Chronic fluoxetine treatment in middle-aged rats induces changes in the expression of plasticity-related molecules and in neurogenesis

BMC Neuroscience

Volumn 13, Issue 1, 2012, Pages

  Guirado, Ramon ^a,b   Sanchez Matarredona, David ^a   Varea, Emilo ^a,b   Crespo, Carlos ^a,b   Blasco Ibáñez, José M ^a,b   Nacher, Juan ^a,b  

^a UNIVERSITY OF VALENCIA   (Spain)

^b HOSPITAL CLÍNICO UNIVERSITARIO   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

DOUBLECORTIN; FLUOXETINE; GLUTAMATE DECARBOXYLASE 65; GLUTAMATE DECARBOXYLASE 67; KI 67 ANTIGEN; NERVE CELL ADHESION MOLECULE; POLYSIALYLATED NEURAL CELL ADHESION MOLECULE; SYNAPTOPHYSIN; UNCLASSIFIED DRUG; VESICULAR GLUTAMATE TRANSPORTER 1; ANTIDEPRESSANT AGENT; DOUBLECORTIN PROTEIN; GLUTAMATE DECARBOXYLASE; GLUTAMATE DECARBOXYLASE 2; MICROTUBULE ASSOCIATED PROTEIN; NERVE CELL ADHESION MOLECULE L1; NEUROPEPTIDE; POLYSIALYL NEURAL CELL ADHESION MOLECULE; SIALIC ACID DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL PROLIFERATION; CINGULATE GYRUS; CONTROLLED STUDY; DRUG EFFECT; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; MALE; MEDIAL AMYGDALA; NERVE CELL PLASTICITY; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PREFRONTAL CORTEX; PROTEIN EXPRESSION; RAT; TREATMENT DURATION; TREATMENT RESPONSE; ANIMAL; BODY WEIGHT; CELL COUNT; CYTOLOGY; GENE EXPRESSION REGULATION; GENETICS; LATERAL BRAIN VENTRICLE; METABOLISM; TELENCEPHALON; WISTAR RAT;

ANIMALS; ANTIDEPRESSIVE AGENTS, SECOND-GENERATION; BODY WEIGHT; CELL COUNT; CELL PROLIFERATION; FLUOXETINE; GENE EXPRESSION REGULATION; GLUTAMATE DECARBOXYLASE; KI-67 ANTIGEN; LATERAL VENTRICLES; MALE; MICROTUBULE-ASSOCIATED PROTEINS; NEURAL CELL ADHESION MOLECULE L1; NEUROGENESIS; NEUROPEPTIDES; RATS; RATS, WISTAR; SIALIC ACIDS; SYNAPTOPHYSIN; TELENCEPHALON; VESICULAR GLUTAMATE TRANSPORT PROTEIN 1;

EID: 84855384326     PISSN: None     EISSN: 14712202     Source Type: Journal    
DOI: 10.1186/1471-2202-13-5     Document Type: Article

References (80)

1. Castrén E. Is mood chemistry?. Nature Reviews Neuroscience 2005, 6:241-6.
2. Mattson MP, Maudsley S, Martin B. BDNF and 5-HT: a dynamic duo in age-related neuronal plasticity and neurodegenerative disorders. Trends in Neurosciences 2004, 27:589-94. 10.1016/j.tins.2004.08.001, 15374669.
3. Phillips ML, Drevets WC, Rauch SL, Lane R. Neurobiology of emotion perception II: Implications for major psychiatric disorders. Biological Psychiatry 2003, 54:515-28. 10.1016/S0006-3223(03)00171-9, 12946880.
4. Tata DA, Anderson BJ. The effects of chronic glucocorticoid exposure on dendritic length, synapse numbers and glial volume in animal models: implications for hippocampal volume reductions in depression. Physiology & Behavior 2010, 99:186-93. 10.1016/j.physbeh.2009.09.008, 22279620.
5. Duman RS, Malberg J, Nakagawa S, D'Sa C. Neuronal plasticity and survival in mood disorders. Biological Psychiatry 2000, 48:732-9. 10.1016/S0006-3223(00)00935-5, 11063970.
6. Jacobs BL, van Praag H, Gage FH. Adult brain neurogenesis and psychiatry: a novel theory of depression. Molecular Psychiatry 2000, 5:262-9. 10.1038/sj.mp.4000712, 10889528.
