Systemic methotrexate induces spatial memory deficits and depletes cerebrospinal fluid folate in rats

Pharmacology Biochemistry and Behavior

Volumn 94, Issue 3, 2010, Pages 454-463

  Li, Yan ^a   Vijayanathan, Veena ^a   Gulinello, Maria E ^a   Cole, Peter D ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Cerebrospinal fluid; Homocysteine; Methotrexate; S adenosylhomocysteine; S adenosylmethionine; Spatial memory

Indexed keywords

FOLIC ACID; METHOTREXATE; S ADENOSYLHOMOCYSTEINE; S ADENOSYLMETHIONINE; SODIUM CHLORIDE;

ACUTE LYMPHOBLASTIC LEUKEMIA; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CEREBROSPINAL FLUID LEVEL; COGNITIVE DEFECT; CONTROLLED STUDY; DEPLETION; EXPLORATORY BEHAVIOR; FEMALE; FOLATE METABOLISM; FOLIC ACID BLOOD LEVEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LONG EVANS RAT; MALE; MEMORY DISORDER; MOTOR COORDINATION; NEUROTOXICITY; NONHUMAN; OPEN FIELD TEST; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RAT; SPATIAL MEMORY; VISUAL MEMORY;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FOLIC ACID; FOLIC ACID ANTAGONISTS; MALE; MEMORY; METHOTREXATE; RATS; RATS, LONG-EVANS;

RATTUS; RODENTIA;

EID: 72149134895     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pbb.2009.10.008     Document Type: Article

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