메뉴 건너뛰기




Volumn 151, Issue , 2015, Pages 72-86

Epigenomes as therapeutic targets

Author keywords

Complex Diseases; DNA Methylation; Epigenetics; Epigenomes; Histone Modifications; Therapeutics

Indexed keywords

5 HYDROXYMETHYLCYTOSINE; DNA; DNA METHYLTRANSFERASE; HISTONE DEACETYLASE; UNTRANSLATED RNA; ANTINEOPLASTIC AGENT; CYTIDINE DEAMINASE; HISTONE; HISTONE DEACETYLASE INHIBITOR;

EID: 84930091174     PISSN: 01637258     EISSN: 1879016X     Source Type: Journal    
DOI: 10.1016/j.pharmthera.2015.03.003     Document Type: Review
Times cited : (89)

References (132)
  • 3
    • 79959288936 scopus 로고    scopus 로고
    • DNA packaging: Nucleosomes and chromatin
    • (nature.co006D)
    • A. Annunziato DNA packaging: Nucleosomes and chromatin Nat Educ 2008 (nature.co006D)
    • (2008) Nat Educ
    • Annunziato, A.1
  • 5
    • 84877574817 scopus 로고    scopus 로고
    • The future of epigenetic therapy in solid tumours - Lessons from the past
    • N. Azad, C.A. Zahnow, C.M. Rudin, and S.B. Baylin The future of epigenetic therapy in solid tumours - Lessons from the past Nat Rev Clin Oncol 10 2013 256 266
    • (2013) Nat Rev Clin Oncol , vol.10 , pp. 256-266
    • Azad, N.1    Zahnow, C.A.2    Rudin, C.M.3    Baylin, S.B.4
  • 6
    • 84869064386 scopus 로고    scopus 로고
    • Epigenetic targeting therapies to overcome chemotherapy resistance
    • C. Balch, and K.P. Nephew Epigenetic targeting therapies to overcome chemotherapy resistance Adv Exp Med Biol 754 2013 285 311
    • (2013) Adv Exp Med Biol , vol.754 , pp. 285-311
    • Balch, C.1    Nephew, K.P.2
  • 8
    • 84875129831 scopus 로고    scopus 로고
    • DNA methylation dynamics in health and disease
    • Y. Bergman, and H. Cedar DNA methylation dynamics in health and disease Nat Struct Mol Biol 20 2013 274 281
    • (2013) Nat Struct Mol Biol , vol.20 , pp. 274-281
    • Bergman, Y.1    Cedar, H.2
  • 9
    • 33846260563 scopus 로고    scopus 로고
    • Pharmacokinetics, metabolism, and oral bioavailability of the DNA methyltransferase inhibitor 5-fluoro-2′-deoxycytidine in mice
    • J.H. Beumer, J.L. Eiseman, R.A. Parise, E. Joseph, J.L. Holleran, J.M. Covey, and M.J. Egorin Pharmacokinetics, metabolism, and oral bioavailability of the DNA methyltransferase inhibitor 5-fluoro-2′-deoxycytidine in mice Clin Cancer Res 12 2006 7483 7491
    • (2006) Clin Cancer Res , vol.12 , pp. 7483-7491
    • Beumer, J.H.1    Eiseman, J.L.2    Parise, R.A.3    Joseph, E.4    Holleran, J.L.5    Covey, J.M.6    Egorin, M.J.7
  • 10
    • 43749124047 scopus 로고    scopus 로고
    • Concentrations of the DNA methyltransferase inhibitor 5-fluoro-2′-deoxycytidine (FdCyd) and its cytotoxic metabolites in plasma of patients treated with FdCyd and tetrahydrouridine (THU)
    • J.H. Beumer, R.A. Parise, E.M. Newman, J.H. Doroshow, T.W. Synold, H.J. Lenz, and M.J. Egorin Concentrations of the DNA methyltransferase inhibitor 5-fluoro-2′-deoxycytidine (FdCyd) and its cytotoxic metabolites in plasma of patients treated with FdCyd and tetrahydrouridine (THU) Cancer Chemother Pharmacol 62 2008 363 368
    • (2008) Cancer Chemother Pharmacol , vol.62 , pp. 363-368
    • Beumer, J.H.1    Parise, R.A.2    Newman, E.M.3    Doroshow, J.H.4    Synold, T.W.5    Lenz, H.J.6    Egorin, M.J.7
  • 11
    • 84930086888 scopus 로고    scopus 로고
    • See more at: (Bionor Pharma)
    • Bionor-Pharma First evidence that romidepsin "kicks" HIV out of reservoirs See more at: http://www.bionorpharma.com/First+Evidence+that+Romidepsin+%E2%80%9CKicks%E2%80%9D+HIV+out+of+Reservoirs.b7C-wlvYWU.ips#sthash.niStZLPd.dpuf 2014 (Bionor Pharma)
    • (2014) First Evidence That Romidepsin "kicks" HIV out of Reservoirs
  • 12
    • 0036144048 scopus 로고    scopus 로고
    • DNA methylation patterns and epigenetic memory
    • A. Bird DNA methylation patterns and epigenetic memory Genes Dev 16 2002 6 21
    • (2002) Genes Dev , vol.16 , pp. 6-21
    • Bird, A.1
  • 15
    • 0029984469 scopus 로고    scopus 로고
    • Tetrahymena histone acetyltransferase A: A homolog to yeast Gcn5p linking histone acetylation to gene activation
    • J.E. Brownell, J. Zhou, T. Ranalli, R. Kobayashi, D.G. Edmondson, S.Y. Roth, and C.D. Allis Tetrahymena histone acetyltransferase A: A homolog to yeast Gcn5p linking histone acetylation to gene activation Cell 84 1996 843 851
    • (1996) Cell , vol.84 , pp. 843-851
    • Brownell, J.E.1    Zhou, J.2    Ranalli, T.3    Kobayashi, R.4    Edmondson, D.G.5    Roth, S.Y.6    Allis, C.D.7
  • 16
    • 84875165863 scopus 로고    scopus 로고
    • Epigenetic programming and reprogramming during development
    • I. Cantone, and A.G. Fisher Epigenetic programming and reprogramming during development Nat Struct Mol Biol 20 2013 282 289
    • (2013) Nat Struct Mol Biol , vol.20 , pp. 282-289
    • Cantone, I.1    Fisher, A.G.2
  • 17
    • 84856466661 scopus 로고    scopus 로고
    • The role of EZH2 in tumour progression
    • C.J. Chang, and M.C. Hung The role of EZH2 in tumour progression Br J Cancer 106 2012 243 247
    • (2012) Br J Cancer , vol.106 , pp. 243-247
    • Chang, C.J.1    Hung, M.C.2
  • 18
    • 81055138989 scopus 로고    scopus 로고
    • Preferential binding of the methyl-CpG binding domain protein 2 at methylated transcriptional start site regions
    • A. Chatagnon, L. Perriaud, N. Nazaret, S. Croze, J. Benhattar, J. Lachuer, and R. Dante Preferential binding of the methyl-CpG binding domain protein 2 at methylated transcriptional start site regions Epigenetics 6 2011 1295 1307
