The p53/Mdm2/p14ARF cell cycle control pathway genes may be inactivated by genetic and epigenetic mechanisms in gliomas [1]

Cancer Genetics and Cytogenetics

Volumn 164, Issue 2, 2006, Pages 172-173

  Bello, M Josefa ^a   Rey, Juan A ^a  

^a HOSPITAL UNIVERSITARIO LA PAZ   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN MDM2; PROTEIN P14ARF; PROTEIN P53;

ASTROCYTOMA; CELL CYCLE REGULATION; DNA POLYMORPHISM; EPENDYMOMA; EPIGENETICS; GENE AMPLIFICATION; GENE INACTIVATION; GENE MUTATION; GLIOBLASTOMA; GLIOMA; HUMAN; LETTER; METHYLATION; OLIGODENDROGLIOMA; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE; CELL CYCLE; CENTRAL NERVOUS SYSTEM TUMOR; CPG ISLAND; DNA METHYLATION; GENE EXPRESSION REGULATION; GENE SILENCING; GENETIC EPIGENESIS; GENETICS; MUTATION; PATHOLOGY; PHYSIOLOGY; PROMOTER REGION;

CELL CYCLE; CENTRAL NERVOUS SYSTEM NEOPLASMS; CPG ISLANDS; DNA METHYLATION; EPIGENESIS, GENETIC; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE SILENCING; GENES, P53; GLIOMA; HUMANS; MUTATION; PROMOTER REGIONS (GENETICS); PROTO-ONCOGENE PROTEINS C-MDM2; TUMOR SUPPRESSOR PROTEIN P14ARF;

EID: 31144451624     PISSN: 01654608     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cancergencyto.2005.07.002     Document Type: Letter

References (18)

1. P. Kleihues W.K. Kavenee World Health Organization classification of tumors. Pathology and genetics of tumors of the nervous system 2000 IARC Press Lyon
2. D.N. Louis The p53 gene and protein in human brain tumors J Neuropathol Exp Neurol 53 1993 11 21
3. M.H. Kubbutat, S.N. Jones, and K.H. Vousde Regulation of p53 stability by Mdm2 Nature 387 1997 299 303
4. S.M. Picksley, and D.P. Lame The p53-mdm2 autoregulatory feedback loop: a paradigm for the regulation of growth control by p53? BioEssays 15 1993 689 690
5. Y. Zhang, Y. Xiong, and W.G. Yarbrough ARF promotes MDM2 deregulation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways Cell 92 1998 725 734
6. S.B. Baylin, J.G. Herman, J.R. Graff, M.P. Vertino, and J.P.J. Issa Alterations in the DNA methylation: a fundamental aspect of neoplasia Adv Cancer Res 72 1998 141 146
7. P. Gonzalez-Gomez, M.J. Bello, D. Arjona, J. Lomas, M.E. Alonso, J.M. de Campos, J. Vaquero, A. Isla, M. Gutierrez, and J.A. Rey Promoter hypermethylation of multiple genes in astrocytic gliomas Int J Oncology 22 2003 601 608
8. M.E. Alonso, M.J. Bello, P. Gonzalez-Gomez, D. Arjona, J. Lomas, J.M. de Campos, A. Isla, J.L. Sarasa, and J.A. Rey Aberrant promoter methyaltion of multiple genes in oligodendrolgiomas and ependymomas Cancer Genet Cytogenet 144 2003 134 142
9. P. Gonzalez-Gomez, M.J. Bello, M.E. Alonso, D. Arjona, J. Lomas, J.M. de Campos, A. Isla, and J.A. Rey CpG island methylation status and mutation analysis of the RB1 gene essential promoter region and protein-binding pocket domain in nervous system tumours Br J Cancer 88 2003 109 114
10. M.E. Alonso, M.J. Bello, P. Gonzalez-Gomez, D. Arjona, J.M. de Campos, M. Gutierrez, and J.A. Rey Aberrant CpG island methylation of multiple genes in ependymal tumors J Neuro-Oncology 67 2004 159 165
11. Bello MJ, Gonzalez-Gomez P, Alonso ME, Anselmo NP, Arjona D, Lopez-Marin, de Campos JM, Isla A, Vaquero J, Casartelli C, Rey JA. Methylation analysis of cell cycle control genes RB1, p14ARF and p16INK4a in human gliomas. Cancer Ther. 2004;2:187-94.
12. M.J. Bello, M.E. Alonso, C. Amiñoso, N.P. Anselmo, D. Arjona, P. Gonzalez-Gomez, I. Lopez-Marin, J.M. de Campos, M. Gutierrez, A. Isla, M.E. Kusak, L. Lassaletta, J.L. Sarasa, J. Vaquero, C. Casartelli, and J.A. Rey Hypermethylaiton of the DNA repair gene MGMT: association with TP53 G:C to A:T transitions in a series of 469 nervous system tumors Mutation Res 554 2004 23 32
13. M.E. Alonso, M.J. Bello, D. Arjona, V. Martinez-Glez, J.M. de Campos, A. Isla, M.E. Kusak, J. Vaquero, M. Gutierrez, J.L. Sarasa, and J.A. Rey Real-time quantitative PCR analysis of gene dosages reveals gene amplification in low-grade oligodendrogliomas Am J Clin Pathol 123 2005 900 906
14. Arjona D, Bello MJ, Alonso ME, Isla A, de Campos JM, Vaquero J, Sarasa JL, Gutierrez M, Rey JA. Real-time PCR analysis of regions involved in gene amplification reveals gene overdose in low-grade astrocytic gliomas. Diag Mol Pathology (in press).
15. M.J. Bello, J.M. de Campos, J. Vaquero, P. Ruiz-Barnes, M.E. Kusak, J.L. Sarasa, and J.A. Rey HRAD54 gene and 1p high-resolution deletion mapping analyses in oligodendrogliomas Cancer Genet Cytogenet 116 2000 142 147
16. J.G. Herman, J.R. Graff, S. Myohannen, B.D. Nelkin, and S.B. Baylin Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands Proc Natl Acad Sci USA 93 1996 9821 9826
17. X. Agirre, J.L. Vizmanos, M.J. Calasanz, M. Garcia-Delgado, M.J. Larrayoz, and F.J. Novo Methylation of CpG dinucleotides and/or CCWGG motifs at the promoter of TP53 correlates with decreased gene expression in a subset of acute lymphoblastic leukemia patients Oncogene 22 2003 1070 1072
18. K. Ichimura, M.B. Bolin, H.M. Goike, E.E. Schmidt, A. Mosref, and V.P. Collins Deregulation of the p14ARF/MDM2/p53 pathway is a prerequisite for human astrocytic gliomas with G1-S transition control gene abnormalities Cancer Res 60 2000 417 424