메뉴 건너뛰기




Volumn 59, Issue 8, 2011, Pages 1181-1189

Glutamate and the biology of gliomas

Author keywords

Glioma; Growth; Invasion

Indexed keywords

AMPA RECEPTOR; FOCAL ADHESION KINASE; GLUTAMATE RECEPTOR; GLUTAMATE TRANSPORTER; GLUTAMIC ACID; GLUTATHIONE; MEMANTINE; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE B; SALAZOSULFAPYRIDINE; TALAMPANEL; TEMOZOLOMIDE;

EID: 79957897718     PISSN: 08941491     EISSN: 10981136     Source Type: Journal    
DOI: 10.1002/glia.21113     Document Type: Article
Times cited : (242)

References (81)
  • 2
    • 11944255890 scopus 로고    scopus 로고
    • Reversal or reduction of glutamate and GABA transport in CNS pathology and therapy
    • Allen NJ, Karadottir R, Attwell D. 2004. Reversal or reduction of glutamate and GABA transport in CNS pathology and therapy. Pflugers Arch 449: 132-142.
    • (2004) Pflugers Arch , vol.449 , pp. 132-142
    • Allen, N.J.1    Karadottir, R.2    Attwell, D.3
  • 4
    • 0038810014 scopus 로고    scopus 로고
    • Expression and functional role of mGluR3 and mGluR5 in human astrocytes and glioma cells: Opposite regulation of glutamate transporter proteins
    • Aronica E, Gorter JA, Ijlst-Keizers H, Rozemuller AJ, Yankaya B, Leenstra S, Troost D. 2003. Expression and functional role of mGluR3 and mGluR5 in human astrocytes and glioma cells: Opposite regulation of glutamate transporter proteins. Eur J Neurosci 17: 2106-2118.
    • (2003) Eur J Neurosci , vol.17 , pp. 2106-2118
    • Aronica, E.1    Gorter, J.A.2    Ijlst-Keizers, H.3    Rozemuller, A.J.4    Yankaya, B.5    Leenstra, S.6    Troost, D.7
  • 5
    • 0033909858 scopus 로고    scopus 로고
    • Extracellular glutamate and other metabolites in and around RG2 rat glioma: An intracerebral microdialysis study
    • Behrens PF, Langemann H, Strohschein R, Draeger J, Hennig J. 2000. Extracellular glutamate and other metabolites in and around RG2 rat glioma: An intracerebral microdialysis study. J Neurooncol 47: 11-22.
    • (2000) J Neurooncol , vol.47 , pp. 11-22
    • Behrens, P.F.1    Langemann, H.2    Strohschein, R.3    Draeger, J.4    Hennig, J.5
  • 6
    • 67649871267 scopus 로고    scopus 로고
    • The GluR2 subunit inhibits proliferation by inactivating Src-MAPK signalling and induces apoptosis by means of caspase 3/6-dependent activation in glioma cells
    • Beretta F, Bassani S, Binda E, Verpelli C, Bello L, Galli R, Passafaro M. 2009. The GluR2 subunit inhibits proliferation by inactivating Src-MAPK signalling and induces apoptosis by means of caspase 3/6-dependent activation in glioma cells. Eur J Neurosci 30: 25-34.
    • (2009) Eur J Neurosci , vol.30 , pp. 25-34
    • Beretta, F.1    Bassani, S.2    Binda, E.3    Verpelli, C.4    Bello, L.5    Galli, R.6    Passafaro, M.7
  • 7
    • 0035017203 scopus 로고    scopus 로고
    • Mitogenic signaling and the relationship to cell cycle regulation in astrocytomas
    • Besson A, Yong VW. 2001. Mitogenic signaling and the relationship to cell cycle regulation in astrocytomas. J Neurooncol 51: 245-264.
    • (2001) J Neurooncol , vol.51 , pp. 245-264
    • Besson, A.1    Yong, V.W.2
  • 9
    • 0024093449 scopus 로고
    • Glutamate neurotoxicity and diseases of the nervous system. [Review]
    • Choi DW. 1988. Glutamate neurotoxicity and diseases of the nervous system. [Review]. Neuron 1: 623-634.
