-
1
-
-
0031559933
-
Quantification of information transfer via cellular signal transduction pathways
-
DOI 10.1016/S0014-5793(97)01018-1, PII S0014579397010181
-
Kholodenko, B.N., Hoek, J.B., Westerhoff, H.V. and Brown, G.C. (1997) Quantification of information transfer via cellular signal transduction pathways. FEBS Lett. 414, 430-434 (Pubitemid 27389410)
-
(1997)
FEBS Letters
, vol.414
, Issue.2
, pp. 430-434
-
-
Kholodenko, B.N.1
Hoek, J.B.2
Westerhoff, H.V.3
Brown, G.C.4
-
2
-
-
77952902183
-
Ligand-specific c-Fos expression emerges from the spatiotemporal control of ErbB network dynamics
-
Nakakuki, T., Birtwistle, M.R., Saeki, Y., Yumoto, N., Ide, K., Nagashima, T., Brusch, L., Ogunnaike, B.A., Okada-Hatakeyama, M. and Kholodenko, B.N. (2010) Ligand-specific c-Fos expression emerges from the spatiotemporal control of ErbB network dynamics. Cell 141, 884-896
-
(2010)
Cell
, vol.141
, pp. 884-896
-
-
Nakakuki, T.1
Birtwistle, M.R.2
Saeki, Y.3
Yumoto, N.4
Ide, K.5
Nagashima, T.6
Brusch, L.7
Ogunnaike, B.A.8
Okada-Hatakeyama, M.9
Kholodenko, B.N.10
-
3
-
-
0034820828
-
Phosphatidylinositol 3-kinases in tumor progression
-
DOI 10.1046/j.1432-1327.2001.01936.x
-
Roymans, D. and Slegers, H. (2001) Phosphatidylinositol 3-kinases in tumor progression. Eur. J. Biochem. 268, 487-498 (Pubitemid 32862605)
-
(2001)
European Journal of Biochemistry
, vol.268
, Issue.3
, pp. 487-498
-
-
Roymans, D.1
Slegers, H.2
-
4
-
-
0036632368
-
The phosphatidylinositol 3-kinase-AKT pathway in human cancer
-
Vivanco, I. and Sawyers, C.L. (2002) The phosphatidylinositol 3-kinase AKT pathway in human cancer. Nat. Rev. Cancer 2, 489-501 (Pubitemid 37328931)
-
(2002)
Nature Reviews Cancer
, vol.2
, Issue.7
, pp. 489-501
-
-
Vivanco, I.1
Sawyers, C.L.2
-
5
-
-
0034997845
-
Mitogen-activated protein (MAP) kinase pathways: Regulation and physiological functions
-
DOI 10.1210/er.22.2.153
-
Pearson, G., Robinson, F., Beers Gibson, T., Xu, B.E., Karandikar, M., Berman, K. and Cobb, M.H. (2001) Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions. Endocr. Rev. 22, 153-183 (Pubitemid 32458157)
-
(2001)
Endocrine Reviews
, vol.22
, Issue.2
, pp. 153-183
-
-
Pearson, G.1
Robinson, F.2
Gibson, T.B.3
Xu, B.-E.4
Karandikar, M.5
Berman, K.6
Cobb, M.H.7
-
6
-
-
24944490193
-
The ERK cascade: A prototype of MAPK signaling
-
DOI 10.1385/MB:31:2:151
-
Rubinfeld, H. and Seger, R. (2005) The ERK cascade: a prototype of MAPK signaling. Mol. Biotechnol. 31, 151-174 (Pubitemid 41306584)
-
(2005)
Molecular Biotechnology
, vol.31
, Issue.2
, pp. 151-174
-
-
Rubinfeld, H.1
Seger, R.2
-
7
-
-
34447568476
-
Phospholipase D2-generated phosphatidic acid couples EGFR stimulation to Ras activation by Sos
-
Zhao, C., Du, G., Skowronek, K., Frohman, M.A. and Bar-Sagi, D. (2007) Phospholipase D2-generated phosphatidic acid couples EGFR stimulation to Ras activation by Sos. Nat. Cell Biol. 9, 706-712
-
(2007)
Nat. Cell Biol.
, vol.9
, pp. 706-712
-
-
Zhao, C.1
Du, G.2
Skowronek, K.3
Frohman, M.A.4
Bar-Sagi, D.5
-
8
-
-
0034667593
-
Meaningful relationships: The regulation of the Ras/Raf/MEK/ERK pathway by protein interactions
-
Kolch, W. (2000) Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions. Biochem. J. 351, 289-305
-
(2000)
Biochem. J.
