-
1
-
-
84869212634
-
The kynurenine pathway in brain tumor pathogenesis
-
Adams S, Braidy N, Bessede A, Brew BJ, Grant R, Teo C, Guillemin GJ (2012) The kynurenine pathway in brain tumor pathogenesis. Cancer Res 72:5649–5657
-
(2012)
Cancer Res
, vol.72
, pp. 5649-5657
-
-
Adams, S.1
Braidy, N.2
Bessede, A.3
Brew, B.J.4
Grant, R.5
Teo, C.6
Guillemin, G.J.7
-
2
-
-
84856253626
-
Cross-talk between mitogenic Ras/MAPK and survival PI3K/Akt pathways: A fine balance
-
Aksamitiene E, Kiyatkin A, Kholodenko BN (2011) Cross-talk between mitogenic Ras/MAPK and survival PI3K/Akt pathways: a fine balance. Biochem Soc Trans 40:139–146
-
(2011)
Biochem Soc Trans
, vol.40
, pp. 139-146
-
-
Aksamitiene, E.1
Kiyatkin, A.2
Kholodenko, B.N.3
-
3
-
-
84872160505
-
DNA methylation, histone modifications, and signal transduction pathways: A close relationship in malignant gliomas pathophysiology
-
Alelu-Paz R, Ashour N, Gonzalez-Corpas A, Ropero S (2012) DNA methylation, histone modifications, and signal transduction pathways: a close relationship in malignant gliomas pathophysiology. J Signal Transduct 1–8
-
(2012)
J Signal Transduct
, pp. 1-8
-
-
Alelu-Paz, R.1
Ashour, N.2
Gonzalez-Corpas, A.3
Ropero, S.4
-
5
-
-
78649990580
-
Osteopontin is upregulated and associated with neutrophil and macrophage infiltration in glioblastoma
-
Atai NA, Bansal M, Lo C, Bosman J, Tigchelaar W, Bosch KS, Jonker A, De Witt Hamer PC, Troost D, McCulloch CA, Everts V, Van Noorden CJ, Sodek J (2010) Osteopontin is upregulated and associated with neutrophil and macrophage infiltration in glioblastoma. Immunology 132:39–48
-
(2010)
Immunology
, vol.132
, pp. 39-48
-
-
Atai, N.A.1
Bansal, M.2
Lo, C.3
Bosman, J.4
Tigchelaar, W.5
Bosch, K.S.6
Jonker, A.7
De Witt Hamer, P.C.8
Troost, D.9
McCulloch, C.A.10
Everts, V.11
Van Noorden, C.J.12
Sodek, J.13
-
6
-
-
77952863796
-
Expressions of some vital molecules: Glioblastoma multiforme versus normal tissues
-
Atukeren P, Kemerdere R, Kacira T, Hanimoglu H, Ozlen F, Yavuz B, Tanriverdi T, Gumustas K, Canbaz B (2010) Expressions of some vital molecules: glioblastoma multiforme versus normal tissues. Neurol Res 32:492–501
-
(2010)
Neurol Res
, vol.32
, pp. 492-501
-
-
Atukeren, P.1
Kemerdere, R.2
Kacira, T.3
Hanimoglu, H.4
Ozlen, F.5
Yavuz, B.6
Tanriverdi, T.7
Gumustas, K.8
Canbaz, B.9
-
7
-
-
27644541401
-
Detection of chlorinated DNA and RNA nucleosides by HPLC coupled to tandem mass spectrometry as potential biomarkers of inflammation
-
Badouard C, Masuda M, Nishino H, Cadet J, Favier A, Ravanat JL (2005) Detection of chlorinated DNA and RNA nucleosides by HPLC coupled to tandem mass spectrometry as potential biomarkers of inflammation. J Chromatogr B Analyt Technol Biomed Life Sci 827:26–31
-
(2005)
J Chromatogr B Analyt Technol Biomed Life Sci
, vol.827
, pp. 26-31
-
-
Badouard, C.1
Masuda, M.2
Nishino, H.3
Cadet, J.4
Favier, A.5
Ravanat, J.L.6
-
8
-
-
0035901090
-
Inflammation and cancer: Back to Virchow?
-
Balkwill F, Mantovani A (2001) Inflammation and cancer: back to Virchow? Lancet 357:539–545
-
(2001)
Lancet
, vol.357
, pp. 539-545
-
-
Balkwill, F.1
Mantovani, A.2
-
9
-
-
67749111891
-
Kynurenic acid triggers firm arrest of leukocytes to vascular endothelium under flow conditions
-
Barth MC, Ahluwalia N, Anderson TJ, Hardy GJ, Sinha S, Alvarez-Cardona JA, Pruitt IE, Rhee EP, Colvin RA, Gerszten RE (2009) Kynurenic acid triggers firm arrest of leukocytes to vascular endothelium under flow conditions. J Biol Chem 284:19189–19195
-
(2009)
J Biol Chem
, vol.284
, pp. 19189-19195
-
-
Barth, M.C.1
Ahluwalia, N.2
Erson, T.J.3
Hardy, G.J.4
Sinha, S.5
Alvarez-Cardona, J.A.6
Pruitt, I.E.7
Rhee, E.P.8
Colvin, R.A.9
Gerszten, R.E.10
-
10
-
-
77956627442
-
Replication stress and oxidative damage contribute to aberrant constitutive activation of DNA damage signalling in human gliomas
-
Bartkova J, Hamerlik P, Stockhausen MT, Ehrmann J, Hlobilkova A, Laursen H, Kalita O, Kolar Z, Poulsen HS, Broholm H, Lukas J, Bartek J (2010) Replication stress and oxidative damage contribute to aberrant constitutive activation of DNA damage signalling in human gliomas. Oncogene 29:5095–5102
-
(2010)
Oncogene
, vol.29
, pp. 5095-5102
-
-
Bartkova, J.1
Hamerlik, P.2
Stockhausen, M.T.3
Ehrmann, J.4
Hlobilkova, A.5
Laursen, H.6
Kalita, O.7
Kolar, Z.8
Poulsen, H.S.9
Broholm, H.10
Lukas, J.11
Bartek, J.12
-
11
-
-
0031962269
-
Quinolinic acid in vivo synthesis rates, extracellular concentrations, and intercompartmental distributions in normal and immune-activated brain as determined by multiple-isotope microdialysis
-
Beagles KE, Morrison PF, Heyes MP (1998) Quinolinic acid in vivo synthesis rates, extracellular concentrations, and intercompartmental distributions in normal and immune-activated brain as determined by multiple-isotope microdialysis. J Neurochem 70:281–291
-
(1998)
J Neurochem
, vol.70
, pp. 281-291
-
-
Beagles, K.E.1
Morrison, P.F.2
Heyes, M.P.3
-
12
-
-
31144451624
-
The p53/Mdm2/p14ARF cell cycle control pathway genes may be inactivated by genetic and epigenetic mechanisms in gliomas
-
Bello MJ, Resy JA (2006) The p53/Mdm2/p14ARF cell cycle control pathway genes may be inactivated by genetic and epigenetic mechanisms in gliomas. Cancer Genet Cytogenet 164:172–173
-
(2006)
Cancer Genet Cytogenet
, vol.164
, pp. 172-173
-
-
Bello, M.J.1
Resy, J.A.2
-
14
-
-
0023809607
-
Kynurenate and FG9041 have both competitive and non-competitive antagonist actions at excitatory amino acid receptors
-
Birch PJ, Grossman CJ, Hayes AG (1988) Kynurenate and FG9041 have both competitive and non-competitive antagonist actions at excitatory amino acid receptors. Eur J Pharmacol 151:313–315
-
(1988)
Eur J Pharmacol
, vol.151
, pp. 313-315
-
-
Birch, P.J.1
Grossman, C.J.2
Hayes, A.G.3
-
15
-
-
0033601073
-
Methylation-induced repression—belts, braces, and chromatin
-
Bird AP, Wolffe AP (1999) Methylation-induced repression—belts, braces, and chromatin. Cell 99:451–454
-
(1999)
Cell
, vol.99
, pp. 451-454
-
-
Bird, A.P.1
Wolffe, A.P.2
-
16
-
-
0034769118
-
Nitric oxide and the immune response
-
Bogdan C (2001) Nitric oxide and the immune response. Nat Immunol 2:907–916
-
(2001)
Nat Immunol
, vol.2
, pp. 907-916
-
-
Bogdan, C.1
-
17
-
-
0033552047
-
Morphology and compartmental location of cells exhibiting DNA damage after quinolinic acid injections into rat striatum
-
Bordelon YM, Mackenzie L, Chesselet MF (1999) Morphology and compartmental location of cells exhibiting DNA damage after quinolinic acid injections into rat striatum. J Comp Neurol 412:38–50
-
(1999)
J Comp Neurol
, vol.412
, pp. 38-50
-
-
Bordelon, Y.M.1
Mackenzie, L.2
Chesselet, M.F.3
-
18
-
-
67651228062
-
Effects of kynurenine pathway metabolites on intracellular NAD synthesis and cell death in human primary astrocytes and neurons
-
Braidy N, Grant R, Brew BJ, Adams S, Jayasena T, Guillemin GJ (2009) Effects of kynurenine pathway metabolites on intracellular NAD synthesis and cell death in human primary astrocytes and neurons. Int J Tryptophan Res 2:61–69
-
(2009)
Int J Tryptophan Res
, vol.2
, pp. 61-69
-
-
Braidy, N.1
Grant, R.2
Brew, B.J.3
Adams, S.4
Jayasena, T.5
Guillemin, G.J.6
-
19
-
-
17844397949
-
The role of interleukin-8 and its receptors in gliomagenesis and tumoral angiogenesis
-
Brat DJ, Bellail AC, Van Meir EG (2005) The role of interleukin-8 and its receptors in gliomagenesis and tumoral angiogenesis. Neuro Oncol 7:122–133
-
(2005)
Neuro Oncol
, vol.7
, pp. 122-133
-
-
Brat, D.J.1
Bellail, A.C.2
Van Meir, E.G.3
-
20
-
-
0037106658
-
Synthesis of stable-isotope enriched 5-methylpyrimidines and their use as probes of base reactivity in DNA
-
Burdzy A, Noyes KT, Valinluck V, Sowers LC (2002) Synthesis of stable-isotope enriched 5-methylpyrimidines and their use as probes of base reactivity in DNA. Nucleic Acids Res 30:4068–4074
-
(2002)
Nucleic Acids Res
, vol.30
, pp. 4068-4074
-
-
Burdzy, A.1
Noyes, K.T.2
Valinluck, V.3
Sowers, L.C.4
-
21
-
-
54549108740
-
Comprehensive genomic characterization defines human glioblastoma genes and core pathways
-
Cancer Genome Atlas Research Network
-
Cancer Genome Atlas Research Network (2008) Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 455:1061–1068
-
(2008)
Nature
, vol.455
, pp. 1061-1068
-
-
-
23
-
-
84864659333
-
The promoter hypermethylation status of GATA6, MGMT and FHIT in glioblastoma
-
Cecener G, Tunca B, Egeli U, Bekar A, Tezcan G, Erturk E, Bayram N, Tolunay S (2012) The promoter hypermethylation status of GATA6, MGMT and FHIT in glioblastoma. Cell Mol Neurobiol 32:237–244
-
(2012)
Cell Mol Neurobiol
, vol.32
, pp. 237-244
-
-
Cecener, G.1
Tunca, B.2
Egeli, U.3
Bekar, A.4
Tezcan, G.5
Erturk, E.6
Bayram, N.7
Tolunay, S.8
-
24
-
-
77956803700
-
The perivascular niche microenvironment in brain tumor progression
-
Charles N, Holland EC (2010) The perivascular niche microenvironment in brain tumor progression. Cell Cycle 9:3012–3021
-
(2010)
Cell Cycle
, vol.9
, pp. 3012-3021
-
-
Charles, N.1
Holland, E.C.2
