Functional protein pathway activation mapping of the progression of normal skin to squamous cell carcinoma

Cancer Prevention Research

Volumn 5, Issue 3, 2012, Pages 403-413

  Einspahr, Janine G ^a,b   Calvert, Valerie ^e   Alberts, David S ^a,b   Curiel Lewandrowski, Clara ^a,b,c   Warneke, James ^a,b   Krouse, Robert ^a,b,d   Stratton, Steven P ^a,b   Liotta, Lance ^e   Longo, Caterina ^f   Pellicani, Giovanni ^g   Prasad, Anil ^a,b   Sagerman, Paul ^a   Bermudez, Yira ^a,b   Deng, Jianghong ^e   Bowden, G Timothy ^a,b,c   Petricoin III, Emanuel F ^e  

^a UNIVERSITY OF ARIZONA   (United States)

^b UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF ARIZONA   (United States)

^d SOUTHERN ARIZONA VA HEALTH CARE SYSTEM   (United States)

^e GEORGE MASON UNIVERSITY   (United States)

^f S MARIA NUOVA HOSPITAL   (Italy)

^g UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN BAK; PROTEIN BAX;

ACTINIC KERATOSIS; ADULT; ARTICLE; CANCER GROWTH; CARCINOGENESIS; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SQUAMOUS CELL CARCINOMA;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, SQUAMOUS CELL; DISEASE PROGRESSION; FEMALE; HUMANS; LASER CAPTURE MICRODISSECTION; MALE; MIDDLE AGED; PHOSPHORYLATION; PROGNOSIS; PROSPECTIVE STUDIES; SIGNAL TRANSDUCTION; SKIN; SKIN NEOPLASMS; YOUNG ADULT;

EID: 84859447655     PISSN: 19406207     EISSN: 19406215     Source Type: Journal    
DOI: 10.1158/1940-6207.CAPR-11-0427     Document Type: Article

References (48)