    • (2011) Epigenetics , vol.6 , pp. 1295-1307
    • Chatagnon, A.1    Perriaud, L.2    Nazaret, N.3    Croze, S.4    Benhattar, J.5    Lachuer, J.6    Dante, R.7
  • 19
    • 77950678085 scopus 로고    scopus 로고
    • Coordinated chromatin control: Structural and functional linkage of DNA and histone methylation
    • X. Cheng, and R.M. Blumenthal Coordinated chromatin control: Structural and functional linkage of DNA and histone methylation Biochemistry 49 2010 2999 3008
    • (2010) Biochemistry , vol.49 , pp. 2999-3008
    • Cheng, X.1    Blumenthal, R.M.2
  • 20
    • 84863123659 scopus 로고    scopus 로고
    • TET inhibitors as potential new cancer drugs - An enzyme that converts 5-methylcytosine to 5-hydroxymethylcytosine
    • N. Chia TET inhibitors as potential new cancer drugs - An enzyme that converts 5-methylcytosine to 5-hydroxymethylcytosine Int Drug Discov? Vol. 2014 2012
    • (2012) Int Drug Discov? , vol.2014
    • Chia, N.1
  • 21
    • 79960998933 scopus 로고    scopus 로고
    • CpG islands undermethylation in human genomic regions under selective pressure
    • S. Cocozza, M.M. Akhtar, G. Miele, and A. Monticelli CpG islands undermethylation in human genomic regions under selective pressure PLoS ONE 6 2011 e23156
    • (2011) PLoS ONE , vol.6 , pp. e23156
    • Cocozza, S.1    Akhtar, M.M.2    Miele, G.3    Monticelli, A.4
  • 22
    • 84906271313 scopus 로고    scopus 로고
    • The potential of epigenetic therapies in neurodegenerative diseases
    • F. Coppede The potential of epigenetic therapies in neurodegenerative diseases Front Genet 5 2014 220
    • (2014) Front Genet , vol.5 , pp. 220
    • Coppede, F.1
  • 23
    • 84903362440 scopus 로고    scopus 로고
    • Global changes in DNA methylation and hydroxymethylation in Alzheimer's disease human brain
    • N. Coppieters, B.V. Dieriks, C. Lill, R.L. Faull, M.A. Curtis, and M. Dragunow Global changes in DNA methylation and hydroxymethylation in Alzheimer's disease human brain Neurobiol Aging 6 2013 1334 1344
    • (2013) Neurobiol Aging , Issue.6 , pp. 1334-1344
    • Coppieters, N.1    Dieriks, B.V.2    Lill, C.3    Faull, R.L.4    Curtis, M.A.5    Dragunow, M.6
  • 25
    • 40649111338 scopus 로고    scopus 로고
    • Non-coding RNAs, epigenetics and complexity
    • F.F. Costa Non-coding RNAs, epigenetics and complexity Gene 410 2008 9 17
    • (2008) Gene , vol.410 , pp. 9-17
    • Costa, F.F.1
  • 26
    • 79251504319 scopus 로고    scopus 로고
    • Epigenomics in cancer management
    • F.F. Costa Epigenomics in cancer management Cancer Manag Res 2 2010 255 265
    • (2010) Cancer Manag Res , vol.2 , pp. 255-265
    • Costa, F.F.1
  • 27
    • 33847672389 scopus 로고    scopus 로고
    • Concise review: Cancer/testis antigens, stem cells, and cancer
    • F.F. Costa, K. Le Blanc, and B. Brodin Concise review: Cancer/testis antigens, stem cells, and cancer Stem Cells 25 2007 707 711
    • (2007) Stem Cells , vol.25 , pp. 707-711
    • Costa, F.F.1    Le Blanc, K.2    Brodin, B.3
  • 29
    • 84878425943 scopus 로고    scopus 로고
    • TET proteins: On the frenetic hunt for new cytosine modifications
    • B. Delatte, and F. Fuks TET proteins: On the frenetic hunt for new cytosine modifications Brief Funct Genomics 12 2013 191 204
    • (2013) Brief Funct Genomics , vol.12 , pp. 191-204
    • Delatte, B.1    Fuks, F.2
  • 30
    • 24044481947 scopus 로고    scopus 로고
    • Inactivation of Dnmt3b in mouse embryonic fibroblasts results in DNA hypomethylation, chromosomal instability, and spontaneous immortalization
    • J.E. Dodge, M. Okano, F. Dick, N. Tsujimoto, T. Chen, S. Wang, Y. Ueda, N. Dyson, and E. Li Inactivation of Dnmt3b in mouse embryonic fibroblasts results in DNA hypomethylation, chromosomal instability, and spontaneous immortalization J Biol Chem 280 2005 17986 17991
    • (2005) J Biol Chem , vol.280 , pp. 17986-17991
    • Dodge, J.E.1    Okano, M.2    Dick, F.3    Tsujimoto, N.4    Chen, T.5    Wang, S.6    Ueda, Y.7    Dyson, N.8    Li, E.9
  • 31
    • 36048958965 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors: Overview and perspectives
    • M. Dokmanovic, C. Clarke, and P.A. Marks Histone deacetylase inhibitors: Overview and perspectives Mol Cancer Res 5 2007 981 989
    • (2007) Mol Cancer Res , vol.5 , pp. 981-989
    • Dokmanovic, M.1    Clarke, C.2    Marks, P.A.3
  • 32
    • 0242584454 scopus 로고    scopus 로고
    • Chromosomal instability and tumors promoted by DNA hypomethylation
    • A. Eden, F. Gaudet, A. Waghmare, and R. Jaenisch Chromosomal instability and tumors promoted by DNA hypomethylation Science 300 2003 455
    • (2003) Science , vol.300 , pp. 455
    • Eden, A.1    Gaudet, F.2    Waghmare, A.3    Jaenisch, R.4
  • 33
    • 34249275353 scopus 로고    scopus 로고
    • Phenotypic plasticity and the epigenetics of human disease
    • A.P. Feinberg Phenotypic plasticity and the epigenetics of human disease Nature 447 2007 433 440
    • (2007) Nature , vol.447 , pp. 433-440
    • Feinberg, A.P.1
  • 34
    • 1042278765 scopus 로고    scopus 로고
    • The history of cancer epigenetics
    • A.P. Feinberg, and B. Tycko The history of cancer epigenetics Nat Rev Cancer 4 2004 143 153
    • (2004) Nat Rev Cancer , vol.4 , pp. 143-153
    • Feinberg, A.P.1    Tycko, B.2
  • 35
    • 84866416677 scopus 로고    scopus 로고
    • De novo DNA methyltransferases: Oncogenes, tumor suppressors, or both?