-
25
-
-
84856226955
-
The brain tumor microenvironment
-
Charles NA, Holland EC, Gilbertson R, Glass R, Kettenmann H (2012) The brain tumor microenvironment. Glia 60:502–514
-
(2012)
Glia
, vol.60
, pp. 502-514
-
-
Charles, N.A.1
Holland, E.C.2
Gilbertson, R.3
Glass, R.4
Kettenmann, H.5
-
26
-
-
79956294973
-
DNA methylation and demethylation in mammals
-
Chen ZX, Riggs AD (2011) DNA methylation and demethylation in mammals. J Biol Chem 286:18347–18353
-
(2011)
J Biol Chem
, vol.286
, pp. 18347-18353
-
-
Chen, Z.X.1
Riggs, A.D.2
-
27
-
-
84859183715
-
Malignant glioma: Lessons from genomics, mouse models, and stem cells
-
Chen J, McKay RM, Parada LF (2012) Malignant glioma: lessons from genomics, mouse models, and stem cells. Cell 149:36–47
-
(2012)
Cell
, vol.149
, pp. 36-47
-
-
Chen, J.1
McKay, R.M.2
Parada, L.F.3
-
28
-
-
0034750095
-
Synthesis and release of neurotoxic kynurenine metabolites by human monocyte-derived macrophages
-
Chiarugi A, Calvani M, Meli E, Traggiai E, Moroni F (2001a) Synthesis and release of neurotoxic kynurenine metabolites by human monocyte-derived macrophages. J Neuroimmunol 120:190–198
-
(2001)
J Neuroimmunol
, vol.120
, pp. 190-198
-
-
Chiarugi, A.1
Calvani, M.2
Meli, E.3
Traggiai, E.4
Moroni, F.5
-
29
-
-
0035010218
-
Similarities and differences in the neuronal death processes activated by 3OH-kynurenine and quinolinic acid
-
Chiarugi A, Meli E, Moroni F (2001b) Similarities and differences in the neuronal death processes activated by 3OH-kynurenine and quinolinic acid. J Neurochem 77:1310–1318
-
(2001)
J Neurochem
, vol.77
, pp. 1310-1318
-
-
Chiarugi, A.1
Meli, E.2
Moroni, F.3
-
30
-
-
79952509861
-
Cooperativity within and among Pten, p53 and Rb pathways induces high-grade astrocytoma in adult brain
-
Chow LM, Endersby R, Zhu X, Rankin S, Qu C, Zhang J, Broniscer A, Ellison DW, Baker SJ (2011) Cooperativity within and among Pten, p53 and Rb pathways induces high-grade astrocytoma in adult brain. Cancer Cell 19:305–316
-
(2011)
Cancer Cell
, vol.19
, pp. 305-316
-
-
Chow, L.M.1
Endersby, R.2
Zhu, X.3
Rankin, S.4
Qu, C.5
Zhang, J.6
Broniscer, A.7
Ellison, D.W.8
Baker, S.J.9
-
31
-
-
0014128373
-
Eosinophilic response in glioblastoma tissue culture after addition of autologous lymphocytes
-
Ciembroniewicz J, Kolar O (1967) Eosinophilic response in glioblastoma tissue culture after addition of autologous lymphocytes. Science 157:1054–1055
-
(1967)
Science
, vol.157
, pp. 1054-1055
-
-
Ciembroniewicz, J.1
Kolar, O.2
-
32
-
-
79951810964
-
Embryonic lethal phenotype reveals a function of TDG in maintaining epigenetic stability
-
Cortázar D, Kunz C, Selfridge J, Lettieri T, Saito Y, MacDougall E, Wirz A, Schuermann D, Jacobs AL, Siegrist F, Steinacher R, Jiricny J, Bird A, Schär P (2011) Embryonic lethal phenotype reveals a function of TDG in maintaining epigenetic stability. Nature 470:419–423
-
(2011)
Nature
, vol.470
, pp. 419-423
-
-
Cortázar, D.1
Kunz, C.2
Selfridge, J.3
Lettieri, T.4
Saito, Y.5
Macdougall, E.6
Wirz, A.7
Schuermann, D.8
Jacobs, A.L.9
Siegrist, F.10
Steinacher, R.11
Jiricny, J.12
Bird, A.13
Schär, P.14
-
33
-
-
79959937861
-
Thymine DNA glycosylase is essential for active DNA demethylation by linked deamination-base excision repair
-
Cortellino S, Xu J, Sannai M, Moore R, Caretti E, Cigliano A, Le Coz M, Devarajian K, Wessels A, Soprano D, Abramowitz LK, Bartolomei MS, Rambow F, Bassi MR, Fanciulli M, Renner C, Klein-Szanto AJ, Matsumoto Y, Kobi D, Davidson I, Alberti C, Larue L, Bellacosa A (2011) Thymine DNA glycosylase is essential for active DNA demethylation by linked deamination-base excision repair. Cell 146:67–79
-
(2011)
Cell
, vol.146
, pp. 67-79
-
-
Cortellino, S.1
Xu, J.2
Sannai, M.3
Moore, R.4
Caretti, E.5
Cigliano, A.6
Le Coz, M.7
Devarajian, K.8
Wessels, A.9
Soprano, D.10
Abramowitz, L.K.11
Bartolomei, M.S.12
Rambow, F.13
Bassi, M.R.14
Fanciulli, M.15
Renner, C.16
Klein-Szanto, A.J.17
Matsumoto, Y.18
Kobi, D.19
Davidson, I.20
Alberti, C.21
Larue, L.22
Bellacosa, A.23
more..
-
34
-
-
0029967152
-
Silencing of p16/CDKN2 expression in human gliomas by methylation and chromatin condensation
-
Costello JF, Berger MS, Huang HS, Cavenee WK (1996) Silencing of p16/CDKN2 expression in human gliomas by methylation and chromatin condensation. Cancer Res 56:2405–2410
-
(1996)
Cancer Res
, vol.56
, pp. 2405-2410
-
-
Costello, J.F.1
Berger, M.S.2
Huang, H.S.3
Cavenee, W.K.4
-
35
-
-
79951934032
-
Interferon-γ regulates the proliferation and differentiation of mesenchymal stem cells via activation of indoleamine 2,3 dioxygenase (IDO)
-
Croitoru-Lamoury J, Lamoury FM, Caristo M, Suzuki K, Walker D, Takikawa O, Taylor R, Brew BJ (2011) Interferon-γ regulates the proliferation and differentiation of mesenchymal stem cells via activation of indoleamine 2,3 dioxygenase (IDO). PLoS One 16:e14698
-
(2011)
Plos One
, vol.16
-
-
Croitoru-Lamoury, J.1
Lamoury, F.M.2
Caristo, M.3
Suzuki, K.4
Walker, D.5
Takikawa, O.6
Taylor, R.7
Brew, B.J.8
-
37
-
-
80051617751
-
GM-CSF production by glioblastoma cells has a functional role in eosinophil survival, activation, and growth factor production for enhanced tumor cell proliferation
-
Curran CS, Evans MD, Bertics PJ (2011) GM-CSF production by glioblastoma cells has a functional role in eosinophil survival, activation, and growth factor production for enhanced tumor cell proliferation. J Immunol 187:1254–1263
-
(2011)
J Immunol
, vol.187
, pp. 1254-1263
-
-
Curran, C.S.1
Evans, M.D.2
Bertics, P.J.3
-
38
-
-
84871498059
-
Transcriptional regulation of thymine DNA glycosylase (TDG) by the tumor suppressor protein p53
-
da Costa NM, Hautefeuille A, Cros MP, Melendez ME, Waters T, Swann P, Hainaut P, Pinto LF (2012) Transcriptional regulation of thymine DNA glycosylase (TDG) by the tumor suppressor protein p53. Cell Cycle 11:4570–4578
-
(2012)
Cell Cycle
, vol.11
, pp. 4570-4578
-
-
Da Costa, N.M.1
Hautefeuille, A.2
Cros, M.P.3
Melendez, M.E.4
Waters, T.5
Swann, P.6
Hainaut, P.7
Pinto, L.F.8
-
39
-
-
79957897718
-
Glutamate and the biology of gliomas
-
de Groot J, Sontheimer H (2011) Glutamate and the biology of gliomas. Glia 59:1181–1189
-
(2011)
Glia
, vol.59
, pp. 1181-1189
-
-
De Groot, J.1
Sontheimer, H.2
-
40
-
-
84857036712
-
Quantitative methylation analysis of HOXA3, 7, 9, and 10 genes in glioma: Association with tumor WHO grade and clinical outcome
-
di Vinci A, Casciano I, Marasco E, Banelli B, Ravetti GL, Borzi L, Brigati C, Forlani A, Dorcaratto A, Allemanni G, Zona G, Spaziante R, Gohlke H, Gardin G, Merlo DF, Mantovani V, Romani M (2012) Quantitative methylation analysis of HOXA3, 7, 9, and 10 genes in glioma: association with tumor WHO grade and clinical outcome. J Cancer Res Clin Oncol 138:35–47
-
(2012)
J Cancer Res Clin Oncol
, vol.138
, pp. 35-47
-
-
Di Vinci, A.1
Casciano, I.2
Marasco, E.3
Banelli, B.4
Ravetti, G.L.5
Borzi, L.6
Brigati, C.7
Forlani, A.8
Dorcaratto, A.9
Allemanni, G.10
Zona, G.11
Spaziante, R.12
Gohlke, H.13
Gardin, G.14
Merlo, D.F.15
Mantovani, V.16
Romani, M.17
-
41
-
-
84859847164
-
Emerging insights into the molecular and cellular basis of glioblastoma
-
Dunn GP, Rinne ML, Wykosky J, Genovese G, Quayle SN, Dunn IF, Agarwalla PK, Chheda MG, Campos B, Wang A, Brennan C, Ligon KL, Furnari F, Cavenee WK, Depinho RA, Chin L, Hahn WC (2012) Emerging insights into the molecular and cellular basis of glioblastoma. Genes Dev 26:756–784
-
(2012)
Genes Dev
, vol.26
, pp. 756-784
-
-
Dunn, G.P.1
Rinne, M.L.2
Wykosky, J.3
Genovese, G.4
Quayle, S.N.5
Dunn, I.F.6
Agarwalla, P.K.7
Chheda, M.G.8
Campos, B.9
Wang, A.10
Brennan, C.11
Ligon, K.L.12
Furnari, F.13
Cavenee, W.K.14
Depinho, R.A.15
Chin, L.16
Hahn, W.C.17
-
42
-
-
84855533921
-
Chromatin structure and expression of the AMPA receptor subunit Glur2 in human glioma cells: Major regulatory role of REST and Sp1
-
Ekici M, Keim A, Rössler OG, Hohl M, Thiel G (2012) Chromatin structure and expression of the AMPA receptor subunit Glur2 in human glioma cells: major regulatory role of REST and Sp1. J Cell Biochem 113:528–543
-
(2012)
J Cell Biochem
, vol.113
, pp. 528-543
-
-
Ekici, M.1
Keim, A.2
Rössler, O.G.3
Hohl, M.4
Thiel, G.5
-
43
-
-
0034626988
-
Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents
-
Esteller M, Garcia-Foncillas J, Andion E, Goodman SN, Hidalgo OF, Vanaclocha V, Baylin SB, Herman JG (2000) Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents. N Engl J Med 343:1350–1354
-
(2000)
N Engl J Med
, vol.343
, pp. 1350-1354
-
-
Esteller, M.1
Garcia-Foncillas, J.2
Ion, E.3
Goodman, S.N.4
Hidalgo, O.F.5
Vanaclocha, V.6
Baylin, S.B.7
Herman, J.G.8
-
44
-
-
0036730844
-
Purine, kynurenine, neopterin and lipid peroxidation levels in inflammatory bowel disease
-
Forrest CM, Youd P, Kennedy A, Gould SR, Darlington LG, Stone TW (2002) Purine, kynurenine, neopterin and lipid peroxidation levels in inflammatory bowel disease. J Biomed Sci 9:436–442
-
(2002)
J Biomed Sci
, vol.9
, pp. 436-442
-
-
Forrest, C.M.1
Youd, P.2
Kennedy, A.3