    • (1988) Neuron , vol.1 , pp. 623-634
    • Choi, D.W.1
  • 13
    • 0034103659 scopus 로고    scopus 로고
    • Roles of NMDA receptor activity and nitric oxide production in brain development
    • Contestabile A. 2000. Roles of NMDA receptor activity and nitric oxide production in brain development. Brain Res Brain Res Rev 32: 476-509.
    • (2000) Brain Res Brain Res Rev , vol.32 , pp. 476-509
    • Contestabile, A.1
  • 14
    • 0035001341 scopus 로고    scopus 로고
    • Glutamate uptake
    • Danbolt NC. 2001. Glutamate uptake. Prog Neurobiol 65: 1-105.
    • (2001) Prog Neurobiol , vol.65 , pp. 1-105
    • Danbolt, N.C.1
  • 15
    • 0036177115 scopus 로고    scopus 로고
    • Targeting protein kinase C: New therapeutic opportunities against high-grade malignant gliomas?
    • da Rocha AB, Mans DR, Regner A, Schwartsmann G. 2002. Targeting protein kinase C: New therapeutic opportunities against high-grade malignant gliomas? Oncologist 7: 17-33.
    • (2002) Oncologist , vol.7 , pp. 17-33
    • da Rocha, A.B.1    Mans, D.R.2    Regner, A.3    Schwartsmann, G.4
  • 16
    • 16444366144 scopus 로고    scopus 로고
    • The excitatory amino acid transporter-2 induces apoptosis and decreases glioma growth in vitro and in vivo
    • de Groot JF, Liu TJ, Fuller G, Yung WK. 2005. The excitatory amino acid transporter-2 induces apoptosis and decreases glioma growth in vitro and in vivo. Cancer Res 65: 1934-1940.
    • (2005) Cancer Res , vol.65 , pp. 1934-1940
    • de Groot, J.F.1    Liu, T.J.2    Fuller, G.3    Yung, W.K.4
  • 17
    • 70350003803 scopus 로고    scopus 로고
    • Improving the prognosis for patients with glioblastoma: The rationale for targeting Src
    • de Groot J, Milano V. 2009. Improving the prognosis for patients with glioblastoma: The rationale for targeting Src. J Neurooncol 95: 151-163.
    • (2009) J Neurooncol , vol.95 , pp. 151-163
    • de Groot, J.1    Milano, V.2
  • 18
    • 43149104379 scopus 로고    scopus 로고
    • Knockdown of GluR1 expression by RNA interference inhibits glioma proliferation
    • de Groot JF, Piao Y, Lu L, Fuller GN, Yung WK. 2008. Knockdown of GluR1 expression by RNA interference inhibits glioma proliferation. J Neurooncol 88: 121-133.
    • (2008) J Neurooncol , vol.88 , pp. 121-133
    • de Groot, J.F.1    Piao, Y.2    Lu, L.3    Fuller, G.N.4    Yung, W.K.5
  • 19
    • 0033168351 scopus 로고    scopus 로고
    • The concentration of synaptically released glutamate outside of the climbing fiber-purkinje cell synaptic cleft
    • Dzubay JA, Jahr CE. 1999. The concentration of synaptically released glutamate outside of the climbing fiber-purkinje cell synaptic cleft. JNeurosci 19: 5265-5274.
    • (1999) JNeurosci , vol.19 , pp. 5265-5274
    • Dzubay, J.A.1    Jahr, C.E.2
  • 21
    • 0346097992 scopus 로고    scopus 로고
    • In vivo single-voxel proton MR spectroscopy in the differentiation of high-grade gliomas and solitary metastases
    • Fan G, Sun B, Wu Z, Guo Q, Guo Y. 2004. In vivo single-voxel proton MR spectroscopy in the differentiation of high-grade gliomas and solitary metastases. Clin Radiol 59: 77-85.
