Blockade of 5-Ht3 receptors in the septal area increases Fos expression in selected brain areas

Autonomic Neuroscience: Basic and Clinical

Volumn 181, Issue 1, 2014, Pages 55-68

  Urzedo Rodrigues, Lilia S ^a   Ferreira, Hilda S ^b   Santana, Rejane Conceição ^a   Luz, Carla Patrícia ^c   Perrone, Camila F ^a   Fregoneze, Josmara B ^a  

^a FEDERAL UNIVERSITY OF BAHIA   (Brazil)

^b UNIVERSIDADE DO ESTADO DA BAHIA   (Brazil)

^c UNIVERSIDADE ESTADUAL DO SUDOESTE DA BAHIA   (Brazil)

Author keywords

5 HT3 receptor; Barodenervation; C Fos; Ondansetron; Septal area

Indexed keywords

ONDANSETRON; PROTEIN C FOS; SEROTONIN 3 ANTAGONIST; SEROTONIN 3 RECEPTOR;

5-HT(3) RECEPTOR; ANIMAL; ARTICLE; AUTONOMIC DENERVATION; BARODENERVATION; BLOOD PRESSURE; BRAIN; C-FOS; CELL COUNT; CELL NUCLEUS; DRUG EFFECT; HEART RATE; MALE; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; PRESSORECEPTOR; PRESSORECEPTOR REFLEX; RAT; SEPTUM PELLUCIDUM; WISTAR RAT;

5-HT(3) RECEPTOR; BARODENERVATION; C-FOS; ONDANSETRON; SEPTAL AREA;

ANIMALS; AUTONOMIC DENERVATION; BAROREFLEX; BLOOD PRESSURE; BRAIN; CELL COUNT; CELL NUCLEUS; HEART RATE; MALE; ONDANSETRON; PRESSORECEPTORS; PROTO-ONCOGENE PROTEINS C-FOS; RATS; RATS, WISTAR; RECEPTORS, SEROTONIN, 5-HT3; SEPTUM OF BRAIN; SEROTONIN 5-HT3 RECEPTOR ANTAGONISTS;

EID: 84893979616     PISSN: 15660702     EISSN: 18727484     Source Type: Journal    
DOI: 10.1016/j.autneu.2014.01.003     Document Type: Article

References (98)