7. Kempermann G, Kronenberg G. Depressed new neurons--adult hippocampal neurogenesis and a cellular plasticity hypothesis of major depression. Biological Psychiatry 2003, 54:499-503. 10.1016/S0006-3223(03)00319-6, 12946878.
8. McEwen BS. Effects of adverse experiences for brain structure and function. Biological Psychiatry 2000, 48:721-31. 10.1016/S0006-3223(00)00964-1, 11063969.
9. Boldrini M, Underwood MD, Hen R, Rosoklija GB, Dwork AJ, John Mann J, Arango V. Antidepressants increase neural progenitor cells in the human hippocampus. Neuropsycho-pharmacology 2009, 34:2376-89.
10. Henn FA, Vollmayr B. Neurogenesis and depression: etiology or epiphenomenon?. Biological Psychiatry 2004, 56:146-50. 10.1016/j.biopsych.2004.04.011, 15271582.
11. Magariños AM, Deslandes A, McEwen BS. Effects of antidepressants and benzodiazepine treatments on the dendritic structure of CA3 pyramidal neurons after chronic stress. European Journal of Pharmacology 1999, 371:113-22. 10.1016/S0014-2999(99)00163-6, 10357248.
12. Malberg JE, Eisch AJ, Nestler EJ, Duman RS. Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus. Journal of Neuroscience 2000, 20:9104-10.
13. Vermetten E, Vythilingam M, Southwick SM, Charney DS, Bremner JD. Long-term treatment with paroxetine increases verbal declarative memory and hippocampal volume in posttraumatic stress disorder. Biological Psychiatry 2003, 54:693-702. 10.1016/S0006-3223(03)00634-6, 3233762, 14512209.
14. Ampuero E, Rubio FJ, Falcon R, Sandoval M, Diaz-Veliz G, Gonzalez RE, Earle N, Dagnino-Subiabre A, Aboitiz F, Orrego F, Wyneken U. Chronic fluoxetine treatment induces structural plasticity and selective changes in glutamate receptor subunits in the rat cerebral cortex. Neuroscience 2010, 169:98-108. 10.1016/j.neuroscience.2010.04.035, 20417256.
15. Guirado R, Varea E, Castillo-Gómez E, Gómez-Climent MA, Rovira-Esteban L, Blasco-Ibáñez JM, Crespo C, Martínez-Guijarro FJ, Nàcher J. Effects of chronic fluoxetine treatment on the rat somatosensory cortex: activation and induction of neuronal structural plasticity. Neuroscience Letters 2009, 457:12-5. 10.1016/j.neulet.2009.03.104, 19429152.
16. Hajszan T, MacLusky NJ, Leranth C. Short-term treatment with the antidepressant fluoxetine triggers pyramidal dendritic spine synapse formation in rat hippocampus. European Journal of Neuroscience 2005, 21:1299-303. 10.1111/j.1460-9568.2005.03968.x, 15813939.
17. Sairanen M, O'Leary OF, Knuuttila JE, Castrén E. Chronic antidepressant treatment selectively increases expression of plasticity-related proteins in the hippocampus and medial prefrontal cortex of the rat. Neuroscience 2007, 144:368-74. 10.1016/j.neuroscience.2006.08.069, 17049169.
18. Santarelli L, Saxe M, Gross C, Surget A, Battaglia F, Dulawa S, Weisstaub N, Lee J, Duman R, Arancio O, Belzung C, Hen R. Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. Science 2003, 301:805-9. 10.1126/science.1083328, 12907793.
19. Sandi C. Stress, cognitive impairment and cell adhesion molecules. Nature Reviews Neuroscience 2004, 5:917-930. 10.1038/nrn1555, 15550947.
20. Varea E, Blasco-Ibáñez JM, Gómez-Climent MA, Castillo-Gómez E, Crespo C, Martínez-Guijarro FJ, Nácher J. Chronic fluoxetine treatment increases the expression of PSA-NCAM in the medial prefrontal cortex. Neuropsychopharmacology 2007, 32:803-12. 10.1038/sj.npp.1301183, 16900104.
21. Varea E, Castillo-Gómez E, Gómez-Climent MA, Blasco-Ibáñez JM, Crespo C, Martínez-Guijarro FJ, Nàcher J. Chronic antidepressant treatment induces contrasting patterns of synaptophysin and PSA-NCAM expression in different regions of the adult rat telencephalon. European Neuropsychopharmacology 2007, 17:546-57. 10.1016/j.euroneuro.2007.01.001, 17307340.