    • (2004) Clin Radiol , vol.59 , pp. 77-85
    • Fan, G.1    Sun, B.2    Wu, Z.3    Guo, Q.4    Guo, Y.5
  • 22
    • 85016872313 scopus 로고    scopus 로고
    • Activated astrocytes in areas of kainate-induced neuronal injury upregulate the expression of the metabotropic glutamate receptors 2/3 and 5
    • Ferraguti F, Corti C, Valerio E, Mion S, Xuereb J. 2001. Activated astrocytes in areas of kainate-induced neuronal injury upregulate the expression of the metabotropic glutamate receptors 2/3 and 5. Exp Brain Res 137: 1-11.
    • (2001) Exp Brain Res , vol.137 , pp. 1-11
    • Ferraguti, F.1    Corti, C.2    Valerio, E.3    Mion, S.4    Xuereb, J.5
  • 23
    • 79957917122 scopus 로고    scopus 로고
    • NMDA and AMPA glutamate receptor antagonists in the treatment of human malignant glioma xenografts
    • Goudar RK, Keir ST, Bigner DD, Friedman HS. 2004. NMDA and AMPA glutamate receptor antagonists in the treatment of human malignant glioma xenografts. AACR Meeting Abstracts 2004: 1053-105d.
    • (2004) AACR Meeting Abstracts , vol.2004
    • Goudar, R.K.1    Keir, S.T.2    Bigner, D.D.3    Friedman, H.S.4
  • 25
    • 0036939520 scopus 로고    scopus 로고
    • Human glioma cells and undifferentiated primary astrocytes that express aberrant EAAT2 mRNA inhibit normal EAAT2 protein expression and prevent cell death
    • Guo H, Lai L, Butchbach ME, Lin CL. 2002. Human glioma cells and undifferentiated primary astrocytes that express aberrant EAAT2 mRNA inhibit normal EAAT2 protein expression and prevent cell death. Mol Cell Neurosci 21: 546-560.
    • (2002) Mol Cell Neurosci , vol.21 , pp. 546-560
    • Guo, H.1    Lai, L.2    Butchbach, M.E.3    Lin, C.L.4
  • 27
    • 0033531214 scopus 로고    scopus 로고
    • The AMPA receptor interacts with and signals through the protein tyrosine kinase Lyn
    • Hayashi T, Umemori H, Mishina M, Yamamoto T. 1999. The AMPA receptor interacts with and signals through the protein tyrosine kinase Lyn. Nature 397: 72-76.
    • (1999) Nature , vol.397 , pp. 72-76
    • Hayashi, T.1    Umemori, H.2    Mishina, M.3    Yamamoto, T.4
  • 30
    • 77950286074 scopus 로고    scopus 로고
    • Phase 2 trial of talampanel, a glutamate receptor inhibitor, for adults with recurrent malignant gliomas
    • Iwamoto FM, Kreisl TN, Kim L, Duic JP, Butman JA, Albert PS, Fine HA. 2010. Phase 2 trial of talampanel, a glutamate receptor inhibitor, for adults with recurrent malignant gliomas. Cancer 116: 1776-1782.
    • (2010) Cancer , vol.116 , pp. 1776-1782
    • Iwamoto, F.M.1    Kreisl, T.N.2    Kim, L.3    Duic, J.P.4    Butman, J.A.5    Albert, P.S.6    Fine, H.A.7
  • 31
    • 77249086563 scopus 로고    scopus 로고
    • Glutathione depletion causes a JNK and p38MAPK-mediated increase in expression of cystathionine-gamma-lyase and upregulation of the transsulfuration pathway in C6 glioma cells
    • Kandil S, Brennan L, McBean GJ. 2010. Glutathione depletion causes a JNK and p38MAPK-mediated increase in expression of cystathionine-gamma-lyase and upregulation of the transsulfuration pathway in C6 glioma cells. Neurochem Int 56: 611-619.
