Increasing Adult Hippocampal Neurogenesis is Sufficient to Reduce Anxiety and Depression-Like Behaviors

Neuropsychopharmacology

Volumn 40, Issue 10, 2015, Pages 2368-2378

  Hill, Alexis S ^a   Sahay, Amar ^b,c,d   Hen, René ^a,e  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL CANCER CENTER   (United States)

^c HARVARD STEM CELL INSTITUTE   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

^e NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BROXURIDINE; CORTICOSTERONE; DOUBLECORTIN; PROTEIN BAX; DOUBLECORTIN PROTEIN; MICROTUBULE ASSOCIATED PROTEIN; NEUROPEPTIDE; TAMOXIFEN;

ACUTE STRESS; ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ANXIETY; ARCUATE NUCLEUS; ARTICLE; CHRONIC STRESS; CONTROLLED STUDY; DENTATE GYRUS; DEPRESSION; FORCED SWIM TEST; GENE DELETION; HIPPOCAMPUS; HYPOTHALAMUS; IMMUNOHISTOCHEMISTRY; MOUSE; NERVOUS SYSTEM DEVELOPMENT; NEURAL STEM CELL; NONHUMAN; NOVELTY SUPPRESSED FEEDING TEST; OLIGODENDROGLIA; OPEN FIELD TEST; PRIORITY JOURNAL; REGULATORY MECHANISM; TAIL SUSPENSION TEST; ANIMAL; BLOOD; C57BL MOUSE; CYTOLOGY; DISEASE MODEL; DRUG EFFECTS; DRUG THERAPY; EXPLORATORY BEHAVIOR; GENETICS; HYPOPHYSIS ADRENAL SYSTEM; HYPOTHALAMUS HYPOPHYSIS SYSTEM; METABOLISM; PATHOLOGY; PHYSIOLOGY; TRANSGENIC MOUSE;

ANIMALS; ANXIETY; BCL-2-ASSOCIATED X PROTEIN; BROMODEOXYURIDINE; CORTICOSTERONE; DEPRESSION; DISEASE MODELS, ANIMAL; EXPLORATORY BEHAVIOR; HIPPOCAMPUS; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MICROTUBULE-ASSOCIATED PROTEINS; NEUROGENESIS; NEUROPEPTIDES; PITUITARY-ADRENAL SYSTEM; TAMOXIFEN;

EID: 84939262538     PISSN: 0893133X     EISSN: 1740634X     Source Type: Journal    
DOI: 10.1038/npp.2015.85     Document Type: Article

References (48)

