메뉴 건너뛰기




Volumn 33, Issue 9, 2013, Pages 3711-3714

Differential expression of p-mTOR in cutaneous basal and squamous cell carcinomas likely explains their different response to mTOR inhibitors in organ-transplant recipients

Author keywords

Basal cell carcinoma; Everolimus; Immunohistochemistry; Immunosuppression; MTOR; Organ transplantation; Phospho mTOR; Sirolimus; Skin; Squamous cell carcinoma

Indexed keywords

MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR;

EID: 84885000565     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (28)

References (31)
  • 1
    • 32044465506 scopus 로고    scopus 로고
    • TOR signalling in growth and metabolism
    • Wullschleger S, Loewith R and Hall MN: TOR signalling in growth and metabolism. Cell 124: 471-484, 2006.
    • (2006) Cell , vol.124 , pp. 471-484
    • Wullschleger, S.1    Loewith, R.2    Hall, M.N.3
  • 2
    • 2342545519 scopus 로고    scopus 로고
    • Target of rapamycin (TOR): An integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression
    • Fingar D and Blenis J: Target of rapamycin (TOR): An integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression. Oncogene 23: 3151-3171, 2004.
    • (2004) Oncogene , vol.23 , pp. 3151-3171
    • Fingar, D.1    Blenis, J.2
  • 3
    • 35348820823 scopus 로고    scopus 로고
    • Targeting the mTOR signaling network in cancer
    • Chiang GG and Abraham RT: Targeting the mTOR signaling network in cancer. Trends Mol Med 13: 433-442, 2007.
    • (2007) Trends Mol Med , vol.13 , pp. 433-442
    • Chiang, G.G.1    Abraham, R.T.2
  • 4
    • 33746637660 scopus 로고    scopus 로고
    • Current development of mTOR inhibitors as anticancer agents
    • Faivre S, Kroemer C and Raymond E: Current development of mTOR inhibitors as anticancer agents. Nat Rev Drug Disc 5: 671-688, 2006.
    • (2006) Nat Rev Drug Disc , vol.5 , pp. 671-688
    • Faivre, S.1    Kroemer, C.2    Raymond, E.3
  • 5
    • 84857675728 scopus 로고    scopus 로고
    • The mTOR signalling pathway in human cancer
    • Pópulo H, Lopes JM and Soares P: The mTOR signalling pathway in human cancer. Int J Mol Sci 13: 1886-1918, 2012.
    • (2012) Int J Mol Sci , vol.13 , pp. 1886-1918
    • Pópulo, H.1    Lopes, J.M.2    Soares, P.3
  • 7
    • 0036174289 scopus 로고    scopus 로고
    • Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: Involvement of vascular endothelial growth factor
    • Guba M, von Breitenbuch P, Steinbauer P and Geissler E: Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: Involvement of vascular endothelial growth factor. Nat Med 8: 128-135, 2002.
    • (2002) Nat Med , vol.8 , pp. 128-135
    • Guba, M.1    Von Breitenbuch, P.2    Steinbauer, P.3    Geissler, E.4
  • 8
    • 67650866726 scopus 로고    scopus 로고
    • Conversion from calcineurin inhibitors to sirolimus reduces vascularization and thickness of human posttransplant cutaneous squamous cell carcinomas
    • Rival-Tringali AL, Euvrard S, Decullier E, Claudy A, Faure M and Kanitakis J: Conversion from calcineurin inhibitors to sirolimus reduces vascularization and thickness of human posttransplant cutaneous squamous cell carcinomas. Anticancer Res 29: 1927-1932, 2009.
    • (2009) Anticancer Res , vol.29 , pp. 1927-1932
    • Rival-Tringali, A.L.1    Euvrard, S.2    Decullier, E.3    Claudy, A.4    Faure, M.5    Kanitakis, J.6
  • 9
    • 79960587911 scopus 로고    scopus 로고
    • Clinical activity of mammalian target of rapamycin inhibitors in solid tumors
    • Alvarado Y, Mita M, Vemulapalli S, Mahalingam D and Mita AC: Clinical activity of mammalian target of rapamycin inhibitors in solid tumors. Target Oncol 6: 69-94, 2011.
    • (2011) Target Oncol , vol.6 , pp. 69-94