    • A.F. Fernandez, C. Huidobro, and M.F. Fraga De novo DNA methyltransferases: Oncogenes, tumor suppressors, or both? Trends Genet 28 2012 474 479
    • (2012) Trends Genet , vol.28 , pp. 474-479
    • Fernandez, A.F.1    Huidobro, C.2    Fraga, M.F.3
  • 36
    • 79953163994 scopus 로고    scopus 로고
    • Chromatin states in pluripotent, differentiated, and reprogrammed cells
    • C.L. Fisher, and A.G. Fisher Chromatin states in pluripotent, differentiated, and reprogrammed cells Curr Opin Genet Dev 21 2011 140 146
    • (2011) Curr Opin Genet Dev , vol.21 , pp. 140-146
    • Fisher, C.L.1    Fisher, A.G.2
  • 37
    • 0021722919 scopus 로고
    • DNA methylation in 5-aza-2′-deoxycytidine-resistant variants of C3H 10T1/2 C18 cells
    • E. Flatau, F.A. Gonzales, L.A. Michalowsky, and P.A. Jones DNA methylation in 5-aza-2′-deoxycytidine-resistant variants of C3H 10T1/2 C18 cells Mol Cell Biol 4 1984 2098 2102
    • (1984) Mol Cell Biol , vol.4 , pp. 2098-2102
    • Flatau, E.1    Gonzales, F.A.2    Michalowsky, L.A.3    Jones, P.A.4
  • 39
    • 28044471827 scopus 로고    scopus 로고
    • Acetylation and deacetylation of non-histone proteins
    • M.A. Glozak, N. Sengupta, X. Zhang, and E. Seto Acetylation and deacetylation of non-histone proteins Gene 363 2005 15 23
    • (2005) Gene , vol.363 , pp. 15-23
    • Glozak, M.A.1    Sengupta, N.2    Zhang, X.3    Seto, E.4
  • 40
    • 0024365892 scopus 로고
    • Epigenetic changes may contribute to the formation and spontaneous regression of retinoblastoma
    • V. Greger, E. Passarge, W. Hopping, E. Messmer, and B. Horsthemke Epigenetic changes may contribute to the formation and spontaneous regression of retinoblastoma Hum Genet 83 1989 155 158
    • (1989) Hum Genet , vol.83 , pp. 155-158
    • Greger, V.1    Passarge, E.2    Hopping, W.3    Messmer, E.4    Horsthemke, B.5
  • 41
    • 84875223519 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors as radiosensitisers: Effects on DNA damage signalling and repair
    • B. Groselj, N.L. Sharma, F.C. Hamdy, M. Kerr, and A.E. Kiltie Histone deacetylase inhibitors as radiosensitisers: Effects on DNA damage signalling and repair Br J Cancer 108 2013 748 754
    • (2013) Br J Cancer , vol.108 , pp. 748-754
    • Groselj, B.1    Sharma, N.L.2    Hamdy, F.C.3    Kerr, M.4    Kiltie, A.E.5
  • 42
  • 43
    • 79959739474 scopus 로고    scopus 로고
    • The impact of epigenomics on future drug design and new therapies
    • C.A. Hamm, and F.F. Costa The impact of epigenomics on future drug design and new therapies Drug Discov Today 16 2011 626 635
    • (2011) Drug Discov Today , vol.16 , pp. 626-635
    • Hamm, C.A.1    Costa, F.F.2
  • 44
    • 0036847620 scopus 로고    scopus 로고
    • Function and selectivity of bromodomains in anchoring chromatin-modifying complexes to promoter nucleosomes
    • A.H. Hassan, P. Prochasson, K.E. Neely, S.C. Galasinski, M. Chandy, M.J. Carrozza, and J.L. Workman Function and selectivity of bromodomains in anchoring chromatin-modifying complexes to promoter nucleosomes Cell 111 2002 369 379
    • (2002) Cell , vol.111 , pp. 369-379
    • Hassan, A.H.1    Prochasson, P.2    Neely, K.E.3    Galasinski, S.C.4    Chandy, M.5    Carrozza, M.J.6    Workman, J.L.7
  • 46
    • 0024003456 scopus 로고
    • A direct link between core histone acetylation and transcriptionally active chromatin
    • T.R. Hebbes, A.W. Thorne, and C. Crane-Robinson A direct link between core histone acetylation and transcriptionally active chromatin EMBO J 7 1988 1395 1402
    • (1988) EMBO J , vol.7 , pp. 1395-1402
    • Hebbes, T.R.1    Thorne, A.W.2    Crane-Robinson, C.3
  • 49
    • 84881479358 scopus 로고    scopus 로고
    • Activation-induced cytidine deaminase auto-activates and triggers aberrant gene expression
    • T. Isobe, S.N. Song, P. Tiwari, H. Ito, Y. Yamaguchi, and K. Yoshizaki Activation-induced cytidine deaminase auto-activates and triggers aberrant gene expression FEBS Lett 587 2013 2487 2492
    • (2013) FEBS Lett , vol.587 , pp. 2487-2492
    • Isobe, T.1    Song, S.N.2    Tiwari, P.3    Ito, H.4    Yamaguchi, Y.5    Yoshizaki, K.6
  • 50
    • 84930092474 scopus 로고    scopus 로고
    • Study of the correlation of baseline biomarkers and DNA demethylation to clinical responses in a phase 1/2, randomized study of SGI-110, a novel subcutaneous hypomethylating agent in the treatment of relapsed/refractory acute myeloid leukemia
    • (Amsterdam Netherlands)