    • (2010) Neurochem Int , vol.56 , pp. 611-619
    • Kandil, S.1    Brennan, L.2    McBean, G.J.3
  • 33
    • 0025425558 scopus 로고
    • Swelling-induced release of glutamate, aspartate, and taurine from astrocyte cultures
    • Kimelberg HK, Goderie SK, Higman S, Pang S, Waniewski RA. 1990. Swelling-induced release of glutamate, aspartate, and taurine from astrocyte cultures. J Neurosci 10: 1583-1591.
    • (1990) J Neurosci , vol.10 , pp. 1583-1591
    • Kimelberg, H.K.1    Goderie, S.K.2    Higman, S.3    Pang, S.4    Waniewski, R.A.5
  • 35
    • 0027905017 scopus 로고
    • Modulation of neuronal migration by NMDA receptors
    • Komuro H, Rakic P. 1993. Modulation of neuronal migration by NMDA receptors. Science 260: 95-97.
    • (1993) Science , vol.260 , pp. 95-97
    • Komuro, H.1    Rakic, P.2
  • 36
    • 33644683295 scopus 로고    scopus 로고
    • Glutamatergic regulation of the pZ0S6 kinase in primary mouse neurons
    • Lenz G, Avruch J. 2005. Glutamatergic regulation of the pZ0S6 kinase in primary mouse neurons. J Biol Chem 280: 38121-38124.
    • (2005) J Biol Chem , vol.280 , pp. 38121-38124
    • Lenz, G.1    Avruch, J.2
  • 37
    • 15044338779 scopus 로고    scopus 로고
    • Failures and successes of NMDA receptor antagonists: Molecular basis for the use of open-channel blockers like memantine in the treatment of acute and chronic neurologic insults
    • Lipton SA. 2004. Failures and successes of NMDA receptor antagonists: Molecular basis for the use of open-channel blockers like memantine in the treatment of acute and chronic neurologic insults. NeuroRx 1: 101-110.
    • (2004) NeuroRx , vol.1 , pp. 101-110
    • Lipton, S.A.1
  • 39
    • 0036305484 scopus 로고    scopus 로고
    • AMPA receptor trafficking and synaptic plasticity
    • Malinow R, Malenka RC. 2002. AMPA receptor trafficking and synaptic plasticity. Annu Rev Neurosci 25: 103-126.
    • (2002) Annu Rev Neurosci , vol.25 , pp. 103-126
    • Malinow, R.1    Malenka, R.C.2
  • 40
    • 77949266026 scopus 로고    scopus 로고
    • In vivo assessment of high-grade glioma biochemistry using microdialysis: A study of energy-related molecules, growth factors and cytokines
    • Marcus HJ, Carpenter KL, Price SJ, Hutchinson PJ. 2010. In vivo assessment of high-grade glioma biochemistry using microdialysis: A study of energy-related molecules, growth factors and cytokines. J Neurooncol 97: 11-23.
    • (2010) J Neurooncol , vol.97 , pp. 11-23
    • Marcus, H.J.1    Carpenter, K.L.2    Price, S.J.3    Hutchinson, P.J.4
  • 43
    • 0242382624 scopus 로고    scopus 로고
    • Molecular neuro-oncology and development of targeted therapeutic strategies for brain tumors. I. Growth factor and Ras signaling pathways
    • Newton HB. 2003. Molecular neuro-oncology and development of targeted therapeutic strategies for brain tumors. I. Growth factor and Ras signaling pathways. Expert Rev Anticancer Ther 3: 595-614.
    • (2003) Expert Rev Anticancer Ther , vol.3 , pp. 595-614
    • Newton, H.B.1
  • 45
    • 0025052336 scopus 로고
    • The release and uptake of excitatory amino acids [see comments]
    • Nicholls D, Attwell D. 1990. The release and uptake of excitatory amino acids [see comments]. TIPS 11: 462-468.
    • (1990) TIPS , vol.11 , pp. 462-468
    • Nicholls, D.1    Attwell, D.2
  • 46
    • 70449711757 scopus 로고    scopus 로고
    • Genetic alterations and signaling pathways in the evolution of gliomas
    • Ohgaki H, Kleihues P. 2009. Genetic alterations and signaling pathways in the evolution of gliomas. Cancer Sci 100: 2235-2241.
