.M.2
-
28
-
-
33751348056
-
Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1
-
COI: 1:CAS:528:DC%2BD28XhtlWqs7vJ, PID: 17141160
-
Guertin DA, Stevens DM, Thoreen CC, Burds AA, Kalaany NY, Moffat J et al (2006) Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1. Dev Cell 11(6):859–871
-
(2006)
Dev Cell
, vol.11
, Issue.6
, pp. 859-871
-
-
Guertin, D.A.1
Stevens, D.M.2
Thoreen, C.C.3
Burds, A.A.4
Kalaany, N.Y.5
Moffat, J.6
-
29
-
-
79959543115
-
Caffeine promotes ultraviolet B-induced apoptosis in human keratinocytes without complete DNA repair
-
COI: 1:CAS:528:DC%2BC3MXnvFektbc%3D, PID: 21561856
-
Han W, Ming M, He YY (2011) Caffeine promotes ultraviolet B-induced apoptosis in human keratinocytes without complete DNA repair. J Biol Chem 286(26):22825–22832
-
(2011)
J Biol Chem
, vol.286
, Issue.26
, pp. 22825-22832
-
-
Han, W.1
Ming, M.2
He, Y.Y.3
-
30
-
-
64049090204
-
The role of the Birt–Hogg–Dube protein in mTOR activation and renal tumorigenesis
-
COI: 1:CAS:528:DC%2BD1MXit1agtr8%3D, PID: 19234517
-
Hartman TR, Nicolas E, Klein-Szanto A, Al-Saleem T, Cash TP, Simon MC et al (2009) The role of the Birt–Hogg–Dube protein in mTOR activation and renal tumorigenesis. Oncogene 28(13):1594–1604
-
(2009)
Oncogene
, vol.28
, Issue.13
, pp. 1594-1604
-
-
Hartman, T.R.1
Nicolas, E.2
Klein-Szanto, A.3
Al-Saleem, T.4
Cash, T.P.5
Simon, M.C.6
-
31
-
-
0037108711
-
Ultraviolet-induced phosphorylation of p70(S6K) at Thr(389) and Thr(421)/Ser(424) involves hydrogen peroxide and mammalian target of rapamycin but not Akt and atypical protein kinase C
-
COI: 1:CAS:528:DC%2BD38XotFyksb0%3D, PID: 12384526
-
Huang C, Li J, Ke Q, Leonard SS, Jiang BH, Zhong XS et al (2002) Ultraviolet-induced phosphorylation of p70(S6K) at Thr(389) and Thr(421)/Ser(424) involves hydrogen peroxide and mammalian target of rapamycin but not Akt and atypical protein kinase C. Cancer Res 62(20):5689–5697
-
(2002)
Cancer Res
, vol.62
, Issue.20
, pp. 5689-5697
-
-
Huang, C.1
Li, J.2
Ke, Q.3
Leonard, S.S.4
Jiang, B.H.5
Zhong, X.S.6
-
32
-
-
0345167800
-
TSC2 mediates cellular energy response to control cell growth and survival
-
COI: 1:CAS:528:DC%2BD3sXps1OhtL0%3D, PID: 14651849
-
Inoki K, Zhu T, Guan KL (2003) TSC2 mediates cellular energy response to control cell growth and survival. Cell 115(5):577–590
-
(2003)
Cell
, vol.115
, Issue.5
, pp. 577-590
-
-
Inoki, K.1
Zhu, T.2
Guan, K.L.3
-
33
-
-
84860499082
-
Resveratrol inhibits cancer cell metabolism by down regulating pyruvate kinase M2 via inhibition of mammalian target of rapamycin
-
COI: 1:CAS:528:DC%2BC38Xnt1Ogsr0%3D, PID: 22574221
-
Iqbal MA, Bamezai RN (2012) Resveratrol inhibits cancer cell metabolism by down regulating pyruvate kinase M2 via inhibition of mammalian target of rapamycin. PLoS One 7(5):e36764
-
(2012)
PLoS One
, vol.7
, Issue.5
, pp. e36764
-
-
Iqbal, M.A.1
Bamezai, R.N.2
-
34
-
-
33749076673
-
SIN1/MIP1 maintains rictor–mTOR complex integrity and regulates Akt phosphorylation and substrate specificity
-
COI: 1:CAS:528:DC%2BD28XhtFSitr%2FE, PID: 16962653
-
Jacinto E, Facchinetti V, Liu D, Soto N, Wei S, Jung SY et al (2006) SIN1/MIP1 maintains rictor–mTOR complex integrity and regulates Akt phosphorylation and substrate specificity. Cell 127(1):125–137
-
(2006)
Cell
, vol.127
, Issue.1
, pp. 125-137
-
-
Jacinto, E.1
Facchinetti, V.2
Liu, D.3
Soto, N.4
Wei, S.5
Jung, S.Y.6
-
35
-
-
7944235758
-
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
-
COI: 1:CAS:528:DC%2BD2cXptFentL8%3D, PID: 15467718
-
Jacinto E, Loewith R, Schmidt A, Lin S, Ruegg MA, Hall A et al (2004) Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. Nat Cell Biol 6(11):1122–1128
-
(2004)
Nat Cell Biol
, vol.6
, Issue.11
, pp. 1122-1128
-
-
Jacinto, E.1
Loewith, R.2
Schmidt, A.3
Lin, S.4
Ruegg, M.A.5
Hall, A.6
-
36
-
-
70349098422
-
Resveratrol downregulates PI3K/Akt/mTOR signaling pathways in human U251 glioma cells
-
PID: 19827268
-
Jiang H, Shang X, Wu H, Gautam SC, Al-Holou S, Li C et al (2009) Resveratrol downregulates PI3K/Akt/mTOR signaling pathways in human U251 glioma cells. J Exp Ther Oncol 8(1):25–33
-
(2009)
J Exp Ther Oncol
, vol.8
, Issue.1
, pp. 25-33
