Reversal of age-associated cognitive deficits is accompanied by increased plasticity-related gene expression after chronic antidepressant administration in middle-aged mice

Pharmacology Biochemistry and Behavior

Volumn 135, Issue , 2015, Pages 70-82

  Li, Yan ^a   Abdourahman, Aicha ^a   Tamm, Joseph A ^a   Pehrson, Alan L ^a   Sánchez, Connie ^a   Gulinello, Maria ^b  

^a LUNDBECK RESEARCH USA   (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Antidepressant; Forced swim test; Novel object placement; Spatial memory; SSRI (selective serotonin reuptake inhibitor); Vortioxetine

Indexed keywords

CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; FLUOXETINE; FRAGILE X MENTAL RETARDATION PROTEIN; GLYCOGEN SYNTHASE KINASE 3BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; JANUS KINASE 2; NEUROLIGIN; NEUROLIGIN 2; PROTEIN FOS; RAB PROTEIN; UNCLASSIFIED DRUG; VORTIOXETINE; ANTIDEPRESSANT AGENT; PIPERAZINE DERIVATIVE; SEROTONIN TRANSPORTER; SIGNAL PEPTIDE; SULFIDE;

ADULT; AFFECT; AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL PROLIFERATION; COGNITIVE DEFECT; CONTROLLED STUDY; DENTATE GYRUS; DEPRESSION; FEMALE; FORCED SWIM TEST; LOCOMOTION; LONG TERM CARE; MIDDLE AGED; MOUSE; NERVE CELL PLASTICITY; NEURAL STEM CELL; NONHUMAN; NOVEL OBJECT RECOGNITION TEST; OPEN FIELD TEST; PRIORITY JOURNAL; PROTEIN EXPRESSION; PSYCHOSOCIAL WITHDRAWAL; RECOGNITION; SIGNAL TRANSDUCTION; SPATIAL MEMORY; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; COGNITION DISORDERS; DRUG EFFECTS; GENE EXPRESSION; GENETICS; HIPPOCAMPUS; METABOLISM; MOTOR ACTIVITY; PSYCHOLOGY; SWIMMING;

ANIMALIA; MUS; RODENTIA;

AGING; ANIMALS; ANTIDEPRESSIVE AGENTS; CELL PROLIFERATION; COGNITION DISORDERS; FEMALE; FLUOXETINE; GENE EXPRESSION; HIPPOCAMPUS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MICE, INBRED C57BL; MOTOR ACTIVITY; NEURAL STEM CELLS; NEURONAL PLASTICITY; PIPERAZINES; RECOGNITION (PSYCHOLOGY); SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SULFIDES; SWIMMING;

EID: 84930680422     PISSN: 00913057     EISSN: 18735177     Source Type: Journal    
DOI: 10.1016/j.pbb.2015.05.013     Document Type: Article

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