The promoter hypermethylation status of GATA6, MGMT, and FHIT in glioblastoma

Cellular and Molecular Neurobiology

Volumn 32, Issue 2, 2012, Pages 237-244

  Cecener, Gulsah ^a   Tunca, Berrin ^a   Egeli, Unal ^a   Bekar, Ahmet ^a   Tezcan, Gulcin ^a   Erturk, Elif ^a   Bayram, Nuran ^a   Tolunay, Sahsine ^a  

^a ULUDAG UNIVERSITY   (Turkey)

Author keywords

FHIT; GATA6; Glioblastoma; Hypermethylation; MGMT

Indexed keywords

ADULT; AGED; ARTICLE; DNA METHYLATION; EPIGENETICS; FEMALE; FHIT GENE; GATA6 GENE; GENETIC ASSOCIATION; GLIOBLASTOMA; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MGMT GENE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; TUMOR SUPPRESSOR GENE;

ACID ANHYDRIDE HYDROLASES; ADULT; AGED; DNA METHYLATION; DNA MODIFICATION METHYLASES; DNA REPAIR ENZYMES; FEMALE; GATA6 TRANSCRIPTION FACTOR; GLIOBLASTOMA; HUMANS; KAPLAN-MEIER ESTIMATE; MALE; MIDDLE AGED; NEOPLASM PROTEINS; POLYMERASE CHAIN REACTION; PROMOTER REGIONS, GENETIC; TUMOR SUPPRESSOR PROTEINS;

EID: 84864659333     PISSN: 02724340     EISSN: 15736830     Source Type: Journal    
DOI: 10.1007/s10571-011-9753-7     Document Type: Article

References (42)

