Differential activation of signaling pathways by UVA and UVB radiation in normal human epidermal keratinocytes

Photochemistry and Photobiology

Volumn 88, Issue 5, 2012, Pages 1184-1190

  Syed, Deeba N ^a   Afaq, Farrukh ^b   Mukhtar, Hasan ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 9; MTOR PROTEIN, HUMAN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN C FOS; PROTEIN KINASE B; STAT3 PROTEIN; STAT3 PROTEIN, HUMAN; STRESS ACTIVATED PROTEIN KINASE 1; TARGET OF RAPAMYCIN KINASE;

CLASSIFICATION; CONFERENCE PAPER; CYTOLOGY; EPIDERMIS; GENE EXPRESSION; GENETICS; HUMAN; KERATINOCYTE; METABOLISM; PHOSPHORYLATION; PRIMARY CELL CULTURE; RADIATION EXPOSURE; RADIOMETRY; SIGNAL TRANSDUCTION; ULTRAVIOLET RADIATION; WESTERN BLOTTING;

BIOLOGICAL MARKERS; BLOTTING, WESTERN; EPIDERMIS; GENE EXPRESSION; HUMANS; KERATINOCYTES; MITOGEN-ACTIVATED PROTEIN KINASE 8; MITOGEN-ACTIVATED PROTEIN KINASE 9; NF-KAPPA B; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PRIMARY CELL CULTURE; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-FOS; RADIOMETRY; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; TOR SERINE-THREONINE KINASES; ULTRAVIOLET RAYS;

EID: 84865965845     PISSN: 00318655     EISSN: 17511097     Source Type: Journal    
DOI: 10.1111/j.1751-1097.2012.01115.x     Document Type: Conference Paper

References (25)