1. Batailler M, Droguerre M, Baroncini M, Fontaine C, Prevot V, Migaud M (2014). DCX-expressing cells in the vicinity of the hypothalamic neurogenic niche: a comparative study between mouse, sheep, and human tissues. J Comp Neurol 522: 1966-1985.
2. Boldrini M, Underwood MD, Hen R, Rosoklija GB, Dwork AJ, John Mann J et al (2009). Antidepressants increase neural progenitor cells in the human hippocampus. Neuropsychopharmacology 34: 2376-2389.
3. Brown JP, Couillard-Despres S, Cooper-Kuhn CM, Winkler J, Aigner L, Kuhn HG (2003). Transient expression of doublecortin during adult neurogenesis. J Comp Neurol 467: 1-10.
4. Canteras NS, Swanson LW (1992). Projections of the ventral subiculum to the amygdala, septum, and hypothalamus: a PHAL anterograde tract-tracing study in the rat. J Comp Neurol 324: 180-194.
5. Chetty S, Friedman AR, Taravosh-Lahn K, Kirby ED, Mirescu C, Guo F et al (2014). Stress and glucocorticoids promote oligodendrogenesis in the adult hippocampus. Mol Psychiatry 19: 1275-1283.
6. Couillard-Despres S, Aigner L (2011). In vivo imaging of adult neurogenesis. Eur J Neurosci 33: 1037-1044.
7. Cullinan WE, Herman JP, Watson SJ (1993). Ventral subicular interaction with the hypothalamic paraventricular nucleus: evidence for a relay in the bed nucleus of the stria terminalis. J Comp Neurol 332: 1-20.
8. David DJ, Samuels BA, Rainer Q, Wang JW, Marsteller D, Mendez I et al (2009). Neurogenesis-dependent and -independent effects of fluoxetine in an animal model of anxiety/depression. Neuron 62: 479-493.
9. Dayer AG, Ford AA, Cleaver KM, Yassaee M, Cameron HA (2003). Short-term and long-term survival of new neurons in the rat dentate gyrus. J Comp Neurol 460: 563-572.
10. Denny CA, Burghardt NS, Schachter DM, Hen R, Drew MR (2012). 4- to 6-week-old adult-born hippocampal neurons influence novelty-evoked exploration and contextual fear conditioning. Hippocampus 22: 1188-1201.
11. Dranovsky A, Picchini AM, Moadel T, Sisti AC, Yamada A, Kimura S et al (2011). Experience dictates stem cell fate in the adult hippocampus. Neuron 70: 908-923.
12. Dulawa SC, Holick KA, Gundersen B, Hen R (2004). Effects of chronic fluoxetine in animal models of anxiety and depression. Neuropsychopharmacology 29: 1321-1330.
13. Duman RS, Nakagawa S, Malberg J (2001). Regulation of adult neurogenesis by antidepressant treatment. Neuropsychopharmacology 25: 836-844.
14. Fanselow MS, Dong HW (2010). Are the dorsal and ventral hippocampus functionally distinct structures? Neuron 65: 7-19.
15. Gould E, McEwen BS, Tanapat P, Galea LA, Fuchs E (1997). Neurogenesis in the dentate gyrus of the adult tree shrew is regulated by psychosocial stress and NMDA receptor activation. J Neurosci 17: 2492-2498.
16. Herman JP, Cullinan WE, Young EA, Akil H, Watson SJ (1992). Selective forebrain fiber tract lesions implicate ventral hippocampal structures in tonic regulation of paraventricular nucleus corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP) mRNA expression. Brain Res 592: 228-238.
17. Jiao S, Li Z (2011). Nonapoptotic function of BAD and BAX in long-term depression of synaptic transmission. Neuron 70: 758-772.
18. Kee N, Teixeira CM, Wang AH, Frankland PW (2007). Preferential incorporation of adult-generated granule cells into spatial memory networks in the dentate gyrus. Nature neuroscience 10: 355-362.
19. Kheirbek MA, Drew LJ, Burghardt NS, Costantini DO, Tannenholz L, Ahmari SE et al (2013). Differential control of learning and anxiety along the dorsoventral axis of the dentate gyrus. Neuron 77: 955-968.
20. Kokoeva MV, Yin H, Flier JS (2005). Neurogenesis in the hypothalamus of adult mice: potential role in energy balance. Science 310: 679-683.
21. Lee DA, Blackshaw S (2012). Functional implications of hypothalamic neurogenesis in the adult mammalian brain. Int J Dev Neurosci 30: 615-621.
22. Lehmann ML, Brachman RA, Martinowich K, Schloesser RJ, Herkenham M (2013). Glucocorticoids orchestrate divergent effects on mood through adult neurogenesis. J Neurosci 33: 2961-2972.
23. Li Y, Li Y, McKay RM, Riethmacher D, Parada LF (2012). Neurofibromin modulates adult hippocampal neurogenesis and behavioral effects of antidepressants. J Neurosci 32: 3529-3539.
24. Malberg JE, Eisch AJ, Nestler EJ, Duman RS (2000). Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus. J Neurosci 20: 9104-9110.
25. Namura S, Takada M, Kikuchi H, Mizuno N (1994). Topographical organization of subicular neurons projecting to subcortical regions. Brain Res Bull 35: 221-231.