1. Ang C, Guiot MC, Ramanakumar AV, Roberge D, Kavan P (2010) Clinical significance of molecular biomarkers in glioblastoma. Can J Neurol Sci 37(5):625-630
2. Barker FG, Prados MD, Chang SM et al (1996) Radiation response and survival time in patients with glioblastoma multiforme. J Neurosurg 84:442-448
3. Batchelor TT, Betensky RA, Esposito JM, Pham LD, Dorfman MV, Piscatelli N, Jhung S, Rhee D, Louis DN (2004) Age-dependent prognostic effects of genetic alterations in glioblastoma. Clin Cancer Res 10:228-233
4. Baylin SB, Herman JG (2000) DNA hypermethylation in tumorigenesis: epigenetics joins genetics. Trends Genet 16:168-174
5. Belinsky SA (2004) Gene-promoter hypermethylation as a biomarker in lung cancer. Nat Rev Cancer 4:707-717
6. Cecener G, Tunca B, Egeli U, Bekar A, Guler G, Tolunay S, Aksoy K (2010) FHIT gene sequence variants and reduced Fhit protein expression in glioblastoma multiforme. Cell Mol Neurobiol 30:301-307
7. Chang Q, Pang JC, Li KK, Poon WS, Zhou L, Ng HK (2005) Promoter hypermethylation profile of RASSF1A, FHIT, and sFRP1 in intracranial primitive neuroectodermal tumors. Hum Pathol 36:1265-1272
8. Collins VP (2004) Brain tumours: classification and genes. J Neurol Neurosurg Psychiatry 75:2-11
9. Costello JF, Futscher BW, Kroes RA, Pieper RO (1994a) Methylation- related chromatin structure is associated with exclusion of transcription factors from and suppressed expression of the O-6- Methylguanine DNAmethyltransferase gene in human glioma cell lines. Mol Cell Biol 14:6515-6521
10. Costello JF, Futscher BW, Tano K, Graunke DM, Pieper RO (1994b) Gradedmethylation in the promoter and body of the O6- methylguanine DNA methyltransferase (MGMT) gene correlates with MGMT expression in human glioma cells. J Biol Chem 269:17228-17237
11. Curran WJ Jr, Scott CB, Horton J et al (1993) Recursive partitioning analysis of prognostic factors in three radiation therapy oncology group malignant glioma trials. J Natl Cancer Inst 85:704-710
12. Dong SM, Sun DI, Benoit NE, Kuzmin I, Lerman MI, Sidransky D (2003) Epigenetic inactivation of RASSF1A in head and neck cancer. Clin Cancer Res 9:3635-3640
13. Donson AM, Addo-Yobo SO, Handler MH, Gore L, Foreman NK (2007) MGMT promoter methylation correlates with survival benefit and sensitivity to temozolomide in pediatric glioblastoma. Pediatr Blood Cancer 48:403-407
14. Ehrlich M (2003) Expression of various genes is controlled by DNA methylation during mammalian development. J Cell Biochem 88:899-910
15. EstellerM(2006) Epigenetics provides a new generation of oncogenes and tumour-suppressor genes. Br J Cancer 94:179-183
16. Esteller M, Hamilton SR, Burger PC, Baylin SB, Herman JG (1999) Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia. Cancer Res 59:793-797
17. Everhard S, Kaloshi G, Criniere E et al (2006) MGMT methylation: a marker of response to temozolomide in low-grade gliomas. Ann Neurol 60:740-743
18. Fraga MF, Esteller M (2005) Towards the human cancer epigenome: a first draft of histone modifications. Cell Cycle 4:1377-1381
19. Gerson SL (2004) MGMT: its role in cancer aetiology and cancer therapeutics. Nat Rev Canc 4:296-307
20. Guo M, Akiyama Y, House MG et al (2004) Hypermethylation of the GATA genes in lung cancer. Clin Cancer Res 10:7917-7924
21. Hegi ME, Diserens AC, Gorlia T et al (2005) MGMT gene silencing and benefit from temozolomide in glioblastoma. N Engl J Med 352:997-1003
22. Herman JG, Baylin SB (2003) Gene silencing in cancer in association with promoter hypermethylation. N Engl J Med 349:2042-2054
23. Hill C, Hunter SB, Brat DJ (2003) Genetic markers in glioblastoma: prognostic significance and future therapeutic implications. Adv Anat Pathol 10:212-217
24. Ichimura K, Ohgaki H, Kleihues P, Collins VP (2004) Molecular pathogenesis of astrocytic tumours. J Neurooncol 70:137-160
25. Jansen M, de Witt Hamer PC, Witmer AN, Troost D, van Noorden CJ (2004) Current perspectives on antiangiogenesis strategies in the treatment of malignant gliomas. Brain Res 45:143-163
26. Kamnasaran D, Qian B, Hawkins C, Stanford WL, Guha A (2007) GATA6 is an astrocytoma tumor suppressor gene identified by gene trapping of mouse glioma model. Proc Natl Acad Sci USA 104:8053-8058
27. Kleihues P, Burger PC, Scheithauer BW (1993) The new WHO classification of brain tumours. Brain Pathol 3:255-268
28. Knudson AG (2000) Chasing the cancer demon. Annu Rev Genet 34:1-19
29. Martinez R, Martin-Subero JI, Rohde V, Kirsch M, Alaminos M, Fernandez AF, Ropero S, Schackert G, Esteller M (2009) A microarray-based DNA methylation study of glioblastoma multiforme. Epigenetics 4:255-264
30. McLendon R, Friedman A, Bigner D et al (2008) Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 455:1061-1068
31. Michalowski MB, de Fraipont F, Michelland S, Entz-Werle N, Grill J, Pasquier B, Favrot MC, Plantaz D (2006) Methylation of RASSF1A and TRAIL pathway-related genes is frequent in childhood intracranial ependymomas and benign choroid plexus papilloma. Cancer Genet Cytogenet 166:74-81
32. Myohanen SK, Baylin SB, Herman JG (1998) Hypermethylation can selectively silence individual p16ink4A alleles in neoplasia. Cancer Res 58:591-593
33. Ogishima T, Shiina H, Breault JE et al (2005) Promoter CpG hypomethylation and transcription factor EGR1 hyperactivate heparanase expression in bladder cancer. Oncogene 24:6765-6772
34. Ohgaki H, Kleihues P (2005) Population-based studies on incidence, survival rates, and genetic alterations in astrocytic and oligodendroglial gliomas. J Neuropathol Exp Neurol 64:479-489
35. Ohgaki H, Dessen P, Jourde B et al (2004) Genetic pathways to glioblastoma: a population-based study. Cancer Res 64:6892-6899
36. Pakneshan P, Xing RH, Rabbani SA (2003) Methylation status of uPA promoter as a molecular mechanism regulating prostate cancer invasion and growth in vitro and in vivo. FASEB J 17:1081-1088
37. Perry AS, Foley R, Woodson K, Lawler M (2006) The emerging roles of DNA methylation in the clinical management of prostate cancer. Endocr Relat Cancer 13:357-377
38. Riemenschneider MJ, Hegi ME, Reifenberger G (2010) MGM Tpromoter methylation in malignant gliomas. Target Oncol 5:161-165
39. Tamada H, Kitazawa R, Gohji K, Kitazawa S (2001) Epigenetic regulation of human bone morphogenetic protein 6 gene expression in prostate cancer. J Bone Miner Res 16:487-496
40. Tunca B, Bekar A, Cecener G, Egeli U, Vatan O, Tolunay S, Kocaeli H, Aksoy K (2007) Impact of novel PTEN mutations in Turkish patients with glioblastoma multiforme. J Neurooncol 82:263-269
41. Yang Q, Shan L, Yoshimura G, Nakamura M, Nakamura Y, Suzuma T, Umemura T, Mori I, Sakurai T, Kakudo K (2002) 5-aza-20-deoxycytidine induces retinoic acid receptor beta 2 demethylation, cell cycle arrest and growth inhibition in breast carcinoma cells. Anticancer Res 22:2753-2756
42. Zheng S, Ma X, Zhang L, Gunn L, Smith MT, Wiemels JL, Leung K, Buffler PA, Wiencke JK (2004) Hypermethylation of the 5′ CpG island of the FHIT gene is associated with hyperdiploid and translocation-negative subtypes of pediatric leukemia. Cancer Res 646:2000-2006