Gould, S.R.4
Darlington, L.G.5
Stone, T.W.6
-
45
-
-
0032873307
-
Neutrophil infiltration into human gliomas
-
Fossati G, Ricevuti G, Edwards SW, Walker C, Dalton A, Rossi ML (1999) Neutrophil infiltration into human gliomas. Acta Neuropathol 98:349–354
-
(1999)
Acta Neuropathol
, vol.98
, pp. 349-354
-
-
Fossati, G.1
Ricevuti, G.2
Edwards, S.W.3
Walker, C.4
Dalton, A.5
Rossi, M.L.6
-
46
-
-
0034610723
-
A mutant oncolytic adenovirus targeting the Rb pathway produces anti-glioma effect in vivo
-
Fueyo J, Gomez-Mazano C, Alemany R, Lee PS, McDonnell TJ, Mitlianga P, Shi Y, Levin VA, Yung WK, Kyritsis AP (2000) A mutant oncolytic adenovirus targeting the Rb pathway produces anti-glioma effect in vivo. Oncogene 19:2–12
-
(2000)
Oncogene
, vol.19
, pp. 2-12
-
-
Fueyo, J.1
Gomez-Mazano, C.2
Alemany, R.3
Lee, P.S.4
McDonnell, T.J.5
Mitlianga, P.6
Shi, Y.7
Levin, V.A.8
Yung, W.K.9
Kyritsis, A.P.10
-
47
-
-
84864859391
-
PARP-1 protein expression in glioblastoma multiforme
-
Galia A, Calogero AE, Condorelli R, Fraggetta F, La Corte A, Ridolfo F, Bosco P, Castiglione R, Salemi M (2012) PARP-1 protein expression in glioblastoma multiforme. Eur J Histochem 56:e9
-
(2012)
Eur J Histochem
, vol.56
-
-
Galia, A.1
Calogero, A.E.2
Condorelli, R.3
Fraggetta, F.4
La Corte, A.5
Ridolfo, F.6
Bosco, P.7
Castiglione, R.8
Salemi, M.9
-
48
-
-
78650826181
-
Tissue distribution of 5-hydroxymethylcytosine and search for active demethylation intermediates
-
Globisch D, Munzel M, Muller M, Michalkas S, Wagner M, Koch S, Bruckl T, Biel M, Carell T (2010) Tissue distribution of 5-hydroxymethylcytosine and search for active demethylation intermediates. PLoS One 5:e15367
-
(2010)
Plos One
, vol.5
-
-
Globisch, D.1
Munzel, M.2
Muller, M.3
Michalkas, S.4
Wagner, M.5
Koch, S.6
Bruckl, T.7
Biel, M.8
Carell, T.9
-
49
-
-
79952751250
-
Overcoming temozolomide resistance in glioblastoma via dual inhibition of NAD+ biosynthesis and base excision repair
-
Goellner EM, Grimme B, Brown AR, Lin YC, Wang XH, Sugrue KF, Mitchell L, Trivedi RN, Tang JB, Sobol RW (2011) Overcoming temozolomide resistance in glioblastoma via dual inhibition of NAD+ biosynthesis and base excision repair. Cancer Res 71:2308–2317
-
(2011)
Cancer Res
, vol.71
, pp. 2308-2317
-
-
Goellner, E.M.1
Grimme, B.2
Brown, A.R.3
Lin, Y.C.4
Wang, X.H.5
Sugrue, K.F.6
Mitchell, L.7
Trivedi, R.N.8
Tang, J.B.9
Sobol, R.W.10
-
50
-
-
67651093930
-
Aryl hydrocarbon receptor inhibition downregulates the TGF-beta/smad pathway in human glioblastoma cells
-
Gramatzki D, Pantazis G, Schittenhelm J, Tabatabai G, Köhle C, Wick W, Schwarz M, Weller M, Tritschler I (2009) Aryl hydrocarbon receptor inhibition downregulates the TGF-beta/smad pathway in human glioblastoma cells. Oncogene 28:2593–2605
-
(2009)
Oncogene
, vol.28
, pp. 2593-2605
-
-
Gramatzki, D.1
Pantazis, G.2
Schittenhelm, J.3
Tabatabai, G.4
Köhle, C.5
Wick, W.6
Schwarz, M.7
Weller, M.8
Tritschler, I.9
-
51
-
-
0031930117
-
Murine glial cells regenerate NAD, after peroxide-induced depletion, using either nicotinic acid, nicotinamide, or quinolinic acid as substrates
-
Grant RS, Kapoor V (1998) Murine glial cells regenerate NAD, after peroxide-induced depletion, using either nicotinic acid, nicotinamide, or quinolinic acid as substrates. J Neurochem 70:1759–1763
-
(1998)
J Neurochem
, vol.70
, pp. 1759-1763
-
-
Grant, R.S.1
Kapoor, V.2
-
52
-
-
0028071555
-
Mutations in the p53 tumor suppressor gene: Clues to cancer etiology and molecular pathogenesis
-
Greenblatt MS, Bennett WP, Hollstein M, Harris CC (1994) Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis. Cancer Res 54:4855–4878
-
(1994)
Cancer Res
, vol.54
, pp. 4855-4878
-
-
Greenblatt, M.S.1
Bennett, W.P.2
Hollstein, M.3
Harris, C.C.4
-
53
-
-
0034894035
-
Kynurenine pathway metabolism in human astrocytes: A paradox for neuronal protection
-
Guillemin GJ, Kerr SJ, Smythe GA, Smith DG, Kapoor V, Armati PJ, Croitoru J, Brew BJ (2001) Kynurenine pathway metabolism in human astrocytes: a paradox for neuronal protection. J Neurochem 78:842–853
-
(2001)
J Neurochem
, vol.78
, pp. 842-853
-
-
Guillemin, G.J.1
Kerr, S.J.2
Smythe, G.A.3
Smith, D.G.4
Kapoor, V.5
Armati, P.J.6
Croitoru, J.7
Brew, B.J.8
-
54
-
-
36448939072
-
Characterization of the kynurenine pathway in human neurons
-
Guillemin GJ, Cullen KM, Lim CK, Smythe GA, Garner B, Kapoor V, Takikawa O, Brew BJ (2007) Characterization of the kynurenine pathway in human neurons. J Neurosci 27:12884–12892
-
(2007)
J Neurosci
, vol.27
, pp. 12884-12892
-
-
Guillemin, G.J.1
Cullen, K.M.2
Lim, C.K.3
Smythe, G.A.4
Garner, B.5
Kapoor, V.6
Takikawa, O.7
Brew, B.J.8
-
55
-
-
79955538247
-
Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain
-
Guo JU, Su Y, Zhong C, Ming GL, Song H (2011) Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain. Cell 145:423–434
-
(2011)
Cell
, vol.145
, pp. 423-434
-
-
Guo, J.U.1
Su, Y.2
Zhong, C.3
Ming, G.L.4
Song, H.5
-
56
-
-
84856058152
-
Global 5-hydroxymethylcytosine content is significantly reduced in tissue stem/progenitor cell compartments and in human cancers
-
Haffner MC, Chaux A, Meeker AK, Esopi DM, Gerber J, Pellakuru LG, Toubaji A, Argani P, Iacobuzio-Donahue C, Nelson WG, Netto GJ, De Marzo AM, Yegnasubramanian S (2011) Global 5-hydroxymethylcytosine content is significantly reduced in tissue stem/progenitor cell compartments and in human cancers. Oncotarget 2:627–637
-
(2011)
Oncotarget
, vol.2
, pp. 627-637
-
-
Haffner, M.C.1
Chaux, A.2
Meeker, A.K.3
Esopi, D.M.4
Gerber, J.5
Pellakuru, L.G.6
Toubaji, A.7
Argani, P.8
Iacobuzio-Donahue, C.9
Nelson, W.G.10
Netto, G.J.11
De Marzo, A.M.12
Yegnasubramanian, S.13
-
57
-
-
80052495940
-
Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA
-
He YF, Li BZ, Li Z, Liu P, Wang Y, Tang Q, Ding J, Jia Y, Chen Z, Li L, Sun Y, Li X, Dai Q, Song CX, Zhang K, He C, Xu GL (2011) Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA. Science 333:1303–1307
-
(2011)
Science
, vol.333
, pp. 1303-1307
-
-
He, Y.F.1
Li, B.Z.2
Li, Z.3
Liu, P.4
Wang, Y.5
Tang, Q.6
Ding, J.7
Jia, Y.8
Chen, Z.9
Li, L.10
Sun, Y.11
Li, X.12
Dai, Q.13
Song, C.X.14
Zhang, K.15
He, C.16
Xu, G.L.17
-
58
-
-
67449108171
-
Enzymatic methylation of DNA in cultured human cells studied by stable isotope incorporation and mass spectrometry
-
Herring JL, Rogstad DK, Sowers LC (2009) Enzymatic methylation of DNA in cultured human cells studied by stable isotope incorporation and mass spectrometry. Chem Res Toxicol 22:1060–1068
-
(2009)
Chem Res Toxicol
, vol.22
, pp. 1060-1068
-
-
Herring, J.L.1
Rogstad, D.K.2
Sowers, L.C.3
-
59
-
-
0029960647
-
Human microglia convert l-tryptophan into the neurotoxin quinolinic acid
-
Heyes MP, Achim CL, Wiley CA, Major EO, Saito K, Markey SP (1996) Human microglia convert l-tryptophan into the neurotoxin quinolinic acid. Biochem J 320:595–597
-
(1996)
Biochem J
, vol.320
, pp. 595-597
-
-
Heyes, M.P.1
Achim, C.L.2
Wiley, C.A.3
Major, E.O.4
Saito, K.5
Markey, S.P.6
-
60
-
-
77649232073
-
Formation of 8-nitroguanine, a nitrative DNA lesion, in inflammation-related carcinogenesis and its significance
-
Hiraku Y (2010) Formation of 8-nitroguanine, a nitrative DNA lesion, in inflammation-related carcinogenesis and its significance. Environ Health Prev Med 15:63–72
-
(2010)
Environ Health Prev Med
, vol.15
, pp. 63-72
-
-
Hiraku, Y.1
-
61
-
-
84866330908
-
Elevated cerebrospinal fluid kynurenic acid levels in patients with tick-borne encephalitis
-
Holtze M, Mickiené A, Atlas A, Lindquist L, Schwieler L (2012) Elevated cerebrospinal fluid kynurenic acid levels in patients with tick-borne encephalitis. J Intern Med 272:394–401
-
(2012)
J Intern Med
, vol.272
, pp. 394-401
-
-
Holtze, M.1
Mickiené, A.2
Atlas, A.3
Lindquist, L.4
Schwieler, L.5
-
62
-
-
47749135194
-
Receptor “hijacking” by malignant glioma cells: A tactic for tumor progression
-
Huang J, Chen K, Gong W, Zhou Y, Le Y, Bian X, Wang JM (2008) Receptor “hijacking” by malignant glioma cells: a tactic for tumor progression. Cancer Lett 267:254–261
-
(2008)
Cancer Lett
, vol.267
, pp. 254-261
-
-
Huang, J.1
Chen, K.2
Gong, W.3
Zhou, Y.4
Le, Y.5
Bian, X.6
Wang, J.M.7
-
63
-
-
77951599543
-
Targeting brain cancer: Advances in the molecular pathology of malignant glioma and medulloblastoma
-
Huse JT, Holland EC (2010) Targeting brain cancer: advances in the molecular pathology of malignant glioma and medulloblastoma. Nat Rev Cancer 10:319–331
-
(2010)
Nat Rev Cancer
, vol.10
, pp. 319-331
-
-
Huse, J.T.1
Holland, E.C.2
-
64
-
-
84863876734
-
Overview of primary brain tumors. Pathologic classification, epidemiology, molecular biology, and prognostic markers
-
Huttner A (2012) Overview of primary brain tumors. Pathologic classification, epidemiology, molecular biology, and prognostic markers. Hematol Oncol Clin North Am 26:715–732
-
(2012)
Hematol Oncol Clin North Am
, vol.26
, pp. 715-732
-
-
Huttner, A.1
-
65
-
-
80054888292
-
Hypothesis: Are neoplastic macrophages/microglia present in glioblastoma multiforme?