, vol.351
, pp. 289-305
-
-
Kolch, W.1
-
9
-
-
0036829983
-
The p85 regulatory subunit controls sequential activation of phosphoinositide 3-kinase by Tyr kinases and Ras
-
DOI 10.1074/jbc.M205893200
-
Jimenez, C., Hernandez, C., Pimentel, B. and Carrera, A.C. (2002) The p85 regulatory subunit controls sequential activation of phosphoinositide 3-kinase by Tyr kinases and Ras. J. Biol. Chem. 277, 41556-41562 (Pubitemid 35257459)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.44
, pp. 41556-41562
-
-
Jimenez, C.1
Hernandez, C.2
Pimentel, B.3
Carrera, A.C.4
-
11
-
-
1342342993
-
PDK1, the master regulator of AGC kinase signal transduction
-
DOI 10.1016/j.semcdb.2003.12.022
-
Mora, A., Komander, D., van Aalten, D.M. and Alessi, D.R. (2004) PDK1, the master regulator of AGC kinase signal transduction. Semin. Cell Dev. Biol. 15, 161-170 (Pubitemid 38251644)
-
(2004)
Seminars in Cell and Developmental Biology
, vol.15
, Issue.2
, pp. 161-170
-
-
Mora, A.1
Komander, D.2
Van Aalten, D.M.F.3
Alessi, D.R.4
-
12
-
-
0031918624
-
The IRS-signalling system: A network of docking proteins that mediate insulin action
-
White, M.F. (1998) The IRS-signalling system: a network of docking proteins that mediate insulin action. Mol. Cell. Biochem. 182, 3-11
-
(1998)
Mol. Cell. Biochem.
, vol.182
, pp. 3-11
-
-
White, M.F.1
-
13
-
-
1642471831
-
PI3K/Akt and apoptosis: Size matters
-
DOI 10.1038/sj.onc.1207115, Apoptosis - Part 2
-
Franke, T.F., Hornik, C.P., Segev, L., Shostak, G.A. and Sugimoto, C. (2003) PI3K/Akt and apoptosis: size matters. Oncogene 22, 8983-8998 (Pubitemid 38121699)
-
(2003)
Oncogene
, vol.22
, Issue.56 REV. ISS. 8
, pp. 8983-8998
-
-
Franke, T.F.1
Hornik, C.P.2
Segev, L.3
Shostak, G.A.4
Sugimoto, C.5
-
14
-
-
0034731505
-
p21-activated kinase (PAK1) is phosphorylated and activated by 3-phosphoinositide-dependent kinase-1 (PDK1)
-
DOI 10.1074/jbc.M006553200
-
King, C.C., Gardiner, E.M., Zenke, F.T., Bohl, B.P., Newton, A.C., Hemmings, B.A. and Bokoch, G.M. (2000) p21-activated kinase (PAK1) is phosphorylated and activated by 3-phosphoinositide-dependent kinase-1 (PDK1). J. Biol. Chem. 275, 41201-41209 (Pubitemid 32054952)
-
(2000)
Journal of Biological Chemistry
, vol.275
, Issue.52
, pp. 41201-41209
-
-
King, C.C.1
Gardiner, E.M.M.2
Zenke, F.T.3
Bohl, B.P.4
Newton, A.C.5
Hemmings, B.A.6
Bokoch, G.M.7
-
15
-
-
13844312400
-
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
-
DOI 10.1126/science.1106148
-
Sarbassov, D.D., Guertin, D.A., Ali, S.M. and Sabatini, D.M. (2005) Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 307, 1098-1101 (Pubitemid 40262113)
-
(2005)
Science
, vol.307
, Issue.5712
, pp. 1098-1101
-
-
Sarbassov, D.D.1
Guertin, D.A.2
Ali, S.M.3
Sabatini, D.M.4
-
16
-
-
34250788809
-
AKT/PKB Signaling: Navigating Downstream
-
DOI 10.1016/j.cell.2007.06.009, PII S0092867407007751
-
Manning, B.D. and Cantley, L.C. (2007) AKT/PKB signaling: navigating downstream. Cell 129, 1261-1274 (Pubitemid 46962095)
-
(2007)
Cell
, vol.129
, Issue.7
, pp. 1261-1274
-
-
Manning, B.D.1
Cantley, L.C.2
-
17
-
-
27844461512
-
Epithelial-mesenchymal transition in development and cancer: Role of phosphatidylinositol 3′ kinase/AKT pathways
-
DOI 10.1038/sj.onc.1209091, PII 1209091
-
Larue, L. and Bellacosa, A. (2005) Epithelial-mesenchymal transition in development and cancer: role of phosphatidylinositol 3′ kinase/AKT pathways. Oncogene 24, 7443-7454 (Pubitemid 41637984)
-
(2005)
Oncogene
, vol.24
, Issue.50
, pp. 7443-7454
-
-
Larue, L.1
Bellacosa, A.2
-
18
-
-
77954739303
-
Interactome mapping of the phosphatidylinositol 3-kinase-mammalian target of rapamycin pathway identifies deformed epidermal autoregulatory factor-1 as a new glycogen synthase kinase-3 interactor
-
Pilot-Storck, F., Chopin, E., Rual, J.F., Baudot, A., Dobrokhotov, P., Robinson-Rechavi, M., Brun, C., Cusick, M.E., Hill, D.E., Schaeffer, L. et al. (2010) Interactome mapping of the phosphatidylinositol 3-kinase-mammalian target of rapamycin pathway identifies deformed epidermal autoregulatory factor-1 as a new glycogen synthase kinase-3 interactor. Mol. Cell. Proteomics 9, 1578-1593
-
(2010)
Mol. Cell. Proteomics
, vol.9
, pp. 1578-1593
-
-
Pilot-Storck, F.1
Chopin, E.2
Rual, J.F.3
Baudot, A.4
Dobrokhotov, P.5
Robinson-Rechavi, M.6
Brun, C.7
Cusick, M.E.8
Hill, D.E.9
Schaeffer, L.10
-
19
-
-
77957667140
-
A human MAP kinase interactome
-
Bandyopadhyay, S., Chiang, C.Y., Srivastava, J., Gersten, M., White, S., Bell, R., Kurschner, C., Martin, C.H., Smoot, M., Sahasrabudhe, S. et al. (2010) A human MAP kinase interactome. Nat. Methods 7, 801-805
-
(2010)
Nat. Methods
, vol.7
, pp. 801-805
-
-
Bandyopadhyay, S.1
Chiang, C.Y.2
Srivastava, J.3
Gersten, M.4
White, S.5
Bell, R.6
Kurschner, C.7
Martin, C.H.8
Smoot, M.9
Sahasrabudhe, S.10
-
20
-
-
73349139547
-
Cell fate decisions are specified by the dynamic ERK interactome
-
von Kriegsheim, A., Baiocchi, D., Birtwistle, M., Sumpton, D., Bienvenut, W., Morrice, N., Yamada, K., Lamond, A., Kalna, G., Orton, R. et al. (2009) Cell fate decisions are specified by the dynamic ERK interactome. Nat. Cell Biol. 11, 1458-1464
-
(2009)
Nat. Cell Biol.