    • J.P. Issa Study of the correlation of baseline biomarkers and DNA demethylation to clinical responses in a phase 1/2, randomized study of SGI-110, a novel subcutaneous hypomethylating agent in the treatment of relapsed/refractory acute myeloid leukemia European Cancer Congress 2013 (Amsterdam Netherlands)
    • (2013) European Cancer Congress
    • Issa, J.P.1
  • 51
    • 84930088634 scopus 로고    scopus 로고
    • First clinical results of a randomized phase 2 study of SGI-110, a novel subcutaneous (SQ) hypomethylating agent (HMA), in adult patients with acute myeloid leukemia (AML)
    • J.P. Issa First clinical results of a randomized phase 2 study of SGI-110, a novel subcutaneous (SQ) hypomethylating agent (HMA), in adult patients with acute myeloid leukemia (AML) Am Soc Hematol 2013 http://astx.com/content/resources/2013-SGI-110-Oral-ASH-abst-497-Kantarjian-final2.pdf
    • (2013) Am Soc Hematol
    • Issa, J.P.1
  • 53
    • 77956189495 scopus 로고    scopus 로고
    • Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification
    • S. Ito, A.C. D'Alessio, O.V. Taranova, K. Hong, L.C. Sowers, and Y. Zhang Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification Nature 466 2010 1129 1133
    • (2010) Nature , vol.466 , pp. 1129-1133
    • Ito, S.1    D'Alessio, A.C.2    Taranova, O.V.3    Hong, K.4    Sowers, L.C.5    Zhang, Y.6
  • 54
    • 84886035297 scopus 로고    scopus 로고
    • A screen for hydroxymethylcytosine and formylcytosine binding proteins suggests functions in transcription and chromatin regulation
    • M. Iurlaro, G. Ficz, D. Oxley, E.A. Raiber, M. Bachman, M.J. Booth, S. Andrews, S. Balasubramanian, and W. Reik A screen for hydroxymethylcytosine and formylcytosine binding proteins suggests functions in transcription and chromatin regulation Genome Biol 14 2013 R119
    • (2013) Genome Biol , vol.14 , pp. R119
    • Iurlaro, M.1    Ficz, G.2    Oxley, D.3    Raiber, E.A.4    Bachman, M.5    Booth, M.J.6    Andrews, S.7    Balasubramanian, S.8    Reik, W.9
  • 56
    • 84925582031 scopus 로고    scopus 로고
    • Novel methods of type 1 diabetes treatment
    • S. Jayaraman Novel methods of type 1 diabetes treatment Discov Med 17 2014 347 355
    • (2014) Discov Med , vol.17 , pp. 347-355
    • Jayaraman, S.1
  • 58
    • 84863986133 scopus 로고    scopus 로고
    • Functions of DNA methylation: Islands, start sites, gene bodies and beyond
    • P.A. Jones Functions of DNA methylation: Islands, start sites, gene bodies and beyond Nat Rev Genet 13 2012 484 492
    • (2012) Nat Rev Genet , vol.13 , pp. 484-492
    • Jones, P.A.1
  • 60
    • 0036274359 scopus 로고    scopus 로고
    • The fundamental role of epigenetic events in cancer
    • P.A. Jones, and S.B. Baylin The fundamental role of epigenetic events in cancer Nat Rev Genet 3 2002 415 428
    • (2002) Nat Rev Genet , vol.3 , pp. 415-428
    • Jones, P.A.1    Baylin, S.B.2
  • 61
    • 79851477462 scopus 로고    scopus 로고
    • Distinct and redundant functions of histone deacetylases HDAC1 and HDAC2 in proliferation and tumorigenesis
    • J. Jurkin, G. Zupkovitz, S. Lagger, R. Grausenburger, A. Hagelkruys, L. Kenner, and C. Seiser Distinct and redundant functions of histone deacetylases HDAC1 and HDAC2 in proliferation and tumorigenesis Cell Cycle 10 2011 406 412
    • (2011) Cell Cycle , vol.10 , pp. 406-412
    • Jurkin, J.1    Zupkovitz, G.2    Lagger, S.3    Grausenburger, R.4    Hagelkruys, A.5    Kenner, L.6    Seiser, C.7
  • 62
    • 78751470921 scopus 로고    scopus 로고
    • Structure and function of mammalian DNA methyltransferases
    • R.Z. Jurkowska, T.P. Jurkowski, and A. Jeltsch Structure and function of mammalian DNA methyltransferases Chembiochem 12 2011 206 222
    • (2011) Chembiochem , vol.12 , pp. 206-222
    • Jurkowska, R.Z.1    Jurkowski, T.P.2    Jeltsch, A.3
  • 64
    • 16244400457 scopus 로고    scopus 로고
    • FDA drug approval summary: Azacitidine (5-azacytidine, Vidaza) for injectable suspension
    • E. Kaminskas, A.T. Farrell, Y.C. Wang, R. Sridhara, and R. Pazdur FDA drug approval summary: Azacitidine (5-azacytidine, Vidaza) for injectable suspension Oncologist 10 2005 176 182
    • (2005) Oncologist , vol.10 , pp. 176-182
    • Kaminskas, E.1    Farrell, A.T.2    Wang, Y.C.3    Sridhara, R.4    Pazdur, R.5
  • 66
    • 84930082897 scopus 로고    scopus 로고
    • Kantarjian, H. M. E. E. (2013). Drug Approvals in Acute Myeloid Leukemia: Can We Do Better?. The ASCO Post, 4.