    • Alvarado, Y.1    Mita, M.2    Vemulapalli, S.3    Mahalingam, D.4    Mita, A.C.5
  • 10
    • 84873021780 scopus 로고    scopus 로고
    • The mammalian target of rapamycin inhibitors in breast cancer: Current evidence and future directions
    • Malaguti P, Vari S, Cognetti F and Fabi A: The mammalian target of rapamycin inhibitors in breast cancer: Current evidence and future directions. Anticancer Res 33: 21-28, 2013.
    • (2013) Anticancer Res , vol.33 , pp. 21-28
    • Malaguti, P.1    Vari, S.2    Cognetti, F.3    Fabi, A.4
  • 11
    • 78649434592 scopus 로고    scopus 로고
    • Can immunosuppressive strategies be used to reduce cancer risk in renal transplant patients?
    • Geissler EK: Can immunosuppressive strategies be used to reduce cancer risk in renal transplant patients? Transplant Proc 42 (9 Suppl): S32-35, 2010.
    • (2010) Transplant Proc , vol.42 , Issue.9 SUPPL.
    • Geissler, E.K.1
  • 12
    • 59649130340 scopus 로고    scopus 로고
    • The role of mTOR inhibitors in the management of posttransplant malignancy
    • Monaco A: The role of mTOR inhibitors in the management of posttransplant malignancy. Transplantation 87: 157-163, 2009.
    • (2009) Transplantation , vol.87 , pp. 157-163
    • Monaco, A.1
  • 13
    • 0036860261 scopus 로고    scopus 로고
    • The macrolide immunosuppressants in dermatology: Mechanisms of action
    • Marsland A and Griffiths CE: The macrolide immunosuppressants in dermatology: mechanisms of action. Eur J Dermatol 12: 618-622, 2002.
    • (2002) Eur J Dermatol , vol.12 , pp. 618-622
    • Marsland, A.1    Griffiths, C.E.2
  • 15
    • 4043142865 scopus 로고    scopus 로고
    • Two-year incidence of malignancy in sirolimus-treated renal transplant recipients: Result from five multicentre studies
    • Mathew T, Kreis H and Friend P: Two-year incidence of malignancy in sirolimus-treated renal transplant recipients: Result from five multicentre studies. Clin Transplant 18: 446-449, 2004.
    • (2004) Clin Transplant , vol.18 , pp. 446-449
    • Mathew, T.1    Kreis, H.2    Friend, P.3
  • 16
    • 27644436740 scopus 로고    scopus 로고
    • Maintenance immunosuppression with target-of-rapamycin inhibitors is associated with a reduced incidence of de novo malignancies
    • Kauffman H, Cherikh W, Cheng Y, Hanto DW and Kahan BD: Maintenance immunosuppression with target-of-rapamycin inhibitors is associated with a reduced incidence of de novo malignancies. Transplantation 80: 883-889, 2005.
    • (2005) Transplantation , vol.80 , pp. 883-889
    • Kauffman, H.1    Cherikh, W.2    Cheng, Y.3    Hanto, D.W.4    Kahan, B.D.5
  • 21
    • 33745782733 scopus 로고    scopus 로고
    • Conversion to everolimus in a patient with arterial hypertension and recurrent cutaneous neoplasia-a case report
    • Pascual J, Fernández AM, Marcén R and Ortuño J: Conversion to everolimus in a patient with arterial hypertension and recurrent cutaneous neoplasia-a case report. Nephrol Dial Transplant 21(Suppl 3:iii3): 8-41, 2006.
    • (2006) Nephrol Dial Transplant , vol.21 , Issue.SUPPL. 3 , pp. 8-41
    • Pascual, J.1    Fernández, A.M.2    Marcén, R.3    Ortuño, J.4
  • 22
    • 34250177274 scopus 로고    scopus 로고
    • Use of proliferation signal inhibitors in nonmelanoma skin cancer following renal transplantation
    • de Fijter JW. Use of proliferation signal inhibitors in nonmelanoma skin cancer following renal transplantation. Nephrol Dial Transplant 22(Suppl 1): i23-26, 2007.
    • (2007) Nephrol Dial Transplant , vol.22 , Issue.SUPPL. 1
    • De Fijter, J.W.1
  • 23
    • 77952940222 scopus 로고    scopus 로고