26. Pierce AA, Xu AW (2010). De novo neurogenesis in adult hypothalamus as a compensatory mechanism to regulate energy balance. J Neurosci 30: 723-730.
27. Razzoli M, Carboni L, Andreoli M, Ballottari A, Arban R (2011). Different susceptibility to social defeat stress of BalbC and C57BL6/J mice. Behav Brain Res 216: 100-108.
28. Saaltink DJ, Havik B, Verissimo CS, Lucassen PJ, Vreugdenhil E (2012). Doublecortin and doublecortin-like are expressed in overlapping and non-overlapping neuronal cell population: implications for neurogenesis. J Comp Neurol 520: 2805-2823.
29. Sahay A, Scobie KN, Hill AS, O'Carroll CM, Kheirbek MA, Burghardt NS et al (2011). Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation. Nature 472: 466-470.
30. Santarelli L, Saxe M, Gross C, Surget A, Battaglia F, Dulawa S et al (2003). Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. Science 301: 805-809.
31. Schloesser RJ, Lehmann M, Martinowich K, Manji HK, Herkenham M (2010). Environmental enrichment requires adult neurogenesis to facilitate the recovery from psychosocial stress. Mol Psychiatry 15: 1152-1163.
32. Schloesser RJ, Manji HK, Martinowich K (2009). Suppression of adult neurogenesis leads to an increased hypothalamo-pituitaryadrenal axis response. Neuroreport 20: 553-557.
33. Snyder JS, Soumier A, Brewer M, Pickel J, Cameron HA (2011). Adult hippocampal neurogenesis buffers stress responses and depressive behaviour. Nature 476: 458-461.
34. Sun MY, Yetman MJ, Lee TC, Chen Y, Jankowsky JL (2014). Specificity and efficiency of reporter expression in adult neural progenitors vary substantially among nestin-CreER(T2) lines. J Comp Neurol 522: 1191-1208.
35. Surget A, Tanti A, Leonardo ED, Laugeray A, Rainer Q, Touma C et al (2011). Antidepressants recruit new neurons to improve stress response regulation. Mol Psychiatry 16: 1177-1188.
36. Surget A, Wang Y, Leman S, Ibarguen-Vargas Y, Edgar N, Griebel G et al (2009). Corticolimbic transcriptome changes are state-dependent and region-specific in a rodent model of depression and of antidepressant reversal. Neuropsychopharmacology 34: 1363-1380.
37. Takeuchi O, Fisher J, Suh H, Harada H, Malynn BA, Korsmeyer SJ (2005). Essential role of BAX,BAK in B cell homeostasis and prevention of autoimmune disease. Proc Natl Acad Sci USA 102: 11272-11277.
38. Tanti A, Belzung C (2013a). Hippocampal neurogenesis: a biomarker for depression or antidepressant effects? Methodological considerations and perspectives for future research. Cell Tissue Res 354: 203-219.
39. Tanti A, Belzung C (2013b). Neurogenesis along the septo-temporal axis of the hippocampus: are depression and the action of antidepressants region-specific? Neuroscience 252: 234-252.
40. Toni N, Teng EM, Bushong EA, Aimone JB, Zhao C, Consiglio A et al (2007). Synapse formation on neurons born in the adult hippocampus. Nat Neurosci 10: 727-734.
41. van Praag H, Shubert T, Zhao C, Gage FH (2005). Exercise enhances learning and hippocampal neurogenesis in aged mice. J Neurosci 25: 8680-8685.
42. Walker AK, Rivera PD, Wang Q, Chuang JC, Tran S, Osborne- Lawrence S et al (2014). The P7C3 class of neuroprotective compounds exerts antidepressant efficacy in mice by increasing hippocampal neurogenesis. Mol Psychiatry 20: 500-508.
43. Wang G, Han T, Nijhawan D, Theodoropoulos P, Naidoo J, Yadavalli S et al (2014). P7C3 neuroprotective chemicals function by activating the rate-limiting enzyme in NAD salvage. Cell 158: 1324-1334.
44. Wu MV, Hen R (2014a). Functional dissociation of adult-born neurons along the dorsoventral axis of the dentate gyrus. Hippocampus 24: 751-761.
45. Wu MV, Shamy JL, Bedi G, Choi CW, Wall MM, Arango V et al (2014b). Impact of social status and antidepressant treatment on neurogenesis in the baboon hippocampus. Neuropsychopharmacology 39: 1861-1871.
46. Xu Y, Tamamaki N, Noda T, Kimura K, Itokazu Y, Matsumoto N et al (2005). Neurogenesis in the ependymal layer of the adult rat 3rd ventricle. Exp Neurol 192: 251-264.
47. Yalcin I, Belzung C, Surget A (2008). Mouse strain differences in the unpredictable chronic mild stress: a four-antidepressant survey. Behav Brain Res 193: 140-143.
48. Yin TC, Britt JK, De Jesus-Cortes H, Lu Y, Genova RM, Khan MZ et al (2014). P7C3 neuroprotective chemicals block axonal degeneration and preserve function after traumatic brain injury. Cell Rep 8: 1731-1740.