Inhibition of microglial activation protects hippocampal neurogenesis and improves cognitive deficits in a transgenic mouse model for alzheimer's disease

Neurodegenerative Diseases

Volumn 9, Issue 4, 2012, Pages 187-198

  Biscaro, Barbara ^a,e   Lindvall, Olle ^b,d   Tesco, Giuseppina ^e   Ekdahl, Christine T ^b,c,d   Nitsch, Roger M ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b LUND UNIVERSITY   (Sweden)

^c LUND UNIVERSITY HOSPITAL   (Sweden)

^d LUND UNIVERSITY   (Sweden)

^e TUFTS UNIVERSITY   (United States)

Author keywords

Amyloid; Amyloid precursor protein; Inflammation; Microglia; Minocycline; Presenilin

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; MINOCYCLINE; PRESENILIN 1;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CELL SURVIVAL; COGNITIVE DEFECT; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HIPPOCAMPUS; IMAGE ANALYSIS; IMMUNOHISTOCHEMISTRY; LEARNING; MALE; MICROGLIAL ACTIVATION; MORPHOLOGY; MOUSE; MUTANT; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECOGNITION; RETROVIRUS; STEREOLOGY; TASK PERFORMANCE; WESTERN BLOTTING;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; ANTI-INFLAMMATORY AGENTS; COGNITION DISORDERS; DISEASE MODELS, ANIMAL; FEMALE; HIPPOCAMPUS; HUMANS; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MICROGLIA; MINOCYCLINE; MUTATION; NEUROGENESIS; PRESENILIN-1;

EID: 84862088615     PISSN: 16602854     EISSN: 16602862     Source Type: Journal    
DOI: 10.1159/000330363     Document Type: Article

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