Mutational studies on resurrected ancestral proteins reveal conservation of site-specific amino acid preferences throughout evolutionary history

Molecular Biology and Evolution

Volumn 32, Issue 2, 2015, Pages 440-455

  Risso, Valeria A ^a   Manssour Triedo, Fadia ^a   Delgado Delgado, Asuncion ^a   Arco, Rocio ^a   Barroso delJesus, Alicia ^b   Ingles Prieto, Alvaro ^a,f   Godoy Ruiz, Raquel ^c   Gavira, Jose A ^d   Gaucher, Eric A ^e   Ibarra Molero, Beatriz ^a   Sanchez Ruiz, Jose M ^a  

^a UNIVERSITY OF GRANADA   (Spain)

^b INSTITUTO DE PARASITOLOGÍA Y BIOMEDICINA LÓPEZ NEYRA   (Spain)

^c UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^d LABORATORIO DE ESTUDIOS CRISTALOGRÁFICOS   (Spain)

^e GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

^f INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA   (Austria)

Author keywords

amino acid replacements; ancestral proteins; molecular evolution

Indexed keywords

LEUCINE; LYSINE; METHIONINE; PENICILLINASE; THIOREDOXIN; THREONINE; AMINO ACID;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; ELECTROPHORESIS; ESCHERICHIA COLI; GENE DUPLICATION; GENETIC CONSERVATION; LAST COMMON ANCESTOR; MOLECULAR EVOLUTION; MUTATION; NONHUMAN; PHYLOGENETIC TREE; PHYLOGENY; PROTEIN DEGRADATION; PROTEIN FAMILY; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN SECONDARY STRUCTURE; PROTEIN STABILITY; PROTEIN STRUCTURE; GENETICS;

AMINO ACID SEQUENCE; AMINO ACIDS; EVOLUTION, MOLECULAR; PHYLOGENY; PROTEIN STRUCTURE, SECONDARY;

EID: 84988239865     PISSN: 07374038     EISSN: 15371719     Source Type: Journal    
DOI: 10.1093/molbev/msu312     Document Type: Article

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