-
-
Jiang, H.1
Shang, X.2
Wu, H.3
Gautam, S.C.4
Al-Holou, S.5
Li, C.6
-
37
-
-
84885000565
-
Differential expression of p-mTOR in cutaneous basal and squamous cell carcinomas likely explains their different response to mTOR inhibitors in organ-transplant recipients
-
PID: 24023300
-
Karayannopoulou G, Euvrard S, Kanitakis J (2013) Differential expression of p-mTOR in cutaneous basal and squamous cell carcinomas likely explains their different response to mTOR inhibitors in organ-transplant recipients. Anticancer Res 33(9):3711–3714
-
(2013)
Anticancer Res
, vol.33
, Issue.9
, pp. 3711-3714
-
-
Karayannopoulou, G.1
Euvrard, S.2
Kanitakis, J.3
-
38
-
-
40649126759
-
mTOR is activated in the majority of malignant melanomas
-
COI: 1:CAS:528:DC%2BD1cXjtFOmsL8%3D, PID: 17914450
-
Karbowniczek M, Spittle CS, Morrison T, Wu H, Henske EP (2008) mTOR is activated in the majority of malignant melanomas. J Invest Dermatol 128(4):980–987
-
(2008)
J Invest Dermatol
, vol.128
, Issue.4
, pp. 980-987
-
-
Karbowniczek, M.1
Spittle, C.S.2
Morrison, T.3
Wu, H.4
Henske, E.P.5
-
39
-
-
34447536521
-
Human hair growth enhancement in vitro by green tea epigallocatechin-3-gallate (EGCG)
-
COI: 1:CAS:528:DC%2BD2sXhtFSisL3K, PID: 17092697
-
Kwon OS, Han JH, Yoo HG, Chung JH, Cho KH, Eun HC et al (2007) Human hair growth enhancement in vitro by green tea epigallocatechin-3-gallate (EGCG). Phytomedicine 14(7–8):551–555
-
(2007)
Phytomedicine
, vol.14
, Issue.7-8
, pp. 551-555
-
-
Kwon, O.S.1
Han, J.H.2
Yoo, H.G.3
Chung, J.H.4
Cho, K.H.5
Eun, H.C.6
-
40
-
-
77953026137
-
Angiosarcoma: clinical and molecular insights
-
PID: 20485141
-
Lahat G, Dhuka AR, Hallevi H, Xiao L, Zou C, Smith KD et al (2010) Angiosarcoma: clinical and molecular insights. Ann Surg 251(6):1098–1106
-
(2010)
Ann Surg
, vol.251
, Issue.6
, pp. 1098-1106
-
-
Lahat, G.1
Dhuka, A.R.2
Hallevi, H.3
Xiao, L.4
Zou, C.5
Smith, K.D.6
-
41
-
-
70450204007
-
An emerging role of mTOR in lipid biosynthesis
-
COI: 1:CAS:528:DC%2BD1MXhsV2hu7bK, PID: 19948145
-
Laplante M, Sabatini DM (2009) An emerging role of mTOR in lipid biosynthesis. Curr Biol 19(22):R1046–R1052
-
(2009)
Curr Biol
, vol.19
, Issue.22
, pp. R1046-R1052
-
-
Laplante, M.1
Sabatini, D.M.2
-
42
-
-
84859778293
-
mTOR signaling in growth control and disease
-
COI: 1:CAS:528:DC%2BC38Xls1eguro%3D, PID: 22500797
-
Laplante M, Sabatini DM (2012) mTOR signaling in growth control and disease. Cell 149(2):274–293
-
(2012)
Cell
, vol.149
, Issue.2
, pp. 274-293
-
-
Laplante, M.1
Sabatini, D.M.2
-
43
-
-
34547605613
-
IKK beta suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathway
-
COI: 1:CAS:528:DC%2BD2sXptlyntbw%3D, PID: 17693255
-
Lee DF, Kuo HP, Chen CT, Hsu JM, Chou CK, Wei Y et al (2007) IKK beta suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathway. Cell 130(3):440–455
-
(2007)
Cell
, vol.130
, Issue.3
, pp. 440-455
-
-
Lee, D.F.1
Kuo, H.P.2
Chen, C.T.3
Hsu, J.M.4
Chou, C.K.5
Wei, Y.6
-
44
-
-
84882866782
-
A comprehensive immunohistochemical approach of AKT/mTOR pathway and p-STAT3 in mycosis fungoides
-
COI: 1:CAS:528:DC%2BC3sXnvVGru74%3D, PID: 23685026
-
Levidou G, Siakantaris M, Papadaki T, Papadavid E, Vassilakopoulos TP, Angelopoulou MK et al (2013) A comprehensive immunohistochemical approach of AKT/mTOR pathway and p-STAT3 in mycosis fungoides. J Am Acad Dermatol 69(3):375–384
-
(2013)
J Am Acad Dermatol
, vol.69
, Issue.3
, pp. 375-384
-
-
Levidou, G.1
Siakantaris, M.2
Papadaki, T.3
Papadavid, E.4
Vassilakopoulos, T.P.5
Angelopoulou, M.K.6
-
45
-
-
78449241484
-
Resveratrol inhibits mTOR signaling by promoting the interaction between mTOR and DEPTOR
-
COI: 1:CAS:528:DC%2BC3cXhsVWgsr%2FP, PID: 20851890
-
Liu M, Wilk SA, Wang A, Zhou L, Wang RH, Ogawa W et al (2010) Resveratrol inhibits mTOR signaling by promoting the interaction between mTOR and DEPTOR. J Biol Chem 285(47):36387–36394
-
(2010)
J Biol Chem
, vol.285
, Issue.47
, pp. 36387-36394
-
-
Liu, M.1
Wilk, S.A.2
Wang, A.3
Zhou, L.4
Wang, R.H.5
Ogawa, W.6
-
46
-
-
84878569773
-
The effect of gartanin, a naturally occurring xanthone in mangosteen juice, on the mTOR pathway, autophagy, apoptosis, and the growth of human urinary bladder cancer cell lines