-
Huysentruyt LC, Akgoc Z, Seyfried TN (2011) Hypothesis: are neoplastic macrophages/microglia present in glioblastoma multiforme? ASN Neuro 3:183–193
-
(2011)
ASN Neuro
, vol.3
, pp. 183-193
-
-
Huysentruyt, L.C.1
Akgoc, Z.2
Seyfried, T.N.3
-
66
-
-
34547438107
-
Ca2+-permeable AMPA receptors regulate growth of human glioblastoma via Akt activation
-
Ishiuchi S, Yoshida Y, Sugawara K, Aihara M, Ohtani T, Watanabe T, Saito N, Tsuzuki K, Okado H, Miwa A, Nakazato Y, Ozawa S (2007) Ca2+-permeable AMPA receptors regulate growth of human glioblastoma via Akt activation. J Neurosci 27:7987–8001
-
(2007)
J Neurosci
, vol.27
, pp. 7987-8001
-
-
Ishiuchi, S.1
Yoshida, Y.2
Sugawara, K.3
Aihara, M.4
Ohtani, T.5
Watanabe, T.6
Saito, N.7
Tsuzuki, K.8
Okado, H.9
Miwa, A.10
Nakazato, Y.11
Ozawa, S.12
-
67
-
-
33750327219
-
Expression analyses of 27 DNA repair genes in astrocytoma by TaqMan low-density array
-
Jiang Z, Hu J, Li X, Jiang Y, Zhou W, Lu D (2006) Expression analyses of 27 DNA repair genes in astrocytoma by TaqMan low-density array. Neurosci Lett 409:112–117
-
(2006)
Neurosci Lett
, vol.409
, pp. 112-117
-
-
Jiang, Z.1
Hu, J.2
Li, X.3
Jiang, Y.4
Zhou, W.5
Lu, D.6
-
68
-
-
84255200412
-
Pfeifer GP (2011) 5-Hydroxymethylcytosine is strongly depleted in human cancers but its levels do not correlate with IDH1 mutations
-
Jin SG, Jiang Y, Qui R, Rauch TA, Wang Y, Schackert G, Krex D, Lu Q, Pfeifer GP (2011) 5-Hydroxymethylcytosine is strongly depleted in human cancers but its levels do not correlate with IDH1 mutations. Cancer Res 71:7360–7365
-
Cancer Res
, vol.71
, pp. 7360-7365
-
-
Jin, S.G.1
Jiang, Y.2
Qui, R.3
Rauch, T.A.4
Wang, Y.5
Schackert, G.6
Krex, D.7
Lu, Q.8
-
69
-
-
47049119999
-
Examination of hypochlorous acid-induced damage to cytosine residues in a CpG dinucleotide in DNA
-
Kang JI, Sowers LC (2008) Examination of hypochlorous acid-induced damage to cytosine residues in a CpG dinucleotide in DNA. Chem Res Toxicol 21:1211–1218
-
(2008)
Chem Res Toxicol
, vol.21
, pp. 1211-1218
-
-
Kang, J.I.1
Sowers, L.C.2
-
70
-
-
80053215336
-
TET2 promoter methylation in low-grade diffuse gliomas lacking IDH1/2 mutations
-
Kim YH, Pierscianek D, Mittlebronn M, Vital A, Mariani L, Hassleblatt M, Oghaki H (2011) TET2 promoter methylation in low-grade diffuse gliomas lacking IDH1/2 mutations. J Clin Pathol 64:850–852
-
(2011)
J Clin Pathol
, vol.64
, pp. 850-852
-
-
Kim, Y.H.1
Pierscianek, D.2
Mittlebronn, M.3
Vital, A.4
Mariani, L.5
Hassleblatt, M.6
Oghaki, H.7
-
71
-
-
79960318983
-
Distinguishing inflammation from tumor and peritumoral edema by myeloperoxidase magnetic resonance imaging
-
Kleijn A, Chen JW, Buhrman JS, Wojtkiewicz GR, Iwamoto Y, Lamfers ML, Stemmer- Rachamimov AO, Rabkin SD, Weissleder R, Martuza RL, Fulci G (2011) Distinguishing inflammation from tumor and peritumoral edema by myeloperoxidase magnetic resonance imaging. Clin Cancer Res 17:4484–4493
-
(2011)
Clin Cancer Res
, vol.17
, pp. 4484-4493
-
-
Kleijn, A.1
Chen, J.W.2
Buhrman, J.S.3
Wojtkiewicz, G.R.4
Iwamoto, Y.5
Lamfers, M.L.6
Stemmer- Rachamimov, A.O.7
Rabkin, S.D.8
Weissleder, R.9
Martuza, R.L.10
Fulci, G.11
-
72
-
-
32344450824
-
Genomic DNA methylation: The mark and its mediators
-
Klose RJ, Bird AP (2006) Genomic DNA methylation: the mark and its mediators. Trends Biochem Sci 31:89–97
-
(2006)
Trends Biochem Sci
, vol.31
, pp. 89-97
-
-
Klose, R.J.1
Bird, A.P.2
-
74
-
-
84864463122
-
Low values of 5-hydroxymethylcytosine (5hmC), the “sixth base”, are associated with anaplasia in human brain tumors
-
Kraus TF, Globisch D, Wagner M, Eigenbrod S, Widmann D, Munzel M, Muller M, Pfaffender T, Hackner B, Feiden W, Schuller U, Carell T, Kretzschmar HA (2012) Low values of 5-hydroxymethylcytosine (5hmC), the “sixth base”, are associated with anaplasia in human brain tumors. Int J Cancer 131:1577–1590
-
(2012)
Int J Cancer
, vol.131
, pp. 1577-1590
-
-
Kraus, T.F.1
Globisch, D.2
Wagner, M.3
Eigenbrod, S.4
Widmann, D.5
Munzel, M.6
Muller, M.7
Pfaffender, T.8
Hackner, B.9
Feiden, W.10
Schuller, U.11
Carell, T.12
Kretzschmar, H.A.13
-
75
-
-
66149123748
-
The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain
-
Kriaucionis S, Heintz N (2009) The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain. Science 324:929–930
-
(2009)
Science
, vol.324
, pp. 929-930
-
-
Kriaucionis, S.1
Heintz, N.2
-
76
-
-
65549089202
-
Incorporation of 5-chlorocytosine into mammalian DNA results in heritable gene silencing and altered cytosine methylation patterns
-
Lao VV, Herring JL, Kim CH, Darwanto A, Soto U, Sowers C (2009) Incorporation of 5-chlorocytosine into mammalian DNA results in heritable gene silencing and altered cytosine methylation patterns. Carcinogenesis 30:886–893
-
(2009)
Carcinogenesis
, vol.30
, pp. 886-893
-
-
Lao, V.V.1
Herring, J.L.2
Kim, C.H.3
Darwanto, A.4
Soto, U.5
Sowers, C.6
-
77
-
-
78649496745
-
Impact of base analogues within a CpG dinucleotide on the binding of DNA by the methyl-binding domain of MeCP2 and methylation by DNMT1
-
Lao VV, Darwanto A, Sowers LC (2010) Impact of base analogues within a CpG dinucleotide on the binding of DNA by the methyl-binding domain of MeCP2 and methylation by DNMT1. Biochemistry 49:10228–10236
-
(2010)
Biochemistry
, vol.49
, pp. 10228-10236
-
-
Lao, V.V.1
Darwanto, A.2
Sowers, L.C.3
-
78
-
-
84857303269
-
Effects of translocator protein (18 kDa) ligands on microglial activation and neuronal death in the quinolinic- acid-injected rat striatum
-
Leaver KR, Reynolds A, Bodard S, Guilloteau D, Chalon S, Kassiou M (2012) Effects of translocator protein (18 kDa) ligands on microglial activation and neuronal death in the quinolinic- acid-injected rat striatum. ACS Chem Neurosci 3:114–119
-
(2012)
ACS Chem Neurosci
, vol.3
, pp. 114-119
-
-
Leaver, K.R.1
Reynolds, A.2
Bodard, S.3
Guilloteau, D.4
Chalon, S.5
Kassiou, M.6
-
79
-
-
0023551933
-
Inflammation, oxidative DNA damage, and carcinogenesis
-
Lewis JG, Adams DO (1987) Inflammation, oxidative DNA damage, and carcinogenesis. Environ Health Perspect 76:19–27
-
(1987)
Environ Health Perspect
, vol.76
, pp. 19-27
-
-
Lewis, J.G.1
Adams, D.O.2
-
81
-
-
0028762647
-
Excitatory amino acids as a final common pathway for neurologic disorders
-
Lipton SA, Rosenberg PA (1994) Excitatory amino acids as a final common pathway for neurologic disorders. N Engl J Med 330:613–622
-
(1994)
N Engl J Med
, vol.330
, pp. 613-622
-
-
Lipton, S.A.1
Rosenberg, P.A.2
-
82
-
-
84866018949
-
IDH1 mutations inhibit multiple α-ketoglutarate-dependent dioxygenase activities in astroglioma
-
Liu Y, Jiang W, Liu J, Zhao S, Xiong J, Mao Y, Wang Y (2012) IDH1 mutations inhibit multiple α-ketoglutarate-dependent dioxygenase activities in astroglioma. J Neurooncol 109:253–260
-
(2012)
J Neurooncol
, vol.109
, pp. 253-260
-
-
Liu, Y.1
Jiang, W.2
Liu, J.3
Zhao, S.4
Xiong, J.5
Mao, Y.6
Wang, Y.7
-
83
-
-
79952474331
-
Reactive species and DNA damage in chronic inflammation: Reconciling chemical mechanisms and biological fates
-
Lonkar P, Dedon PC (2011) Reactive species and DNA damage in chronic inflammation: reconciling chemical mechanisms and biological fates. Int J Cancer 128:1999–2009
-
(2011)
Int J Cancer
, vol.128
, pp. 1999-2009
-
-
Lonkar, P.1
Dedon, P.C.2
-
84
-
-
61649089532
-
RASSF1A, BLU, NORE1A, PTEN, and MGMT expression and promoter methylation in gliomas and glioma cell lines and evidence of deregulated expression of de novo DNMTs
-
Lorent A, Mueller W, Urdangarin E, Lazcoz P, Lass U, von Deimling A, Castresana JS (2008) RASSF1A, BLU, NORE1A, PTEN, and MGMT expression and promoter methylation in gliomas and glioma cell lines and evidence of deregulated expression of de novo DNMTs. Brain Pathol 19:279–292
-
(2008)
Brain Pathol
, vol.19
, pp. 279-292
-
-
Lorent, A.1
Mueller, W.2
Urdangarin, E.3
Lazcoz, P.4
Lass, U.5
Von Deimling, A.6
Castresana, J.S.7
-
85
-
-
34547122001
-
The 2007 WHO classification of tumors of the central nervous system
-
Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Burger PC, Jouvet A, Scheithauer BW, Kleihues P (2007) The 2007 WHO classification of tumors of the central nervous system. Acta Neuropathol 114:97–109
-
(2007)
Acta Neuropathol
, vol.114
, pp. 97-109
-
-
Louis, D.N.1
Ohgaki, H.2
Wiestler, O.D.3
Cavenee, W.K.4
Burger, P.C.5
Jouvet, A.6
Scheithauer, B.W.7
Kleihues, P.8
-
86
-
-
35148854098
-
Autocrine glutamate signaling promotes glioma cell invasion
-
Lyons SA, Chung WJ, Weaver AK, Ogunrinu T, Sontheimer H (2007) Autocrine glutamate signaling promotes glioma cell invasion. Cancer Res 167:9463–9471
-
(2007)
Cancer Res
, vol.167
, pp. 9463-9471
-
-
Lyons, S.A.1
Chung, W.J.2
Weaver, A.K.3
Ogunrinu, T.4
Sontheimer, H.5
-
87
-
-
59149101258
-
Aberrant expression of myeloperoxidase in astrocytes promotes phospholipid oxidation and memory deficits in a mouse model of Alzheimer disease
-
Maki RA, Tyurin VA, Lyon RC, Hamilton RL, DeKosky ST, Kagan VE, Reynolds WF (2009) Aberrant expression of myeloperoxidase in astrocytes promotes phospholipid oxidation and memory deficits in a mouse model of Alzheimer disease. J Biol Chem 284:3158–3169
-
(2009)
J Biol Chem
, vol.284
, pp. 3158-3169
-
-
Maki, R.A.1
Tyurin, V.A.2
Lyon, R.C.3
Hamilton, R.L.4
Dekosky, S.T.5
Kagan, V.E.6
Reynolds, W.F.7
-
88
-
-
84857625769
-
The kynurenine system and immunoregulation
-
Mándi Y, Vécsei L (2012) The kynurenine system and immunoregulation. J Neural Transm 119:197–209
-
(2012)
J Neural Transm
, vol.119
, pp. 197-209
-
-
Mándi, Y.1
Vécsei, L.2
-
89
-
-
84863582087
-
Infection-induced colitis in mice causes dynamic and tissue-specific changes in stress response and DNA damage leading to colon cancer
-