22. Rutishauser U. Polysialic acid in the plasticity of the developing and adult vertebrate nervous system. Nature Reviews. Neuroscience 2008, 9:26-35. 2266937, 18294400.
23. Varea E, Castillo-Gómez E, Gómez-Climent MA, Blasco-Ibáñez JM, Crespo C, Martínez-Guijarro FJ, Nàcher J. PSA-NCAM expression in the human prefrontal cortex. Journal of Chemical Neuroanatomy 2007, 33:202-9. 10.1016/j.jchemneu.2007.03.006, 17467233.
24. Varea E, Nácher J, Blasco-Ibáñez JM, Gómez-Climent MA, Castillo-Gómez E, Crespo C, Martínez-Guijarro FJ. PSA-NCAM expression in the rat medial prefrontal cortex. Neuroscience 2005, 136:435-43. 10.1016/j.neuroscience.2005.08.009, 16216431.
25. Nacher J, Lanuza E, McEwen BS. Distribution of PSA-NCAM expression in the amygdala of the adult rat. Neuroscience 2002, 113:479-84. 10.1016/S0306-4522(02)00219-1, 12150768.
26. Seki T, Arai Y. Distribution and possible roles of the highly polysialylated neural cell adhesion molecule (NCAM-H) in the developing and adult central nervous system. Neuroscience Research 1993, 17:265-90. 10.1016/0168-0102(93)90111-3, 8264989.
27. Seki T, Arai Y. The persistent expression of a highly polysialylated NCAM in the dentate gyrus of the adult rat. Neuroscience Research 1991, 12:503-13. 10.1016/S0168-0102(09)80003-5, 1665554.
28. Rousselot P, Lois C, Alvarez-Buylla A. Embryonic (PSA) N-CAM reveals chains of migrating neuroblasts between the lateral ventricle and the olfactory bulb of adult mice. Journal of Comparative Neurology 1995, 351:51-61. 10.1002/cne.903510106, 7896939.
29. Nacher J, Blasco-Ibáñez JM, McEwen BS. Non-granule PSA-NCAM immunoreactive neurons in the rat hippocampus. Brain Research 2002, 930:1-11. 10.1016/S0006-8993(01)03365-0, 11879789.
30. Gómez-Climent M, Guirado R, Castillo-Gómez E, Varea E, Gutierrez-Mecinas M, Gilabert-Juan J, García-Mompó C, Vidueira S, Sanchez-Mataredona D, Hernández S, Blasco-Ibáñez JM, Crespo C, Rutishauser U, Schachner M, Nacher J. The Polysialylated Form of the Neural Cell Adhesion Molecule (PSA-NCAM) Is Expressed in a Subpopulation of Mature Cortical Interneurons Characterized by Reduced Structural Features and Connectivity. Cerebral Cortex 2010, 21:1028-41.
31. Nasrallah HA, Hopkins T, Pixley SK. Differential effects of antipsychotic and antidepressant drugs on neurogenic regions in rats. Brain Research 2010, 1354:23-9.
32. Couillard-Despres S, Wuertinger C, Kandasamy M, Caioni M, Stadler K, Aigner R, Bogdahn U, Aigner L. Ageing abolishes the effects of fluoxetine on neurogenesis. Molecular Psychiatry 2009, 14:856-64. 10.1038/mp.2008.147, 19139747.
33. Marlatt MW, Lucassen PJ, van Praag H. Comparison of neurogenic effects of fluoxetine, duloxetine and running in mice. Brain Research 2010, 1341:93-9. 2884062, 20381469.
34. Navailles S, Hof PR, Schmauss C. Antidepressant drug-induced stimulation of mouse hippocampal neurogenesis is age-dependent and altered by early life stress. Journal of Comparative Neurology 2008, 509:372-81. 10.1002/cne.21775, 2502065, 18512685.
35. Kuhn HG, Dickinson-Anson H, Gage FH. Neurogenesis in the dentate gyrus of the adult rat ceases during aging. European Journal of Neuroscience 1995, 8(Suppl):89.
36. Varea E, Castillo-Gómez E, Gómez-Climent MA, Guirado R, Blasco-Ibáñez JM, Crespo C, Martínez-Guijarro FJ, Nácher J. Differential evolution of PSA-NCAM expression during aging of the rat telencephalon. Neurobiology of Aging 2009, 30:808-18. 10.1016/j.neurobiolaging.2007.08.016, 17904697.