1. Afaq, F., and, H. Mukhtar, (2006) Botanical antioxidants in the prevention of photocarcinogenesis and photoaging. Exp. Dermatol. 15, 678-684. (Pubitemid 44145238)
2. Bowden, G. T., (2004) Prevention of non-melanoma skin cancer by targeting ultraviolet-B-light signalling. Nat. Rev. Cancer 4, 23-35. (Pubitemid 38082151)
3. Chaturvedi, V., J. Z. Qin, M. F. Denning, D. Choubey, M. O. Diaz, and, B. J. Nickoloff, (2001) Abnormal NF-kappaB signaling pathway with enhanced susceptibility to apoptosis in immortalized keratinocytes. J. Dermatol. Sci. 26, 67-78. (Pubitemid 32372657)
4. Chen, W., Q. Tang, M. S. Gonzales, and, G. T. Bowden, (2001) Role of p38 MAP kinases and ERK in mediating ultraviolet-B induced cyclooxygenase-2 gene expression in human keratinocytes. Oncogene 20, 3921-3926. (Pubitemid 32646203)
5. Chouinard, N., K. Valerie, M. Rouabhia, and, J. Huot, (2002) UVB-mediated activation of p38 mitogen-activated protein kinase enhances resistance of normal human keratinocytes to apoptosis by stabilizing cytoplasmic p53. Biochem. J. 365, 133-145. (Pubitemid 34756148)
6. D'Errico, M., T. Lemma, A. Calcagnile, L. Proietti De Santis, and, E. Dogliotti, (2007) Cell type and DNA damage specific response of human skin cells to environmental agents. Mutat. Res. 614, 37-47. (Pubitemid 44909215)
7. Lisby, S., R. Gniadecki, and, H. C. Wulf, (2005) UV-induced DNA damage in human keratinocytes: quantitation and correlation with long-term survival. Exp. Dermatol. 14, 349-355. (Pubitemid 40691656)
8. Hampton, P. J., P. M. Farr, B. L. Diffey, and, J. J. Lloyd, (2004) Implication for photosensitive patients of ultraviolet A exposure in vehicles. Br. J. Dermatol. 151, 873-876. (Pubitemid 39482122)
9. Kaidbey, K. H., P. P. Agin, R. M. Sayre, and, A. M. Kligman, (1979) Photoprotection by melanin - a comparison of black and Caucasian skin. J. Am. Acad. Dermatol. 1, 249-260. (Pubitemid 11159972)
10. He, Y. Y., J. L. Huang, and, C. F. Chignell, (2004) Delayed and sustained activation of extracellular signal-regulated kinase in human keratinocytes by UVA: implications in carcinogenesis. J. Biol. Chem. 279, 53867-53874. (Pubitemid 40051896)
11. Adachi, M., A. Gazel, G. Pintucci, A. Shuck, S. Shifteh, D. Ginsburg, L. S. Rao, T. Kaneko, I. M. Freedberg, K. Tamaki, and, M. Blumenberg, (2003) Specificity in stress response: epidermal keratinocytes exhibit specialized UV-responsive signal transduction pathways. DNA Cell Biol. 22, 665-677. (Pubitemid 37357737)
12. Katiyar, S. K., F. Afaq, K. Azizuddin, and, H. Mukhtar, (2001) Inhibition of UVB-induced oxidative stress-mediated phosphorylation of mitogen-activated protein kinase signaling pathways in cultured human epidermal keratinocytes by green tea polyphenol (-)-epigallocatechin-3-gallate. Toxicol. Appl. Pharmacol. 176, 110-117. (Pubitemid 33015861)
13. Andersson, E., I. Rosdahl, H. Torma, and, A. Vahlquist, (2003) Differential effects of UV irradiation on nuclear retinoid receptor levels in cultured keratinocytes and melanocytes. Exp. Dermatol. 12, 563-571. (Pubitemid 37270718)
14. Brellier, F., C. Marionnet, O. Chevallier-Lagente, R. Toftgard, A. Mauviel, A. Sarasin, and, T. Magnaldo, (2004) Ultraviolet irradiation represses PATCHED gene transcription in human epidermal keratinocytes through an activator protein-1-dependent process. Cancer Res. 64, 2699-2704. (Pubitemid 38500604)
15. Ramsauer, K., I. Sadzak, A. Porras, A. Pilz, A. R. Nebreda, T. Decker, and, P. Kovarik, (2002) p38 MAPK enhances STAT1-dependent transcription independently of Ser-727 phosphorylation. Proc. Natl Acad. Sci. USA 99, 12859-12864.
16. Ahsan, H., M. H. Aziz, and, N. Ahmad, (2005) Ultraviolet B exposure activates Stat3 signaling via phosphorylation at tyrosine705 in skin of SKH1 hairless mouse: a target for the management of skin cancer? Biochem. Biophys. Res. Commun. 333, 241-246. (Pubitemid 40813470)
17. Bito, T., N. Sumita, T. Masaki, T. Shirakawa, M. Ueda, R. Yoshiki, Y. Tokura, and, C. Nishigori, (2010) Ultraviolet light induces Stat3 activation in human keratinocytes and fibroblasts through reactive oxygen species and DNA damage. Exp. Dermatol. 19, 654-660.
18. Jean, C., H. Hernandez-Pigeon, A. Blanc, M. Charveron, and, G. Laurent, (2007) Epidermal growth factor receptor pathway mitigates UVA-induced G2/M arrest in keratinocyte cells. J. Invest. Dermatol. 127, 2418-2424. (Pubitemid 47619744)
19. Zhang, Q. S., D. A. Maddock, J. P. Chen, S. Heo, C. Chiu, D. Lai, K. Souza, S. Mehta, and, Y. S. Wan, (2001) Cytokine-induced p38 activation feedback regulates the prolonged activation of AKT cell survival pathway initiated by reactive oxygen species in response to UV irradiation in human keratinocytes. Int. J. Oncol. 19, 1057-1061.
20. Cao, C., S. Lu, R. Kivlin, B. Wallin, E. Card, A. Bagdasarian, T. Tamakloe, W. M. Chu, K. L. Guan, and, Y. Wan, (2008) AMP-activated protein kinase contributes to UV- and H2O2-induced apoptosis in human skin keratinocytes. J. Biol. Chem. 283, 28897-28908.
21. Huang, C., J. Li, Q. Ke, S. S. Leonard, B. H. Jiang, X. S. Zhong, M. Costa, V. Castranova, and, X. Shi, (2002) Ultraviolet-induced phosphorylation of p70(S6K) at Thr(389) and Thr(421)/Ser(424) involves hydrogen peroxide and mammalian target of rapamycin but not Akt and atypical protein kinase C. Cancer Res. 62, 5689-5697. (Pubitemid 35204723)
22. Afaq, F., V. M. Adhami, N. Ahmad, and, H. Mukhtar, (2003) Inhibition of ultraviolet B-mediated activation of nuclear factor kappaB in normal human epidermal keratinocytes by green tea Constituent (-)-epigallocatechin-3-gallate. Oncogene 22, 1035-1044. (Pubitemid 36313147)
23. Sanchez Ruderisch, H., C. Schwarz, J. Shang, and, B. Tebbe, (2002) Trioxsalen in the presence of UVA is able to induce nuclear factor kappa B binding activity in HaCaT keratinocytes. Skin Pharmacol. Appl. Skin Physiol. 15, 335-341.
24. Shang, J., C. Schwarz, H. Sanchez Ruderisch, T. Hertting, C. E. Orfanos, and, B. Tebbe, (2002) Effects of UVA and l-ascorbic acid on nuclear factor-kappa B in melanocytes and in HaCaT keratinocytes. Skin Pharmacol. Appl. Skin Physiol. 15, 353-359.
25. Pastore, S., D. Lulli, A. I. Potapovich, P. Fidanza, V. A. Kostyuk, E. Dellambra, C. De Luca, R. Maurelli, and, L. G. Korkina, (2011) Differential modulation of stress-inflammation responses by plant polyphenols in cultured normal human keratinocytes and immortalized HaCaT cells. J. Dermatol. Sci. 63, 104-114.