Wnt/β-Catenin signaling induces the aging of Mesenchymal stem cells through the DNA damage response and the P53/P21 pathway

PLoS ONE

Volumn 6, Issue 6, 2011, Pages

  Zhang, Da yong ^a   Wang, Hai jie ^a   Tan, Yu zhen ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; CYCLIN DEPENDENT KINASE INHIBITOR 2A; GLYCOGEN SYNTHASE KINASE 3BETA; HISTONE H2AX; MYC PROTEIN; PROTEIN P21; PROTEIN P53; WNT PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 1A; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL AGING; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; DNA DAMAGE; MESENCHYMAL STEM CELL; NONHUMAN; PROTEIN EXPRESSION; RAT; SENESCENCE; SIGNAL TRANSDUCTION; ANIMAL; CELL CULTURE; CYTOLOGY; GENETICS; METABOLISM; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ANIMALIA; RATTUS;

ANIMALS; APOPTOSIS; BETA CATENIN; CELL AGING; CELL PROLIFERATION; CELL SURVIVAL; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DNA DAMAGE; MESENCHYMAL STEM CELLS; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53; WNT PROTEINS;

EID: 79959340540     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0021397     Document Type: Article

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