    • Kantarjian, H. M. E. E. (2013). Drug Approvals in Acute Myeloid Leukemia: Can We Do Better?. The ASCO Post, 4.
  • 67
    • 34250634403 scopus 로고    scopus 로고
    • A potential role for epigenetic modulatory drugs in the enhancement of cancer/germ-line antigen vaccine efficacy
    • A.R. Karpf A potential role for epigenetic modulatory drugs in the enhancement of cancer/germ-line antigen vaccine efficacy Epigenetics 1 2006 116 120
    • (2006) Epigenetics , vol.1 , pp. 116-120
    • Karpf, A.R.1
  • 68
    • 84878273525 scopus 로고    scopus 로고
    • The physiological roles of histone deacetylase (HDAC) 1 and 2: Complex co-stars with multiple leading parts
    • R.D. Kelly, and S.M. Cowley The physiological roles of histone deacetylase (HDAC) 1 and 2: Complex co-stars with multiple leading parts Biochem Soc Trans 41 2013 741 749
    • (2013) Biochem Soc Trans , vol.41 , pp. 741-749
    • Kelly, R.D.1    Cowley, S.M.2
  • 69
    • 77955051048 scopus 로고    scopus 로고
    • Role of histone acetylation in cell physiology and diseases: An update
    • S.N. Khan, and A.U. Khan Role of histone acetylation in cell physiology and diseases: An update Clin Chim Acta 411 2010 1401 1411
    • (2010) Clin Chim Acta , vol.411 , pp. 1401-1411
    • Khan, S.N.1    Khan, A.U.2
  • 70
    • 84899849424 scopus 로고    scopus 로고
    • Pharmacokinetics of different formulations of oral azacitidine (CC-486) and the effect of food and modified gastric pH on pharmacokinetics in subjects with hematologic malignancies
    • E. Laille, M.R. Savona, B.L. Scott, T.E. Boyd, Q. Dong, and B. Skikne Pharmacokinetics of different formulations of oral azacitidine (CC-486) and the effect of food and modified gastric pH on pharmacokinetics in subjects with hematologic malignancies J Clin Pharmacol 54 2014 630 639
    • (2014) J Clin Pharmacol , vol.54 , pp. 630-639
    • Laille, E.1    Savona, M.R.2    Scott, B.L.3    Boyd, T.E.4    Dong, Q.5    Skikne, B.6
  • 72
    • 0026708177 scopus 로고
    • Targeted mutation of the DNA methyltransferase gene results in embryonic lethality
    • E. Li, T.H. Bestor, and R. Jaenisch Targeted mutation of the DNA methyltransferase gene results in embryonic lethality Cell 69 1992 915 926
    • (1992) Cell , vol.69 , pp. 915-926
    • Li, E.1    Bestor, T.H.2    Jaenisch, R.3
  • 73
    • 0014872738 scopus 로고
    • Cytotoxicity and mode of action of 5-azacytidine on L1210 leukemia
    • L.H. Li, E.J. Olin, H.H. Buskirk, and L.M. Reineke Cytotoxicity and mode of action of 5-azacytidine on L1210 leukemia Cancer Res 30 1970 2760 2769
    • (1970) Cancer Res , vol.30 , pp. 2760-2769
    • Li, L.H.1    Olin, E.J.2    Buskirk, H.H.3    Reineke, L.M.4
  • 76
    • 84877336241 scopus 로고    scopus 로고
    • Decrease of 5-hydroxymethylcytosine is associated with progression of hepatocellular carcinoma through downregulation of TET1
    • C. Liu, L. Liu, X. Chen, J. Shen, J. Shan, Y. Xu, Z. Yang, L. Wu, F. Xia, P. Bie, Y. Cui, X.W. Bian, and C. Qian Decrease of 5-hydroxymethylcytosine is associated with progression of hepatocellular carcinoma through downregulation of TET1 PLoS ONE 8 2013 e62828
    • (2013) PLoS ONE , vol.8 , pp. e62828
    • Liu, C.1    Liu, L.2    Chen, X.3    Shen, J.4    Shan, J.5    Xu, Y.6    Yang, Z.7    Wu, L.8    Xia, F.9    Bie, P.10    Cui, Y.11    Bian, X.W.12    Qian, C.13
  • 78
    • 84871563384 scopus 로고    scopus 로고
    • MeCP2 binds to 5hmC enriched within active genes and accessible chromatin in the nervous system
    • M. Mellen, P. Ayata, S. Dewell, S. Kriaucionis, and N. Heintz MeCP2 binds to 5hmC enriched within active genes and accessible chromatin in the nervous system Cell 151 2012 1417 1430
    • (2012) Cell , vol.151 , pp. 1417-1430
    • Mellen, M.1    Ayata, P.2    Dewell, S.3    Kriaucionis, S.4    Heintz, N.5
  • 80
    • 34848911647 scopus 로고    scopus 로고
    • DNA methylation: The nuts and bolts of repression
    • T.B. Miranda, and P.A. Jones DNA methylation: The nuts and bolts of repression J Cell Physiol 213 2007 384 390
    • (2007) J Cell Physiol , vol.213 , pp. 384-390
    • Miranda, T.B.1    Jones, P.A.2
  • 82
    • 84881403918 scopus 로고    scopus 로고
    • Activation-induced cytidine deaminase (AID) is necessary for the epithelial-mesenchymal transition in mammary epithelial cells
    • D.P. Munoz, E.L. Lee, S. Takayama, J.P. Coppe, S.J. Heo, D. Boffelli, J.M. Di Noia, and D.I. Martin Activation-induced cytidine deaminase (AID) is necessary for the epithelial-mesenchymal transition in mammary epithelial cells Proc Natl Acad Sci U S A 110 2013 E2977 E2986
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. E2977-E2986
    • Munoz, D.P.1    Lee, E.L.2    Takayama, S.3    Coppe, J.P.4    Heo, S.J.5    Boffelli, D.6    Di Noia, J.M.7    Martin, D.I.8
  • 83
