Why human disease-associated residues appear as the wild-type in other species: Genome-scale structural evidence for the compensation hypothesis

Molecular Biology and Evolution

Volumn 31, Issue 7, 2014, Pages 1787-1792

  Xu, Jinrui ^a   Zhang, Jianzhi ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

Author keywords

disease mutation; epistasis; evolution; intramolecular interaction; protein stability

Indexed keywords

AMINO ACID; PROTEIN;

AMINO ACID SUBSTITUTION; ARTICLE; DISEASES; EPISTASIS; EVOLUTION; GENOMICS; HYPOTHESIS; PROTEIN STABILITY; PROTEIN STRUCTURE; WILD TYPE; ANIMAL; BIOLOGICAL MODEL; CHEMISTRY; GENETICS; GENOME; HUMAN; MOLECULAR EVOLUTION; MUTATION; PROTEIN CONFORMATION; SPECIES DIFFERENCE;

AMINO ACID SUBSTITUTION; ANIMALS; DISEASE; EPISTASIS, GENETIC; EVOLUTION, MOLECULAR; GENOME; HUMANS; MODELS, GENETIC; MUTATION; PROTEIN CONFORMATION; PROTEIN STABILITY; PROTEINS; SPECIES SPECIFICITY;

EID: 84903742512     PISSN: 07374038     EISSN: 15371719     Source Type: Journal    
DOI: 10.1093/molbev/msu130     Document Type: Article

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