Effects of S-citalopram, citalopram, and R-citalopram on the firing patterns of dopamine neurons in the ventral tegmental area, N-methyl-D-aspartate receptor-mediated transmission in the medial prefrontal cortex and cognitive function in the rat

Synapse

Volumn 65, Issue 5, 2011, Pages 357-367

  Schilström, Björn ^a   Konradsson Geuken, Åsa ^a   Ivanov, Vladimir ^a   Gertow, Jens ^a   Feltmann, Kristin ^a   Marcus, Monica M ^a   Jardemark, Kent ^a   Svensson, Torgny H ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Antidepressant; Antipsychotic; Atypical; Burst; Electrophysiology; Serotonin

Indexed keywords

8 CHLORO 2,3,4,5 TETRAHYDRO 3 METHYL 5 PHENYL 1H 3 BENZAZEPIN 7 OL HYDROGEN MALEATE; CITALOPRAM; ESCITALOPRAM; N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; COGNITION; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; DRUG ANTAGONISM; DRUG EFFECT; ELECTROPHYSIOLOGY; IN VIVO STUDY; MAJOR DEPRESSION; MALE; MEMORY CONSOLIDATION; NERVE CELL EXCITABILITY; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; RAT; RECOGNITION; VENTRAL TEGMENTUM; VENTROMEDIAL PREFRONTAL CORTEX;

ACTION POTENTIALS; ANALYSIS OF VARIANCE; ANIMALS; BENZAZEPINES; CITALOPRAM; COGNITION; DOPAMINE; DOPAMINE AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; MALE; NEURONS; NEUROPSYCHOLOGICAL TESTS; PATCH-CLAMP TECHNIQUES; PREFRONTAL CORTEX; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE; RECOGNITION (PSYCHOLOGY); SEROTONIN UPTAKE INHIBITORS; VENTRAL TEGMENTAL AREA;

EID: 79952219529     PISSN: 08874476     EISSN: 10982396     Source Type: Journal    
DOI: 10.1002/syn.20853     Document Type: Article

References (60)

