Strong evidence for protein epistasis, weak evidence against it

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 15, 2014, Pages

  Pollock, David D ^a   Goldstein, Richard A ^b  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; PROTEIN;

AMINO ACID SUBSTITUTION; EPISTASIS; GENE DELETION; LETTER; MOLECULAR EVOLUTION; MUTATION RATE; POPULATION BIOLOGY; PRIORITY JOURNAL; PROTEIN EPISTASIS; PROTEIN STABILITY; PROTEIN STRUCTURE; REVERTANT; SELECTIVE SWEEP; VIRUS STRAIN;

EVOLUTION, MOLECULAR; MUTATION; PHYLOGENY; PROTEIN STABILITY; PROTEINS;

EID: 84898811791     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1401112111     Document Type: Letter

References (4)

1. Ashenberg O, Gong LI, Bloom JD (2013) Mutational effects on stability are largely conserved during protein evolution. Proc Natl Acad Sci USA 110(52):21071-21076.
2. Pollock DD, Thiltgen G, Goldstein RA (2012) Amino acid coevolution induces an evolutionary Stokes shift. Proc Natl Acad Sci USA 109(21):E1352-E1359.
3. Tokuriki N, Oldfield CJ, Uversky VN, Berezovsky IN, Tawfik DS (2009) Do viral proteins possess unique biophysical features? Trends Biochem Sci 34(2):53-59.
4. Marks DS, et al. (2011) Protein 3D structure computed from evolutionary sequence variation. PLoS ONE 6(12):e28766.