Contingency and entrenchment in protein evolution under purifying selection

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 25, 2015, Pages E3226-E3235

  Shah, Premal ^a   McCandlish, David M ^a   Plotkin, Joshua B ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Coevolution; Intragenic epistasis; Near neutrality; Protein stability

Indexed keywords

PROTEIN;

AMINO ACID SEQUENCE; ARTICLE; CONTROLLED STUDY; EPISTASIS; LIGAND BINDING; MUTATION; PHENOTYPE; PREDICTION; PRIORITY JOURNAL; PROTEIN STABILITY; PURIFYING SELECTION; SIMULATION; GENETICS; MOLECULAR EVOLUTION; THEORETICAL MODEL; THERMODYNAMICS;

EPISTASIS, GENETIC; EVOLUTION, MOLECULAR; MODELS, THEORETICAL; MUTATION; PROTEIN STABILITY; PROTEINS; THERMODYNAMICS;

EID: 84934908389     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1412933112     Document Type: Article

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