    • (2009) Cancer Sci , vol.100 , pp. 2235-2241
    • Ohgaki, H.1    Kleihues, P.2
  • 47
    • 0027468201 scopus 로고
    • Vulnerability of oligodendroglia to glutamate: Pharamacology, mechanisms, and prevention
    • Oka A, Belliveau MJ, Rosenberg PA, Volpe JJ. 1993. Vulnerability of oligodendroglia to glutamate: Pharamacology, mechanisms, and prevention. J Neurosci 13: 1441-1453.
    • (1993) J Neurosci , vol.13 , pp. 1441-1453
    • Oka, A.1    Belliveau, M.J.2    Rosenberg, P.A.3    Volpe, J.J.4
  • 49
    • 0347480436 scopus 로고    scopus 로고
    • Differentiation of substrate and non-substrate inhibitors of transport system xc(-): An obligate exchanger of L-glutamate and L-cystine
    • Patel SA, Warren BA, Rhoderick JF, Bridges RJ. 2004. Differentiation of substrate and non-substrate inhibitors of transport system xc(-): An obligate exchanger of L-glutamate and L-cystine. Neuropharmacology 46: 273-284.
    • (2004) Neuropharmacology , vol.46 , pp. 273-284
    • Patel, S.A.1    Warren, B.A.2    Rhoderick, J.F.3    Bridges, R.J.4
  • 50
    • 67649619278 scopus 로고    scopus 로고
    • AMPA receptors promote perivascular glioma invasion via beta1 integrin-dependent adhesion to the extracellular matrix
    • Piao Y, Lu L, de Groot J. 2009. AMPA receptors promote perivascular glioma invasion via beta1 integrin-dependent adhesion to the extracellular matrix. Neuro Oncol 11: 260-273.
    • (2009) Neuro Oncol , vol.11 , pp. 260-273
    • Piao, Y.1    Lu, L.2    de Groot, J.3
  • 51
    • 0242361561 scopus 로고    scopus 로고
    • Oncogenic Ras and Akt signaling contribute to glioblastoma formation by differential recruitment of existing mRNAs to polysomes
    • Rajasekhar VK, Viale A, Socci ND, Wiedmann M, Hu X, Holland EC. 2003. Oncogenic Ras and Akt signaling contribute to glioblastoma formation by differential recruitment of existing mRNAs to polysomes. Mol Cell 12: 889-901.
    • (2003) Mol Cell , vol.12 , pp. 889-901
    • Rajasekhar, V.K.1    Viale, A.2    Socci, N.D.3    Wiedmann, M.4    Hu, X.5    Holland, E.C.6
  • 55
    • 70450228522 scopus 로고    scopus 로고
    • Early termination of ISRCTN45828668, a phase 1/2 prospective, randomized study of sulfasalazine for the treatment of progressing malignant gliomas in adults
    • Robe PA, Martin DH, Nguyen-Khac MT, Artesi M, Deprez M, Albert A, Vanbelle S, Califice S, Bredel M, Bours V. 2009. Early termination of ISRCTN45828668, a phase 1/2 prospective, randomized study of sulfasalazine for the treatment of progressing malignant gliomas in adults. BMC Cancer 9: 372.
    • (2009) BMC Cancer , vol.9 , pp. 372
    • Robe, P.A.1    Martin, D.H.2    Nguyen-Khac, M.T.3    Artesi, M.4    Deprez, M.5    Albert, A.6    Vanbelle, S.7    Califice, S.8    Bredel, M.9    Bours, V.10
  • 56
    • 0344642991 scopus 로고    scopus 로고
    • Baseline levels of glucose metabolites, glutamate and glycerol in malignant glioma assessed by stereotactic microdialysis
    • Roslin M, Henriksson R, Bergstrom P, Ungerstedt U, Bergenheim AT. 2003. Baseline levels of glucose metabolites, glutamate and glycerol in malignant glioma assessed by stereotactic microdialysis. J Neurooncol 61: 151-160.