, vol.11
, pp. 1458-1464
-
-
Von Kriegsheim, A.1
Baiocchi, D.2
Birtwistle, M.3
Sumpton, D.4
Bienvenut, W.5
Morrice, N.6
Yamada, K.7
Lamond, A.8
Kalna, G.9
Orton, R.10
-
21
-
-
33746021158
-
Scaffolding protein Grb2-associated binder 1 sustains epidermal growth factor-induced mitogenic and survival signaling by multiple positive feedback loops
-
DOI 10.1074/jbc.M600482200
-
Kiyatkin, A., Aksamitiene, E., Markevich, N.I., Borisov, N.M., Hoek, J.B. and Kholodenko, B.N. (2006) Scaffolding protein Grb2-associated binder 1 sustains epidermal growth factor-induced mitogenic and survival signaling by multiple positive feedback loops. J. Biol. Chem. 281, 19925-19938 (Pubitemid 44065766)
-
(2006)
Journal of Biological Chemistry
, vol.281
, Issue.29
, pp. 19925-19938
-
-
Kiyatkin, A.1
Aksamitiene, E.2
Markevich, N.I.3
Borisov, N.M.4
Hoek, J.B.5
Kholodenko, B.N.6
-
22
-
-
0033959896
-
A novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signaling
-
DOI 10.1128/MCB.20.4.1448-1459.2000
-
Rodrigues, G.A., Falasca, M., Zhang, Z., Ong, S.H. and Schlessinger, J. (2000) A novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signaling. Mol. Cell. Biol. 20, 1448-1459 (Pubitemid 30069264)
-
(2000)
Molecular and Cellular Biology
, vol.20
, Issue.4
, pp. 1448-1459
-
-
Rodrigues, G.A.1
Falasca, M.2
Zhang, Z.3
Ong, S.H.4
Schlessinger, J.5
-
23
-
-
77955599451
-
Function, regulation and pathological roles of the Gab/DOS docking proteins
-
Wohrle, F.U., Daly, R.J. and Brummer, T. (2009) Function, regulation and pathological roles of the Gab/DOS docking proteins. Cell Commun. Signaling 7, 22
-
(2009)
Cell Commun. Signaling
, vol.7
, pp. 22
-
-
Wohrle, F.U.1
Daly, R.J.2
Brummer, T.3
-
24
-
-
38349168403
-
Coupling of Grb2 to Gab1 mediates hepatocyte growth factor-induced high intensity ERK signal required for inhibition of HepG2 hepatoma cell proliferation
-
Kondo, A., Hirayama, N., Sugito, Y., Shono, M., Tanaka, T. and Kitamura, N. (2008) Coupling of Grb2 to Gab1 mediates hepatocyte growth factor-induced high intensity ERK signal required for inhibition of HepG2 hepatoma cell proliferation. J. Biol. Chem. 283, 1428-1436
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 1428-1436
-
-
Kondo, A.1
Hirayama, N.2
Sugito, Y.3
Shono, M.4
Tanaka, T.5
Kitamura, N.6
-
25
-
-
0037064549
-
Role of the SHP-2 tyrosine phosphatase in cytokine-induced signaling and cellular response
-
Qu, C.K. (2002) Role of the SHP-2 tyrosine phosphatase in cytokine-induced signaling and cellular response. Biochim. Biophys. Acta 1592, 297-301
-
(2002)
Biochim. Biophys. Acta
, vol.1592
, pp. 297-301
-
-
Qu, C.K.1
-
26
-
-
0035869175
-
PTEN inhibits insulin-stimulated MEK/MAPK activation and cell growth by blocking IRS-1 phosphorylation and IRS-1/Grb-2/Sos complex formation in a breast cancer model
-
Weng, L.P., Smith, W.M., Brown, J.L. and Eng, C. (2001) PTEN inhibits insulin-stimulated MEK/MAPK activation and cell growth by blocking IRS-1 phosphorylation and IRS-1/Grb-2/Sos complex formation in a breast cancer model. Hum. Mol. Genet. 10, 605-616 (Pubitemid 32229365)
-
(2001)
Human Molecular Genetics
, vol.10
, Issue.6
, pp. 605-616
-
-
Weng, L.-P.1
Smith, W.M.2
Brown, J.L.3
Eng, C.4
-
27
-
-
0037088682
-
Regulation of the mitogen-activated protein kinase signaling pathway by SHP2
-
DOI 10.1074/jbc.M110547200
-
Cunnick, J.M., Meng, S., Ren, Y., Desponts, C., Wang, H.G., Djeu, J.Y. and Wu, J. (2002) Regulation of the mitogen-activated protein kinase signaling pathway by SHP2. J. Biol. Chem. 277, 9498-9504 (Pubitemid 34953038)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.11