    • 79959987448 scopus 로고    scopus 로고
    • 5-hydroxymethylcytosine, the sixth base of the genome
    • M. Munzel, D. Globisch, and T. Carell 5-hydroxymethylcytosine, the sixth base of the genome Angew Chem Int Ed Engl 50 2011 6460 6468
    • (2011) Angew Chem Int Ed Engl , vol.50 , pp. 6460-6468
    • Munzel, M.1    Globisch, D.2    Carell, T.3
  • 84
    • 0034268780 scopus 로고    scopus 로고
    • Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme
    • M. Muramatsu, K. Kinoshita, S. Fagarasan, S. Yamada, Y. Shinkai, and T. Honjo Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme Cell 102 2000 553 563
    • (2000) Cell , vol.102 , pp. 553-563
    • Muramatsu, M.1    Kinoshita, K.2    Fagarasan, S.3    Yamada, S.4    Shinkai, Y.5    Honjo, T.6
  • 86
    • 0033615717 scopus 로고    scopus 로고
    • DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development
    • M. Okano, D.W. Bell, D.A. Haber, and E. Li DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development Cell 99 1999 247 257
    • (1999) Cell , vol.99 , pp. 247-257
    • Okano, M.1    Bell, D.W.2    Haber, D.A.3    Li, E.4
  • 87
    • 0031860739 scopus 로고    scopus 로고
    • Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases
    • M. Okano, S. Xie, and E. Li Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases Nat Genet 19 1998 219 220
    • (1998) Nat Genet , vol.19 , pp. 219-220
    • Okano, M.1    Xie, S.2    Li, E.3
  • 89
    • 84864053192 scopus 로고    scopus 로고
    • Decreased 5-hydroxymethylcytosine is associated with neural progenitor phenotype in normal brain and shorter survival in malignant glioma
    • B.A. Orr, M.C. Haffner, W.G. Nelson, S. Yegnasubramanian, and C.G. Eberhart Decreased 5-hydroxymethylcytosine is associated with neural progenitor phenotype in normal brain and shorter survival in malignant glioma PLoS ONE 7 2012 e41036
    • (2012) PLoS ONE , vol.7 , pp. e41036
    • Orr, B.A.1    Haffner, M.C.2    Nelson, W.G.3    Yegnasubramanian, S.4    Eberhart, C.G.5
  • 90
    • 84863604791 scopus 로고    scopus 로고
    • Between a chicken and a grape: Estimating the number of human genes
    • M. Pertea, and S.L. Salzberg Between a chicken and a grape: Estimating the number of human genes Genome Biol 11 2010 206
    • (2010) Genome Biol , vol.11 , pp. 206
    • Pertea, M.1    Salzberg, S.L.2
  • 92
    • 84893004880 scopus 로고    scopus 로고
    • Getting rid of DNA methylation
    • F.M. Piccolo, and A.G. Fisher Getting rid of DNA methylation Trends Cell Biol 24 2014 136 143
    • (2014) Trends Cell Biol , vol.24 , pp. 136-143
    • Piccolo, F.M.1    Fisher, A.G.2
  • 93
    • 67650462249 scopus 로고    scopus 로고
    • DNA hypomethylation in the origin and pathogenesis of human diseases
    • I.P. Pogribny, and F.A. Beland DNA hypomethylation in the origin and pathogenesis of human diseases Cell Mol Life Sci 66 2009 2249 2261
    • (2009) Cell Mol Life Sci , vol.66 , pp. 2249-2261
    • Pogribny, I.P.1    Beland, F.A.2
  • 94
    • 77957970301 scopus 로고    scopus 로고
    • Epigenetic modifications and human disease
    • A. Portela, and M. Esteller Epigenetic modifications and human disease Nat Biotechnol 28 2010 1057 1068
    • (2010) Nat Biotechnol , vol.28 , pp. 1057-1068
    • Portela, A.1    Esteller, M.2
  • 95
    • 0032722062 scopus 로고    scopus 로고
    • Recombinant human DNA (cytosine-5) methyltransferase. I. Expression, purification, and comparison of de novo and maintenance methylation
    • S. Pradhan, A. Bacolla, R.D. Wells, and R.J. Roberts Recombinant human DNA (cytosine-5) methyltransferase. I. Expression, purification, and comparison of de novo and maintenance methylation J Biol Chem 274 1999 33002 33010
    • (1999) J Biol Chem , vol.274 , pp. 33002-33010
    • Pradhan, S.1    Bacolla, A.2    Wells, R.D.3    Roberts, R.J.4
  • 96
    • 60249094793 scopus 로고    scopus 로고
    • Mechanisms of resistance to 5-aza-2′-deoxycytidine in human cancer cell lines
    • T. Qin, J. Jelinek, J. Si, J. Shu, and J.P. Issa Mechanisms of resistance to 5-aza-2′-deoxycytidine in human cancer cell lines Blood 113 2009 659 667
    • (2009) Blood , vol.113 , pp. 659-667
    • Qin, T.1    Jelinek, J.2    Si, J.3    Shu, J.4    Issa, J.P.5
  • 97
    • 0034625064 scopus 로고    scopus 로고
    • Non-CpG methylation is prevalent in embryonic stem cells and may be mediated by DNA methyltransferase 3a
    • B.H. Ramsahoye, D. Biniszkiewicz, F. Lyko, V. Clark, A.P. Bird, and R. Jaenisch Non-CpG methylation is prevalent in embryonic stem cells and may be mediated by DNA methyltransferase 3a Proc Natl Acad Sci U S A 97 2000 5237 5242
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 5237-5242
    • Ramsahoye, B.H.1    Biniszkiewicz, D.2    Lyko, F.3    Clark, V.4    Bird, A.P.5    Jaenisch, R.6
  • 98