1. Alheid G.F., Beltramino C.A., De Olmos J.S., Forbes M.S., Swanson D.J., Heimer L. The neuronal organization of the supracapsular part of the stria terminalis in the rat: the dorsal component of the extended amygdala. Neuroscience 1998, 84:967-996.
2. Alves F.H.F., Crestani C.C., Resstel L.B.M., Correa F.M.A. Cardiovascular effects of carbachol microinjected into the bed nucleus of the stria terminalis of the rat brain. Brain Res. 2007, 1143:161-168.
3. Bandler R., Keay K.A., Floyd N., Price J. Central circuits mediating patterned autonomic activity during active vs passive emotional coping. Brain Res. Bull. 2000, 53:95-104.
4. Behbehani M.M. Functional characteristics of the midbrain periaqueductal gray. Prog. Neurobiol. 1995, 46:575-605.
5. Bell A.A., Butz B.L., Alper R.H. Cardiovascular responses produced by microinjection of serotonin-receptor agonists into the paraventricular nucleus in conscious rats. J. Cardiovasc. Pharmacol. 1999, 33:175-180.
6. Berk M.L., Finkelstein J.A. Afferent projections to the preoptic area and hypothalamic regions in the rat brain. Neuroscience 1981, 6:1601-1624.
7. Bowman B.R., Kumar N.N., Hassan S.F., McMullan S., Goodchild A.K. Brain sources of inhibitory input to the rat rostral ventrolateral medulla. J. Comp. Neurol. 2013, 521:213-232.
8. Brady J.V., Nauta W.H.J. Subcortical mechanisms in emotional behavior: affective changes following septal forebrain lesions in the albino rat. J. Comp. Physiol. 1953, 46:339-346.
9. Calaresu F.R., Ciriello J., Mogenson G.J. Identification of pathways mediating cardiovascular responses elicited by stimulation of the septum in the rat. J. Physiol. 1976, 260:515-530.
10. Carrasco G.A., Van de Kar L.D. Neuroendocrine pharmacology of stress. Eur. J. Pharmacol. 2003, 463:235-272.
11. Chan R.K.W., Brown E.R., Ericsson A., Kovacs K.J., Sawchenko P.E. A comparison of two immediate-early genes, c-fos and NGFI-B, as markers for functional activation in stress-related neuroendocrine circuitry. J. Neurosci. 1993, 13:5126-5138.
12. Chaouloff F., Berton O., Mormède P. Serotonin and stress. Neuropsychopharmacology 1999, 21:28S-32S.
13. Chen X., Herbert J. Regional changes in c-fos expression in the basal forebrain and brainstem during adaptation to repeated stress: correlations with cardiovascular, hypothermic and endocrine responses. Neuroscience 1995, 64:675-685.
14. Chen F., Lawrence A.J. 5-HT transporter sites and 5-HT1A and 5-HT3 receptors in fawn-hooded rats: a quantitative autoradiography study. Alcohol. Clin. Exp. Res. 2000, 24:1093-1102.
15. Chikada N., Imaki T., Seki T., Harada S., Nakajima K., Yoshimoto T., Naruse M., Demura H., Minami S., Takano K. Distribution of c-fos mRNA in the brain following intracerebroventricular injection of nitric oxide (NO)-releasing compounds: possible role of NO in central cardiovascular regulation. J. Neuroendocrinol. 2003, 12:1112-1123.
16. Chung K.K., Martinez M., Herbert J. Central serotonin depletion modulates the behavioural, endocrine and physiological responses to repeated social stress and subsequent c-fos expression in the brains of male rats. Neurosci. 1999, 92:613-625.
17. Chung K.K., Martinez M., Herbert J. c-Fos expression, behavioural, endocrine and autonomic responses to acute social stress in male rats after chronic restraint: modulation by serotonin. Neurosci. 2000, 95:453-463.
18. Cullinan W.E., Zaborszky L. Organization of ascending hypothalamic projections to the rostral forebrain with special reference to the innervation of cholinergic projection neurons. J. Comp. Neurol. 1991, 306:631-667.