, pp. 9498-9504
-
-
Cunnick, J.M.1
Meng, S.2
Ren, Y.3
Desponts, C.4
Wang, H.-G.5
Djeu, J.Y.6
Wu, J.7
-
28
-
-
0037033797
-
Mechanisms through which Sos-1 coordinates the activation of Ras and Rac
-
DOI 10.1083/jcb.200108035
-
Innocenti, M., Tenca, P., Frittoli, E., Faretta, M., Tocchetti, A., Di Fiore, P.P. and Scita, G. (2002) Mechanisms through which Sos-1 coordinates the activation of Ras and Rac. J. Cell Biol. 156, 125-136 (Pubitemid 34846941)
-
(2002)
Journal of Cell Biology
, vol.156
, Issue.1
, pp. 125-136
-
-
Innocenti, M.1
Tenca, P.2
Frittoli, E.3
Faretta, M.4
Tocchetti, A.5
Di, F.P.P.6
Scita, G.7
-
29
-
-
0038538430
-
Phosphoinositide 3-kinase-dependent activation of Rac
-
DOI 10.1016/S0014-5793(03)00454-X
-
Welch, H.C., Coadwell, W.J., Stephens, L.R. and Hawkins, P.T. (2003) Phosphoinositide 3-kinase-dependent activation of Rac. FEBS Lett. 546, 93-97 (Pubitemid 36782287)
-
(2003)
FEBS Letters
, vol.546
, Issue.1
, pp. 93-97
-
-
Welch, H.C.E.1
Coadwell, W.J.2
Stephens, L.R.3
Hawkins, P.T.4
-
30
-
-
0034193426
-
Phosphatidylinositol 3-kinase regulates Raf1 through Pak phosphorylation of serine 338
-
DOI 10.1016/S0960-9822(00)00475-9
-
Chaudhary, A., King, W.G., Mattaliano, M.D., Frost, J.A., Diaz, B., Morrison, D.K., Cobb, M.H., Marshall, M.S. and Brugge, J.S. (2000) Phosphatidylinositol 3-kinase regulates Raf1 through Pak phosphorylation of serine 338. Curr. Biol. 10, 551-554 (Pubitemid 30308316)
-
(2000)
Current Biology
, vol.10
, Issue.9
, pp. 551-554
-
-
Chaudhary, A.1
King, W.G.2
Mattaliano, M.D.3
Frost, J.A.4
Diaz, B.5
Morrison, D.K.6
Cobb, M.H.7
Marshall, M.S.8
Brugge, J.S.9
-
31
-
-
0037159456
-
341 regulates specific interaction between Raf-1 and MEK1
-
DOI 10.1074/jbc.M203953200
-
Xiang, X., Zang, M., Waelde, C.A., Wen, R. and Luo, Z. (2002) Phosphorylation of 338SSYY341 regulates specific interaction between Raf-1 and MEK1. J. Biol. Chem. 277, 44996-45003 (Pubitemid 36159098)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.47
, pp. 44996-45003
-
-
Xiang, X.1
Zang, M.2
Waelde, C.A.3
Wen, R.4
Luo, Z.5
-
32
-
-
0036333485
-
Rac-PAK signaling stimulates extracellular signal-regulated kinase (ERK) activation by regulating formation of MEK1-ERK complexes
-
DOI 10.1128/MCB.22.17.6023-6033.2002
-
Eblen, S.T., Slack, J.K., Weber, M.J. and Catling, A.D. (2002) Rac-PAK signaling stimulates extracellular signal-regulated kinase (ERK) activation by regulating formation of MEK1-ERK complexes. Mol. Cell. Biol. 22, 6023-6033 (Pubitemid 34857823)
-
(2002)
Molecular and Cellular Biology
, vol.22
, Issue.17
, pp. 6023-6033
-
-
Eblen, S.T.1
Slack, J.K.2
Weber, M.J.3
Catling, A.D.4
-
33
-
-
77956556826
-
EGF-induced Grb7 recruits and promotes Ras activity essential for the tumorigenicity of Sk-Br3 breast cancer cells
-
Chu, P.Y., Li, T.K., Ding, S.T., Lai, I.R. and Shen, T.L. (2010) EGF-induced Grb7 recruits and promotes Ras activity essential for the tumorigenicity of Sk-Br3 breast cancer cells. J. Biol. Chem. 285, 29279-29285
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 29279-29285
-
-
Chu, P.Y.1
Li, T.K.2
Ding, S.T.3
Lai, I.R.4
Shen, T.L.5
-
34
-
-
67651085772
-
Signal transduction by focal adhesion kinase in cancer
-
Zhao, J. and Guan, J.L. (2009) Signal transduction by focal adhesion kinase in cancer. Cancer Metastasis Rev. 28, 35-49
-
(2009)
Cancer Metastasis Rev.