1. Rigel DS. Cutaneous ultraviolet exposure and its relationship to the development of skin cancer. J Am Acad Dermatol 2008;58:S129-32. (Pubitemid 351506511)
2. Harvey I, Frankel S, Marks R, Shalom D, Nolan-Farrell M. Non-melanoma skin cancer and solar keratoses II analytical results of the South Wales Skin Cancer Study. Br J Cancer 1996;74:1308-12. (Pubitemid 26360125)
3. ACS. Cancer facts and figures 2011. Atlanta: American Cancer Society; 2011.
4. Greenlee RT, Murray T, Bolden S, Wingo PA. Cancer statistics, 2000. CA Cancer J Clin 2000;50:7-33.
5. Moller R, Reymann F, Hou-Jensen K. Metastases in dermatological patients with squamous cell carcinoma. Arch Dermatol 1979;115:703-5. (Pubitemid 9249657)
6. Kwa RE, Campana K, Moy RL. Biology of cutaneous squamous cell carcinoma. J Am Acad Dermatol 1992;26:1-26.
7. Marks R, Rennie G, Selwood TS. Malignant transformation of solar keratoses to squamous cell carcinoma. Lancet 1988;1:795-7. (Pubitemid 18094914)
8. Graham J. Precancerous lesions of the skin. Prim Care 1976;2:699-716.
9. Salasche SJ. Epidemiology of actinic keratoses and squamous cell carcinoma. J Am Acad Dermatol 2000;42:4-7.
10. Linden KG. Screening and early detection of skin cancer. Curr Oncol Rep 2004;6:491-6. (Pubitemid 39585696)
11. Marcil I, Stern RS. Risk of developing a subsequent nonmelanoma skin cancer in patients with a history of nonmelanoma skin cancer: a critical review of the literature and meta-analysis. Arch Dermatol 2000;136:1524-30. (Pubitemid 32009273)
12. Frankel DH, Hanusa BH, Zitelli JA. New primary nonmelanoma skin cancer in patients with a history of squamous cell carcinoma of the skin. Implications and recommendations for follow-up. J Am Acad Dermatol 1992;26:720-6.
13. Warino L, Tusa M, Camacho F, Teuschler H, Fleischer AB Jr, Feldman SR. Frequency and cost of actinic keratosis treatment. Dermatol Surg 2006;32:1045-9. (Pubitemid 44197455)
14. Brash DE. Roles of the transcription factor p53 in keratinocyte carcinomas. Br J Dermatol 2006;154 Suppl 1:8-10.
15. Benjamin CL, Ananthaswamy HN. p53 and the pathogenesis of skin cancer. Toxicol Appl Pharmacol 2007;224:241-8. (Pubitemid 47575673)
16. Jennings L, Schmults CD. Management of high-risk cutaneous squamous cell carcinoma. J Clin Aesthet Dermatol 2010;3:39-48.
17. Pfundt R, van Vlijmen-Willems I, Bergers M, Wingens M, Cloin W, Schalkwijk J. In situ demonstration of phosphorylated c-jun and p38 MAP kinase in epidermal keratinocytes following ultraviolet B irradiation of human skin. J Pathol 2001;193:248-55. (Pubitemid 32118137)
18. Bender K, Gottlicher M, Whiteside S, Rahmsdorf HJ, Herrlich P. Sequential DNA damage-independent and -dependent activation of NF-kappaB by UV. EMBO J 1998;17:5170-81. (Pubitemid 28408483)
19. Bowden GT. Prevention of non-melanoma skin cancer by targeting ultraviolet-B-light signalling. Nat Rev Cancer 2004;4:23-35. (Pubitemid 38082151)
20. Bode AM, Dong Z. Molecular and cellular targets. Mol Carcinog 2006;45:422-30. (Pubitemid 43865850)
21. Rapkiewicz A, Espina V, Zujewski JA, Lebowitz PF, Filie A, Wulfkuhle J, et al. The needle in the haystack: application of breast fine-needle aspirate samples to quantitative protein microarray technology. Cancer 2007;111:173-84. (Pubitemid 46982695)
22. Wulfkuhle JD, Speer R, Pierobon M, Laird J, Espina V, Deng J, et al. Multiplexed cell signaling analysis of humanbreast cancer applications for personalized therapy. J Proteome Res 2008;7:1508-17.
23. Petricoin EF 3rd, Espina V, Araujo RP, Midura B, Yeung C, Wan X, et al. Phosphoprotein pathway mapping: Akt/mammalian target of rapamycin activation is negatively associated with childhood rhabdomyosarcoma survival. Cancer Res 2007;67:3431-40. (Pubitemid 46724884)
24. Horman SR, Svoboda P, Luning Prak ET. The potential regulation of L1 mobility by RNA interference. J Biomed Biotechnol 2006;2006:32713.
25. Kayampilly PP, Menon KM. Follicle-stimulating hormone inhibits adenosine 50-monophosphate-activated protein kinase activation and promotes cell proliferation of primary granulosa cells in culture through an Akt-dependent pathway. Endocrinology 2009;150:929-35.