    • 79952111963 scopus 로고    scopus 로고
    • Nucleosome dynamics and histone variants
    • D. Ray-Gallet, and G. Almouzni Nucleosome dynamics and histone variants Essays Biochem 48 2010 75 87
    • (2010) Essays Biochem , vol.48 , pp. 75-87
    • Ray-Gallet, D.1    Almouzni, G.2
  • 99
    • 0035839126 scopus 로고    scopus 로고
    • Epigenetic reprogramming in mammalian development
    • W. Reik, W. Dean, and J. Walter Epigenetic reprogramming in mammalian development Science 293 2001 1089 1093
    • (2001) Science , vol.293 , pp. 1089-1093
    • Reik, W.1    Dean, W.2    Walter, J.3
  • 100
    • 0038392721 scopus 로고    scopus 로고
    • Catalytic mechanism of DNA-(cytosine-C5)-methyltransferases revisited: Covalent intermediate formation is not essential for methyl group transfer by the murine Dnmt3a enzyme
    • S. Reither, F. Li, H. Gowher, and A. Jeltsch Catalytic mechanism of DNA-(cytosine-C5)-methyltransferases revisited: covalent intermediate formation is not essential for methyl group transfer by the murine Dnmt3a enzyme J Mol Biol 329 2003 675 684
    • (2003) J Mol Biol , vol.329 , pp. 675-684
    • Reither, S.1    Li, F.2    Gowher, H.3    Jeltsch, A.4
  • 103
    • 0033153303 scopus 로고    scopus 로고
    • The human DNA methyltransferases (DNMTs) 1, 3a and 3b: Coordinate mRNA expression in normal tissues and overexpression in tumors
    • K.D. Robertson, E. Uzvolgyi, G. Liang, C. Talmadge, J. Sumegi, F.A. Gonzales, and P.A. Jones The human DNA methyltransferases (DNMTs) 1, 3a and 3b: Coordinate mRNA expression in normal tissues and overexpression in tumors Nucleic Acids Res 27 1999 2291 2298
    • (1999) Nucleic Acids Res , vol.27 , pp. 2291-2298
    • Robertson, K.D.1    Uzvolgyi, E.2    Liang, G.3    Talmadge, C.4    Sumegi, J.5    Gonzales, F.A.6    Jones, P.A.7
  • 104
    • 84889068258 scopus 로고    scopus 로고
    • An HDAC in the cytoplasm, not the nucleus, plays a pathogenic role in Huntington's disease
    • R. Robinson An HDAC in the cytoplasm, not the nucleus, plays a pathogenic role in Huntington's disease PLoS Biol 11 2013 e1001718
    • (2013) PLoS Biol , vol.11 , pp. e1001718
    • Robinson, R.1
  • 105
    • 84892363964 scopus 로고    scopus 로고
    • Histone deacetylases and their inhibitors: New implications for asthma and chronic respiratory conditions
    • S.G. Royce, and T.C. Karagiannis Histone deacetylases and their inhibitors: New implications for asthma and chronic respiratory conditions Curr Opin Allergy Clin Immunol 14 2014 44 48
    • (2014) Curr Opin Allergy Clin Immunol , vol.14 , pp. 44-48
    • Royce, S.G.1    Karagiannis, T.C.2
  • 106
    • 70149105669 scopus 로고    scopus 로고
    • The role of human bromodomains in chromatin biology and gene transcription
    • R. Sanchez, and M.M. Zhou The role of human bromodomains in chromatin biology and gene transcription Curr Opin Drug Discov Devel 12 2009 659 665
    • (2009) Curr Opin Drug Discov Devel , vol.12 , pp. 659-665
    • Sanchez, R.1    Zhou, M.M.2
  • 107
    • 84858439628 scopus 로고    scopus 로고
    • Cancer epigenomics: Beyond genomics
    • J. Sandoval, and M. Esteller Cancer epigenomics: Beyond genomics Curr Opin Genet Dev 22 2012 50 55
    • (2012) Curr Opin Genet Dev , vol.22 , pp. 50-55
    • Sandoval, J.1    Esteller, M.2
  • 108
    • 0036145567 scopus 로고    scopus 로고
    • Dynamic reprogramming of DNA methylation in the early mouse embryo
    • F. Santos, B. Hendrich, W. Reik, and W. Dean Dynamic reprogramming of DNA methylation in the early mouse embryo Dev Biol 241 2002 172 182
    • (2002) Dev Biol , vol.241 , pp. 172-182
    • Santos, F.1    Hendrich, B.2    Reik, W.3    Dean, W.4
  • 109
    • 74049130225 scopus 로고    scopus 로고
    • Solving the Dnmt2 enigma
    • M. Schaefer, and F. Lyko Solving the Dnmt2 enigma Chromosoma 119 2010 35 40
    • (2010) Chromosoma , vol.119 , pp. 35-40
    • Schaefer, M.1    Lyko, F.2
  • 110
    • 43949136445 scopus 로고    scopus 로고
    • Modes of action of the DNA methyltransferase inhibitors azacytidine and decitabine
    • C. Stresemann, and F. Lyko Modes of action of the DNA methyltransferase inhibitors azacytidine and decitabine Int J Cancer 123 2008 8 13
    • (2008) Int J Cancer , vol.123 , pp. 8-13
    • Stresemann, C.1    Lyko, F.2
  • 111
    • 0032030770 scopus 로고    scopus 로고
    • Histone acetylation and transcriptional regulatory mechanisms
    • K. Struhl Histone acetylation and transcriptional regulatory mechanisms Genes Dev 12 1998 599 606
    • (1998) Genes Dev , vol.12 , pp. 599-606
    • Struhl, K.1
  • 113
    • 84891135858 scopus 로고    scopus 로고
    • Histone deacetylases in cardiac fibrosis: Current perspectives for therapy
    • H. Tao, K.H. Shi, J.J. Yang, C. Huang, H.Y. Zhan, and J. Li Histone deacetylases in cardiac fibrosis: Current perspectives for therapy Cell Signal 26 2014 521 527
