Activity and onset of action of reboxetine and effect of combination with sertraline in an animal model of depression

European Journal of Pharmacology

Volumn 364, Issue 2-3, 1999, Pages 123-132

  Harkin, Andrew ^a   Kelly, John P ^a   McNamara, Mairead ^a   Connor, Thomas J ^a   Dredge, Keith ^a   Redmond, Anna ^a   Leonard, Brian E ^a  

^a NATIONAL UNIVERSITY OF IRELAND   (Ireland)

Author keywords

8 OH DPAT (8 hydroxy 2 (di n propylamino)tetralin); Clonidine; Depression; Olfactory bulbectomy; Reboxetine; Sertraline

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; 5 HYDROXYINDOLEACETIC ACID; ANTIDEPRESSANT AGENT; CLONIDINE; NORADRENALIN; REBOXETINE; SEROTONIN; SEROTONIN UPTAKE INHIBITOR; SERTRALINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DEPRESSION; DRUG ACTIVITY; DRUG EFFECT; FORCED SWIMMING TEST; HYPERACTIVITY; HYPOTHERMIA; INTRAPERITONEAL DRUG ADMINISTRATION; LOCOMOTION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SUBCUTANEOUS DRUG ADMINISTRATION;

8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN; AMYGDALA; ANALGESICS; ANIMALS; ANTIDEPRESSIVE AGENTS; BODY TEMPERATURE; CLONIDINE; DEPRESSION; DISEASE MODELS, ANIMAL; DRUG THERAPY, COMBINATION; EXPLORATORY BEHAVIOR; HYDROXYINDOLEACETIC ACID; MALE; MORPHOLINES; MOTOR ACTIVITY; OLFACTORY BULB; RATS; RATS, SPRAGUE-DAWLEY; SEROTONIN AGONISTS; SERTRALINE; SWIMMING;

EID: 0032923998     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(98)00838-3     Document Type: Article

References (42)