19. Dampney R.A., Tagawa T., Horiuchi J., Potts P.D., Fontes M., Polson J.W. What drives the tonic activity of presympathetic neurons in the rostral ventrolateral medulla?. Clin. Exp. Pharmacol. Physiol. 2000, 27:1049-1053.
20. Dampney R.A., Coleman M.J., Fontes M.A., Hirooka Y., Horiuchi J., Li Y.W., Polson J.W., Potts P.D., Tagawa T. Central mechanisms underlying short- and long-term regulation of the cardiovascular system. Clin. Exp. Pharmacol. Physiol. 2002, 29:261-268.
21. Dampney R.A., Horiuchi J., Killinger S., Sheriff M.J., Tan P.S., McDowall L.M. Long-term regulation of arterial blood pressure by hypothalamic nuclei: some critical questions. Clin. Exp. Pharmacol. Physiol. 2005, 32:419-425.
22. De Olmos J., Alheid G.F., Belatramino C.A. Amygdala. The Rat Nervous System, Vol. 1. - Forebrain and Midbrain 1985, 223-334. Academic Press, San Diego, CA. G. Paxinos (Ed.).
23. DiMicco J.A., Sarkar S., Zaretskaia M.V., Zaretsky D.V. Stress-induced cardiac stimulation and fever: common hypothalamic origins and brainstem mechanisms. Auton. Neurosci. 2006, 126-127:106-119.
24. Dyer R.G., Ellendorff F., MacLeod N.K. Non-random distribution of cell types in the preoptic and anterior hypothalamic areas. J. Physiol. 1976, 261:495-504.
25. Ferreira H.S., De Castro e Silva E., Cointeiro C., Oliveira E., Faustino T.N., Fregoneze J.B. Role of central 5-HT3 receptors in the control of blood pressure in stressed and non-stressed rats. Brain Res. 2004, 1028:48-58.
26. Fontes M.A.P., Tagawa T., Polson J.W., Cavanagh S.-J., Dampney R.A.L. Descending pathways mediating cardiovascular response from dorsomedial hypothalamic nucleus. Am. J. Physiol. 2001, 280:H2891-H2901.
27. Frishman W.H., Grewall P. Serotonin and the heart. Ann. Med. 2000, 32:195-209.
28. Gaster L.M., King F.D. Serotonin 5-HT3 and 5-HT4 receptor antagonists. Med. Res. Rev. 1997, 17:163-214.
29. Gaykema R.P.A., Luiten P.G.M., Nyakas C., Taber J. Cortical projection patterns of the medial septum-diagonal band complex. J. Comp. Neurol. 1990, 293:103-124.
30. Gelsema A.J., McKitrick D.J., Calaresu F.R. Cardiovascular responses to chemical and electrical stimulation of amygdala in rats. Am. J. Physiol. 1987, 253:R712-R718.
31. Giancola S.B., Roder S., Ciriello J. Contribution of caudal ventrolateral medulla to the cardiovascular response elicited by activations of bed nucleus of the stria terminalis. Brain Res. 1993, 606:162-166.
32. Graeff F.G., Guimarães F.S., De Andrade T.G., Deakin J.F. Role of 5-HT in stress, anxiety, and depression. Pharmacol. Biochem. Behav. 1996, 54:129-141.
33. Graham J.C., Hoffman G.E., Sved A.F. c-Fos expression in brain in response to hypotension and hypertension in conscious rats. J. Auton. Nerv. Syst. 1995, 55:92-104.
34. Guyenet P.G. The sympathetic control of blood pressure. Nat. Rev. Neurosci. 2006, 7:335-346.
35. Hayward L.F. Midbrain modulation of the cardiac baroreflex involves excitation of lateral parabrachial neurons in the rat. Brain Res. 2007, 1145:117-127.
36. Henderson L.A., Keay K.A., Bandler R. The ventrolateral periaqueductal gray projects to caudal brainstem depressor regions: a functional-anatomical and physiological study. Neurosci. 1998, 82:201-221.
37. Herdegen T., Leah J.D. Inducible and constitutive transcription factors in the mammalian nervous system: control of gene expression by Jun, Fos, and Krox, and CREB/ATF protein. Brain Res. Rev. 1998, 28:370-490.
38. Hoffman G.E., Smith M.S., Verbalis J.G. C-Fos and related immediate early gene products as markers of activity in neuroendocrine systems. Front. Neuroendocrinol. 1993, 14:173-213.