Mangerich A, Knutson CG, Parry NM, Muthupalani S, Ye W, Prestwich E, Cui L, McFaline JL, Mobley M, Ge Z, Taghizadeh K, Wishnok JS, Wogan GN, Fox JG, Tannenbaum SR, Dedon PC (2012) Infection-induced colitis in mice causes dynamic and tissue-specific changes in stress response and DNA damage leading to colon cancer. Proc Natl Acad Sci USA 109:E1820–E1829
-
(2012)
Proc Natl Acad Sci USA
, vol.109
-
-
Mangerich, A.1
Knutson, C.G.2
Parry, N.M.3
Muthupalani, S.4
Ye, W.5
Prestwich, E.6
Cui, L.7
McFaline, J.L.8
Mobley, M.9
Ge, Z.10
Taghizadeh, K.11
Wishnok, J.S.12
Wogan, G.N.13
Fox, J.G.14
Tannenbaum, S.R.15
Dedon, P.C.16
-
90
-
-
77949266026
-
In vivo assessment of high-grade glioma biochemistry using microdialysis: A study of energy-related molecules, growth factors and cytokines
-
Marcus HJ, Carpenter KL, Price SJ, Hutchinson PJ (2010) In vivo assessment of high-grade glioma biochemistry using microdialysis: a study of energy-related molecules, growth factors and cytokines. J Neurooncol 97:11–23
-
(2010)
J Neurooncol
, vol.97
, pp. 11-23
-
-
Marcus, H.J.1
Carpenter, K.L.2
Price, S.J.3
Hutchinson, P.J.4
-
91
-
-
84872158426
-
Beyond genetics in glioma pathways: The ever-increasing crosstalk between epigenomic and genomic events
-
Martinez R (2012) Beyond genetics in glioma pathways: the ever-increasing crosstalk between epigenomic and genomic events. J Signal Transduct 1–9
-
(2012)
J Signal Transduct
, pp. 1-9
-
-
Martinez, R.1
-
92
-
-
77952888433
-
The DNA methylome of glioblastoma multiforme
-
Martinez R, Esteller M (2010) The DNA methylome of glioblastoma multiforme. Neurobiol Dis 39:40–46
-
(2010)
Neurobiol Dis
, vol.39
, pp. 40-46
-
-
Martinez, R.1
Esteller, M.2
-
93
-
-
69949087520
-
A microarray-based DNA methylation study of glioblastoma multiforme
-
Martinez R, Martin-Subero JI, Rohde V, Kirsch M, Alaminos M, Fernandez AF, Ropero S, Schackert G, Esteller M (2009) A microarray-based DNA methylation study of glioblastoma multiforme. Epigenetics 4:255–264
-
(2009)
Epigenetics
, vol.4
, pp. 255-264
-
-
Martinez, R.1
Martin-Subero, J.I.2
Rohde, V.3
Kirsch, M.4
Alaminos, M.5
Fernandez, A.F.6
Ropero, S.7
Schackert, G.8
Esteller, M.9
-
94
-
-
0027257707
-
Structures of base pairs with 5-(Hydroxymethyl)- 2’-deoxyuridine in DNA determined by NMR spectroscopy
-
Mellac S, Fazakerley GV, Sowers LC (1993) Structures of base pairs with 5-(hydroxymethyl)- 2’-deoxyuridine in DNA determined by NMR spectroscopy. Biochemistry 32:7779–7786
-
(1993)
Biochemistry
, vol.32
, pp. 7779-7786
-
-
Mellac, S.1
Fazakerley, G.V.2
Sowers, L.C.3
-
95
-
-
84878865462
-
Expression of indoleamine 2,3-dioxygenase and correlation with pathological malignancy in gliomas
-
Epub ahead of print
-
Mitsuka K, Kawataki T, Satoh E, Asahara T, Horikoshi T, Kinouchi H (2013) Expression of indoleamine 2,3-dioxygenase and correlation with pathological malignancy in gliomas. Neurosurgery. 19 Feb 2013 (Epub ahead of print)
-
(2013)
Neurosurgery
, pp. 19
-
-
Mitsuka, K.1
Kawataki, T.2
Satoh, E.3
Asahara, T.4
Horikoshi, T.5
Kinouchi, H.6
-
96
-
-
68849112548
-
Indoleamine 2,3-dioxygenase as a new target for malignant glioma therapy: Laboratory investigation
-
Miyazaki T, Moritake K, Yamada K, Hara N, Osago H, Shibata T, Akiyama Y, Tsuchiya M (2009) Indoleamine 2,3-dioxygenase as a new target for malignant glioma therapy: laboratory investigation. J Neurosurg 111:230–237
-
(2009)
J Neurosurg
, vol.111
, pp. 230-237
-
-
Miyazaki, T.1
Moritake, K.2
Yamada, K.3
Hara, N.4
Osago, H.5
Shibata, T.6
Akiyama, Y.7
Tsuchiya, M.8
-
97
-
-
17144460369
-
Quinolinate immunoreactivity in experimental rat brain tumors is present in macrophages but not in astrocytes
-
Moffett JR, Els T, Espey MG, Walter SA, Streit WJ, Namboodiri MA (1997) Quinolinate immunoreactivity in experimental rat brain tumors is present in macrophages but not in astrocytes. Exp Neurol 144:287–301
-
(1997)
Exp Neurol
, vol.144
, pp. 287-301
-
-
Moffett, J.R.1
Els, T.2
Espey, M.G.3
Walter, S.A.4
Streit, W.J.5
Namboodiri, M.A.6
-
98
-
-
79951951235
-
TET genes: New players in DNA demethylation and important determinants for stemness
-
Mohr F, Dohner K, Buske C, Rawat VP (2011) TET genes: new players in DNA demethylation and important determinants for stemness. Exp Hematol 39:272–281
-
(2011)
Exp Hematol
, vol.39
, pp. 272-281
-
-
Mohr, F.1
Dohner, K.2
Buske, C.3
Rawat, V.P.4
-
99
-
-
0033056044
-
Tryptophan metabolism and brain function: Focus on kynurenine and other indole metabolites
-
Moroni F (1999) Tryptophan metabolism and brain function: focus on kynurenine and other indole metabolites. Eur J Pharmacol 375:87–100
-
(1999)
Eur J Pharmacol
, vol.375
, pp. 87-100
-
-
Moroni, F.1
-
100
-
-
0032707364
-
Autocrine growth regulation by granulocyte colony-stimulating factor and granulocyte macrophage colony-stimulating factor in human gliomas with tumor progression
-
Mueller MM, Herold-Mende CC, Riede D, Lange M, Steiner HH, Fusenig NE (1999) Autocrine growth regulation by granulocyte colony-stimulating factor and granulocyte macrophage colony-stimulating factor in human gliomas with tumor progression. Am J Pathol 155:1557–1567
-
(1999)
Am J Pathol
, vol.155
, pp. 1557-1567
-
-
Mueller, M.M.1
Herold-Mende, C.C.2
Riede, D.3
Lange, M.4
Steiner, H.H.5
Fusenig, N.E.6
-
101
-
-
84864120277
-
Nuclear exclusion of TET1 is associated with loss of 5-hydroxymethylcytosine in IDH1 wild-type gliomas
-
Muller T, Gessi M, Waha A, Isselstein LJ, Luxen D, Freihoff D, Freihoff J, Becker A, Simon M, Hammes J, Denkhaus D, Zur Muhlen A, Pietsch T, Waha A (2012) Nuclear exclusion of TET1 is associated with loss of 5-hydroxymethylcytosine in IDH1 wild-type gliomas. Am J Pathol 181:675–683
-
(2012)
Am J Pathol
, vol.181
, pp. 675-683
-
-
Muller, T.1
Gessi, M.2
Waha, A.3
Isselstein, L.J.4
Luxen, D.5
Freihoff, D.6
Freihoff, J.7
Becker, A.8
Simon, M.9
Hammes, J.10
Denkhaus, D.11
Zur Muhlen, A.12
Pietsch, T.13
Waha, A.14
-
102
-
-
70350055199
-
Arginase: An emerging key player in the mammalian immune system
-
Munder M (2009) Arginase: an emerging key player in the mammalian immune system. Br J Pharmacol 158:638–651
-
(2009)
Br J Pharmacol
, vol.158
, pp. 638-651
-
-
Munder, M.1
-
103
-
-
77954842819
-
Quantification of the sixth DNA base hydroxymethylcytosine in the brain
-
Munzel M, Globisch D, Bruckl T, Wagner M, Welzmiller V, Michalkis S, Muller M, Biel M, Carell T (2010) Quantification of the sixth DNA base hydroxymethylcytosine in the brain. Angew Chem Int Ed Engl 49:5375–5377
-
(2010)
Angew Chem Int Ed Engl
, vol.49
, pp. 5375-5377
-
-
Munzel, M.1
Globisch, D.2
Bruckl, T.3
Wagner, M.4
Welzmiller, V.5
Michalkis, S.6
Muller, M.7
Biel, M.8
Carell, T.9
-
104
-
-
79959987448
-
Carell T (2011) 5-hydroxymethylcytosine, the sixth base of the genome
-
Munzel M, Globisch D, Carell T (2011) 5-hydroxymethylcytosine, the sixth base of the genome. Angew Chem Int Ed Engl 50:6460–6468
-
Angew Chem Int Ed Engl
, vol.50
, pp. 6460-6468
-
-
Munzel, M.1
Globisch, D.2
-
105
-
-
67650135901
-
Modulation of angiogenic and inflammatory response in glioblastoma by hypoxia
-
Murat A, Migliavacca E, Hussain SF, Heimberger AB, Desbaillets I, Hamou MF, Ruegg C, Stupp R, Delorenzi M, Hegi ME (2009) Modulation of angiogenic and inflammatory response in glioblastoma by hypoxia. PLoS One 4:e5947
-
(2009)
Plos One
, vol.4
-
-
Murat, A.1
Migliavacca, E.2
Hussain, S.F.3
Heimberger, A.B.4
Desbaillets, I.5
Hamou, M.F.6
Ruegg, C.7
Stupp, R.8
Delorenzi, M.9
Hegi, M.E.10
-
107
-
-
78650560167
-
Aryl hydrocarbon receptor negatively regulates dendritic cell immunogenicity via a kynurenine-dependent mechanism
-
Nguyen NT, Kimura A, Nakahama T, Chinen I, Masuda K, Nohara K, Fujii-Kuriyama Y, Kishimoto T (2010) Aryl hydrocarbon receptor negatively regulates dendritic cell immunogenicity via a kynurenine-dependent mechanism. Proc Natl Acad Sci USA 107:19961–19966
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 19961-19966
-
-
Nguyen, N.T.1
Kimura, A.2
Nakahama, T.3
Chinen, I.4
Masuda, K.5
Nohara, K.6
Fujii-Kuriyama, Y.7
Kishimoto, T.8
-
108
-
-
77956294131
-
Targeting EGFR induced oxidative stress by PARP1 inhibition in glioblastoma therapy
-
Nitta M, Kozono D, Kennedy R, Stommel J, Ng K, Zinn PO, Kushwaha D, Kesari S, Inda MD, Wykosky J, Furnari F, Hoadley KA, Chin L, DePinho RA, Cavenee WK, D’Andrea A, Chen CC (2010) Targeting EGFR induced oxidative stress by PARP1 inhibition in glioblastoma therapy. PLoS One 5:e10767
-
(2010)
Plos One
, vol.5
-
-
Nitta, M.1
Kozono, D.2
Kennedy, R.3
Stommel, J.4
Ng, K.5
Zinn, P.O.6
Kushwaha, D.7
Kesari, S.8
Inda, M.D.9
Wykosky, J.10
Furnari, F.11
Hoadley, K.A.12
Chin, L.13
Depinho, R.A.14
Cavenee, W.K.15
D’Andrea, A.16
Chen, C.C.17
-
109
-
-
77952108366
-
The Cancer Genome Atlas Research Network
-
Noushmehr H, Weisenberger DJ, Diefes K, Phillips HS, Pujara K, Berman BP, Pan F, Pelloski CE, Sulman EP, Bhat KP, Verhaak RG, Hoadley KA, Hayes DN, Perou CM, Schmidt HK, Ding L, Wilson RK, Van Den Berg D, Shen H, Bengtsson H, Neuvial P, Cope LM, Buckley J, Herman JG, Baylin SB, Laird PW, Aldape K, The Cancer Genome Atlas Research Network (2010) Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma. Cancer Cell 17:510–522
-
(2010)
Identification of a Cpg Island Methylator Phenotype that Defines a Distinct Subgroup of Glioma. Cancer Cell
, vol.17
, pp. 510-522
-
-
Noushmehr, H.1
Weisenberger, D.J.2
Diefes, K.3
Phillips, H.S.4
Pujara, K.5
Berman, B.P.6
Pan, F.7
Pelloski, C.E.8
Sulman, E.P.9
Bhat, K.P.10
Verhaak, R.G.11
Hoadley, K.A.12
Hayes, D.N.13
Perou, C.M.14
Schmidt, H.K.15
Ding, L.16
Wilson, R.K.17
Van Den Berg, D.18
Shen, H.19
Bengtsson, H.20
Neuvial, P.21
Cope, L.M.22
Buckley, J.23
Herman, J.G.24
Baylin, S.B.25
Laird, P.W.26
Aldape, K.27
more..