26. Warden SM, Richardson C, O'Donnell J Jr, Stapleton D, Kemp BE, Witters LA. Post-translational modifications of the beta-1 subunit of AMP-activated protein kinase affect enzyme activity and cellular localization. Biochem J 2001;354:275-83. (Pubitemid 32209863)
27. Tyrrell RM. UV activation of mammalian stress proteins. EXS 1996;77:255-71.
28. Webster GA, Perkins ND. Transcriptional cross talk between NF-kappaB and p53. Mol Cell Biol 1999;19:3485-95. (Pubitemid 29193808)
29. Fisher GJ, Talwar HS, Lin J, Lin P, McPhillips F, Wang Z, et al. Retinoic acid inhibits induction of c-Jun protein by ultraviolet radiation that occurs subsequent to activation of mitogen-activated protein kinase pathways in human skin in vivo. J Clin Invest 1998;101:1432-40. (Pubitemid 28145261)
30. Cooper S, MacGowan J, Young MR, Colburn NH, Bowden GT. A dominant negative c-jun inhibits UVB induced skin tumor size and burden in an SKH-1 hairless mouse model. Mol Can Res 2003;11:848-54. (Pubitemid 37174456)
31. Mahns A, Wolber R, Stab F, Klotz LO, Sies H. Contribution of UVB and UVA to UV-dependent stimulation of cyclooxygenase-2 expression in artificial epidermis. Photochem Photobiol Sci 2004;3:257-62. (Pubitemid 38849370)
32. Einspahr JG, Bowden GT, Alberts DS, McKenzie N, Saboda K, Warneke J, et al. Cross-validation of murine UV signal transduction pathways in human skin. Photochem Photobiol 2008;84:463-76. (Pubitemid 351421399)
33. Gonzales M, Bowden GT. Ultraviolet B (UVB) induction of the c-fos promoter is mediated by phospho-cAMP response element binding protein (CREB) binding to CRE and c-fos activator protein 1 site (FAP1) cis elements. Gene 2002;293:169-79. (Pubitemid 34876473)
34. Gonzales M, Bowden GT. The role of PI 3-kinase in the UVB-induced expression of c-fos. Oncogene 2002;21:2721-8. (Pubitemid 34478330)
35. Wan YS, Wang ZQ, Shao Y, Voorhees JJ, Fisher GJ. Ultraviolet irradiation activates PI 3-kinase/AKT survival pathway via EGF receptors in human skin in vivo. Int J Oncol 2001;18:461-6.
36. Bachelor MA, Cooper SJ, Sikorski ET, Bowden GT. Inhibition of p38 mitogen-activated protein kinase and phosphatidylinositol 3-kinase decreases UVB-induced activator protein-1 and cyclooxygenase- 2 in a SKH-1 hairless mouse model. Mol Cancer Res 2005;3:90-9. (Pubitemid 40271139)
37. Chen W, Tang Q, Gonzales MS, Bowden GT. Role of p38 MAP kinases and ERK in mediating ultraviolet-B induced cyclooxygenase-2 gene expression in human keratinocytes. Oncogene 2001;20:3921-6. (Pubitemid 32646203)
38. Tang Q, Chen W, Gonzales MS, Finch J, Inoue H, Bowden GT. Role of cyclic AMP responsive element in the UVB induction of cyclooxygenase-2 transcription in human keratinocytes. Oncogene 2001;20:5164-72. (Pubitemid 32844045)
39. Tang Q, Gonzales M, Inoue H, Bowden GT. Roles of Akt and glycogen synthase kinase 3beta in the ultraviolet B induction of cyclooxygenase-2 transcription in human keratinocytes. Cancer Res 2001;61:4329-32. (Pubitemid 32685753)
40. Fisher GJ, Voorhees JJ. Molecular mechanisms of photoaging and its prevention by retinoic acid: ultraviolet irradiation induces MAP kinase signal transduction cascades that induce Ap-1-regulated matrix metalloproteinases that degrade human skin in vivo. J Investig Dermatol Symp Proc 1998;3:61-8.
41. + keratinocyte stem cells and skin tumors during multi-stage mouse skin carcinogenesis. Anticancer Res 2006;26:2805-20.
42. Segrelles C, Lu J, Hammann B, Santos M, Moral M, Cascallana JL, et al. Deregulated activity of Akt in epithelial basal cells induces spontaneous tumors and heightened sensitivity to skin carcinogenesis. Cancer Res 2007;67:10879-88. (Pubitemid 350145917)
43. Segrelles C, Moral M, Lara MF, Ruiz S, Santos M, Leis H, et al. Molecular determinants of Akt-induced keratinocyte transformation. Oncogene 2006;25:1174-85.
44. Checkley LA, Rho O, Moore T, Hursting S, Digiovanni J. Rapamycin is a potent inhibitor of skin tumor promotion by 12-o-tetradecanoylphorbol-13- acetate. Cancer Prev Res 2011;4:1011-20.
45. Chen SJ, Nakahara T, Takahara M, Kido M, Dugu L, Uchi H, et al. Activation of the mammalian target of rapamycin signalling pathway in epidermal tumours and its correlation with cyclin-dependent kinase 2. Br J Dermatol 2009;160:442-5.
46. Available from: www.cellsignal.com.
47. Available from: http://code.google.com/apis/maps.
48. Available from: http://www.cpan.org.