, vol.28
, pp. 35-49
-
-
Zhao, J.1
Guan, J.L.2
-
35
-
-
28244479373
-
2 by Rac GTPases
-
DOI 10.1074/jbc.M509396200
-
Piechulek, T., Rehlen, T., Walliser, C., Vatter, P., Moepps, B. and Gierschik, P. (2005) Isozyme-specific stimulation of phospholipase Cγ2 by Rac GTPases. J. Biol. Chem. 280, 38923-38931 (Pubitemid 41713841)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.47
, pp. 38923-38931
-
-
Piechulek, T.1
Rehlen, T.2
Walliser, C.3
Vatter, P.4
Moepps, B.5
Gierschik, P.6
-
36
-
-
0031005028
-
Evidence for MEK-independent pathways regulating the prolonged activation of the ERK-MAP kinases
-
Grammer, T.C. and Blenis, J. (1997) Evidence for MEK-independent pathways regulating the prolonged activation of the ERK-MAP kinases. Oncogene 14, 1635-1642 (Pubitemid 27198935)
-
(1997)
Oncogene
, vol.14
, Issue.14
, pp. 1635-1642
-
-
Grammer, T.C.1
Blenis, J.2
-
37
-
-
0029789967
-
Protein kinase C activates the MEK-ERK pathway in a manner independent of Ras and dependent on Raf
-
DOI 10.1074/jbc.271.38.23512
-
Ueda, Y., Hirai, S., Osada, S., Suzuki, A., Mizuno, K. and Ohno, S. (1996) Protein kinase C activates the MEK-ERK pathway in a manner independent of Ras and dependent on Raf. J. Biol. Chem. 271, 23512-23519 (Pubitemid 26314803)
-
(1996)
Journal of Biological Chemistry
, vol.271
, Issue.38
, pp. 23512-23519
-
-
Ueda, Y.1
Hirai, S.-I.2
Osada, S.-I.3
Suzuki, A.4
Mizuno, K.5
Ohno, S.6
-
38
-
-
33745353037
-
Protein kinase Cα trigger Ras and Raf-independent MEK/ERK activation for TPA-induced growth inhibition of human hepatoma cell HepG2
-
Wen-Sheng, W. (2006) Protein kinase Cα trigger Ras and Raf-independent MEK/ERK activation for TPA-induced growth inhibition of human hepatoma cell HepG2. Cancer Lett. 239, 27-35
-
(2006)
Cancer Lett.
, vol.239
, pp. 27-35
-
-
Wen-Sheng, W.1
-
39
-
-
4043102610
-
Involvement of 3-phosphoinositide-dependent protein kinase-1 in the MEK/MAPK signal transduction pathway
-
DOI 10.1074/jbc.M402055200
-
Sato, S., Fujita, N. and Tsuruo, T. (2004) Involvement of 3-phosphoinositide-dependent protein kinase-1 in the MEK/MAPK signal transduction pathway. J. Biol. Chem. 279, 33759-33767 (Pubitemid 39063025)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.32
, pp. 33759-33767
-
-
Sato, S.1
Fujita, N.2
Tsuruo, T.3
-
40
-
-
34548333594
-
Phosphorylation of Irs1 at SER-522 inhibits insulin signaling
-
DOI 10.1210/me.2007-0159
-
Giraud, J., Haas, M., Feener, E.P., Copps, K.D., Dong, X., Dunn, S.L. and White, M.F. (2007) Phosphorylation of Irs1 at SER-522 inhibits insulin signaling. Mol. Endocrinol. 21, 2294-2302 (Pubitemid 47347389)
-
(2007)
Molecular Endocrinology
, vol.21
, Issue.9
, pp. 2294-2302
-
-
Giraud, J.1
Haas, M.2
Feener, E.P.3
Copps, K.D.4
Dong, X.5
Dunn, S.L.6
White, M.F.7
-
41
-
-
0037080536
-
PKB-mediated negative feedback tightly regulates mitogenic signalling via Gab2
-
DOI 10.1093/emboj/21.1.72
-
Lynch, D.K. and Daly, R.J. (2002) PKB-mediated negative feedback tightly regulates mitogenic signalling via Gab2. EMBO J. 21, 72-82 (Pubitemid 34087076)
-
(2002)
EMBO Journal
, vol.21
, Issue.1-2
, pp. 72-82
-
-
Lynch, D.K.1
Daly, R.J.2
-
42
-
-
0037040867
-
Dephosphorylation of Ser-259 regulates Raf-1 membrane association
-
DOI 10.1074/jbc.M108733200
-
Kubicek, M., Pacher, M., Abraham, D., Podar, K., Eulitz, M. and Baccarini, M. (2002) Dephosphorylation of Ser-259 regulates Raf-1 membrane association. J. Biol. Chem. 277, 7913-7919 (Pubitemid 34968241)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.10
, pp. 7913-7919
-
-
Kubicek, M.1
Pacher, M.2
Abraham, D.3
Podar, K.4
Eulitz, M.5
Baccarini, M.6
-
43
-
-
0034614606
-
Akt protein kinase inhibits Rac1-GTP binding through phosphorylation at serine 71 of Rac1
-
DOI 10.1074/jbc.275.1.423
-
Kwon, T., Kwon, D.Y., Chun, J., Kim, J.H. and Kang, S.S. (2000) Akt protein kinase inhibits Rac1-GTP binding through phosphorylation at serine 71 of Rac1. J. Biol. Chem. 275, 423-428 (Pubitemid 30039001)