-
110
-
-
0034939136
-
Quinolinic acid accumulation during neuroinflammation. Does it imply excitotoxicity?
-
Obrenovitch TP (2001) Quinolinic acid accumulation during neuroinflammation. Does it imply excitotoxicity? Ann NY Acad Sci 939:1–10
-
(2001)
Ann NY Acad Sci
, vol.939
, pp. 1-10
-
-
Obrenovitch, T.P.1
-
111
-
-
84867890070
-
Overexpression of calcium-permeable glutamate receptors in glioblastoma derived brain tumor initiating cells
-
Oh MC, Kim JM, Safaee M, Kaur G, Sun MZ, Kaur R, Celli A, Mauro TM, Parsa AT (2012) Overexpression of calcium-permeable glutamate receptors in glioblastoma derived brain tumor initiating cells. PLoS One 7:e47846
-
(2012)
Plos One
, vol.7
-
-
Oh, M.C.1
Kim, J.M.2
Safaee, M.3
Kaur, G.4
Sun, M.Z.5
Kaur, R.6
Celli, A.7
Mauro, T.M.8
Parsa, A.T.9
-
112
-
-
45449114804
-
The colorful history of active DNA demethylation
-
Ooi SK, Bestor TH (2008) The colorful history of active DNA demethylation. Cell 133:1145–1148
-
(2008)
Cell
, vol.133
, pp. 1145-1148
-
-
Ooi, S.K.1
Bestor, T.H.2
-
113
-
-
80054041992
-
An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor
-
Opitz CA, Litzenburger UM, Sahm F, Ott M, Tritschler I, Trump S, Schumacher T, Jestaedt L, Schrenk D, Weller M, Jugold M, Guillemin GJ, Miller CL, Lutz C, Radlwimmer B, Lehmann I, von Deimling A, Wick W, Platten M (2011) An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor. Nature 478:197–203
-
(2011)
Nature
, vol.478
, pp. 197-203
-
-
Opitz, C.A.1
Litzenburger, U.M.2
Sahm, F.3
Ott, M.4
Tritschler, I.5
Trump, S.6
Schumacher, T.7
Jestaedt, L.8
Schrenk, D.9
Weller, M.10
Jugold, M.11
Guillemin, G.J.12
Miller, C.L.13
Lutz, C.14
Radlwimmer, B.15
Lehmann, I.16
Von Deimling, A.17
Wick, W.18
Platten, M.19
-
114
-
-
84864053192
-
Decreased 5-hydroxymethylcytosine is associated with neural progenitor phenotype in normal brain and shorter survival in malignant glioma
-
Orr BA, Haffner MC, Nelson WG, Yegnasubramanian S, Eberhart CG (2012) Decreased 5-hydroxymethylcytosine is associated with neural progenitor phenotype in normal brain and shorter survival in malignant glioma. PLoS One 7:e41036
-
(2012)
Plos One
, vol.7
-
-
Orr, B.A.1
Haffner, M.C.2
Nelson, W.G.3
Yegnasubramanian, S.4
Eberhart, C.G.5
-
115
-
-
84906914088
-
The role of Nrf2 in migration and invasion of human glioma cell U251
-
(Epub ahead of print)
-
Pan H, Wang H, Zhu L, Mao L, Qiao L, Su X (2012) The role of Nrf2 in migration and invasion of human glioma cell U251. World Neurosurg. 7 Nov 2011 (Epub ahead of print)
-
(2012)
World Neurosurg
, pp. 7
-
-
Pan, H.1
Wang, H.2
Zhu, L.3
Mao, L.4
Qiao, L.5
Su, X.6
-
116
-
-
79956205060
-
Human kynurenine aminotransferase II–reactivity with substrates and inhibitors
-
Passera E, Campanini B, Rossi F, Casazza V, Rizzi M, Pellicciari R, Mozzarelli A (2011) Human kynurenine aminotransferase II–reactivity with substrates and inhibitors. FEBS J 278:1882–1900
-
(2011)
FEBS J
, vol.278
, pp. 1882-1900
-
-
Passera, E.1
Campanini, B.2
Rossi, F.3
Casazza, V.4
Rizzi, M.5
Pellicciari, R.6
Mozzarelli, A.7
-
117
-
-
60149108789
-
Oncolytic adenovirus retargeted to delta-EGFR induces selective antiglioma activity
-
Piao Y, Jiang H, Alemany R, Krasnykh V, Marini FC, Xu J, Alonso MM, Conrad CA, Aldape KD, Gomez-Manzano C, Fueyo J (2009) Oncolytic adenovirus retargeted to delta-EGFR induces selective antiglioma activity. Cancer Gene Ther 16:256–265
-
(2009)
Cancer Gene Ther
, vol.16
, pp. 256-265
-
-
Piao, Y.1
Jiang, H.2
Alemany, R.3
Krasnykh, V.4
Marini, F.C.5
Xu, J.6
Alonso, M.M.7
Conrad, C.A.8
Aldape, K.D.9
Gomez-Manzano, C.10
Fueyo, J.11
-
118
-
-
0029894026
-
Photochemical deamination and demethylation of 5-methylcytosine
-
Privat E, Sowers LC (1996) Photochemical deamination and demethylation of 5-methylcytosine. Chem Res Toxicol 9:745–750
-
(1996)
Chem Res Toxicol
, vol.9
, pp. 745-750
-
-
Privat, E.1
Sowers, L.C.2
-
119
-
-
77950022119
-
CSF concentrations of brain tryptophan and kynurenines during immune stimulation with IFN-alpha: Relationship to CNS immune responses and depression
-
Raison CL, Dantzer R, Kelley KW, Lawson MA, Woolwine BJ, Vogt G, Spivey JR, Saito K, Miller AH (2010) CSF concentrations of brain tryptophan and kynurenines during immune stimulation with IFN-alpha: relationship to CNS immune responses and depression. Mol Psychiatry 15:393–403
-
(2010)
Mol Psychiatry
, vol.15
, pp. 393-403
-
-
Raison, C.L.1
Dantzer, R.2
Kelley, K.W.3
Lawson, M.A.4
Woolwine, B.J.5
Vogt, G.6
Spivey, J.R.7
Saito, K.8
Miller, A.H.9
-
120
-
-
0242361561
-
Oncogenic Ras and Akt signaling contribute to glioblastoma formation by differential recruitment of existing mRNAs to polysomes
-
Rajasekhar VK, Viale A, Socci ND, Wiedmann M, Hu X, Holland EC (2003) Oncogenic Ras and Akt signaling contribute to glioblastoma formation by differential recruitment of existing mRNAs to polysomes. Mol Cell 12:889–901
-
(2003)
Mol Cell
, vol.12
, pp. 889-901
-
-
Rajasekhar, V.K.1
Viale, A.2
Socci, N.D.3
Wiedmann, M.4
Hu, X.5
Holland, E.C.6
-
121
-
-
0019318994
-
DNA methylation and gene function
-
Razin A, Riggs AD (1980) DNA methylation and gene function. Science 210:604–610
-
(1980)
Science
, vol.210
, pp. 604-610
-
-
Razin, A.1
Riggs, A.D.2
-
122
-
-
77954697566
-
Isocitrate dehydrogenase 1 and 2 mutations in cancer: Alterations at a crossroads of cellular metabolism
-
Reitman ZJ, Yan H (2010) Isocitrate dehydrogenase 1 and 2 mutations in cancer: alterations at a crossroads of cellular metabolism. J Natl Cancer Inst 102:932–941
-
(2010)
J Natl Cancer Inst
, vol.102
, pp. 932-941
-
-
Reitman, Z.J.1
Yan, H.2
-
123
-
-
84856399697
-
Granulocyte-macrophage colony-stimulating factor as an autocrine survival-growth factor in human gliomas
-
Revoltella RP, Menicagli M, Campani D (2011) Granulocyte-macrophage colony-stimulating factor as an autocrine survival-growth factor in human gliomas. Cytokine 57:347–359
-
(2011)
Cytokine
, vol.57
, pp. 347-359
-
-
Revoltella, R.P.1
Menicagli, M.2
Campani, D.3
-
124
-
-
0343819885
-
Amplification and overexpression of the MDM4 (MDMX) gene from 1q32 in a subset of malignant gliomas without TP53 mutation or MDM2 amplification
-
Riemenschneider MJ, Buschges R, Wolter M, Reifenberger J, Bostrom J, Kraus JA, Schlegel U, Reifenberger G (1999) Amplification and overexpression of the MDM4 (MDMX) gene from 1q32 in a subset of malignant gliomas without TP53 mutation or MDM2 amplification. Cancer Res 59:6091–6096
-
(1999)
Cancer Res
, vol.59
, pp. 6091-6096
-
-
Riemenschneider, M.J.1
Buschges, R.2
Wolter, M.3
Reifenberger, J.4
Bostrom, J.5
Kraus, J.A.6
Schlegel, U.7
Reifenberger, G.8
-
125
-
-
0023239736
-
Immunohistological study of mononuclear cell infiltrate in malignant gliomas
-
Rossi ML, Hughes JT, Esri MM, Coakham HB, Brownell DB (1987) Immunohistological study of mononuclear cell infiltrate in malignant gliomas. Acta Neurpathol 74:269–277
-
(1987)
Acta Neurpathol
, vol.74
, pp. 269-277
-
-
Rossi, M.L.1
Hughes, J.T.2
Esri, M.M.3
Coakham, H.B.4
Brownell, D.B.5
-
126
-
-
0034687768
-
An unexpectedly high excision capacity for mispaired 5-hydroxymethyluracil in human cell extracts
-
Rusmintratip V, Sowers LC (2000) An unexpectedly high excision capacity for mispaired 5-hydroxymethyluracil in human cell extracts. Proc Natl Acad Sci USA 97:14183–14187
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 14183-14187
-
-
Rusmintratip, V.1
Sowers, L.C.2
-
127
-
-
83555174898
-
Detection of 2-hydroxyglutarate in formalin-fixed paraffin-embedded glioma specimens by gas chromatography/mass spectrometry
-
Sahm F, Capper D, Pusch S, Balss J, Koch A, Langhans CD, Okun JG, von Deimling A (2011) Detection of 2-hydroxyglutarate in formalin-fixed paraffin-embedded glioma specimens by gas chromatography/mass spectrometry. Brain Path 22:1–6
-
(2011)
Brain Path
, vol.22
, pp. 1-6
-
-
Sahm, F.1
Capper, D.2
Pusch, S.3
Balss, J.4
Koch, A.5
Langhans, C.D.6
Okun, J.G.7
Von Deimling, A.8
-
128
-
-
84878595867
-
The endogenous tryptophan metabolite and NAD+ precursor quinolinic acid confers resistance of gliomas to oxidative stress
-
(Epub ahead of print)
-
Sahm F, Oezen I, Opitz CA, Radlwimmer B, von Deimling A, Ahrendt T, Adams S, Bode HB, Guillemin GJ, Wick W, Platten M (2013) The endogenous tryptophan metabolite and NAD+ precursor quinolinic acid confers resistance of gliomas to oxidative stress. Cancer Res. 2 Apr 2013 (Epub ahead of print)
-
(2013)
Cancer Res
, pp. 2
-
-
Sahm, F.1
Oezen, I.2
Opitz, C.A.3
Radlwimmer, B.4
Von Deimling, A.5
Ahrendt, T.6
Adams, S.7
Bode, H.B.8
Guillemin, G.J.9
Wick, W.10
Platten, M.11
-
129
-
-
0027408778
-
Heyes MP (1993) 4-Chloro-3- hydroxyanthranilate, 6-chloro tryptophan and norharman attenuate quinolinic acid formation by interferon-gamma-stimulated monocytes (THP-1 cells)