-
COI: 1:CAS:528:DC%2BC3sXot1Knsbs%3D, PID: 23682785
-
Liu Z, Antalek M, Nguyen L, Li X, Tian X, Le A et al (2013) The effect of gartanin, a naturally occurring xanthone in mangosteen juice, on the mTOR pathway, autophagy, apoptosis, and the growth of human urinary bladder cancer cell lines. Nutr Cancer 65(Suppl 1):68–77
-
(2013)
Nutr Cancer
, vol.65
, pp. 68-77
-
-
Liu, Z.1
Antalek, M.2
Nguyen, L.3
Li, X.4
Tian, X.5
Le, A.6
-
47
-
-
33646060747
-
Sgk kinases and their role in epithelial transport
-
COI: 1:CAS:528:DC%2BD28XksFWks7s%3D, PID: 16460280
-
Loffing J, Flores SY, Staub O (2006) Sgk kinases and their role in epithelial transport. Annu Rev Physiol 68:461–490
-
(2006)
Annu Rev Physiol
, vol.68
, pp. 461-490
-
-
Loffing, J.1
Flores, S.Y.2
Staub, O.3
-
48
-
-
77951026717
-
Mammalian target of rapamycin activator RHEB is frequently overexpressed in human carcinomas and is critical and sufficient for skin epithelial carcinogenesis
-
COI: 1:CAS:528:DC%2BC3cXkslShurg%3D, PID: 20388784
-
Lu ZH, Shvartsman MB, Lee AY, Shao JM, Murray MM, Kladney RD et al (2010) Mammalian target of rapamycin activator RHEB is frequently overexpressed in human carcinomas and is critical and sufficient for skin epithelial carcinogenesis. Cancer Res 70(8):3287–3298
-
(2010)
Cancer Res
, vol.70
, Issue.8
, pp. 3287-3298
-
-
Lu, Z.H.1
Shvartsman, M.B.2
Lee, A.Y.3
Shao, J.M.4
Murray, M.M.5
Kladney, R.D.6
-
49
-
-
84872469432
-
Irradiated riboflavin diminishes the aggressiveness of melanoma in vitro and in vivo
-
COI: 1:CAS:528:DC%2BC3sXhs1ymtbc%3D, PID: 23342114
-
Machado D, Shishido SM, Queiroz KC, Oliveira DN, Faria AL, Catharino RR et al (2013) Irradiated riboflavin diminishes the aggressiveness of melanoma in vitro and in vivo. PLoS One 8(1):e54269
-
(2013)
PLoS One
, vol.8
, Issue.1
, pp. e54269
-
-
Machado, D.1
Shishido, S.M.2
Queiroz, K.C.3
Oliveira, D.N.4
Faria, A.L.5
Catharino, R.R.6
-
50
-
-
76149121826
-
FoxO1––the key for the pathogenesis and therapy of acne?
-
PID: 20151947
-
Melnik BC (2010) FoxO1––the key for the pathogenesis and therapy of acne? J Dtsch Dermatol Ges 8(2):105–114
-
(2010)
J Dtsch Dermatol Ges
, vol.8
, Issue.2
, pp. 105-114
-
-
Melnik, B.C.1
-
51
-
-
14644415484
-
Signal transducer and activator of transcription (STAT) signalling and T-cell lymphomas
-
COI: 1:CAS:528:DC%2BD2MXit1Wgsr0%3D, PID: 15720432
-
Mitchell TJ, John S (2005) Signal transducer and activator of transcription (STAT) signalling and T-cell lymphomas. Immunology 114(3):301–312
-
(2005)
Immunology
, vol.114
, Issue.3
, pp. 301-312
-
-
Mitchell, T.J.1
John, S.2
-
52
-
-
79959961628
-
Caffeine activates tumor suppressor PTEN in sarcoma cells
-
COI: 1:CAS:528:DC%2BC3MXpvVegsbk%3D, PID: 21617855
-
Miwa S, Sugimoto N, Shirai T, Hayashi K, Nishida H, Ohnari I et al (2011) Caffeine activates tumor suppressor PTEN in sarcoma cells. Int J Oncol 39(2):465–472
-
(2011)
Int J Oncol
, vol.39
, Issue.2
, pp. 465-472
-
-
Miwa, S.1
Sugimoto, N.2
Shirai, T.3
Hayashi, K.4
Nishida, H.5
Ohnari, I.6
-
53
-
-
84866999366
-
Caffeine induces apoptosis of osteosarcoma cells by inhibiting AKT/mTOR/S6K, NF-kappaB and MAPK pathways
-
COI: 1:CAS:528:DC%2BC38XhsFKmt7vN, PID: 22993301
-
Miwa S, Sugimoto N, Yamamoto N, Shirai T, Nishida H, Hayashi K et al (2012) Caffeine induces apoptosis of osteosarcoma cells by inhibiting AKT/mTOR/S6K, NF-kappaB and MAPK pathways. Anticancer Res 32(9):3643–3649
-
(2012)
Anticancer Res
, vol.32
, Issue.9
, pp. 3643-3649
-
-
Miwa, S.1
Sugimoto, N.2
Yamamoto, N.3
Shirai, T.4
Nishida, H.5
Hayashi, K.6
-
54
-
-
27744565979
-
Synergistic inhibition of human melanoma proliferation by combination treatment with B-Raf inhibitor BAY43-9006 and mTOR inhibitor rapamycin
-
PID: 16255777
-
Molhoek KR, Brautigan DL, Slingluff CL Jr (2005) Synergistic inhibition of human melanoma proliferation by combination treatment with B-Raf inhibitor BAY43-9006 and mTOR inhibitor rapamycin. J Transl Med 3:39
-
(2005)
J Transl Med
, vol.3
, pp. 39
-
-
Molhoek, K.R.1
Brautigan, D.L.2
Slingluff, C.L.3
-
55
-
-
0035866812
-