    • Switch to a sirolimusbased immunosuppression in long-term renal transplant recipients: Reduced rate of (pre-)malignancies and nonmelanoma skin cancer in a prospective, randomized, assessor-blinded, controlled clinical trial
    • Salgo R, Gossmann J, Schöfer H, Kachel HG, Kuck J, Geiger H, Kaufmann R and Scheuermann EH: Switch to a sirolimusbased immunosuppression in long-term renal transplant recipients: Reduced rate of (pre-)malignancies and nonmelanoma skin cancer in a prospective, randomized, assessor-blinded, controlled clinical trial. Am J Transplant 10: 1385-1393, 2010.
    • (2010) Am J Transplant , vol.10 , pp. 1385-1393
    • Salgo, R.1    Gossmann, J.2    Schöfer, H.3    Kachel, H.G.4    Kuck, J.5    Geiger, H.6    Kaufmann, R.7    Scheuermann, E.H.8
  • 24
    • 77954509263 scopus 로고    scopus 로고
    • Effect of everolimus conversion on skin cancers in calcineurin-inhibitor treated heart transplant recipients
    • Euvrard S, Boissonnat P, Roussoullières A, Kanitakis J, Decullier E, Claudy and Sebbag L: Effect of everolimus conversion on skin cancers in calcineurin-inhibitor treated heart transplant recipients. Transpl Int 23: 855-857, 2010.
    • (2010) Transpl Int , vol.23 , pp. 855-857
    • Euvrard, S.1    Boissonnat, P.2    Roussoullières, A.3    Kanitakis, J.4    Decullier, E.5    Claudy6    Sebbag, L.7
  • 25
    • 80053294998 scopus 로고    scopus 로고
    • Lower malignancy rates in renal allograft recipients converted to sirolimus-based, calcineurin inhibitor-free immunotherapy: 24-Month results from the CONVERT trial
    • Sirolimus CONVERT Trial Study Group
    • Alberú J, Pascoe MD, Campistol JM, Schena FP, Rial Mdel C, Polinsky M, Neylan JF, Korth-Bradley J, Goldberg-Alberts R, Maller ES, Sirolimus CONVERT Trial Study Group: Lower malignancy rates in renal allograft recipients converted to sirolimus-based, calcineurin inhibitor-free immunotherapy: 24-Month results from the CONVERT trial. Transplantation 92: 303-310, 2011.
    • (2011) Transplantation , vol.92 , pp. 303-310
    • Alberú, J.1    Pascoe, M.D.2    Campistol, J.M.3    Schena, F.P.4    Rial Mdel, C.5    Polinsky, M.6    Neylan, J.F.7    Korth-Bradley, J.8    Goldberg-Alberts, R.9    Maller, E.S.10
  • 27
    • 84860471709 scopus 로고    scopus 로고
    • Randomized controlled trial o sirolimus for renal transplanrt recipients at high risk for nonmelanoma skin cancer
    • Campbell S, Walker R, See Tai S, Jiang Q and Russ G. Randomized controlled trial o sirolimus for renal transplanrt recipients at high risk for nonmelanoma skin cancer. Am J Transplant 12: 1146-1156, 2012.
    • (2012) Am J Transplant , vol.12 , pp. 1146-1156
    • Campbell, S.1    Walker, R.2    See Tai, S.3    Jiang, Q.4    Russ, G.5
  • 29
    • 58349122896 scopus 로고    scopus 로고
    • Activation of the mammalian target of rapamycin signalling pathway in epidermal tumours and its correlation with cyclin-dependent kinase 2
    • Chen SJ, Nakahara T, Takahara M, Kido M, Dugu L, Uchi H, Takeuchi S, Tu YT, Moroi Y and Furue M: Activation of the mammalian target of rapamycin signalling pathway in epidermal tumours and its correlation with cyclin-dependent kinase 2. Br J Dermatol 160: 442-445, 2009.
    • (2009) Br J Dermatol , vol.160 , pp. 442-445
    • Chen, S.J.1    Nakahara, T.2    Takahara, M.3    Kido, M.4    Dugu, L.5    Uchi, H.6    Takeuchi, S.7    Tu, Y.T.8    Moroi, Y.9    Furue, M.10
  • 31
    • 0037464506 scopus 로고    scopus 로고
    • Skin cancers after organ transplantation
    • Euvrard S, Kanitakis J and Claudy A: Skin cancers after organ transplantation. N Engl J Med 348: 1681-1691, 2003.
    • (2003) N Engl J Med , vol.348 , pp. 1681-1691
    • Euvrard, S.1    Kanitakis, J.2    Claudy, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.