1. Arborelius L, Chergui K, Murase S, Nomikos GG, Backlund Höök B, Chouvet G, Hacksell U, Svensson TH. 1993. The 5-HT1A receptor selective ligands (R)-8-OH-DPAT and (S)-UH-301, differentially affect the activity of midbrain dopamine neurons. Naunyn-Scmiedebergs Arch Pharmacol 347: 353-362.
2. Arvanov VL, Liang X, Magro P, Roberts R, Wang RY. 1999. A pre- and postsynaptic modulatory action of 5-HT and the 5-HT2A, 2C receptor agonist DOB on NMDA-evoked responses in the rat medial prefrontal cortex. Eur J Neurosci 11: 3064-3072.
3. Atre-Vaidya N, Taylor MA, Seidenberg M, Reed R, Perrine A, Glick-Oberwise F. 1998. Cognitive deficits, psychopathology, and psychosocial functioning in bipolar mood disorder. Neuropsychiatry Neuropsychol Behav Neurol 11: 120-126.
4. Beneyto M, Meador-Woodruff JH. 2008. Lamina-specific abnormalities of NMDA receptor-associated postsynaptic protein transcripts in the prefrontal cortex in schizophrenia and biopolar disorder. Neuropsychopharmacology 33: 2175-2186.
5. Bortolozzi A, Díaz-Mataix L, Scorza MC, Celada PArtigas F. 2005. The activation of 5-HT receptors in the prefrontal cortex enhances dopaminergic activity. J Neurochem 95: 1597-1607.
6. Bubar MJ, Cunningham KA. 2007. Distribution of serotonin 5-HT2C receptors in the ventral tegmental area. Neuroscience 146: 286-297.
7. Chamberlain SR, Muller U, Blackwell AD, Clark L, Robbins TW, Sahakian BJ. 2006. Neurochemical modulation of response inhibition and probabilistic learning in humans. Science 311: 861-863.
8. Chanrion B, Mannoury la Cour C, Bertaso F, Lerner-Natoli M, Freissmuth M, Millan MJ, Bockaert J, Marin P. 2007. Physical interaction between the serotonin transporter and neuronal nitric oxide synthase underlies reciprocal modulation of their activity. Proc Natl Acad Sci 104: 8119-8124.
9. Chergui K, Charléty PJ, Akaoka H, Saunier CF, Brunet JL, Buda M, Svensson TH, Chouvet G. 1993. Tonic activation of NMDA receptors causes spontaneous burst discharge of rat midbrain dopamine neurons in vivo. Eur J Neurosci 5: 137-144.
10. Danish University Antidepressant Group. 1986. Citalopram: Clinical effect profiles in comparison with clomipramine. A controlled multicenter study. Psychopharmacology 90: 131-138.
11. Danish University Antidepressant Group. 1990. Paroxetine: A selective serotonin reuptake inhibitor showing better tolerance but weaker antidepressant effect than clomipramine in a controlled multicenter study. J Affect Dis 18: 289-299.
12. Di Mascio M, Di Giovanni G, Di Matteo V, Prisco S, Esposito E. 1998. Selective serotonin reuptake inhibitors reduce the spontaneous activity of dopaminergic neurons in the ventral tegmental area. Brain Res Bull 46: 547-554.
13. Di Pietro NC, Seamans JK. 2007. Dopamine and serotonin interactions in the prefrontal cortex: Insights on antipsychotic drugs and their mechanism of action. Pharmacopsychiatry 40 (Suppl 1): S27-S33.
14. Doherty MD, Pickel VM. 2000. Ultrastructural localization of the serotonin 2A receptor in dopaminergic neurons in the ventral tegmental area. Brain Res 864: 176-185.
15. Dremencov E, El Mansari M, Blier P. 2009. Effects of sustained serotonin reuptake inhibition on the firing of dopamine neurons in the ventral tegmental area. J Psychiatry Neurosci 34: 223-229.
16. Dunlop BW, Nemeroff CB. 2007. The role of dopamine in the pathophysiology of depression. Arch Gen Psychiatry 64: 327-337.
17. Egeland J, Sundet K, Rund BR, Asbjørnsen A, Hugdahl K, Landrø NI, Roness A, Stordal KI. 2003. Sensitivity and specificity of memory dysfunction in schizophrenia: A comparison with major depression. J Clin Exp Neuropsychol 25: 79-93.
18. Ennaceur A, Delacour J. 1988. A new one-trial test for neurobiological studies of memory in rats. I. Behavioral data. Behav Brain Res 31: 47-59.
19. Ferguson JM, Wesnes KA, Schwartz GE. 2003. Reboxetine versus paroxetine versus placebo: Effects on cognitive functioning in depressed patients. Int Clin Psychopharmacol 18: 9-14.
20. Feyissa AM, Chandran A, Stockmeier CA, Karolewicz B. 2009. Reduced levels of NR2A and NR2B subunits of NMDA receptor and PSD-95 in the prefrontal cortex in major depression. Prog Neuropsychopharmacol Biol Psychiatry 33: 70-75.