The Kaposi’s sarcoma-associated herpesvirus G protein-coupled receptor promotes endothelial cell survival through the activation of Akt/protein kinase B
-
COI: 1:CAS:528:DC%2BD3MXisVSksL4%3D, PID: 11289142
-
Montaner S, Sodhi A, Pece S, Mesri EA, Gutkind JS (2001) The Kaposi’s sarcoma-associated herpesvirus G protein-coupled receptor promotes endothelial cell survival through the activation of Akt/protein kinase B. Cancer Res 61(6):2641–2648
-
(2001)
Cancer Res
, vol.61
, Issue.6
, pp. 2641-2648
-
-
Montaner, S.1
Sodhi, A.2
Pece, S.3
Mesri, E.A.4
Gutkind, J.S.5
-
56
-
-
84868618609
-
Immunohistochemical analysis of the Akt/mTOR/4E-BP1 signalling pathway in canine haemangiomas and haemangiosarcomas
-
COI: 1:CAS:528:DC%2BC38XhtVWgtbfE, PID: 22789858
-
Murai A, Abou Asa S, Kodama A, Sakai H, Hirata A, Yanai T (2012) Immunohistochemical analysis of the Akt/mTOR/4E-BP1 signalling pathway in canine haemangiomas and haemangiosarcomas. J Comp Pathol 147(4):430–440
-
(2012)
J Comp Pathol
, vol.147
, Issue.4
, pp. 430-440
-
-
Murai, A.1
Abou Asa, S.2
Kodama, A.3
Sakai, H.4
Hirata, A.5
Yanai, T.6
-
57
-
-
84863277615
-
Activation of PI3K signaling in Merkel cell carcinoma
-
COI: 1:CAS:528:DC%2BC38Xjt1Wltr0%3D, PID: 22261808
-
Nardi V, Song Y, Santamaria-Barria JA, Cosper AK, Lam Q, Faber AC et al (2012) Activation of PI3K signaling in Merkel cell carcinoma. Clin Cancer Res 18(5):1227–1236
-
(2012)
Clin Cancer Res
, vol.18
, Issue.5
, pp. 1227-1236
-
-
Nardi, V.1
Song, Y.2
Santamaria-Barria, J.A.3
Cosper, A.K.4
Lam, Q.5
Faber, A.C.6
-
58
-
-
0033429554
-
Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation
-
COI: 1:CAS:528:DC%2BD3cXltFKm, PID: 10567225
-
Nave BT, Ouwens M, Withers DJ, Alessi DR, Shepherd PR (1999) Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation. Biochem J 344(Pt 2):427–431
-
(1999)
Biochem J
, vol.344
, pp. 427-431
-
-
Nave, B.T.1
Ouwens, M.2
Withers, D.J.3
Alessi, D.R.4
Shepherd, P.R.5
-
59
-
-
24044466113
-
Inhibition of epidermal growth factor-induced cell transformation and Akt activation by caffeine
-
COI: 1:CAS:528:DC%2BD2MXpvFKku7w%3D, PID: 16044420
-
Nomura M, Ichimatsu D, Moritani S, Koyama I, Dong Z, Yokogawa K et al (2005) Inhibition of epidermal growth factor-induced cell transformation and Akt activation by caffeine. Mol Carcinog 44(1):67–76
-
(2005)
Mol Carcinog
, vol.44
, Issue.1
, pp. 67-76
-
-
Nomura, M.1
Ichimatsu, D.2
Moritani, S.3
Koyama, I.4
Dong, Z.5
Yokogawa, K.6
-
60
-
-
77954731182
-
Quercetin potentiates UVB-induced c-Fos expression: implications for its use as a chemopreventive agent
-
COI: 1:CAS:528:DC%2BC3cXht1GjurfF
-
Olson ER, Melton T, Dickinson SE, Dong Z, Alberts DS, Bowden GT (2010) Quercetin potentiates UVB-induced c-Fos expression: implications for its use as a chemopreventive agent. Cancer Prev Res (Phila) 3(7):876–884
-
(2010)
Cancer Prev Res (Phila)
, vol.3
, Issue.7
, pp. 876-884
-
-
Olson, E.R.1
Melton, T.2
Dickinson, S.E.3
Dong, Z.4
Alberts, D.S.5
Bowden, G.T.6
-
61
-
-
17644374126
-
Treatment of psoriasis with topical sirolimus: preclinical development and a randomized, double-blind trial
-
COI: 1:CAS:528:DC%2BD2MXksFyms7o%3D, PID: 15840110
-
Ormerod AD, Shah SA, Copeland P, Omar G, Winfield A (2005) Treatment of psoriasis with topical sirolimus: preclinical development and a randomized, double-blind trial. Br J Dermatol 152(4):758–764
-
(2005)
Br J Dermatol
, vol.152
, Issue.4
, pp. 758-764
-
-
Ormerod, A.D.1
Shah, S.A.2
Copeland, P.3
Omar, G.4
Winfield, A.5
-
62
-
-
84872893327
-
Combined blockade of AKT/mTOR pathway inhibits growth of human hemangioma via downregulation of proliferating cell nuclear antigen
-
COI: 1:CAS:528:DC%2BC3sXislSntbs%3D, PID: 23298485
-
Ou JM, Qui MK, Dai YX, Dong Q, Shen J, Dong P et al (2012) Combined blockade of AKT/mTOR pathway inhibits growth of human hemangioma via downregulation of proliferating cell nuclear antigen. Int J Immunopathol Pharmacol 25(4):945–953
-
(2012)
Int J Immunopathol Pharmacol
, vol.25
, Issue.4
, pp. 945-953
-
-
Ou, J.M.1
Qui, M.K.2
Dai, Y.X.3
Dong, Q.4
Shen, J.5
Dong, P.6
-
63
-
-
34247373748
-
AKT1 overexpression in endothelial cells leads to the development of cutaneous vascular malformations in vivo
-
PID: 17438183
-