    • (2003) J Neurooncol , vol.61 , pp. 151-160
    • Roslin, M.1    Henriksson, R.2    Bergstrom, P.3    Ungerstedt, U.4    Bergenheim, A.T.5
  • 57
    • 0036732403 scopus 로고    scopus 로고
    • Paving new pathways
    • Rothstein JD. 2002. Paving new pathways. Nat Med 8: 938-940.
    • (2002) Nat Med , vol.8 , pp. 938-940
    • Rothstein, J.D.1
  • 60
    • 0033597349 scopus 로고    scopus 로고
    • Cloning and expression of a plasma membrane cystine/glutamate exchange transporter composed of two distinct proteins
    • Sato H, Tamba M, Ishii T, Bannai S. 1999. Cloning and expression of a plasma membrane cystine/glutamate exchange transporter composed of two distinct proteins. J Biol Chem 274: 11455-11458.
    • (1999) J Biol Chem , vol.274 , pp. 11455-11458
    • Sato, H.1    Tamba, M.2    Ishii, T.3    Bannai, S.4
  • 63
    • 0027536702 scopus 로고
    • Neuronal-astrocytic interactions in glutamate metabolism
    • Schousboe A, Westergaard N, Hertz L. 1993. Neuronal-astrocytic interactions in glutamate metabolism. Biochem Soc Trans 21: 49-53.
    • (1993) Biochem Soc Trans , vol.21 , pp. 49-53
    • Schousboe, A.1    Westergaard, N.2    Hertz, L.3
  • 65
    • 0035784004 scopus 로고    scopus 로고
    • Ionotropic glutamate receptors in astrocytes
    • Seifert G, Steinhauser C. 2001. Ionotropic glutamate receptors in astrocytes. Prog Brain Res 132: 287-299.
    • (2001) Prog Brain Res , vol.132 , pp. 287-299
    • Seifert, G.1    Steinhauser, C.2
  • 66
    • 0141533202 scopus 로고    scopus 로고
    • Malignant gliomas: Perverting glutamate and ion homeostasis for selective advantage
    • Sontheimer H. 2003. Malignant gliomas: Perverting glutamate and ion homeostasis for selective advantage. Trends Neurosci 26: 543-549.
    • (2003) Trends Neurosci , vol.26 , pp. 543-549
    • Sontheimer, H.1
  • 69
    • 41049090828 scopus 로고    scopus 로고
    • Relative expression of mRNAS coding for glutaminase isoforms in CNS tissues and CNS tumors
    • Szeliga M, Matyja E, Obara M, Grajkowska W, Czernicki T, Albrecht J. 2008. Relative expression of mRNAS coding for glutaminase isoforms in CNS tissues and CNS tumors. Neurochem Res 33: 808-813.
    • (2008) Neurochem Res , vol.33 , pp. 808-813
    • Szeliga, M.1    Matyja, E.2    Obara, M.3    Grajkowska, W.4    Czernicki, T.5    Albrecht, J.6
  • 71
    • 1342289413 scopus 로고    scopus 로고
    • MAPK cascade signalling and synaptic plasticity
    • Thomas GM, Huganir RL. 2004. MAPK cascade signalling and synaptic plasticity. Nat Rev Neurosci 5: 173-183.
    • (2004) Nat Rev Neurosci , vol.5 , pp. 173-183
    • Thomas, G.M.1    Huganir, R.L.2
  • 72
    • 0034083370 scopus 로고    scopus 로고
    • Expression of metabotropic glutamate receptor 5 is increased in astrocytes after kainate-induced epileptic seizures
    • Ulas J, Satou T, Ivins KJ, Kesslak JP, Cotman CW, Balazs R. 2000. Expression of metabotropic glutamate receptor 5 is increased in astrocytes after kainate-induced epileptic seizures. Glia 30: 352-361.