-
(2000)
Journal of Biological Chemistry
, vol.275
, Issue.1
, pp. 423-428
-
-
Kwon, T.1
Kwon, D.Y.2
Chun, J.3
Kim, J.H.4
Kang, S.S.5
-
44
-
-
41549160315
-
Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survival
-
DOI 10.1096/fj.06-7859rev
-
Junttila, M.R., Li, S.P. and Westermarck, J. (2008) Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survival. FASEB J. 22, 954-965 (Pubitemid 351519953)
-
(2008)
FASEB Journal
, vol.22
, Issue.4
, pp. 954-965
-
-
Junttila, M.R.1
Li, S.-P.2
Westermarck, J.3
-
45
-
-
70349576367
-
Dependence of EGF-induced increases in corneal epithelial proliferation and migration on GSK-3 inactivation
-
Wang, Z., Yang, H., Zhang, F., Pan, Z., Capo-Aponte, J. and Reinach, P.S. (2009) Dependence of EGF-induced increases in corneal epithelial proliferation and migration on GSK-3 inactivation. Invest. Ophthalmol. Visual Sci. 50, 4828-4835
-
(2009)
Invest. Ophthalmol. Visual Sci.
, vol.50
, pp. 4828-4835
-
-
Wang, Z.1
Yang, H.2
Zhang, F.3
Pan, Z.4
Capo-Aponte, J.5
Reinach, P.S.6
-
46
-
-
77953719496
-
PI3K/Akt-sensitive MEK-independent compensatory circuit of ERK activation in ER-positive PI3K-mutant T47D breast cancer cells
-
Aksamitiene, E., Kholodenko, B.N., Kolch, W., Hoek, J.B. and Kiyatkin, A. (2010) PI3K/Akt-sensitive MEK-independent compensatory circuit of ERK activation in ER-positive PI3K-mutant T47D breast cancer cells. Cell. Signalling 22, 1369-1378
-
(2010)
Cell. Signalling
, vol.22
, pp. 1369-1378
-
-
Aksamitiene, E.1
Kholodenko, B.N.2
Kolch, W.3
Hoek, J.B.4
Kiyatkin, A.5
-
47
-
-
4644245263
-
Identification of major ERK-related phosphorylation sites in Gab1
-
DOI 10.1021/bi049753e
-
Lehr, S., Kotzka, J., Avci, H., Sickmann, A., Meyer, H.E., Herkner, A. and Muller-Wieland, D. (2004) Identification of major ERK-related phosphorylation sites in Gab1. Biochemistry 43, 12133-12140 (Pubitemid 39280557)
-
(2004)
Biochemistry
, vol.43
, Issue.38
, pp. 12133-12140
-
-
Lehr, S.1
Kotzka, J.2
Avci, H.3
Sickmann, A.4
Meyer, H.E.5
Herkner, A.6
Muller-Wieland, D.7
-
48
-
-
50849127803
-
Down-regulation of the PI3-kinase/Akt pathway by ERK MAP kinase in growth factor signaling
-
Hayashi, H., Tsuchiya, Y., Nakayama, K., Satoh, T. and Nishida, E. (2008) Down-regulation of the PI3-kinase/Akt pathway by ERK MAP kinase in growth factor signaling. Genes Cells 13, 941-947
-
(2008)
Genes Cells
, vol.13
, pp. 941-947
-
-
Hayashi, H.1
Tsuchiya, Y.2
Nakayama, K.3
Satoh, T.4
Nishida, E.5
-
49
-
-
0037205479
-
ERK negatively regulates the epidermal growth factor-mediated interaction of Gab1 and the phosphatidylinositol 3-kinase
-
DOI 10.1074/jbc.M200732200
-
Yu, C.F., Liu, Z.X. and Cantley, L.G. (2002) ERK negatively regulates the epidermal growth factor-mediated interaction of Gab1 and the phosphatidylinositol 3-kinase. J. Biol. Chem. 277, 19382-19388 (Pubitemid 34967445)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.22
, pp. 19382-19388
-
-
Yu, C.F.1
Liu, Z.-X.2
Cantley, L.G.3
-
50
-
-
0035980153
-
ERK regulates the hepatocyte growth factor-mediated interaction of Gab1 and the phosphatidylinositol 3-kinase
-
Yu, C.F., Roshan, B., Liu, Z.X. and Cantley, L.G. (2001) ERK regulates the hepatocyte growth factor-mediated interaction of Gab1 and the phosphatidylinositol 3-kinase. J. Biol. Chem. 276, 32552-32558
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 32552-32558
-
-
Yu, C.F.1
Roshan, B.2
Liu, Z.X.3
Cantley, L.G.4
-
51
-
-
77249165660
-
2αrepresses IGF-I-stimulated IRS1/phosphatidylinositol-3-kinase/AKT signaling in the corpus luteum: Role of ERK and p70 ribosomal S6 kinase
-
2αrepresses IGF-I-stimulated IRS1/phosphatidylinositol-3- kinase/AKT signaling in the corpus luteum: role of ERK and p70 ribosomal S6 kinase. Mol. Endocrinol. 24, 632-643
-
(2010)
Mol. Endocrinol.