    • (2014) Cell Signal , vol.26 , pp. 521-527
    • Tao, H.1    Shi, K.H.2    Yang, J.J.3    Huang, C.4    Zhan, H.Y.5    Li, J.6
  • 115
    • 84859817450 scopus 로고    scopus 로고
    • The role of methylation in the intrinsic dynamics of B- and Z-DNA
    • N.A. Temiz, D.E. Donohue, A. Bacolla, B.T. Luke, and J.R. Collins The role of methylation in the intrinsic dynamics of B- and Z-DNA PLoS ONE 7 2012 e35558
    • (2012) PLoS ONE , vol.7 , pp. e35558
    • Temiz, N.A.1    Donohue, D.E.2    Bacolla, A.3    Luke, B.T.4    Collins, J.R.5
  • 118
    • 0033569641 scopus 로고    scopus 로고
    • Epigenetics: Regulation through repression
    • A.P. Wolffe, and M.A. Matzke Epigenetics: Regulation through repression Science 286 1999 481 486
    • (1999) Science , vol.286 , pp. 481-486
    • Wolffe, A.P.1    Matzke, M.A.2
  • 121
    • 84880148510 scopus 로고    scopus 로고
    • Epigenetics: Reversible tags
    • J. Wright Epigenetics: Reversible tags Nature 498 2013 S10 S11
    • (2013) Nature , vol.498 , pp. S10-S11
    • Wright, J.1
  • 122
    • 79956292024 scopus 로고    scopus 로고
    • Dual functions of Tet1 in transcriptional regulation in mouse embryonic stem cells
    • H. Wu, A.C. D'Alessio, S. Ito, K. Xia, Z. Wang, K. Cui, K. Zhao, Y.E. Sun, and Y. Zhang Dual functions of Tet1 in transcriptional regulation in mouse embryonic stem cells Nature 473 2011 389 393
    • (2011) Nature , vol.473 , pp. 389-393
    • Wu, H.1    D'Alessio, A.C.2    Ito, S.3    Xia, K.4    Wang, Z.5    Cui, K.6    Zhao, K.7    Sun, Y.E.8    Zhang, Y.9
  • 123
    • 80053572636 scopus 로고    scopus 로고
    • Evidence for non-CpG methylation in mammals
    • J. Yan, J.R. Zierath, and R. Barres Evidence for non-CpG methylation in mammals Exp Cell Res 317 2011 2555 2561
    • (2011) Exp Cell Res , vol.317 , pp. 2555-2561
    • Yan, J.1    Zierath, J.R.2    Barres, R.3
  • 125
    • 77958150580 scopus 로고    scopus 로고
    • Targeting DNA methylation for epigenetic therapy
    • X. Yang, F. Lay, H. Han, and P.A. Jones Targeting DNA methylation for epigenetic therapy Trends Pharmacol Sci 31 2010 536 546
    • (2010) Trends Pharmacol Sci , vol.31 , pp. 536-546
    • Yang, X.1    Lay, F.2    Han, H.3    Jones, P.A.4
  • 126
    • 34547924046 scopus 로고    scopus 로고
    • HATs and HDACs: From structure, function and regulation to novel strategies for therapy and prevention
    • X.J. Yang, and E. Seto HATs and HDACs: From structure, function and regulation to novel strategies for therapy and prevention Oncogene 26 2007 5310 5318
    • (2007) Oncogene , vol.26 , pp. 5310-5318
    • Yang, X.J.1    Seto, E.2
  • 127
    • 79952204427 scopus 로고    scopus 로고
    • Beyond histone and deacetylase: An overview of cytoplasmic histone deacetylases and their nonhistone substrates
    • Y.L. Yao, and W.M. Yang Beyond histone and deacetylase: An overview of cytoplasmic histone deacetylases and their nonhistone substrates J Biomed Biotechnol 2011 2011 146493
    • (2011) J Biomed Biotechnol , vol.2011 , pp. 146493
    • Yao, Y.L.1    Yang, W.M.2
  • 128
    • 84988375135 scopus 로고    scopus 로고
    • 5-hydroxymethylcytosine: A new insight into epigenetics in cancer
    • C. Ye, and L. Li 5-hydroxymethylcytosine: A new insight into epigenetics in cancer Cancer Biol Ther 15 2013
    • (2013) Cancer Biol Ther , vol.15
    • Ye, C.1    Li, L.2
  • 130
    • 33644856123 scopus 로고    scopus 로고
    • Epigenetic therapy of cancer: Past, present and future
    • C.B. Yoo, and P.A. Jones Epigenetic therapy of cancer: Past, present and future Nat Rev Drug Discov 5 2006 37 50
    • (2006) Nat Rev Drug Discov , vol.5 , pp. 37-50
    • Yoo, C.B.1    Jones, P.A.2
  • 131
    • 84876737019 scopus 로고    scopus 로고
    • Molecular modeling studies of the novel inhibitors of DNA methyltransferases SGI-1027 and CBC12: Implications for the mechanism of inhibition of DNMTs
    • J. Yoo, S. Choi, and J.L. Medina-Franco Molecular modeling studies of the novel inhibitors of DNA methyltransferases SGI-1027 and CBC12: Implications for the mechanism of inhibition of DNMTs PLoS ONE 8 2013 e62152
    • (2013) PLoS ONE , vol.8 , pp. e62152
    • Yoo, J.1    Choi, S.2    Medina-Franco, J.L.3
  • 132
    • 84873489946 scopus 로고    scopus 로고
    • Inhibition of cancer cell proliferation by 5-fluoro-2′-deoxycytidine, a DNA methylation inhibitor, through activation of DNA damage response pathway
    • Q. Zhao, J. Fan, W. Hong, L. Li, and M. Wu Inhibition of cancer cell proliferation by 5-fluoro-2′-deoxycytidine, a DNA methylation inhibitor, through activation of DNA damage response pathway Springerplus 1 2012 65
    • (2012) Springerplus , vol.1 , pp. 65
    • Zhao, Q.1    Fan, J.2    Hong, W.3    Li, L.4    Wu, M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.