37. Cowen DS, Takase LF, Fornal CA, Jacobs BL. Age-dependent decline in hippocampal neurogenesis is not altered by chronic treatment with fluoxetine. Brain Research 2008, 1228:14-9.
38. Magariños AM, McEwen BS. Stress-induced atrophy of apical dendrites of hippocampal CA3c neurons: involvement of glucocorticoid secretion and excitatory amino acid receptors. Neuroscience 1995, 69:89-98. 10.1016/0306-4522(95)00259-L, 8637636.
39. Marcuzzo S, Dall'oglio A, Ribeiro MFM, Achaval M, Rasia-Filho AA. Dendritic spines in the posterodorsal medial amygdala after restraint stress and ageing in rats. Neuroscience Letters 2007, 424:16-21. 10.1016/j.neulet.2007.07.019, 17709204.
40. Mitra R, Jadhav S, McEwen BS, Vyas A, Chattarji S. Stress duration modulates the spatiotemporal patterns of spine formation in the basolateral amygdala. Proceedings of the National Academy of Sciences of the United States of America 2005, 102:9371-6. 10.1073/pnas.0504011102, 1166638, 15967994.
41. Radley JJ, Sisti HM, Hao J, Rocher AB, McCall T, Hof PR, McEwen BS, Morrison JH. Chronic behavioral stress induces apical dendritic reorganization in pyramidal neurons of the medial prefrontal cortex. Neuroscience 2004, 125:1-6. 10.1016/j.neuroscience.2004.01.006, 15051139.
42. Radley JJ, Rocher AB, Miller M, Janssen WGM, Liston C, Hof PR, McEwen BS, Morrison JH. Repeated stress induces dendritic spine loss in the rat medial prefrontal cortex. Cerebral Cortex 2006, 16:313-20.
43. Hansson AC, Nixon K, Rimondini R, Damadzic R, Sommer WH, Eskay R, Crews FT, Heilig M. Long-term suppression of forebrain neurogenesis and loss of neuronal progenitor cells following prolonged alcohol dependence in rats. International Journal of Neuropsychopharmacology 2010, 13:583-93. 10.1017/S1461145710000246, 20334723.
44. McNamara RK, Able JA, Rider T, Tso P, Jandacek R. Effect of chronic fluoxetine treatment on male and female rat erythrocyte and prefrontal cortex fatty acid composition. Progress in Neuro-psychopharmacology & Biological Psychiatry 2010, 34:1317-21. 10.1016/j.pnpbp.2010.07.016, 17360094.
45. Thompson MR, Li KM, Clemens KJ, Gurtman CG, Hunt GE, Cornish JL, McGregor IS. Chronic fluoxetine treatment partly attenuates the long-term anxiety and depressive symptoms induced by MDMA ('Ecstasy') in rats. Neuropsychopharmacology 2004, 29:694-704. 10.1038/sj.npp.1300347, 14627999.
46. Hewlett WA, Trivedi BL, Zhang Z-J, de Paulis T, Schmidt DE, Lovinger DM, Ansari MS, Ebert MH. Characterization of (S)-Des-4-amino-3-[125I]iodozacopride ([125I]DAIZAC), a Selective High-Affinity Radioligand for 5-Hydroxytryptamine3 Receptors. Journal of Pharmacology and Experimental Therapies 1999, 288:221-231.
47. Li Q, Wichems CH, Ma L, Van de Kar LD, Garcia F, Murphy DL. Brain region-specific alterations of 5-HT 2A and 5-HT 2C receptors in serotonin transporter knockout mice. Journal of Neurochemistry 2003, 84:1256-1265. 10.1046/j.1471-4159.2003.01607.x, 12614326.
48. McDonald AJ, Mascagni F. Neuronal localization of 5-HT type 2A receptor immunoreactivity in the rat basolateral amygdala. Neuroscience 2007, 146:306-20. 10.1016/j.neuroscience.2007.01.047, 1941573, 17331657.
49. Morales M, Battenberg E, Bloom FE. Distribution of neurons expressing immunoreactivity for the 5HT3 receptor subtype in the rat brain and spinal cord. Journal of Comparative Neurology 1998, 402:385-401. 10.1002/(SICI)1096-9861(19981221)402:3<385::AID-CNE7>3.0.CO;2-Q, 9853906.
50. Puig MV, Santana N, Celada P, Mengod G, Artigas F. In vivo excitation of GABA interneurons in the medial prefrontal cortex through 5-HT3 receptors. Cerebral Cortex 2004, 14:1365-75. 10.1093/cercor/bhh097, 15166106.