21. Friedman A, Friedman Y, Dremencov E, Yadid G. 2008. VTA dopamine neuron bursting is altered in an animal model of depression and corrected by desipramine. J Mol Neurosci 34: 201-209.
22. Giggliucci V, Buckley KN, Nunan J, O'shea K, Harkin A. 2010. A role for serotonin in the antidepressant activity of NG-nitro-L-arginine, in the rat forced swimming test. Pharmacol Biochem Behav 94: 524-533.
23. Grace AA, Bunney BS. 1983. Intracellular and extracellular electrophysiology of dopaminergic neurons 1. Identification and characterization. Neuroscience 10: 301-315.
24. Grace AA, Bunney BS. 1984. The control of firing pattern in nigral dopamine neurons: Burst firing. J Neurosci 4: 2877-2890.
25. Gronier B. 2008. Involvement of glutamate neurotransmission and N-methyl-D-aspartate receptor in the activation of midbrain dopamine neurons by 5-HT1A receptor agonists: An electrophysiological study in the rat. Neuroscience 156: 995-1004.
26. Hammar Å, Årdal G. 2009. Cognitive functioning in major depression-A summary. Front Hum Neurosci 3: 1-7.
27. Harmer CJ, Goodwin GM, Cowen PJ. 2009a. Why do antidepressants take so long to work? A cognitive neuropsychological model of antidepressant action. Br J Psych 195: 102-108.
28. Harmer CJ, O'sullivan U, Favaron E, Massey-Chase R, Ayres R, Reinecke A, Goodwin GM, Cowen PJ. 2009b. Effect of acute antidepressants administration on negative affective bias in depressed patients. Am J Psychiatry 166: 1178-1184.
29. Herrera-Guzmán I, Herrera-Abarca JE, Gudayol-Ferré E, Herrera-Guzman D, Gomez-Carbajal L, Peña-Olvira M, Villuendas-González E, Joan GO. 2010. Effects of selective serotonin reuptake and dual serotonergic-noradrenic reuptake treatments on attention and executive functions in patients with major depressive disorder. Psychiatry Res 177: 323-329.
30. Honey RA, Turner DC, Honey GD, Sharar SR, Kumaran D, Pomarol-Clotet E, McKenna P, Sahakian BJ, Robbins TW, Fletcher PC. 2003. Subdissociative dose ketamine produces a deficit in manipulation but not maintenance of the contents of working memory. Neuropsychopharmacology 28: 2037-2044.
31. Jardemark K, Marcus MM, Konradsson A, Svensson TH. 2005. The combination of nicotine with the D2 antagonist raclopride or the weak D4 antagonist L-745870 generates a clozapine-like facilitation of NMDA receptor-mediated neurotransmission in pyramidal cells of the rat medial prefrontal cortex. Int J Neuropsychopharmacol 8: 157-162.
32. Jefferys D, Funder J. 1996. Nitric oxide modulates retention of immobility in the forced swimming test in rats. Eur J Pharmacol 295: 131-135.
33. Konradsson Å, Marcus MM, Hertel P, Svensson TH, Jardemark K. 2006. Inhibition of the glycine transporter GlyT-1 potentiates the effect of risperidone, but not clozapine, on glutamatergic transmission in the rat medial prefrontal cortex. Synapse 60: 102-108.
34. Linnér L, Endersz H, Ohman D, Bengtsson F, Schalling M, Svensson TH. 2001. Reboxetine modulates the firing pattern of dopamine cells in the ventral tegmental area and selectively increases dopamine availability in the prefrontal cortex. J Pharmacol Exp Ther 297: 540-546.
35. McCabe C, Mishor Z, Cowen PJ, Harmer CJ. 2010. Diminished neural processing of aversive and rewarding stimuli during selective serotonin reutake inhibitor treatment. Biol Psychiatry 67: 439-445.
36. Mansari ME, Wiborg O, Mnie-Filali O, Benturquia N, Sánchez C, Haddjeri N. 2007. Allosteric modulation of the effect of escitalopram, paroxetine and fluoxetine: In-vitro and in-vivo studies. Int J Neuropsychopharmacol 10: 31-40.
37. Millan MJ. 2006. Multi-target strategies for the improved treatment of depressive states: Conceptual foundations and neuronal substrates, drug discovery and therapeutic application. Pharmacol Ther 110: 135-370.
38. Minabe Y, Ashby CR, Jr, Wang RY. 1991. The effect of acute and chronic LY 277359, a selective 5-HT3 receptor antagonist, on the number of spontaneously active midbrain dopamine neurons. Eur J Pharmacol 209: 151-156.
39. Montgomery SA, Baldwin DS, Blier P, Fineberg NA, Kasper S, Lader M, Lam RW, Lépine J-P, Möller H-J, Nutt DJ, Rouillon F, Schatzberg AF, Thase ME. 2007. Which antidepressants have demonstrated superior efficacy? A review of the evidence. Int Clin Psychopharm 22: 323-329.
