Infection-induced colitis in mice causes dynamic and tissue-specific changes in stress response and DNA damage leading to colon cancer

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 27, 2012, Pages

  Mangerich, Aswin ^a,c   Knutson, Charles G ^a   Parry, Nicola M ^b   Muthupalani, Sureshkumar ^b   Ye, Wenjie ^a   Prestwich, Erin ^a   Cui, Liang ^a,d   McFaline, Jose L ^a   Mobley, Melissa ^b   Ge, Zhongming ^b   Taghizadeh, Koli ^b   Wishnok, John S ^a,b   Wogan, Gerald N ^a,b   Fox, James G ^a,b   Tannenbaum, Steven R ^a,b   Dedon, Peter C ^a,b  

^a Massachusetts Institute of Technology Cambridge   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c UNIVERSITY OF KONSTANZ   (Germany)

^d NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Biomarkers; Mass spectrometry

Indexed keywords

5 CHLOROCYTOSINE; CYTOSINE DERIVATIVE; DNA; GLUTATHIONE; HYPOXANTHINE; NUCLEIC ACID; RNA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL STRAIN; CANCER GROWTH; CECUM; CELL DEATH; COLITIS; COLON; COLON CARCINOGENESIS; COLON CARCINOMA; CONTROLLED STUDY; CYCLOADDITION; DISEASE COURSE; DISEASE SEVERITY; DNA DAMAGE; DNA REPAIR; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE MUTATION; HELICOBACTER HEPATICUS; HELICOBACTER INFECTION; HEPATITIS; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; INFLAMMATION; LIQUID CHROMATOGRAPHY TANDEM MASS SPECTROMETRY; LIVER; MOLECULAR DYNAMICS; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; OXIDATIVE STRESS; PHAGOCYTE; PHAGOCYTOSIS; PRIORITY JOURNAL; TANDEM MASS SPECTROMETRY; TISSUE SPECIFICITY; TRANSCRIPTION REGULATION;

ANIMALS; BIOLOGICAL MARKERS; CHRONIC DISEASE; COLITIS; COLONIC NEOPLASMS; DISEASE MODELS, ANIMAL; DNA DAMAGE; DNA-BINDING PROTEINS; GENE EXPRESSION; HELICOBACTER HEPATICUS; HELICOBACTER INFECTIONS; HEPATITIS; MACROPHAGES; MASS SPECTROMETRY; MICE; MICE, 129 STRAIN; MICE, MUTANT STRAINS; NEUTROPHILS; OXIDATIVE STRESS; RNA;

HELICOBACTER HEPATICUS; MUS;

EID: 84863582087     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1207829109     Document Type: Article

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