51. Weber ET, Andrade R. Htr2a Gene and 5-HT(2A) Receptor Expression in the Cerebral Cortex Studied Using Genetically Modified Mice. Frontiers in Neuroscience 2010, 4.
52. Gilabert-Juan J, Castillo-Gomez E, Pérez-Rando M, Moltó MD, Nacher J. Chronic stress induces changes in the structure of interneurons and in the expression of molecules related to neuronal structural plasticity and inhibitory neurotransmission in the amygdala of adult mice. Experimental Neurology 2011, 232:33-40. 10.1016/j.expneurol.2011.07.009, 21819983.
53. Castillo-Gómez E, Gómez-Climent MA, Varea E, Guirado R, Blasco-Ibáñez JM, Crespo C, Martínez-Guijarro FJ, Nácher J. Dopamine acting through D2 receptors modulates the expression of PSA-NCAM, a molecule related to neuronal structural plasticity, in the medial prefrontal cortex of adult rats. Experimental neurology 2008, 214:97-111. 10.1016/j.expneurol.2008.07.018, 18718470.
54. Tordera RM, Pei Q, Sharp T. Evidence for increased expression of the vesicular glutamate transporter, VGLUT1, by a course of antidepressant treatment. Journal of Neurochemistry 2005, 94:875-83. 10.1111/j.1471-4159.2005.03192.x, 15992385.
55. Seki T, Arai Y. Different polysialic acid-neural cell adhesion molecule expression patterns in distinct types of mossy fiber boutons in the adult hippocampus. Journal of Comparative Neurology 1999, 410:115-25. 10.1002/(SICI)1096-9861(19990719)410:1<115::AID-CNE10>3.0.CO;2-C, 10397399.
56. Kobayashi K, Ikeda Y, Sakai A, Yamasaki N, Haneda E, Miyakawa T, Suzuki H. Reversal of hippocampal neuronal maturation by serotonergic antidepressants. Proceedings of the National Academy of Sciences of the United States of America 2010, 107:8434-9. 10.1073/pnas.0912690107, 2889553, 20404165.
57. Nacher J, Guirado R, Varea E, Alonso-Llosa G, Röckle I, Hildebrandt H. Divergent impact of the polysialyltransferases ST8SiaII and ST8SiaIV on polysialic acid expression in immature neurons and interneurons of the adult cerebral cortex. Neuroscience 2010, 167:825-37. 10.1016/j.neuroscience.2010.02.067, 20206239.
58. Reinés A, Cereseto M, Ferrero A, Sifonios L, Podestá MF, Wikinski S. Maintenance treatment with fluoxetine is necessary to sustain normal levels of synaptic markers in an experimental model of depression: correlation with behavioral response. Neuropsychopharmacology 2008, 33:1896-908. 10.1038/sj.npp.1301596, 17955054.
59. Homberg JR, Olivier JDA, Blom T, Arentsen T, van Brunschot C, Schipper P, Korte-Bouws G, van Luijtelaar G, Reneman L. Fluoxetine exerts age-dependent effects on behavior and amygdala neuroplasticity in the rat. PloS one 2011, 6:e16646. 10.1371/journal.pone.0016646, 3031607, 21304948.
60. Arivazhagan P, Panneerselvam C. Neurochemical changes related to ageing in the rat brain and the effect of DL-α-lipoic acid. Experimental Gerontology 2002, 37:1489-1494. 10.1016/S0531-5565(02)00122-5, 12559418.
61. Blier P. Altered function of the serotonin 1A autoreceptor and the antidepressant response. Neuron 2010, 65:1-2. 10.1016/j.neuron.2009.12.028, 20152106.
62. Hensler JG. Differential regulation of 5-HT1A receptor-G protein interactions in brain following chronic antidepressant administration. Neuropsychopharmacology 2002, 26:565-73. 10.1016/S0893-133X(01)00395-5, 11927181.
63. Lolova I, Davidoff M. Changes in GABA-immunoreactivity and GABA-transaminase activity in rat amygdaloid complex in aging. Journal für Hirnforschung 1991, 32:231-8. 3263529, 22279619.
64. Nakanishi H. Hyperexcitability of amygdala neurons of Senescence-Accelerated Mouse revealed by electrical and optical recordings in an in vitro slice preparation. Brain Research 1998, 812:142-149. 10.1016/S0006-8993(98)00968-8, 9813291.