39. Horiuchi J., McDowall L.M., Dampney R.A.L. Differential control of cardiac and sympathetic vasomotor activity from the dorsomedial hypothalamus. Clin. Exp. Pharmacol. 2006, 33:1265-1268.
40. Hoyer D., Hannon J.P., Martin G.R. Molecular, pharmacological and functional diversity of 5-HT receptors. Pharmacol. Biochem. Behav. 2002, 71:533-554.
41. Hunt J.L., Zaretsky D.V., Sarkar S., DiMicco J.A. Dorsomedial hypothalamus mediates autonomic, neuroendocrine, and locomotor responses evoked from the medial preoptic area. Am. J. Physiol. 2010, 298:130-140.
42. Iwata J., Chida K., LeDoux J.E. Cardiovascular responses elicited by stimulation of neurons in the central amygdaloid nucleus in awake but not anesthetized rats resemble conditioned emotional responses. Brain Res. 1987, 418:183-188.
43. Kilpatrick G.J., Jones B.J., Tyers M.B. Identification and distribution of 5-HT3 receptors in rat brain using radioligand binding. Nature 1987, 330:746-748.
44. Krieger E.M. Neurogenic hypertension in the rat. Circ. Res. 1964, 15:511-521.
45. Kubo T., Yamaguchi H., Tsujimura M., Hagiwara Y., Fukumori R. Blockade of angiotensin receptors in the anterior hypothalamic preoptic area lowers blood pressure in DOCA-salt hypertensive rats. Hypertens. Res. 2000, 23:109-118.
46. Len W., Chan J.Y. Glutamatergic projection to RVLM mediates suppression of reflex bradycardia by parabrachial nucleus. Am. J. Physiol. 1999, 276:1482-1492.
47. Len W., Chan S.H., Chan J.Y. Parabrachial nucleus induces suppression of baroreflex bradycardia by the release of glutamate in the rostral ventrolateral medulla of the rat. J. Biomed. Sci. 2000, 7:401-411.
48. McQuade R., Sharp T. Functional mapping of dorsal and median raphe 5-hydroxytryptamine pathways in forebrain of the rat using microdialysis. J. Neurochem. 1997, 69:791-796.
49. Miura M., Takayama K., Okada J. Neuronal expression of Fos protein in the rat brain after baroreceptor stimulation. J. Auton. Nerv. Syst. 1994, 50:31-43.
50. Moga M.M., Herbert H., Hurley K.M., Yasui Y., Gray T.S., Saper C.B. Organization of cortical, basal forebrain, and hypothalamic afferents to the parabrachial nucleus in the rat. J. Comp. Neurol. 1990, 295:624-661.
51. Myers B., Mark Dolgas C., Kasckow J., Cullinan W.E., Herman J.P. Central stress-integrative circuits: forebrain glutamatergic and GABAergic projections to the dorsomedial hypothalamus, medial preoptic area, and bed nucleus of the stria terminalis. Brain Struct. Funct 2013, (Published online: May-10-2013. Accessed 23/07/2013). 10.1007/s00429-013-0566-y.
52. Nalivaiko E., Sgoifo A. Central 5-HT receptors in cardiovascular control during stress. Neurosci. Biobehav. Rev. 2009, 33:95-106.
53. Ohta H., Watanabe S., Ueki S. Cardiovascular changes induced by chemical stimulation of the amygdala in rats. Brain Res. Bull. 1991, 26:575-581.
54. Paxinos G., Watson C. The Rat Brain in Stereotaxic Coordinates 1998, Academic Press, San Diego. fourth ed.
55. Peters J.A., Barnes N.M., Hales T.G., Lummis S.C.R., Niesler B. 5-HT3 receptors. Last modified on 08/03/2013. Accessed on 23/07/2013. IUPHAR database (IUPHAR-DB) http://www.iuphar-db.org/DATABASE/FamilyMenuForward?familyId=68.
56. Porter J.P., Brody M.J. A comparison of the hemodynamic effects produced by electrical stimulation of subnuclei of the paraventricular nucleus. Brain Res. 1986, 375:20-29.
57. Potts P.D., Polson J.W., Hirooka Y., Dampney R.A. Effects of sinoaortic denervation on Fos expression in the brain evoked by hypertension and hypotension in conscious rabbits. Neuroscience 1997, 77:503-520.