Perry B, Banyard J, McLaughlin ER, Watnick R, Sohn A, Brindley DN et al (2007) AKT1 overexpression in endothelial cells leads to the development of cutaneous vascular malformations in vivo. Arch Dermatol 143(4):504–506
-
(2007)
Arch Dermatol
, vol.143
, Issue.4
, pp. 504-506
-
-
Perry, B.1
Banyard, J.2
McLaughlin, E.R.3
Watnick, R.4
Sohn, A.5
Brindley, D.N.6
-
64
-
-
80052115140
-
Curcumin inhibits skin squamous cell carcinoma tumor growth in vivo
-
PID: 21493306
-
Phillips JM, Clark C, Herman-Ferdinandez L, Moore-Medlin T, Rong X, Gill JR et al (2011) Curcumin inhibits skin squamous cell carcinoma tumor growth in vivo. Otolaryngol Head Neck Surg 145(1):58–63
-
(2011)
Otolaryngol Head Neck Surg
, vol.145
, Issue.1
, pp. 58-63
-
-
Phillips, J.M.1
Clark, C.2
Herman-Ferdinandez, L.3
Moore-Medlin, T.4
Rong, X.5
Gill, J.R.6
-
65
-
-
0036714127
-
Akt regulates growth by directly phosphorylating Tsc2
-
COI: 1:CAS:528:DC%2BD38Xms1ahtLw%3D, PID: 12172554
-
Potter CJ, Pedraza LG, Xu T (2002) Akt regulates growth by directly phosphorylating Tsc2. Nat Cell Biol 4(9):658–665
-
(2002)
Nat Cell Biol
, vol.4
, Issue.9
, pp. 658-665
-
-
Potter, C.J.1
Pedraza, L.G.2
Xu, T.3
-
66
-
-
69149097139
-
An imbalance in Akt/mTOR is involved in the apoptotic and acantholytic processes in a mouse model of pemphigus vulgaris
-
COI: 1:CAS:528:DC%2BD1MXhtFCktLjI, PID: 19552768
-
Pretel M, Espana A, Marquina M, Pelacho B, Lopez-Picazo JM, Lopez-Zabalza MJ (2009) An imbalance in Akt/mTOR is involved in the apoptotic and acantholytic processes in a mouse model of pemphigus vulgaris. Exp Dermatol 18(9):771–780
-
(2009)
Exp Dermatol
, vol.18
, Issue.9
, pp. 771-780
-
-
Pretel, M.1
Espana, A.2
Marquina, M.3
Pelacho, B.4
Lopez-Picazo, J.M.5
Lopez-Zabalza, M.J.6
-
67
-
-
0034786155
-
Efficacy of sirolimus (rapamycin) administered concomitantly with a subtherapeutic dose of cyclosporin in the treatment of severe psoriasis: a randomized controlled trial
-
COI: 1:CAS:528:DC%2BD3MXnvVanurc%3D, PID: 11531834
-
Reitamo S, Spuls P, Sassolas B, Lahfa M, Claudy A, Griffiths CE (2001) Efficacy of sirolimus (rapamycin) administered concomitantly with a subtherapeutic dose of cyclosporin in the treatment of severe psoriasis: a randomized controlled trial. Br J Dermatol 145(3):438–445
-
(2001)
Br J Dermatol
, vol.145
, Issue.3
, pp. 438-445
-
-
Reitamo, S.1
Spuls, P.2
Sassolas, B.3
Lahfa, M.4
Claudy, A.5
Griffiths, C.E.6
-
68
-
-
84879410701
-
RSK regulates activated BRAF signalling to mTORC1 and promotes melanoma growth
-
COI: 1:CAS:528:DC%2BC38XhtVehsLzN, PID: 22797077
-
Romeo Y, Moreau J, Zindy PJ, Saba-El-Leil M, Lavoie G, Dandachi F et al (2013) RSK regulates activated BRAF signalling to mTORC1 and promotes melanoma growth. Oncogene 32(24):2917–2926
-
(2013)
Oncogene
, vol.32
, Issue.24
, pp. 2917-2926
-
-
Romeo, Y.1
Moreau, J.2
Zindy, P.J.3
Saba-El-Leil, M.4
Lavoie, G.5
Dandachi, F.6
-
69
-
-
79551508637
-
Caffeine induces apoptosis by enhancement of autophagy via PI3K/Akt/mTOR/p70S6K inhibition
-
COI: 1:CAS:528:DC%2BC3MXivVSmu7g%3D, PID: 21081844
-
Saiki S, Sasazawa Y, Imamichi Y, Kawajiri S, Fujimaki T, Tanida I et al (2011) Caffeine induces apoptosis by enhancement of autophagy via PI3K/Akt/mTOR/p70S6K inhibition. Autophagy 7(2):176–187
-
(2011)
Autophagy
, vol.7
, Issue.2
, pp. 176-187
-
-
Saiki, S.1
Sasazawa, Y.2
Imamichi, Y.3
Kawajiri, S.4
Fujimaki, T.5
Tanida, I.6
-
70
-
-
3342895823
-
Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
-
COI: 1:CAS:528:DC%2BD2cXmtVamsLs%3D, PID: 15268862
-
Sarbassov DD, Ali SM, Kim DH, Guertin DA, Latek RR, Erdjument-Bromage H et al (2004) Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr Biol 14(14):1296–1302
-
(2004)
Curr Biol
, vol.14
, Issue.14
, pp. 1296-1302
-
-
Sarbassov, D.D.1
Ali, S.M.2
Kim, D.H.3
Guertin, D.A.4
Latek, R.R.5
Erdjument-Bromage, H.6
-
71
-
-
33646023695
-
Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB
-
COI: 1:CAS:528:DC%2BD28Xkt1GmtLo%3D, PID: 16603397
-
Sarbassov DD, Ali SM, Sengupta S, Sheen JH, Hsu PP, Bagley AF et al (2006) Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB. Mol Cell 22(2):159–168
-
(2006)
Mol Cell
, vol.22
, Issue.2
, pp. 159-168