, vol.24
, pp. 632-643
-
-
Arvisais, E.1
Hou, X.2
Wyatt, T.A.3
Shirasuna, K.4
Bollwein, H.5
Miyamoto, A.6
Hansen, T.R.7
Rueda, B.R.8
Davis, J.S.9
-
52
-
-
0141738653
-
EGFR and FGFR signalling through FRS2 is subject to negative feedback control by ERK1/2
-
DOI 10.1515/BC.2003.134
-
Wu, Y., Chen, Z. and Ullrich, A. (2003) EGFR and FGFR signaling through FRS2 is subject to negative feedback control by ERK1/2. Biol. Chem. 384, 1215-1226 (Pubitemid 37121193)
-
(2003)
Biological Chemistry
, vol.384
, Issue.8
, pp. 1215-1226
-
-
Wu, Y.1
Chen, Z.2
Ullrich, A.3
-
54
-
-
27444445782
-
Cooperative phosphorylation of the tumor suppressor phosphatase and tensin homologue (PTEN) by casein kinases and glycogen synthase kinase 3β
-
DOI 10.1074/jbc.M503045200
-
Al-Khouri, A.M., Ma, Y., Togo, S.H., Williams, S. and Mustelin, T. (2005) Cooperative phosphorylation of the tumor suppressor phosphatase and tensin homologue (PTEN) by casein kinases and glycogen synthase kinase 3β. J. Biol. Chem. 280, 35195-35202 (Pubitemid 41532706)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.42
, pp. 35195-35202
-
-
Al-Khouri, A.M.1
Ma, Y.2
Togo, S.H.3
Williams, S.4
Mustelin, T.5
-
55
-
-
67649950283
-
FAK phosphorylation by ERK primes ras-induced tyrosine dephosphorylation of FAK mediated by PIN1 and PTP-PEST
-
Zheng, Y., Xia, Y., Hawke, D., Halle, M., Tremblay, M.L., Gao, X., Zhou, X.Z., Aldape, K., Cobb, M.H., Xie, K. et al. (2009) FAK phosphorylation by ERK primes ras-induced tyrosine dephosphorylation of FAK mediated by PIN1 and PTP-PEST. Mol. Cell 35, 11-25
-
(2009)
Mol. Cell
, vol.35
, pp. 11-25
-
-
Zheng, Y.1
Xia, Y.2
Hawke, D.3
Halle, M.4
Tremblay, M.L.5
Gao, X.6
Zhou, X.Z.7
Aldape, K.8
Cobb, M.H.9
Xie, K.10
-
56
-
-
0033564256
-
Protein kinase C activation inhibits tyrosine phosphorylation of Cbl and its recruitment of Src homology 2 domain-containing proteins
-
Liu, Y., Liu, Y.C., Meller, N., Giampa, L., Elly, C., Doyle, M. and Altman, A. (1999) Protein kinase C activation inhibits tyrosine phosphorylation of Cbl and its recruitment of Src homology 2 domain-containing proteins. J. Immunol. 162, 7095-7101 (Pubitemid 29277678)
-
(1999)
Journal of Immunology
, vol.162
, Issue.12
, pp. 7095-7101
-
-
Liu, Y.1
Liu, Y.-C.2
Meller, N.3
Giampa, L.4
Elly, C.5
Doyle, M.6
Altman, A.7
-
57
-
-
0035473477
-
Beyond the RING: CBL proteins as multivalent adapters
-
DOI 10.1038/sj.onc.1204781
-
Tsygankov, A.Y., Teckchandani, A.M., Feshchenko, E.A. and Swaminathan, G. (2001) Beyond the RING: CBL proteins as multivalent adapters. Oncogene 20, 6382-6402 (Pubitemid 32977846)
-
(2001)
Oncogene
, vol.20
, Issue.44 REV. ISS. 5
, pp. 6382-6402
-
-
Tsygankov, A.Y.1
Teckchandani, A.M.2
Feshchenko, E.A.3
Swaminathan, G.4
-
58
-
-
0037067728
-
Inhibition of Src family kinases blocks epidermal growth factor (EGF)-induced activation of Akt, phosphorylation of c-Cbl, and ubiquitination of the EGF receptor
-
DOI 10.1074/jbc.M201026200
-
Kassenbrock, C.K., Hunter, S., Garl, P., Johnson, G.L. and Anderson, S.M. (2002) Inhibition of Src family kinases blocks epidermal growth factor (EGF)-induced activation of Akt, phosphorylation of c-Cbl, and ubiquitination of the EGF receptor. J. Biol. Chem. 277, 24967-24975 (Pubitemid 34951798)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.28
, pp. 24967-24975
-
-
Kenneth, K.C.1
Hunter, S.2