58. Potts P.D., Hirooka Y., Dampney R.A.L. Activation of brain neurons by circulating angiotensin II: direct effects and baroreceptors mediated secondary effects. Neurosci. 1999, 90:581-594.
59. Prewitt C.M., Herman J.P. Anatomical interactions between the central amygdaloid nucleus and the hypothalamic paraventricular nucleus of the rat: a dual tract-tracing analysis. J. Chem. Neuroanat. 1998, 15:173-185.
60. Ramage A.G. Central cardiovascular regulation and 5-hydroxytryptamine receptors. Brain Res. Bull. 2001, 56:425-439.
61. Ramage A.G., Villalón C.M. 5-Hydroxytryptamine and cardiovascular regulation. Trends Pharmacol. Sci. 2008, 29:472-481.
62. Risold P.Y., Swanson L.W. Connections of the rat lateral septal complex. Brain Res. Rev. 1997, 24:115-195.
63. Rossi F., Maione S., Berrino L. Periaqueductal gray area and cardiovascular function. Pharmacol. Res. 1994, 29:27-36.
64. Rowland N.E., Farnbauch L.J., Roberstson K.L. Brain muscarinic receptor subtypes mediating water intake and Fos following cerebroventricular administration of bethanacol in rats. Psychopharmacol. 2003, 167:174-179.
65. Sah P., Faber E.S., Lopez De Armentia M., Power J. The amygdaloid complex: anatomy and physiology. Physiol. Rev. 2003, 83:803-834.
66. Saha S. Role of the central nucleus of the amygdala in the control of blood pressure: descending pathways to medullary cardiovascular nuclei. Clin. Exp. Pharmacol. Physiol. 2005, 32:450-456.
67. Saha S., Drinkhill M.J., Moore J.P., Batten T.F. Central nucleus of amygdala projections to rostral ventrolateral medulla neurones activated by decreased blood pressure. Eur. J. Neurosci. 2005, 21:1921-1930.
68. Samuels B.B., Zaretsky D.V., DiMicco J.A. Tachycardia evoked by disinhibition of the dorsomedial hypothalamus in rats is mediated through medullary raphe. J. Physiol. 2002, 583:941-946.
69. Samuels B.B., Zaretsky D.V., DiMicco J.A. Dorsomedial hypothalamic sites where disinhibition evokes tachycardia correlate with location of raphe-projecting neurons. Am. J. Physiol. 2004, 287:472-478.
70. Saper C.B., Loewy A.D. Efferent connections of the parabrachial nucleus in the rat. Brain Res. 1980, 197:291-317.
71. Sawchenko P.E., Swanson L.W. Central noradrenergic pathways for the integration of hypothalamic neuroendocrine and autonomic responses. Science 1981, 214:685-687.
72. Sawchenko P.E., Swanson L.W. The organization of forebrain afferents to the paraventricular and supraoptic nuclei of the rat. J. Comp. Neurol. 1983, 218:121-144.
73. Senba E., Ueyama T. Stress-induced expression of immediate early genes in the brain and peripheral organs of the rat. Neurosci. Res. 1997, 29:183-207.
74. Senba E., Matsunaga K., Tohyama M., Noguchi K. Stress induced c-fos expression in the rat brain: activation mechanism of sympathetic pathway. Brain Res. Bull. 1993, 31:329-341.
75. Shin J.W., Geerling J.C., Loewy A.D. Inputs to the ventrolateral bed nucleus of the stria terminalis. J. Comp. Neurol. 2008, 511:628-657.
76. Shioya M., Tanaka J. Inputs from the nucleus of the solitary tract to subfornical organ neurons projecting to the paraventricular nucleus in the rat. Brain Res. 1989, 483:192-195.
77. Siegel A., Schubert K.L., Shaikh M.B. Neurotransmitters regulating defensive rage behavior in the cat. Neurosci. Biobehav. Rev. 1997, 21:733-742.
78. Sun N., Roberts L., Cassell M.D. Rat central amygdaloid nucleus projections to the bed nucleus of the stria terminalis. Brain Res. Bull. 1991, 27:651-662.