-
Saito K, Chen CY, Masana M, Crowley JS, Markey SP, Heyes MP (1993) 4-Chloro-3- hydroxyanthranilate, 6-chloro tryptophan and norharman attenuate quinolinic acid formation by interferon-gamma-stimulated monocytes (THP-1 cells). Biochem J 291:11–14
-
Biochem J
, vol.291
, pp. 11-14
-
-
Saito, K.1
Chen, C.Y.2
Masana, M.3
Crowley, J.S.4
Markey, S.P.5
-
130
-
-
77955709724
-
Glutamate promotes cell growth by EGFR signaling on U-87MG human glioblastoma cell line
-
Schunemann DP, Grivicich I, Regner A, Leal LF, de Araújo DR, Jotz GP, Fedrigo CA, Simon D, da Rocha AB (2010) Glutamate promotes cell growth by EGFR signaling on U-87MG human glioblastoma cell line. Pathol Oncol Res 16:285–293
-
(2010)
Pathol Oncol Res
, vol.16
, pp. 285-293
-
-
Schunemann, D.P.1
Grivicich, I.2
Regner, A.3
Leal, L.F.4
De Araújo, D.R.5
Jotz, G.P.6
Fedrigo, C.A.7
Simon, D.8
Da Rocha, A.B.9
-
131
-
-
0036784518
-
Manipulation of brain kynurenines: Glial targets, neuronal effects, and clinical opportunities
-
Schwarcz R, Pellicciari R (2012) Manipulation of brain kynurenines: glial targets, neuronal effects, and clinical opportunities. J Pharmacol Exp Ther 303:1–10
-
(2012)
J Pharmacol Exp Ther
, vol.303
, pp. 1-10
-
-
Schwarcz, R.1
Pellicciari, R.2
-
132
-
-
0020702374
-
Quinolinic acid: An endogenous metabolite that produces axon-sparing lesions in rat brain
-
Schwarcz R, Whetsell WO Jr, Mangano RM (1983) Quinolinic acid: an endogenous metabolite that produces axon-sparing lesions in rat brain. Science 219:316–318
-
(1983)
Science
, vol.219
, pp. 316-318
-
-
Schwarcz, R.1
Whetsell, W.O.2
Mangano, R.M.3
-
135
-
-
82255162738
-
Targeting inflammation-induced transcription factor activation: An open frontier for glioma therapy
-
Sen E (2011) Targeting inflammation-induced transcription factor activation: an open frontier for glioma therapy. Drug Discov Today 16:1044–1051
-
(2011)
Drug Discov Today
, vol.16
, pp. 1044-1051
-
-
Sen, E.1
-
136
-
-
84874363487
-
DNA methylation profiles of long- and short-term glioblastoma survivors
-
Shinawi T, Hill VK, Krex D, Schackert G, Gentle D, Morris MR, Wei W, Cruickshank G, Maher ER, Latif F (2013) DNA methylation profiles of long- and short-term glioblastoma survivors. Epigenetics 8:149–156
-
(2013)
Epigenetics
, vol.8
, pp. 149-156
-
-
Shinawi, T.1
Hill, V.K.2
Krex, D.3
Schackert, G.4
Gentle, D.5
Morris, M.R.6
Wei, W.7
Cruickshank, G.8
Maher, E.R.9
Latif, F.10
-
137
-
-
81255129169
-
Neutrophil degranulation and immunosuppression in patients with GBM: Restoration of cellular immune function by targeting arginase I
-
Sippel TR, White J, Nag K, Tsvankin V, Klaassen M, Kleinschmidt-DeMasters BK, Waziri A (2011) Neutrophil degranulation and immunosuppression in patients with GBM: restoration of cellular immune function by targeting arginase I. Clin Cancer Res 17:6992–7002
-
(2011)
Clin Cancer Res
, vol.17
, pp. 6992-7002
-
-
Sippel, T.R.1
White, J.2
Nag, K.3
Tsvankin, V.4
Klaassen, M.5
Kleinschmidt-Demasters, B.K.6
Waziri, A.7
-
138
-
-
77955210829
-
Acyclovir inhibition of IDO to decrease tregs as a glioblastoma treatment adjunct
-
Söderlund J, Erhardt S, Kast RE (2010) Acyclovir inhibition of IDO to decrease tregs as a glioblastoma treatment adjunct. J Neuroinflammation 7:44
-
(2010)
J Neuroinflammation
, vol.7
, pp. 44
-
-
Söderlund, J.1
Erhardt, S.2
Kast, R.E.3
-
139
-
-
78650831721
-
Beyond effector caspase inhibition: Bcl2L12 neutralizes p53 signaling in glioblastoma
-
Stegh AH, DePinho RA (2011) Beyond effector caspase inhibition: Bcl2L12 neutralizes p53 signaling in glioblastoma. Cell Cycle 10:33–38
-
(2011)
Cell Cycle
, vol.10
, pp. 33-38
-
-
Stegh, A.H.1
Depinho, R.A.2
-
140
-
-
66549106623
-
The aryl hydrocarbon receptor: A perspective on potential roles in the immune system
-
Stevens EA, Mezrich JD, Bradfield CA (2009) The aryl hydrocarbon receptor: a perspective on potential roles in the immune system. Immunology 127:299–311
-
(2009)
Immunology
, vol.127
, pp. 299-311
-
-
Stevens, E.A.1
Mezrich, J.D.2
Bradfield, C.A.3
-
141
-
-
34147218086
-
Interleukin-1beta but not tumor necrosis factor-alpha potentiates neuronal damage by quinolinic acid: Protection by an adenosine A2A receptor antagonist
-
Stone TW, Behan WM (2007) Interleukin-1beta but not tumor necrosis factor-alpha potentiates neuronal damage by quinolinic acid: protection by an adenosine A2A receptor antagonist. J Neurosci Res 85:1077–1085
-
(2007)
J Neurosci Res
, vol.85
, pp. 1077-1085
-
-
Stone, T.W.1
Behan, W.M.2
-
142
-
-
0027160681
-
Human glioblastoma cells produce 77 amino acid interleukin-8 (IL-8(77))
-
Tada M, Suzuki K, Yamakawa Y, Sawamura Y, Sakuma S, Abe H, van Meir E, de Tribolet N (1993) Human glioblastoma cells produce 77 amino acid interleukin-8 (IL-8(77)). J Neurooncol 16:25–34
-
(1993)
J Neurooncol
, vol.16
, pp. 25-34
-
-
Tada, M.1
Suzuki, K.2
Yamakawa, Y.3
Sawamura, Y.4
Sakuma, S.5
Abe, H.6
Van Meir, E.7
De Tribolet, N.8
-
143
-
-
66149146320
-
Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MML partner TET1
-
Tahiliani M, Koh KP, Shen Y, Pastor WA, Bandukwala H, Brudno Y, Agarwal S, Iyer LM, Liu DR, Aravind L, Rao A (2009) Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MML partner TET1. Science 324:930–935
-
(2009)
Science
, vol.324
, pp. 930-935
-
-
Tahiliani, M.1
Koh, K.P.2
Shen, Y.3
Pastor, W.A.4
Bandukwala, H.5
Brudno, Y.6
Agarwal, S.7
Iyer, L.M.8
Liu, D.R.9
Aravind, L.10
Rao, A.11
-
144
-
-
0030842443
-
Solid phase synthesis and restriction endonuclease cleavage of oligooxynucleotides containing 5-(Hydroxymethyl)-cytosine
-
Tardy-Planechaud S, Fujimoto J, Lin SS, Sowers LC (1997) Solid phase synthesis and restriction endonuclease cleavage of oligooxynucleotides containing 5-(hydroxymethyl)-cytosine. Nucleic Acids Res 25:553–559
-
(1997)
Nucleic Acids Res
, vol.25
, pp. 553-559
-
-
Tardy-Planechaud, S.1
Fujimoto, J.2
Lin, S.S.3
Sowers, L.C.4
-
145
-
-
0029027343
-
Complete and tissue-independent methylation of CpG sites in the p53 gene: Implications for mutations in human cancers
-
Tornaletti S, Pfeifer GP (1995) Complete and tissue-independent methylation of CpG sites in the p53 gene: implications for mutations in human cancers. Oncogene 10:1493–1499
-
(1995)
Oncogene
, vol.10
, pp. 1493-1499
-
-
Tornaletti, S.1
Pfeifer, G.P.2
-
146
-
-
84876765634
-
Aryl hydrocarbon receptor and lung cancer
-
Tsay JJ, Tchou-Wong KM, Greenberg AK, Pass H, Rom WN (2013) Aryl hydrocarbon receptor and lung cancer. Anticancer Res 33:1247–1256
-
(2013)
Anticancer Res
, vol.33
, pp. 1247-1256
-
-
Tsay, J.J.1
Tchou-Wong, K.M.2
Greenberg, A.K.3
Pass, H.4
Rom, W.N.5
-
147
-
-
33847014439
-
Relationship between DNA damage and total antioxidant capacity in patients with glioblastoma multiforme
-
Tuzgen S, Hanimoglu H, Tanriverdi T, Kacira T, Sanus GZ, Atukeren P, Dashti R, Gumustas K, Canbaz B, Kaynar MY (2007) Relationship between DNA damage and total antioxidant capacity in patients with glioblastoma multiforme. Clin Oncol 19:177–181
-
(2007)
Clin Oncol
, vol.19
, pp. 177-181
-
-
Tuzgen, S.1
Hanimoglu, H.2
Tanriverdi, T.3
Kacira, T.4
Sanus, G.Z.5
Atukeren, P.6
Dashti, R.7
Gumustas, K.8
Canbaz, B.9
Kaynar, M.Y.10
-
148
-
-
0030070484
-
CDKN2/p16 or RB alterations occur in the majority of glioblastomas and are inversely correlated
-
Ueki K, Ono Y, Henson JW, Efird JT, von Demling A, Louis DN (1996) CDKN2/p16 or RB alterations occur in the majority of glioblastomas and are inversely correlated. Cancer Res 56:150–153
-
(1996)
Cancer Res
, vol.56
, pp. 150-153
-
-
Ueki, K.1
Ono, Y.2
Henson, J.W.3
Efird, J.T.4
Von Demling, A.5
Louis, D.N.6
-
149
-
-
33847055935
-
Endogenous cytosine damage products alter the site selectivity of human DNA maintenance methyltransferase DNMT1
-
Valinluck V, Sowers LC (2007a) Endogenous cytosine damage products alter the site selectivity of human DNA maintenance methyltransferase DNMT1. Cancer Res 67:946–950
-
(2007)
Cancer Res
, vol.67
, pp. 946-950
-
-
Valinluck, V.1
Sowers, L.C.2
-
150
-
-
34250860821
-
Inflammation-mediated cytosine damage: A mechanistic link between inflammation and the epigenetic alterations in human cancers
-
Valinluck V, Sowers LC (2007b) Inflammation-mediated cytosine damage: a mechanistic link between inflammation and the epigenetic alterations in human cancers. Cancer Res 67:5583–5586
-
(2007)
Cancer Res
, vol.67
, pp. 5583-5586
-
-
Valinluck, V.1
Sowers, L.C.2
-
151
-
-
4043112183
-
Oxidative damage to methyl-CpG sequences inhibits the binding of the methyl-CpG binding domain (MBD) of methyl-CpG binding protein 2 (MeCP2)
-