1. Artigas F., Perez V., Alverez E. Pindolol induces a rapid improvement of depressed patients treated with serotonin reuptake inhibitors. Arch. Gen. Psychiatry. 51:1994;248-251.
2. Baron B.M., Ogden A.M., Siegel B.W., Stegeman J., Ursillo R.C., Dudley M.W. Rapid down regulation of β-adrenoceptors by co-administration of desipramine and fluoxetine. Eur. J. Pharmacol. 154:1988;125-134.
3. 2-agonists in reserpinized and normal mice. Br. J. Pharmacol. 96:1989;144-152.
4. Blier P., De Montigny C. Current advances in the treatment of depression. Trends Pharmacol. Sci. 15:1994;220-226.
5. Borsini F., Meli A. Is the forced swimming test a suitable model for revealing antidepressant activity? Psychopharmacology. 94:1988;147-161.
6. Cairncross K.D., Wren A.F., Cox B., Schnieden H. Effects of olfactory bulbectomy and domicile on stress induced corticosterone release in the rat. Physiol. Behav. 19:1977;485-487.
7. Cryan J.F., McGrath C., Leonard B.E., Norman T.R. Combining pindolol and paroxetine in an animal model of chronic antidepressant action - can early onset of action be detected? Eur. J. Pharmacol. 352:1998;23-28.
8. Danish University Antidepressant Group Citalopram: clinical effect profile in comparison with clomipramine. A controlled multicenter study. Psychopharmacology. 90:1986;131-138.
9. Danish University Antidepressant Group Paroxetine: a selective serotonin reuptake inhibitor showing better tolerance but weaker antidepressant effect than clomipramine in a controlled multicenter study. J. Affect. Disord. 18:1990;289-299.
10. Doogan D.P., Caillard V. Sertraline: a new antidepressant. J. Clin. Psychiatry. 49:1988;s46-s51.
11. Dostert P., Benedetti M.S., Poggesi I. Review of the pharmacokinetics and metabolism of reboxetine, a selective noradrenaline reuptake inhibitor. Eur. Neuropsychopharmacol. 7:1997;s23-s35.
12. 1A receptor antagonist, WAY-100635. Eur. J. Pharmacol. 281:1995;81-88.
13. 1A receptor-mediated hypothermia and serotonin syndrome produced by 8-OH DPAT in the rat. Psychopharmacology. 91:1987;500-505.
14. Gray J.A., Lalljee B. Sex differences in emotional behaviour in the rat: correlation between the 'open field' defaecation and active avoidance. Anim. Behav. 22:1974;856-861.
15. Guelfi J.D., White C., Hackett D., Gaichoux J.Y., Magni G. Effectiveness of venlafaxine in patients hospitalized for major depression and melancholia. J. Clin. Psychiatry. 56:1995;450-458.
16. Kelly J.P., Leonard B.E. The effect of tianeptine and sertraline in three animal models of depression. Neuropharmacology. 33:1994;1011-1016.
17. Kelly J.P., Wrynn A.S., Leonard B.E. The olfactory bulbectomized rat as a model of depression: an update. Pharmacol. Ther. 75:1997;1-17.
18. Koe B.K., Weissman A., Welch W.M. Sertraline 1S, 4-S-N-methyl-4-(3,4,dichlorophenyl)-1,2,3,4-tetrahydro-1-napthylamine, a new uptake inhibitor with selectivity for serotonin. J. Pharmacol. Exp. Ther. 226:1983;686-700.
19. Leonard, B.E., 1997. Animal models of depression. In: Briley, M., Montgomery, S. (Eds.), Antidepressant Therapy at the Dawn of the Third Millennium. Martin Dunitz, UK, pp. 87-109.
20. Leonard B.E., Tuite T.E. Anatomical, physiological and behavioural aspects of olfactory bulbectomy in the rat. Int. Rev. Neurobiol. 22:1981;251-286.
21. Lumia A.R., Teicher M.H., Slachli F., Ayers E., Possidente B. Olfactory bulbectomy as a model of agitated hyposerotonergic depression. Brain Res. 587:1992;181-185.
22. Melloni P., Carniel G., Della Torre A., Bonsignori A., Buonamici M., Pozzi O., Ricciardi S., Rossi S.C. Potential antidepressant agents: a aryloxy-benzyl derivatives of ethanolamine and morpholine. Eur. J. Med. Chem. 19:1984;235-242.
23. Nelson, J.C., 1997. Synergistic effects of serotonergic and noradrenergic antidepressants in combination. In: Briley, M., Montgomery, S. (Eds.), Antidepressant Therapy at the Dawn of the Third Millennium. Martin Dunitz, UK, pp. 297-305.
24. Nelson J.C., Mazure C.M., Bowers M.B., Jatlaw P.I. A preliminary open study of the combination of fluoxetine and desipramine for rapid treatment of major depression. Arch. Gen. Psychiatry. 48:1991;303-307.
25. 2-adrenoceptors and depression. Journal of Psychopharmacology. 10:1996;s35-s42.
26. 1A receptor activation. Br. J. Pharmacol. 106:1992;603-609.
27. O'Donnell J.M., Banyasz T., Kovaks T. Altered thermoregulatory responses to clonidine in streptozocin-diabetic rats. Br. J. Pharmacol. 117:1996;938-942.
28. Pilc A. The role of alpha-2-adrenoceptors in the mechanism of action of antidepressant drugs. Pol. J. Pharmacol. Pharm. 39:1987;691-713.
29. Pinder R.M. Designing a new generation of antidepressant drugs. Acta Psychiatrica Scandinavica. 96:1997;7-13.
30. Porsolt R.D., Bertin A., Blavet M., Jalfre M. Behavioural despair in rats: a new model sensitive to antidepressant treatments. Eur. J. Pharmacol. 47:1978;379-391.
31. Potter W.Z. Adrenoceptors and serotonin receptor function. Relevance to antidepressant mechanisms of action. J. Clin. Psychiatry. 57:1996;4-8.
32. Redmond A.M., Leonard B.E. An evaluation of the role of the noradrenergic system in the neurobiology of depression: a review. Hum. Psychopharmacol. 12:1997;407-430.
33. Redmond A.M., Kelly J.P., Leonard B.E. The effects of acute and chronic antidepressant treatments on temperature and locomotor activity responses to 8-OH DPAT, clonidine and apomorphine. J. Serotonin Res. 2:1995;139-148.
34. Riva M., Brunello N., Rosecalli A.C., Galimberti R., Carfragna N. Effect of reboxetine, a new antidepressant drug, on the central noradrenergic system: behavioural and biochemical studies. J. Drug Dev. 1:1989;243-252.
35. Schweizer E., Weise C., Clary C., Fox I., Rickels K. Placebo-controlled trial of venlafaxine for the treatment of major depression. J. Clin. Psychopharmacol. 11:1991;233-236.
36. Seyfried C.A., Adams G., Greve T. An automated direct-injection HPLC method for the electrochemical/fluorometric quantitation of monoamines and related compounds optimized for screening of large numbers of animals. Biomed. Chromatogr. 1:1986;78-88.
37. Song C., Leonard B.E. The effect of olfactory bulbectomy in the rat, alone or in combination with antidepressants and endogenous factors, on immune function. Hum. Psychopharmacol. 10:1995;7-18.
38. Tremaine L.M., Welch W.M., Ronfeld R.A. Metabolism and distribution of the 5-hydroxytryptamine uptake blocker sertraline in the rat and dog. Drug Metab. Dispos. 17:1989;542-550.
39. Van Riezen, H., Leonard, B.E., 1991. Effects of psychotropic drugs on the behaviour and neurochemistry of olfactory bulbectomized rats. In: Psychopharmacology of Anxiolytics and Antidepressants. Pergammon, New York, pp. 231-250.
40. Von Voigtlander P.F., Triezenberg H.J., Losey E.G. Interactions between clonidine and antidepressant drugs: a method for identifying antidepressant-like agents. Neuropharmacology. 17:1978;375-381.
41. Wozniak K.M., Aulakh C.S., Hill J.L., Murphy D.L. The effect of 8-OH DPAT on temperature in the rat and its modification by chronic antidepressant treatments. Pharmacol. Biochem. Behav. 30:1988;451-456.
42. Yu H., Lewander T. Pharmacokinetic and pharmacodynamic studies of (R)-8 hydroxy-2-(di-n-propylamino)tetralin in the rat. Eur. Neuropsychopharmacol. 7:1997;165-172.