-
-
Sarbassov, D.D.1
Ali, S.M.2
Sengupta, S.3
Sheen, J.H.4
Hsu, P.P.5
Bagley, A.F.6
-
72
-
-
13844312400
-
Phosphorylation and regulation of Akt/PKB by the rictor–mTOR complex
-
COI: 1:CAS:528:DC%2BD2MXhtlSrtbY%3D, PID: 15718470
-
Sarbassov DD, Guertin DA, Ali SM, Sabatini DM (2005) Phosphorylation and regulation of Akt/PKB by the rictor–mTOR complex. Science 307(5712):1098–1101
-
(2005)
Science
, vol.307
, Issue.5712
, pp. 1098-1101
-
-
Sarbassov, D.D.1
Guertin, D.A.2
Ali, S.M.3
Sabatini, D.M.4
-
73
-
-
0016713286
-
Rapamycin (AY-22,989), a new antifungal antibiotic. II. Fermentation, isolation and characterization
-
COI: 1:CAS:528:DyaE28Xis1eqsg%3D%3D
-
Sehgal SN, Baker H, Vezina C (1975) Rapamycin (AY-22,989), a new antifungal antibiotic. II. Fermentation, isolation and characterization. J Antibiot (Tokyo) 28(10):727–732
-
(1975)
J Antibiot (Tokyo)
, vol.28
, Issue.10
, pp. 727-732
-
-
Sehgal, S.N.1
Baker, H.2
Vezina, C.3
-
74
-
-
42149148782
-
IGF-1 induces SREBP-1 expression and lipogenesis in SEB-1 sebocytes via activation of the phosphoinositide 3-kinase/Akt pathway
-
COI: 1:CAS:528:DC%2BD1cXksFyhs7k%3D, PID: 17989724
-
Smith TM, Gilliland K, Clawson GA, Thiboutot D (2008) IGF-1 induces SREBP-1 expression and lipogenesis in SEB-1 sebocytes via activation of the phosphoinositide 3-kinase/Akt pathway. J Invest Dermatol 128(5):1286–1293
-
(2008)
J Invest Dermatol
, vol.128
, Issue.5
, pp. 1286-1293
-
-
Smith, T.M.1
Gilliland, K.2
Clawson, G.A.3
Thiboutot, D.4
-
75
-
-
1842687489
-
Akt plays a central role in sarcomagenesis induced by Kaposi’s sarcoma herpesvirus-encoded G protein-coupled receptor
-
COI: 1:CAS:528:DC%2BD2cXjsFCjurk%3D, PID: 15047889
-
Sodhi A, Montaner S, Patel V, Gomez-Roman JJ, Li Y, Sausville EA et al (2004) Akt plays a central role in sarcomagenesis induced by Kaposi’s sarcoma herpesvirus-encoded G protein-coupled receptor. Proc Natl Acad Sci USA 101(14):4821–4826
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, Issue.14
, pp. 4821-4826
-
-
Sodhi, A.1
Montaner, S.2
Patel, V.3
Gomez-Roman, J.J.4
Li, Y.5
Sausville, E.A.6
-
76
-
-
79952662483
-
The integral role of mTOR in lipid metabolism
-
COI: 1:CAS:528:DC%2BC3MXkvFCqsrg%3D, PID: 21325894
-
Soliman GA (2011) The integral role of mTOR in lipid metabolism. Cell Cycle 10(6):861–862
-
(2011)
Cell Cycle
, vol.10
, Issue.6
, pp. 861-862
-
-
Soliman, G.A.1
-
77
-
-
77956283576
-
Accelerated wound healing by mTOR activation in genetically defined mouse models
-
PID: 20498714
-
Squarize CH, Castilho RM, Bugge TH, Gutkind JS (2010) Accelerated wound healing by mTOR activation in genetically defined mouse models. PLoS One 5(5):e10643
-
(2010)
PLoS One
, vol.5
, Issue.5
, pp. e10643
-
-
Squarize, C.H.1
Castilho, R.M.2
Bugge, T.H.3
Gutkind, J.S.4
-
78
-
-
84865965845
-
Differential activation of signaling pathways by UVA and UVB radiation in normal human epidermal keratinocytes
-
COI: 1:CAS:528:DC%2BC38XhsVenu7rO, PID: 22335604
-
Syed DN, Afaq F, Mukhtar H (2012) Differential activation of signaling pathways by UVA and UVB radiation in normal human epidermal keratinocytes. Photochem Photobiol 88(5):1184–1190
-
(2012)
Photochem Photobiol
, vol.88
, Issue.5
, pp. 1184-1190
-
-
Syed, D.N.1
Afaq, F.2
Mukhtar, H.3
-
79
-
-
84879785656
-
Resveratrol-induced apoptosis is enhanced by inhibition of autophagy in esophageal squamous cell carcinoma
-
COI: 1:CAS:528:DC%2BC3sXmtVahurs%3D, PID: 23541682
-
Tang Q, Li G, Wei X, Zhang J, Chiu JF, Hasenmayer D et al (2013) Resveratrol-induced apoptosis is enhanced by inhibition of autophagy in esophageal squamous cell carcinoma. Cancer Lett 336(2):325–337
-
(2013)
Cancer Lett
, vol.336
, Issue.2
, pp. 325-337
-
-
Tang, Q.1
Li, G.2
Wei, X.3
Zhang, J.4
Chiu, J.F.5
Hasenmayer, D.6
-
80
-
-
0042701991
-
Tuberous sclerosis complex gene products, tuberin and hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb
-
COI: 1:CAS:528:DC%2BD3sXmt1Kitr0%3D, PID: 12906785
-
Tee AR, Manning BD, Roux PP, Cantley LC, Blenis J (2003) Tuberous sclerosis complex gene products, tuberin and hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb. Curr Biol 13(15):1259–1268
-
(2003)
Curr Biol
