Phloridzin isolated from Acanthopanax senticosus promotes proliferation of α6 integrin (CD 49f) and β1 integrin (CD29) enriched for a primary keratinocyte population through the ERK-mediated mTOR pathway

Archives of Dermatological Research

Volumn 305, Issue 8, 2013, Pages 747-754

  Lee, Jienny ^a   Jung, Eunsun ^a   Kim, Young Soo ^a   Park, Deokhoon ^a   Toyama, Kazumi ^b   Date, Akira ^c   Lee, Jongsung ^d  

^a Biospectrum Life Science Institute   (South Korea)

^b PROCTER AND GAMBLE COMPANY   (United States)

^c HYOGO COLLEGE OF MEDICINE   (Japan)

^d Eulji University   (South Korea)

Author keywords

Acanthopanax senticosus; ERK; mTOR; Phloridzin; Proliferation

Indexed keywords

ALPHA6 INTEGRIN; BETA1 INTEGRIN; ELEUTHEROCOCCUS SENTICOSUS EXTRACT; INTERLEUKIN 6; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE; PHLORIZIN; PROTEIN P44; PROTEIN S6; S6 KINASE; VASCULOTROPIN;

ARTICLE; CELL POPULATION; CELL PROLIFERATION; CONTROLLED STUDY; DRUG DETERMINATION; DRUG EFFECT; DRUG ISOLATION; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME PHOSPHORYLATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; KERATINOCYTE; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION;

ACANTHOPANAX; ANTIGENS, CD29; CELL PROLIFERATION; CELLS, CULTURED; EUKARYOTIC INITIATION FACTOR-4E; EUKARYOTIC INITIATION FACTORS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FLAVONOIDS; FORESKIN; HUMANS; INTEGRIN ALPHA6; KERATINOCYTES; MALE; PHLORHIZIN; PHOSPHORYLATION; PLANT EXTRACTS; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; TOR SERINE-THREONINE KINASES;

EID: 84885476531     PISSN: 03403696     EISSN: 1432069X     Source Type: Journal    
DOI: 10.1007/s00403-013-1398-6     Document Type: Article

References (30)

1. Barrandon Y, Green H (1987) Three clonal types of keratinocyte with different capacities for multiplication. Proc Natl Acad Sci USA 84:2302-2306
2. Bateman JM, McNeill H (2004) Temporal control of differentiation by the insulin receptor/tor pathway in Drosophila. Cell 119:87-96
3. Bork S, Pfister S, Witt H, Horn P (2010) DNA methylation pattern changes upon long-term culture and aging of human mesenchymal stromal cells. Aging Cell 9:54-63
4. Boyer J, Liu RH (2004) Apple phytochemicals and their health benefits. Nutr J 3:5
5. Casadio A, Martin KC, Giustetto M, Zhu H, Chen M, Bartsch D, Bailey CH, Kandel ER (1999) A transient, neuron-wide form of CREB-mediated long-term facilitation can be stabilized at specific synapses by local protein synthesis. Cell 99:221-237
6. Davydov M, Krikorian AD (2000) Eleutherococcus senticosus (Rupr. & Maxim.) Maxim. (Araliaceae) as an adaptogen: a closer look. J Ethnopharmacol 72:345-393
7. de Jong JS, van Diest PJ, van der Valk P, Baak JP (1998) Expression of growth factors, growth-inhibiting factors, and their receptors in invasive breast cancer. II: correlations with proliferation and angiogenesis. J Pathol 184:53-57
8. Dufner A (1999) Thomas G. Ribosomal S6 kinase signaling and the control of translation. Exp Cell Res 253:100-109
9. Ferrara N (1995) Molecular and biological properties of vascular endothelial growth factor. J Mol Med 77:527-543
10. Fong TA, Shawver LK, Sun L, Tang C (1999) SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types. Cancer Res 59:99-106
11. Green H (1977) Terminal differentiation of cultured human epidermal cells. Cell 11:405-416
12. Heinrich PC, Behrmann I, Müller-Newen G, Schaper F (1998) Interleukin-6-type cytokine signaling through the gp130/Jak/STAT pathway. Biochem J 334:297-314
13. Hertle MD, Adams JC, Watt FM (1991) Integrin expression during human epidermal development in vivo and in vitro. Development 112:193-206
14. Ihle JN (2001) The Stat family in cytokine signaling. Curr Opin Cell Biol 13:211-217
15. Jones PH, Watt FM (1993) Separation of human epidermal stem cells from transit amplifying cells on the basis of differences in integrin function and expression. Cell 73:713-724
16. Kim DS, Cho HJ, Choi HR, Kwon SB, Park KC (2004) Isolation of human epidermal stem cells by adherence and the reconstruction of skin equivalents. Cell Mol Life Sci 61:2774-2781
17. Li A, Simmons PJ, Kaur P (1998) Identification and isolation of candidate human keratinocyte stem cells based on cell surface phenotype. Proc Natl Acad Sci USA 95:3902-3907
18. Lin QY, Jin LJ, Cao ZH, Xu YP (2008) Inhibition of inducible nitric oxide synthase by Acanthopanax senticosus extract in RAW264.7 macrophages. J Ethnopharmacol 118:231-236
19. Long X, Spycher C, Han ZS, Rose AM, Muller F, Avruch J (2002) TOR deficiency in C. elegans causes developmental arrest and intestinal atrophy by inhibition of mRNA translation. Curr Biol 12:1448-1461
20. Oldham S, Montagne J, Radimerski T, Thomas G, Hafen E (2000) Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of rapamycin. Genes Dev 14:2689-2694
21. Panayotova-Heiermann M, Loo DDR, Wright EM (1995) Kinetics of steady-state currents and charge movements associated with the rat Na+/glucose cotransporter. J Biol Chem 270:27099-27105
22. Pullen N, Thomas G (1997) The modular phosphorylation and activation of p70S6K. FEBS Lett 410:78-82
23. Ridgway T, O'Reilly J, West G, Tucker G, Wiseman H (1997) Antioxidant action of novel derivatives of the apple-derived flavonoid phloridzin compared to oestrogen; relevance to potential cardioprotective action. Biochem Soc Trans 25:106S
24. Robak J, Gryglewski R (1988) Flavonoids are scavengers of superoxide anion. Biochem Pharmacol 37:83-88
25. Shoji T, Kobori M, Shinmoto H, Tanabe M, Tsushida T (1997) Progressive effects of phloridzin on melanogenesis in B16 mouse melanoma cells. Biosci Biotechnol Biochem 61:1963-1967
26. Strawn LM, McMahon G, App H, Schreck R (1996) Flk-1 as a target for tumor growth inhibition. Cancer Res 56:3540-3545
27. Tischmeyer W, Schicknick H, Kraus M, Seidenbecher CI, Staak S, Scheich H, Gundelfinger ED (2003) Rapamycin-sensitive signalling in long-term consolidation of auditory cortex-dependent memory. Eur J Neurosci 18:942-950
28. Tsang CK, Qi H, Liu LF, Zheng XF (2007) Targeting mammalian target of rapamycin (mTOR) for health and diseases. Drug Discov Today 12:112-124
29. Xi M, Hai C, Tang H, Chen M, Fang K, Liang X (2008) Antioxidant and antiglycation properties of total saponins extracted from traditional Chinese medicine used to treat diabetes mellitus. Phytother Res 22:228-237
30. Zhang H, Stallock JP, Ng JC, Reinhard C, Neufeld TP (2000) Regulation of cellular growth by the Drosophila target of rapamycin dTOR. Genes Dev 14:2712-2724