Valinluck V, Tsai HH, Rogstad DK, Burdzy A, Bird A, Sowers LC (2004) Oxidative damage to methyl-CpG sequences inhibits the binding of the methyl-CpG binding domain (MBD) of methyl-CpG binding protein 2 (MeCP2). Nuleic Acids Res 32:4100–4108
-
(2004)
Nuleic Acids Res
, vol.32
, pp. 4100-4108
-
-
Valinluck, V.1
Tsai, H.H.2
Rogstad, D.K.3
Burdzy, A.4
Bird, A.5
Sowers, L.C.6
-
152
-
-
20044370689
-
Sowers LC (2005) 5-halogenated pyrimidine lesions within a CpG sequence context mimic 5-methylcytosine by enhancing the binding of the methyl-CpG-binding domain of methyl-CpG-binding protein 2 (MeCP2)
-
Valinluck V, Liu P, Kang JI Jr, Burdzy A, Sowers LC (2005) 5-halogenated pyrimidine lesions within a CpG sequence context mimic 5-methylcytosine by enhancing the binding of the methyl-CpG-binding domain of methyl-CpG-binding protein 2 (MeCP2). Nucleic Acids Res 33:3057–3064
-
Nucleic Acids Res
, vol.33
, pp. 3057-3064
-
-
Valinluck, V.1
Liu, P.2
Kang, J.I.3
Burdzy, A.4
-
153
-
-
84862003367
-
Unique mutational profile associated with a loss of TDG expression in the rectal cancer of a patient with a constitutional PMS2 deficiency
-
Vasovcak P, Krepelova A, Menigatti M, Puchmajerova A, Skapa P, Augustinakova A, Amann G, Wernstedt A, Jiricny J, Marra G, Wimmer K (2012) Unique mutational profile associated with a loss of TDG expression in the rectal cancer of a patient with a constitutional PMS2 deficiency. DNA Repair 11:616–623
-
(2012)
DNA Repair
, vol.11
, pp. 616-623
-
-
Vasovcak, P.1
Krepelova, A.2
Menigatti, M.3
Puchmajerova, A.4
Skapa, P.5
Augustinakova, A.6
Amann, G.7
Wernstedt, A.8
Jiricny, J.9
Marra, G.10
Wimmer, K.11
-
155
-
-
84869232447
-
IDO expression in brain tumors increases the recruitment of regulatory T cells and negatively impacts survival
-
Wainwright DA, Balyasnikova IV, Chang AL, Ahmed AU, Moon KS, Auffinger B, Tobias AL, Han Y, Lesniak MS (2012) IDO expression in brain tumors increases the recruitment of regulatory T cells and negatively impacts survival. Clin Cancer Res 18:6110–6121
-
(2012)
Clin Cancer Res
, vol.18
, pp. 6110-6121
-
-
Wainwright, D.A.1
Balyasnikova, I.V.2
Chang, A.L.3
Ahmed, A.U.4
Moon, K.S.5
Auffinger, B.6
Tobias, A.L.7
Han, Y.8
Lesniak, M.S.9
-
156
-
-
70350538957
-
The small molecule GMX1778 is a potent inhibitor of NAD+ biosynthesis: Strategy for enhanced therapy in nicotinic acid phosphoribosyltransferase 1-deficient tumors
-
Watson M, Roulston A, Bélec L, Billot X, Marcellus R, Bédard D, Bernier C, Branchaud S, Chan H, Dairi K, Gilbert K, Goulet D, Gratton MO, Isakau H, Jang A, Khadir A, Koch E, Lavoie M, Lawless M, Nguyen M, Paquette D, Turcotte E, Berger A, Mitchell M, Shore GC, Beauparlant P (2009) The small molecule GMX1778 is a potent inhibitor of NAD+ biosynthesis: strategy for enhanced therapy in nicotinic acid phosphoribosyltransferase 1-deficient tumors. Mol Cell Biol 29:5872–5888
-
(2009)
Mol Cell Biol
, vol.29
, pp. 5872-5888
-
-
Watson, M.1
Roulston, A.2
Bélec, L.3
Billot, X.4
Marcellus, R.5
Bédard, D.6
Bernier, C.7
Branchaud, S.8
Chan, H.9
Dairi, K.10
Gilbert, K.11
Goulet, D.12
Gratton, M.O.13
Isakau, H.14
Jang, A.15
Khadir, A.16
Koch, E.17
Lavoie, M.18
Lawless, M.19
Nguyen, M.20
Paquette, D.21
Turcotte, E.22
Berger, A.23
Mitchell, M.24
Shore, G.C.25
Beauparlant, P.26
more..
-
157
-
-
75149166496
-
MGMT promoter methylation in malignant gliomas: Ready for personalized medicine?
-
Weller M, Stupp R, Reifenberger G, Brandes AA, van den Bent MJ, Wick W, Hegi ME (2010) MGMT promoter methylation in malignant gliomas: ready for personalized medicine? Nat Rev Neurol 6:39–51
-
(2010)
Nat Rev Neurol
, vol.6
, pp. 39-51
-
-
Weller, M.1
Stupp, R.2
Reifenberger, G.3
Brandes, A.A.4
Van Den Bent, M.J.5
Wick, W.6
Hegi, M.E.7
-
158
-
-
0030777056
-
Hypochlorous acid-induced base modifications in isolated calf thymus DNA
-
Whiteman M, Jenner A, Halliwell B (1997) Hypochlorous acid-induced base modifications in isolated calf thymus DNA. Chem Res Toxicol 10:1240–1246
-
(1997)
Chem Res Toxicol
, vol.10
, pp. 1240-1246
-
-
Whiteman, M.1
Jenner, A.2
Halliwell, B.3
-
159
-
-
0034282230
-
Biomarkers of myeloperoxidase-derived hypochlorous acid
-
Winterbourn CC, Kettle AJ (2000) Biomarkers of myeloperoxidase-derived hypochlorous acid. Free Radical Biol Med 29:403–409
-
(2000)
Free Radical Biol Med
, vol.29
, pp. 403-409
-
-
Winterbourn, C.C.1
Kettle, A.J.2
-
160
-
-
84862632865
-
Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressor
-
Xiao M, Yang H, Xu W, Ma S, Lin H, Zhu H, Liu L, Liu Y, Yang C, Xu Y, Zhao S, Ye D, Xiong Y, Guan KL (2012) Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressor. Genes Dev 26:1326–1338
-
(2012)
Genes Dev
, vol.26
, pp. 1326-1338
-
-
Xiao, M.1
Yang, H.2
Xu, W.3
Ma, S.4
Lin, H.5
Zhu, H.6
Liu, L.7
Liu, Y.8
Yang, C.9
Xu, Y.10
Zhao, S.11
Ye, D.12
Xiong, Y.13
Guan, K.L.14
-
161
-
-
77956470503
-
Modulation of polymorphonuclear neutrophil functions by astrocytes
-
Xie L, Poteet EC, Li W, Scott AE, Liu R, Wen Y, Ghorpade A, Simpkins JW, Yang SH (2010) Modulation of polymorphonuclear neutrophil functions by astrocytes. J Neuroinflammation 7:1–15
-
(2010)
J Neuroinflammation
, vol.7
, pp. 1-15
-
-
Xie, L.1
Poteet, E.C.2
Li, W.3
Scott, A.E.4
Liu, R.5
Wen, Y.6
Ghorpade, A.7
Simpkins, J.W.8
Yang, S.H.9
-
162
-
-
78651463452
-
Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases
-
Xu W, Yang H, Liu Y, Yang Y, Wang P, Kim SH, Ito S, Yang C, Wang P, Xiao MT, Liu LX, Jiang WQ, Liu J, Zhang JY, Wang B, Frye S, Zhang Y, Xu YH, Lei QY, Guan KL, Zhao SM, Xiong Y (2011) Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases. Cancer Cell 19:17–30
-
(2011)
Cancer Cell
, vol.19
, pp. 17-30
-
-
Xu, W.1
Yang, H.2
Liu, Y.3
Yang, Y.4
Wang, P.5
Kim, S.H.6
Ito, S.7
Yang, C.8
Wang, P.9
Xiao, M.T.10
Liu, L.X.11
Jiang, W.Q.12
Liu, J.13
Zhang, J.Y.14
Wang, B.15
Frye, S.16
Zhang, Y.17
Xu, Y.H.18
Lei, Q.Y.19
Guan, K.L.20
Zhao, S.M.21
Xiong, Y.22
more..
-
163
-
-
80052343970
-
Immune cell infiltrate differences in pilocytic astrocytoma and glioblastoma: Evidence of distinct immunological microenvironments that reflect tumor biology
-
Yang I, Han SJ, Sughrue ME, Tihan T, Parsa AT (2011a) Immune cell infiltrate differences in pilocytic astrocytoma and glioblastoma: evidence of distinct immunological microenvironments that reflect tumor biology. J Neurosurg 115:505–511
-
(2011)
J Neurosurg
, vol.115
, pp. 505-511
-
-
Yang, I.1
Han, S.J.2
Sughrue, M.E.3
Tihan, T.4
Parsa, A.T.5
-
164
-
-
80052854250
-
Annexin 1 released by necrotic human glioblastoma cells stimulates tumor cell growth through the formyl peptide receptor 1
-
Yang Y, Liu Y, Yao X, Ping Y, Jiang T, Liu Q, Xu S, Huang J, Mou H, Gong W, Chen K, Bian X, Wang JM (2011b) Annexin 1 released by necrotic human glioblastoma cells stimulates tumor cell growth through the formyl peptide receptor 1. Am J Pathol 179:1504–1512
-
(2011)
Am J Pathol
, vol.179
, pp. 1504-1512
-
-
Yang, Y.1
Liu, Y.2
Yao, X.3
Ping, Y.4
Jiang, T.5
Liu, Q.6
Xu, S.7
Huang, J.8
Mou, H.9
Gong, W.10
Chen, K.11
Bian, X.12
Wang, J.M.13
-
165
-
-
0033198997
-
Glioma cells release excitotoxic concentrations of glutamate
-
Ye ZC, Sontheimer H (1999) Glioma cells release excitotoxic concentrations of glutamate. Cancer Res 59:4383–4391
-
(1999)
Cancer Res
, vol.59
, pp. 4383-4391
-
-
Ye, Z.C.1
Sontheimer, H.2
-
166
-
-
84455167621
-
Mbd3/NURD complex regulates expression of 5-hydroxymethylcytosine marked genes in embryonic stem cells
-
Yildirim O, Li R, Hung JH, Chen PB, Dong X, Ee LS, Weng Z, Rando OJ, Fazzio TG (2011) Mbd3/NURD complex regulates expression of 5-hydroxymethylcytosine marked genes in embryonic stem cells. Cell 147:1498–1510
-
(2011)
Cell
, vol.147
, pp. 1498-1510
-
-
Yildirim, O.1
Li, R.2
Hung, J.H.3
Chen, P.B.4
Dong, X.5
Ee, L.S.6
Weng, Z.7
Rando, O.J.8
Fazzio, T.G.9
-
167
-
-
84863770814
-
Cancer genetics and epigenetics: Two sides of the same coin?
-
You JS, Jones PA (2012) Cancer genetics and epigenetics: two sides of the same coin? Cancer Cell 22:9–20
-
(2012)
Cancer Cell
, vol.22
, pp. 9-20
-
-
You, J.S.1
Jones, P.A.2
-
168
-
-
54549095950
-
DePinho RA (2008) p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation
-
Zheng H, Ying H, Yan H, Kimmelman AC, Hiller DJ, Chen AJ, Perry SR, Tonon G, Chu GC, Ding Z, Stommel JM, Dunn KL, Wiedemeyer R, You MJ, Brennan C, Wang YA, Ligon KL, Wong WH, Chin L, DePinho RA (2008) p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation. Nature 455:1129–1134
-
Nature
, vol.455
, pp. 1129-1134
-
-
Zheng, H.1
Ying, H.2
Yan, H.3
Kimmelman, A.C.4
Hiller, D.J.5
Chen, A.J.6
Perry, S.R.7
Tonon, G.8
Chu, G.C.9
Ding, Z.10
Stommel, J.M.11
Dunn, K.L.12
Wiedemeyer, R.13
You, M.J.14
Brennan, C.15
Wang, Y.A.16
Ligon, K.L.17
Wong, W.H.18
Chin, L.19
|