, vol.13
, Issue.15
, pp. 1259-1268
-
-
Tee, A.R.1
Manning, B.D.2
Roux, P.P.3
Cantley, L.C.4
Blenis, J.5
-
81
-
-
0842304506
-
The K1 protein of Kaposi’s sarcoma-associated herpesvirus activates the Akt signaling pathway
-
COI: 1:CAS:528:DC%2BD2cXhtFKnsrg%3D, PID: 14747556
-
Tomlinson CC, Damania B (2004) The K1 protein of Kaposi’s sarcoma-associated herpesvirus activates the Akt signaling pathway. J Virol 78(4):1918–1927
-
(2004)
J Virol
, vol.78
, Issue.4
, pp. 1918-1927
-
-
Tomlinson, C.C.1
Damania, B.2
-
82
-
-
84871757601
-
Pterostilbene, a natural analogue of resveratrol, potently inhibits 7,12-dimethylbenz[a]anthracene (DMBA)/12-O-tetradecanoylphorbol-13-acetate (TPA)-induced mouse skin carcinogenesis
-
COI: 1:CAS:528:DC%2BC38XhsFGmtbfM, PID: 22842666
-
Tsai ML, Lai CS, Chang YH, Chen WJ, Ho CT, Pan MH (2012) Pterostilbene, a natural analogue of resveratrol, potently inhibits 7,12-dimethylbenz[a]anthracene (DMBA)/12-O-tetradecanoylphorbol-13-acetate (TPA)-induced mouse skin carcinogenesis. Food Funct 3(11):1185–1194
-
(2012)
Food Funct
, vol.3
, Issue.11
, pp. 1185-1194
-
-
Tsai, M.L.1
Lai, C.S.2
Chang, Y.H.3
Chen, W.J.4
Ho, C.T.5
Pan, M.H.6
-
83
-
-
79952440161
-
Epigallocatechin gallate (EGCG), a major component of green tea, is a dual phosphoinositide-3-kinase/mTOR inhibitor
-
PID: 21300025
-
Van Aller GS, Carson JD, Tang W, Peng H, Zhao L, Copeland RA et al (2011) Epigallocatechin gallate (EGCG), a major component of green tea, is a dual phosphoinositide-3-kinase/mTOR inhibitor. Biochem Biophys Res Commun 406(2):194–199
-
(2011)
Biochem Biophys Res Commun
, vol.406
, Issue.2
, pp. 194-199
-
-
Van Aller, G.S.1
Carson, J.D.2
Tang, W.3
Peng, H.4
Zhao, L.5
Copeland, R.A.6
-
84
-
-
33847397874
-
Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40
-
COI: 1:CAS:528:DC%2BD2sXit12rsr0%3D, PID: 17277771
-
Vander Haar E, Lee SI, Bandhakavi S, Griffin TJ, Kim DH (2007) Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40. Nat Cell Biol 9(3):316–323
-
(2007)
Nat Cell Biol
, vol.9
, Issue.3
, pp. 316-323
-
-
Vander Haar, E.1
Lee, S.I.2
Bandhakavi, S.3
Griffin, T.J.4
Kim, D.H.5
-
85
-
-
79251556232
-
Novel synthetic small-molecule activators of AMPK as enhancers of autophagy and amyloid-beta peptide degradation
-
COI: 1:CAS:528:DC%2BC3MXls1GmtA%3D%3D, PID: 20852062
-
Vingtdeux V, Chandakkar P, Zhao H, d’Abramo C, Davies P, Marambaud P (2011) Novel synthetic small-molecule activators of AMPK as enhancers of autophagy and amyloid-beta peptide degradation. FASEB J 25(1):219–231
-
(2011)
FASEB J
, vol.25
, Issue.1
, pp. 219-231
-
-
Vingtdeux, V.1
Chandakkar, P.2
Zhao, H.3
d’Abramo, C.4
Davies, P.5
Marambaud, P.6
-
86
-
-
47949101732
-
Kaposi’s sarcoma-associated herpesvirus confers a survival advantage to endothelial cells
-
COI: 1:CAS:528:DC%2BD1cXnt1aqtb0%3D, PID: 18559509
-
Wang L, Damania B (2008) Kaposi’s sarcoma-associated herpesvirus confers a survival advantage to endothelial cells. Cancer Res 68(12):4640–4648
-
(2008)
Cancer Res
, vol.68
, Issue.12
, pp. 4640-4648
-
-
Wang, L.1
Damania, B.2
-
87
-
-
33645741486
-
Immortalization of primary endothelial cells by the K1 protein of Kaposi’s sarcoma-associated herpesvirus
-
COI: 1:CAS:528:DC%2BD28XjtVOrsbc%3D, PID: 16585191
-
Wang L, Dittmer DP, Tomlinson CC, Fakhari FD, Damania B (2006) Immortalization of primary endothelial cells by the K1 protein of Kaposi’s sarcoma-associated herpesvirus. Cancer Res 66(7):3658–3666
-
(2006)
Cancer Res
, vol.66
, Issue.7
, pp. 3658-3666
-
-
Wang, L.1
Dittmer, D.P.2
Tomlinson, C.C.3
Fakhari, F.D.4
Damania, B.5
-
88
-
-
0033968596
-
Serine phosphorylation and maximal activation of STAT3 during CNTF signaling is mediated by the rapamycin target mTOR
-
COI: 1:CAS:528:DC%2BD3cXls1WrtQ%3D%3D, PID: 10660304
-
Yokogami K, Wakisaka S, Avruch J, Reeves SA (2000) Serine phosphorylation and maximal activation of STAT3 during CNTF signaling is mediated by the rapamycin target mTOR. Curr Biol 10(1):47–50
-
(2000)
Curr Biol
, vol.10
, Issue.1
, pp. 47-50
-
-
Yokogami, K.1
Wakisaka, S.2
Avruch, J.3
Reeves, S.A.4
-
89
-
-
53949113624
-
Reactive oxygen species in tumor necrosis factor-alpha-activated primary human keratinocytes: implications for psoriasis and inflammatory skin disease