    • (2000) Glia , vol.30 , pp. 352-361
    • Ulas, J.1    Satou, T.2    Ivins, K.J.3    Kesslak, J.P.4    Cotman, C.W.5    Balazs, R.6
  • 73
    • 67349208235 scopus 로고    scopus 로고
    • Enhanced expression of the high affinity glutamate transporter GLT-1 in C6 glioma cells delays tumour progression in rat
    • Vanhoutte N, Abarca-Quinones J, Jordan BF, Gallez B, Maloteaux JM, Hermans E. 2009. Enhanced expression of the high affinity glutamate transporter GLT-1 in C6 glioma cells delays tumour progression in rat. Exp Neurol 218: 56-63.
    • (2009) Exp Neurol , vol.218 , pp. 56-63
    • Vanhoutte, N.1    Abarca-Quinones, J.2    Jordan, B.F.3    Gallez, B.4    Maloteaux, J.M.5    Hermans, E.6
  • 74
    • 0028981361 scopus 로고
    • alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid, but not N-methyl-D-aspartate, activates mitogen-activated protein kinase through G-protein beta gamma subunits in rat cortical neurons
    • Wang Y, Durkin JP. 1995. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid, but not N-methyl-D-aspartate, activates mitogen-activated protein kinase through G-protein beta gamma subunits in rat cortical neurons. J Biol Chem 270: 22783-22787.
    • (1995) J Biol Chem , vol.270 , pp. 22783-22787
    • Wang, Y.1    Durkin, J.P.2
  • 77
    • 70350217425 scopus 로고    scopus 로고
    • Glioblastoma cells require glutamate dehydrogenase to survive impairments of glucose metabolism or Akt signaling
    • Yang C, Sudderth J, Dang T, Bachoo RM, McDonald JG, DeBerardinis RJ. 2009. Glioblastoma cells require glutamate dehydrogenase to survive impairments of glucose metabolism or Akt signaling. Cancer Res 69: 7986-7993.
    • (2009) Cancer Res , vol.69 , pp. 7986-7993
    • Yang, C.1    Sudderth, J.2    Dang, T.3    Bachoo, R.M.4    McDonald, J.G.5    DeBerardinis, R.J.6
  • 78
    • 0033573392 scopus 로고    scopus 로고
    • Compromised glutamate transport in human glioma cells: Reduction-mislocalization of sodium-dependent glutamate transporters and enhanced activity of cystine-glutamate exchange
    • Ye ZC, Rothstein JD, Sontheimer H. 1999. Compromised glutamate transport in human glioma cells: Reduction-mislocalization of sodium-dependent glutamate transporters and enhanced activity of cystine-glutamate exchange. J Neurosci 19: 10767-10777.
    • (1999) J Neurosci , vol.19 , pp. 10767-10777
    • Ye, Z.C.1    Rothstein, J.D.2    Sontheimer, H.3
  • 79
    • 0033198997 scopus 로고    scopus 로고
    • Glioma cells release excitotoxic concentrations of glutamate
    • Ye ZC, Sontheimer H. 1999a. Glioma cells release excitotoxic concentrations of glutamate. Cancer Res 59: 4383-4391.
    • (1999) Cancer Res , vol.59 , pp. 4383-4391
    • Ye, Z.C.1    Sontheimer, H.2
  • 80
    • 0033083661 scopus 로고    scopus 로고
    • Metabotropic glutamate receptor agonists reduce glutamate release from cultured astrocytes [In Process Citation]
    • Ye ZC, Sontheimer H. 1999b. Metabotropic glutamate receptor agonists reduce glutamate release from cultured astrocytes [In Process Citation]. Glia 25: 270-281.
    • (1999) Glia , vol.25 , pp. 270-281
    • Ye, Z.C.1    Sontheimer, H.2
  • 81
    • 0037531231 scopus 로고    scopus 로고
    • Functional hemichannels in astrocytes: A novel mechanism of glutamate release
    • Ye ZC, Wyeth MS, Baltan-Tekkok S, Ransom BR. 2003. Functional hemichannels in astrocytes: A novel mechanism of glutamate release. J Neurosci 23: 3588-3596.
    • (2003) J Neurosci , vol.23 , pp. 3588-3596
    • Ye, Z.C.1    Wyeth, M.S.2    Baltan-Tekkok, S.3    Ransom, B.R.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.