Activation-induced cytidine deaminase auto-activates and triggers aberrant gene expression

FEBS Letters

Volumn 587, Issue 16, 2013, Pages 2487-2492

  Isobe, Tomoyasu ^a,b   Song, Soken Nakazawa J ^a   Tiwari, Prabha ^a   Ito, Hiroki ^a   Yamaguchi, Yuki ^b   Yoshizaki, Kazuyuki ^a,c  

^a OSAKA UNIVERSITY   (Japan)

^b TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

^c Tokusyukai Medical Cooperation   (Japan)

Author keywords

AID; Demethylation; Pax5

Indexed keywords

ACTIVATION INDUCED CYTIDINE DEAMINASE; GENOMIC DNA; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45; TRANSCRIPTION FACTOR PAX5;

ANIMAL CELL; ARTICLE; DNA METHYLATION; ENZYME ACTIVATION; GENE CONSTRUCT; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; REPORTER GENE;

5-AZA-2′-DEOXYCYTIDINE; 5-AZA-DC; AID; CHIP; CHROMATIN IMMUNOPRECIPITATION; COBRA; COMBINED BISULFITE RESTRICTION ANALYSIS; DEMETHYLATION; GADD45; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45; H-RAS; HARVEY RAT SARCOMA VIRAL ONCOGENE HOMOLOG; HERPES SIMPLEX VIRUS-THYMIDINE KINASE; HSV-TK; NF-ΚB; NUCLEAR FACTOR-ΚB; PAIRED BOX GENE 5; PAX5; PGCS; PRIMORDIAL GERM CELLS; QRT-PCR; QUANTITATIVE RT-PCR; REVERSE TRANSCRIPTION-POLYMERASE CHAIN REACTION; RT-PCR; SIMIAN VACUOLATING VIRUS 40; SV40; TNFΑ; TRANSCRIPTION START SITE; TSS; TUMOR NECROSIS FACTOR Α;

B-CELL-SPECIFIC ACTIVATOR PROTEIN; CELL CYCLE PROTEINS; CPG ISLANDS; CYTIDINE DEAMINASE; DNA METHYLATION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; HEK293 CELLS; HELA CELLS; HUMANS; NUCLEAR PROTEINS; POINT MUTATION; PROMOTER REGIONS, GENETIC; PROTEIN BINDING;

EID: 84881479358     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2013.06.028     Document Type: Article

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