-
COI: 1:CAS:528:DC%2BD1cXht1CmsLjE, PID: 18463678
-
Young CN, Koepke JI, Terlecky LJ, Borkin MS, Boyd Savoy L, Terlecky SR (2008) Reactive oxygen species in tumor necrosis factor-alpha-activated primary human keratinocytes: implications for psoriasis and inflammatory skin disease. J Invest Dermatol 128(11):2606–2614
-
(2008)
J Invest Dermatol
, vol.128
, Issue.11
, pp. 2606-2614
-
-
Young, C.N.1
Koepke, J.I.2
Terlecky, L.J.3
Borkin, M.S.4
Boyd Savoy, L.5
Terlecky, S.R.6
-
90
-
-
33751100885
-
Green tea extract and (−)-epigallocatechin-3-gallate inhibit mast cell-stimulated type I collagen expression in keloid fibroblasts via blocking PI-3K/AkT signaling pathways
-
COI: 1:CAS:528:DC%2BD28Xht1Sgt7bP, PID: 16841034
-
Zhang Q, Kelly AP, Wang L, French SW, Tang X, Duong HS et al (2006) Green tea extract and (−)-epigallocatechin-3-gallate inhibit mast cell-stimulated type I collagen expression in keloid fibroblasts via blocking PI-3K/AkT signaling pathways. J Invest Dermatol 126(12):2607–2613
-
(2006)
J Invest Dermatol
, vol.126
, Issue.12
, pp. 2607-2613
-
-
Zhang, Q.1
Kelly, A.P.2
Wang, L.3
French, S.W.4
Tang, X.5
Duong, H.S.6
-
91
-
-
80055113353
-
Activation of Sirt1 by resveratrol inhibits TNF-alpha induced inflammation in fibroblasts
-
COI: 1:CAS:528:DC%2BC3MXhsV2lurfP, PID: 22069489
-
Zhu X, Liu Q, Wang M, Liang M, Yang X, Xu X et al (2011) Activation of Sirt1 by resveratrol inhibits TNF-alpha induced inflammation in fibroblasts. PLoS One 6(11):e27081
-
(2011)
PLoS One
, vol.6
, Issue.11
, pp. e27081
-
-
Zhu, X.1
Liu, Q.2
Wang, M.3
Liang, M.4
Yang, X.5
Xu, X.6
-
92
-
-
79952293503
-
Activation of mTORC2 by association with the ribosome
-
COI: 1:CAS:528:DC%2BC3MXjsFeqt7o%3D, PID: 21376236
-
Zinzalla V, Stracka D, Oppliger W, Hall MN (2011) Activation of mTORC2 by association with the ribosome. Cell 144(5):757–768
-
(2011)
Cell
, vol.144
, Issue.5
, pp. 757-768
-
-
Zinzalla, V.1
Stracka, D.2
Oppliger, W.3
Hall, M.N.4
-
93
-
-
84898837690
-
Phytotherapy in the management of psoriasis: a review of the efficacy and safety of oral interventions and the pharmacological actions of the main plants
-
COI: 1:CAS:528:DC%2BC3sXhvVahu7vN, PID: 24253308
-
Deng S, May BH, Zhang AL, Lu C, Xue CC (2014) Phytotherapy in the management of psoriasis: a review of the efficacy and safety of oral interventions and the pharmacological actions of the main plants. Arch Dermatol Res 306:211–229
-
(2014)
Arch Dermatol Res
, vol.306
, pp. 211-229
-
-
Deng, S.1
May, B.H.2
Zhang, A.L.3
Lu, C.4
Xue, C.C.5
-
94
-
-
84876462270
-
Topical herbal medicine combined with pharmacotherapy for psoriasis: a systematic review and meta-analysis
-
COI: 1:CAS:528:DC%2BC3sXkvVKisrg%3D, PID: 23354931
-
Deng S, May BH, Zhang AL, Lu C, Xue CC (2013) Topical herbal medicine combined with pharmacotherapy for psoriasis: a systematic review and meta-analysis. Arch Dermatol Res 305:179–189
-
(2013)
Arch Dermatol Res
, vol.305
, pp. 179-189
-
-
Deng, S.1
May, B.H.2
Zhang, A.L.3
Lu, C.4
Xue, C.C.5
-
95
-
-
84885476531
-
Phloridzin isolated from Acanthopanax senticosus promotes proliferation of alpha6 integrin (CD 49f) and beta1 integrin (CD29) enriched for a primary keratinocyte population through the ERK-mediated mTOR pathway
-
COI: 1:CAS:528:DC%2BC3sXht1eltL3F, PID: 23912479
-
Lee J, Jung E, Kim YS, Park D, Toyama K, Date A, Lee J (2013) Phloridzin isolated from Acanthopanax senticosus promotes proliferation of alpha6 integrin (CD 49f) and beta1 integrin (CD29) enriched for a primary keratinocyte population through the ERK-mediated mTOR pathway. Arch Dermatol Res 305:747–754
-
(2013)
Arch Dermatol Res
, vol.305
, pp. 747-754
-
-
Lee, J.1
Jung, E.2
Kim, Y.S.3
Park, D.4
Toyama, K.5
Date, A.6
Lee, J.7
-
96
-
-
84878849124
-
Visible effects of rapamycin (sirolimus) on human skin explants in vitro
-
COI: 1:CAS:528:DC%2BC3sXivFOkt70%3D, PID: 22960739
-
Peramo A, Marcelo CL (2013) Visible effects of rapamycin (sirolimus) on human skin explants in vitro. Arch Dermatol Res 305:163–171
-
(2013)
Arch Dermatol Res
, vol.305
, pp. 163-171
-
-
Peramo, A.1
Marcelo, C.L.2
|