40. Montgomery SA, Möller HJ. 2009. Is the significant superiority of escitalopram compared with other antidepressants clinically relevant? Int Clin Psychopharmacol 24: 111-118.
41. Mur M, Portella MJ, Martinez-Aran A, Pifarre J, Vieta E. 2009. Influence of clinical and neuropsychological variables on the psychosocial and occupational outcome of remitted bipolar patients. Psychopathology 42: 148-156.
42. Murase S, Grenhoff J, Chouvet G, Gonon FG, Svensson TH. 1993. Prefrontal cortex regulates burst firing and transmitter release in rat mesolimbic dopamine neurons studied in vivo. Neurosci Lett 157: 53-56.
43. Nagai T, Takuma K, Kamei H, Ito Y, Nakamichi N, Ibi D, Nakanishi Y, Murai M, Mizoguchi H, Nabeshima T, Yamada K. 2007. Dopamine D1 receptors regulate protein synthesis-dependent long-term recognition memory via extracellular signal-regulated kinase 1/2 in the prefrontal cortex. Learn Mem 14: 117-125.
44. Ninan I, Jardemark KE, Wang RY. 2003. Differential effects of atypical and typical antipsychotic drugs on N-methyl-D-aspartate- and electrically evoked responses in the pyramidal cells of the rat medial prefrontal cortex. Synapse 48: 66-79.
45. Paxinos G, Watson C. 1998. The rat brain in stereotaxic coordinates, 4th ed. New York: Academic Press.
46. Prisco S, Esposito E. 1995. Differential effects of acute and chronic fluoxetine administration on the spontaneous activity of dopaminergic neurones in the ventral tegmental area. Br J Pharmacol 116: 1923-1931.
47. Prisco S, Pagannone S, Esposito E. 1994. Serotonin-dopamine interaction in the rat ventral tegmental area: An electrophysiological study in the rat. J Pharmacol Exp Ther 271: 83-90.
48. Sánchez C, Bøgesø KP, Ebert B, Reines EH, Braestrup C. 2004. Escitalopram versus citalopram: The surprising role of the R-enantiomer. Psychopharmacology 174: 163-176.
49. Sánchez C. 2006. The pharmacology of citalopram enantiomers: The antagonism by R-citalopram on the effect of S-citalopram. Basic Clin Pharmacol Toxicol 99: 91-95.
50. Sartorius N, Baghai TC, Baldwin DS, Barrett B, Brand U, Fleischhacker W, Goodwin G, Grunze H, Knapp M, Leonard BE, Lieberman J, Nakane Y, Pinder RM, Schatzberg AF, Svestka J, Baumann P, Ghalib K, Markowitz JC, Padberg F, Fink M, Furukawa T, Fountoulakis KN, Jensen P, Kanba S, Riecher-Rössler A. 2007. Antidepressant medications and other treatments of depressive disorders: A CINP Task Force report based on a review of evidence. Int J Neuropsychopharmacol 10 (Suppl 1): S1-S207.
51. Sawaguchi T, Goldman-Rakic PS. 1991. D1 dopamine receptors in prefrontal cortex: Involvement in working memory. Science 251: 947-950.
52. Schultz W. 1998. Predictive reward signal of dopamine neurons. J Neurophysiol 80: 1-27.
53. Sesack SR, Pickel VM. 1992. Prefrontal cortical efferents in the rat synapse on unlabeled neuronal targets of catecholamine terminals in the nucleus accumbens septi and on dopamine neurons in the ventral tegmental area. J Comp Neurol 320: 145-160.
54. Wang RY. 1981. Dopaminergic neurons in the rat ventral tegmental area. I. Identification and characterization. Brain Res Rev 3: 123-140.
55. Williams GV, Castner SA. 2006. Under the curve: Critical issues for elucidating D1 receptor function in working memory. Neuroscience 139: 263-276.
56. Wright DE, Seroogy KB, Lundgren KH, Davis BM, Jennes L. 1995. Comparative localization of serotonin1A, 1C, and 2 receptor subtype mRNAs in rat brain. J Comp Neurol 351: 357-373.
57. Wroolie TE, Williams KE, Keller J, Zappert LN, Shelton SD, Kenna HA, Reynolds MF, Rasgon NL. 2006. Mood and neuropsychological changes in women with midlife depression treated with escitalopram. J Clin Psychopharmacol 26: 361-366.
58. Yang CR, Seamans JK, Gorelova N. 1996. Electrophysiological and morphological properties of layers V-VI principal pyramidal cells in rat prefrontal cortex in vitro. J Neurosci 16: 1904-1921.
59. Zhang J, Xiong B, Zhen X, Zhang A. 2009. Dopamine D1 receptor ligands: Where are now and where are we going. Med Res Rev 29: 272-294.
60. Zheng P, Zhang XX, Bunney BS, Shi WX. 1999. Opposite modulation of cortical N-methyl-D-aspartate receptor-mediated responses by low and high concentrations of dopamine. Neuroscience 91: 527-535.