65. Marcusson J, Morgan D, Winblad B, Finch C. Serotonin-2 binding sites in human frontal cortex and hippocampus. Selective loss of S-2A sites with age. Brain Research 1984, 311:51-56. 10.1016/0006-8993(84)91397-0, 6488044.
66. Mcewen BS, Magarinos AM, Reagan LP. Structural plasticity and tianeptine: cellular and molecular targets. Psychiatry: Interpersonal and Biological Processes 2002, 5-9.
67. Slotkin TA, McCook EC, Ritchie JC, Carroll BJ, Seidler FJ. Serotonin transporter expression in rat brain regions and blood platelets: aging and glucocorticoid effects. Biological Psychiatry 1997, 41:172-83. 10.1016/S0006-3223(96)00215-6, 9018387.
68. Huang G-J, Herbert J. Stimulation of neurogenesis in the hippocampus of the adult rat by fluoxetine requires rhythmic change in corticosterone. Biological Psychiatry 2006, 59:619-24. 10.1016/j.biopsych.2005.09.016, 16325782.
69. Seib LM, Wellman CL. Daily injections alter spine density in rat medial prefrontal cortex. Neuroscience Letters 2003, 337:29-32. 10.1016/S0304-3940(02)01287-9, 12524164.
70. Nacher J, McEwen BS. The role of N-methyl-D-asparate receptors in neurogenesis. Hippocampus 2006, 16:267-70. 10.1002/hipo.20160, 16425227.
71. Markwardt S, Overstreet-Wadiche L. GABAergic signalling to adult-generated neurons. Journal of Physiology 2008, 586:3745-9. 10.1113/jphysiol.2008.155713, 2538938, 18511482.
72. Marlatt MW, Philippens I, Manders E, Czeh B, Joels M, Krugers H, Lucassen PJ. Distinct structural plasticity in the hippocampus and amygdala of the middle-aged common marmoset (Callithrix jacchus). Experimental neurology 2011, 230:291-301. 10.1016/j.expneurol.2011.05.008, 21605555.
73. Castrén E, Rantamäki T. The role of BDNF and its receptors in depression and antidepressant drug action: Reactivation of developmental plasticity. Developmental Neurobiology 2010, 70:289-97. 10.1002/dneu.20758, 20186711.
74. Wu X, Castrén E. Co-treatment with diazepam prevents the effects of fluoxetine on the proliferation and survival of hippocampal dentate granule cells. Biological Psychiatry 2009, 66:5-8. 10.1016/j.biopsych.2009.01.023, 19251245.
75. Li Y-F, Zhang Y-Z, Liu Y-Q, Wang H-L, Cao J-B, Guan T-T, Luo Z-P. Inhibition of N-methyl-D-aspartate receptor function appears to be one of the common actions for antidepressants. Journal of Psychopharmacology 2006, 20:629-35. 10.1177/0269881106059692, 16401669.
76. Saarelainen T, Hendolin P, Lucas G, Koponen E, Sairanen M, MacDonald E, Agerman K, Haapasalo A, Nawa H, Aloyz R, Ernfors P, Castren E. Activation of the TrkB Neurotrophin Receptor Is Induced by Antidepressant Drugs and Is Required for Antidepressant-Induced Behavioral Effects. Journal of Neuroscience 2003, 23:349-357.
77. Banasr M, Hery M, Printemps R, Daszuta A. Serotonin-induced increases in adult cell proliferation and neurogenesis are mediated through different and common 5-HT receptor subtypes in the dentate gyrus and the subventricular zone. Neuropsychopharmacology 2004, 29:450-60. 10.1038/sj.npp.1300320, 14872203.
78. Ohira K, Miyakawa T. Chronic treatment with fluoxetine for more than 6 weeks decreases neurogenesis in the subventricular zone of adult mice. Molecular Brain 2011, 4:10. 10.1186/1756-6606-4-10, 3060120, 21385396.
79. Sairanen M, Lucas G, Ernfors P, Castrén M, Castrén E. Brain-derived neurotrophic factor and antidepressant drugs have different but coordinated effects on neuronal turnover, proliferation, and survival in the adult dentate gyrus. Journal of Neuroscience 2005, 25:1089-94. 10.1523/JNEUROSCI.3741-04.2005, 15689544.
80. Roozendaal B, McEwen BS, Chattarji S. Stress, memory and the amygdala. Nature Reviews Neuroscience 2009, 10:423-33.