79. Swanson L.W. The amygdala and its place in the cerebral hemisphere. Ann. N. Y. Acad. Sci. 2003, 985:174-184.
80. Swanson L.W., Cowan W.M. The connection of the septal region in rats. J. Comp. Neurol. 1979, 186:621-656.
81. Szabadi E. 2013 functional neuroanatomy of the central noradrenergic system. J. Psychopharmacol. 2013 Aug, 27(8):659-693. (Epub 2013 Jun 12). 10.1177/0269881113490326.
82. Szabo A., Butz B.L., Alper R.H. Further characterization of forebrain serotonin receptors mediating tachycardia in conscious rats. Brain Res. Bull. 1998, 45:583-588.
83. Takeuchi Y., Hopkins D.A. Light and electron microscopic demonstration of hypothalamic projections to the parabrachial nuclei in the cat. Neurosci. Lett. 1984, 46:53-58.
84. Tavares R.F., Corrêa F.M.A. Pressor effects of l-glutamate injected into the diagonal band of Broca of unanesthetized rats. Brain Res. 2003, 959:312-319.
85. Tavares R.F., Resstel L.B., Corrêa F.M. Interaction between glutamatergic and nitrergic mechanisms mediating cardiovascular responses to l-glutamate injection in the diagonal band of Broca in anesthetized rats. Life Sci. 2007, 81:855-862.
86. Taylor E.W., Jordan D., Coote J.H. Central control of the cardiovascular and respiratory systems and their interactions in vertebrates. Physiol. Rev. 1999, 79:855-916.
87. Ter Horst G.J., Luiten P.G. The projections of the dorsomedial hypothalamic nucleus in the rat. Brain Res. Bull. 1986, 16:231-248.
88. Thompson R.H., Canteras N.S., Swanson L.W. Organization of projections from the dorsomedial nucleus of the hypothalamus: a PHA-L study in the rat. J. Comp. Neurol. 1996, 376:143-173.
89. Tomimoto H., Kamo H., Kameyam A.M., McGeer P.L., Kimura H. Descending projections of the basal forebrain in the rat demonstrated by the anterograde neural tracer Phaseolus vulgaris leukoagglutinin (PHA-L). Brain Res. 1987, 425:248-255.
90. Ulrich-Lai Y.M., Herman J.P. Neural regulation of endocrine and autonomic stress responses. Nat. Rev. Neurosci. 2009, 10:397-409.
91. Urzedo-Rodrigues L.S., Ferreira H.S., Almeida D.O., Medeiros J.P., Batista A., De-Castro-e-Silva E., Fregoneze J.B. Blockade of 5-HT3 receptors at septal area increase blood pressure in unanaesthetized rats. Auton. Neurosci. Basic Clin. 2011, 159:51-61.
92. Wei S., Lei M., Tong M., Ding J., Han Q., Xiao M. Acute baroreceptor unloading evokes Fos expression in anesthetized rat brain. Brain Res. Bull. 2008, 76:63-69.
93. Weller K.L., Smith D.A. Afferent connections to the bed nucleus of the stria terminalis. Brain Res. 1982, 232:255-270.
94. Weston M., Wang H., Stornetta R.L., Sevigny C.P., Guyenet P.G. Fos expression by glutamatergic neurons of the solitary tract nucleus after phenylephrine-induced hypertension in rats. J. Comp. Neurol. 2003, 460:525-541.
95. Wilkinson M.F., Pittman Q.J. Changes in arterial blood pressure alter activity of electrophysiologically identified single units of the bed nucleus of the stria terminalis. Neurosci. 1995, 64:835-844.
96. Wirtshafter D. Role of dopamine D1 receptors in the striatal and cortical fos expression induced by the muscarinic agonist pilocarpine. Eur. J. Pharmacol. 2004, 488:85-90.
97. Xu Z., Pekarek E., Ge J., Yao J. Functional relationship between subfornical organ cholinergic stimulation and cellular activation in the hypothalamus and AV3V region. Brain Res. 2001, 922:191-200.
98. Zaretskaia M.V., Zaretsky D.V., Sarkar S., Shekhar A., DiMicco J.A. Induction of Fos-immunoreactivity in the rat brain following disinhibition of the dorsomedial hypothalamus. Brain Res. 2008, 1200:39-50.