Garl, P.3
Johnson, G.L.4
Anderson, S.M.5
-
59
-
-
19644367829
-
Negative regulation of receptor tyrosine kinases: Unexpected links to c-Cbl and receptor ubiquitylation
-
DOI 10.1038/sj.cr.7290268
-
Rubin, C., Gur, G. and Yarden, Y. (2005) Negative regulation of receptor tyrosine kinases: unexpected links to c-Cbl and receptor ubiquitylation. Cell Res. 15, 66-71 (Pubitemid 41653969)
-
(2005)
Cell Research
, vol.15
, Issue.1
, pp. 66-71
-
-
Rubin, C.1
Gur, G.2
Yarden, Y.3
-
60
-
-
0034801558
-
Erk pathway positively regulates the expression of sprouty genes
-
DOI 10.1006/bbrc.2001.5295
-
Ozaki, K., Kadomoto, R., Asato, K., Tanimura, S., Itoh, N. and Kohno, M. (2001) ERK pathway positively regulates the expression of Sprouty genes. Biochem. Biophys. Res. Commun. 285, 1084-1088 (Pubitemid 32912891)
-
(2001)
Biochemical and Biophysical Research Communications
, vol.285
, Issue.5
, pp. 1084-1088
-
-
Ozaki, K.1
Kadomoto, R.2
Asato, K.3
Tanimura, S.4
Itoh, N.5
Kohno, M.6
-
61
-
-
3543033477
-
- fibroblasts
-
DOI 10.1081/RRS-120034229
-
Choi, W.S. and Sung, C.K. (2004) Inhibition of phosphatidylinositol-3- kinase enhances insulin stimulation of insulin receptor substrate 1 tyrosine phosphorylation and extracellular signal-regulated kinases in mouse R- fibroblasts. J. Recept. Signal Transduction Res. 24, 67-83 (Pubitemid 39011290)
-
(2004)
Journal of Receptors and Signal Transduction
, vol.24
, Issue.1-2
, pp. 67-83
-
-
Choi, W.S.1
Sung, C.K.2
-
62
-
-
79957917078
-
PI3K inhibition results in enhanced HER signaling and acquired ERK dependency in HER2-overexpressing breast cancer
-
Serra, V., Scaltriti, M., Prudkin, L., Eichhorn, P.J., Ibrahim, Y.H., Chandarlapaty, S., Markman, B., Rodriguez, O., Guzman, M., Rodriguez, S. et al. (2011) PI3K inhibition results in enhanced HER signaling and acquired ERK dependency in HER2-overexpressing breast cancer. Oncogene 30, 2547-2557
-
(2011)
Oncogene
, vol.30
, pp. 2547-2557
-
-
Serra, V.1
Scaltriti, M.2
Prudkin, L.3
Eichhorn, P.J.4
Ibrahim, Y.H.5
Chandarlapaty, S.6
Markman, B.7
Rodriguez, O.8
Guzman, M.9
Rodriguez, S.10
-
63
-
-
78649831949
-
Crosstalk between the PI3K/mTOR and MEK/ERK pathways involved in the maintenance of self-renewal and tumorigenicity of glioblastoma stem-like cells
-
Sunayama, J., Matsuda, K., Sato, A., Tachibana, K., Suzuki, K., Narita, Y., Shibui, S., Sakurada, K., Kayama, T., Tomiyama, A. and Kitanaka, C. (2010) Crosstalk between the PI3K/mTOR and MEK/ERK pathways involved in the maintenance of self-renewal and tumorigenicity of glioblastoma stem-like cells. Stem Cells 28, 1930-1939
-
(2010)
Stem Cells
, vol.28
, pp. 1930-1939
-
-
Sunayama, J.1
Matsuda, K.2
Sato, A.3
Tachibana, K.4
Suzuki, K.5
Narita, Y.6
Shibui, S.7
Sakurada, K.8
Kayama, T.9
Tomiyama, A.10
Kitanaka, C.11
-
64
-
-
64349110975
-
Systems-level interactions between insulin-EGF networks amplify mitogenic signaling
-
Borisov, N., Aksamitiene, E., Kiyatkin, A., Legewie, S., Berkhout, J., Maiwald, T., Kaimachnikov, N.P., Timmer, J., Hoek, J.B. and Kholodenko, B.N. (2009) Systems-level interactions between insulin-EGF networks amplify mitogenic signaling. Mol. Syst. Biol. 5, 256
-
(2009)
Mol. Syst. Biol.
, vol.5
, pp. 256
-
-
Borisov, N.1
Aksamitiene, E.2
Kiyatkin, A.3
Legewie, S.4
Berkhout, J.5
Maiwald, T.6
Kaimachnikov, N.P.7
Timmer, J.8
Hoek, J.B.9
Kholodenko, B.N.10
|